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That's the Way You Do It.

Roop RM 2nd.

J Bacteriol. 2019 May 22;201(12). pii: e00216-19. doi: 10.1128/JB.00216-19. Print 2019 Jun 15.


Identifying the region responsible for Brucella abortus MucR higher-order oligomer formation and examining its role in gene regulation.

Pirone L, Pitzer JE, D'Abrosca G, Fattorusso R, Malgieri G, Pedone EM, Pedone PV, Roop RM 2nd, Baglivo I.

Sci Rep. 2018 Nov 22;8(1):17238. doi: 10.1038/s41598-018-35432-1.


The Manganese-Dependent Pyruvate Kinase PykM Is Required for Wild-Type Glucose Utilization by Brucella abortus 2308 and Its Virulence in C57BL/6 Mice.

Pitzer JE, Zeczycki TN, Baumgartner JE, Martin DW, Roop RM 2nd.

J Bacteriol. 2018 Nov 26;200(24). pii: e00471-18. doi: 10.1128/JB.00471-18. Print 2018 Dec 15.


Endoribonuclease YbeY Is Linked to Proper Cellular Morphology and Virulence in Brucella abortus.

Budnick JA, Sheehan LM, Colquhoun JM, Dunman PM, Walker GC, Roop RM 2nd, Caswell CC.

J Bacteriol. 2018 May 24;200(12). pii: e00105-18. doi: 10.1128/JB.00105-18. Print 2018 Jun 15.


Just When We Thought We Knew Everything We Needed To Know about Zn Acquisition and Bacterial Pathogenesis.

Roop RM 2nd.

J Bacteriol. 2018 Jan 24;200(4). pii: e00694-17. doi: 10.1128/JB.00694-17. Print 2018 Feb 15.


Transcriptome-Wide Identification of Hfq-Associated RNAs in Brucella suis by Deep Sequencing.

Saadeh B, Caswell CC, Chao Y, Berta P, Wattam AR, Roop RM 2nd, O'Callaghan D.

J Bacteriol. 2015 Nov 9;198(3):427-35. doi: 10.1128/JB.00711-15. Print 2016 Feb 1.


The quest for a true One Health perspective of brucellosis.

Godfroid J, DeBolle X, Roop RM, O'Callaghan D, Tsolis RM, Baldwin C, Santos RL, McGiven J, Olsen S, Nymo IH, Larsen A, Al Dahouk S, Letesson JJ.

Rev Sci Tech. 2014 Aug;33(2):521-38. Review.


Coordinated zinc homeostasis is essential for the wild-type virulence of Brucella abortus.

Sheehan LM, Budnick JA, Roop RM 2nd, Caswell CC.

J Bacteriol. 2015 May;197(9):1582-91. doi: 10.1128/JB.02543-14. Epub 2015 Feb 17.


Bacterial persistence: finding the "sweet spot".

Roop RM 2nd, Caswell CC.

Cell Host Microbe. 2013 Aug 14;14(2):119-20. doi: 10.1016/j.chom.2013.07.016.


The ferrous iron transporter FtrABCD is required for the virulence of Brucella abortus 2308 in mice.

Elhassanny AE, Anderson ES, Menscher EA, Roop RM 2nd.

Mol Microbiol. 2013 Jun;88(6):1070-82. doi: 10.1111/mmi.12242. Epub 2013 May 5.


The Brucella abortus general stress response system regulates chronic mammalian infection and is controlled by phosphorylation and proteolysis.

Kim HS, Caswell CC, Foreman R, Roop RM 2nd, Crosson S.

J Biol Chem. 2013 May 10;288(19):13906-16. doi: 10.1074/jbc.M113.459305. Epub 2013 Apr 1.


Diverse genetic regulon of the virulence-associated transcriptional regulator MucR in Brucella abortus 2308.

Caswell CC, Elhassanny AE, Planchin EE, Roux CM, Weeks-Gorospe JN, Ficht TA, Dunman PM, Roop RM 2nd.

Infect Immun. 2013 Apr;81(4):1040-51. doi: 10.1128/IAI.01097-12. Epub 2013 Jan 14.


Characterization of the organic hydroperoxide resistance system of Brucella abortus 2308.

Caswell CC, Baumgartner JE, Martin DW, Roop RM 2nd.

J Bacteriol. 2012 Sep;194(18):5065-72. doi: 10.1128/JB.00873-12. Epub 2012 Jul 20.


The bhuQ gene encodes a heme oxygenase that contributes to the ability of Brucella abortus 2308 to use heme as an iron source and is regulated by Irr.

Ojeda JF, Martinson DA, Menscher EA, Roop RM 2nd.

J Bacteriol. 2012 Aug;194(15):4052-8. doi: 10.1128/JB.00367-12. Epub 2012 May 25.


Metal acquisition and virulence in Brucella.

Roop RM 2nd.

Anim Health Res Rev. 2012 Jun;13(1):10-20. doi: 10.1017/S1466252312000047. Epub 2012 May 25. Review.


Redox-responsive regulation of denitrification genes in Brucella.

Roop RM 2nd, Caswell CC.

Mol Microbiol. 2012 Jul;85(1):5-7. doi: 10.1111/j.1365-2958.2012.08096.x. Epub 2012 May 30.


SodA is a major metabolic antioxidant in Brucella abortus 2308 that plays a significant, but limited, role in the virulence of this strain in the mouse model.

Martin DW, Baumgartner JE, Gee JM, Anderson ES, Roop RM 2nd.

Microbiology. 2012 Jul;158(Pt 7):1767-74. doi: 10.1099/mic.0.059584-0. Epub 2012 May 3.


Mur regulates the gene encoding the manganese transporter MntH in Brucella abortus 2308.

Menscher EA, Caswell CC, Anderson ES, Roop RM 2nd.

J Bacteriol. 2012 Feb;194(3):561-6. doi: 10.1128/JB.05296-11. Epub 2011 Nov 18.


The RNA chaperone Hfq independently coordinates expression of the VirB type IV secretion system and the LuxR-type regulator BabR in Brucella abortus 2308.

Caswell CC, Gaines JM, Roop RM 2nd.

J Bacteriol. 2012 Jan;194(1):3-14. doi: 10.1128/JB.05623-11. Epub 2011 Oct 21.


The iron-responsive regulator irr is required for wild-type expression of the gene encoding the heme transporter BhuA in Brucella abortus 2308.

Anderson ES, Paulley JT, Martinson DA, Gaines JM, Steele KH, Roop RM 2nd.

J Bacteriol. 2011 Oct;193(19):5359-64. doi: 10.1128/JB.00372-11. Epub 2011 Jul 29.


Comparative study of the roles of AhpC and KatE as respiratory antioxidants in Brucella abortus 2308.

Steele KH, Baumgartner JE, Valderas MW, Roop RM 2nd.

J Bacteriol. 2010 Oct;192(19):4912-22. doi: 10.1128/JB.00231-10. Epub 2010 Jul 30.


Subversion of innate immune responses by Brucella through the targeted degradation of the TLR signaling adapter, MAL.

Sengupta D, Koblansky A, Gaines J, Brown T, West AP, Zhang D, Nishikawa T, Park SG, Roop RM 2nd, Ghosh S.

J Immunol. 2010 Jan 15;184(2):956-64. doi: 10.4049/jimmunol.0902008. Epub 2009 Dec 14.


Survival of the fittest: how Brucella strains adapt to their intracellular niche in the host.

Roop RM 2nd, Gaines JM, Anderson ES, Caswell CC, Martin DW.

Med Microbiol Immunol. 2009 Nov;198(4):221-38. doi: 10.1007/s00430-009-0123-8. Epub 2009 Sep 22. Review.


The manganese transporter MntH is a critical virulence determinant for Brucella abortus 2308 in experimentally infected mice.

Anderson ES, Paulley JT, Gaines JM, Valderas MW, Martin DW, Menscher E, Brown TD, Burns CS, Roop RM 2nd.

Infect Immun. 2009 Aug;77(8):3466-74. doi: 10.1128/IAI.00444-09. Epub 2009 Jun 1.


Broad-host-range expression vectors with tightly regulated promoters and their use to examine the influence of TraR and TraM expression on Ti plasmid quorum sensing.

Khan SR, Gaines J, Roop RM 2nd, Farrand SK.

Appl Environ Microbiol. 2008 Aug;74(16):5053-62. doi: 10.1128/AEM.01098-08. Epub 2008 Jul 7.


Brucella abortus requires the heme transporter BhuA for maintenance of chronic infection in BALB/c mice.

Paulley JT, Anderson ES, Roop RM 2nd.

Infect Immun. 2007 Nov;75(11):5248-54. Epub 2007 Aug 20.


Brucella abortus bacA mutant induces greater pro-inflammatory cytokines than the wild-type parent strain.

Parent MA, Goenka R, Murphy E, Levier K, Carreiro N, Golding B, Ferguson G, Roop RM 2nd, Walker GC, Baldwin CL.

Microbes Infect. 2007 Jan;9(1):55-62. Epub 2006 Dec 11.


RecA and RadA proteins of Brucella abortus do not perform overlapping protective DNA repair functions following oxidative burst.

Roux CM, Booth NJ, Bellaire BH, Gee JM, Roop RM 2nd, Kovach ME, Tsolis RM, Elzer PH, Ennis DG.

J Bacteriol. 2006 Jul;188(14):5187-95.


Role of HdeA in acid resistance and virulence in Brucella abortus 2308.

Valderas MW, Alcantara RB, Baumgartner JE, Bellaire BH, Robertson GT, Ng WL, Richardson JM, Winkler ME, Roop RM 2nd.

Vet Microbiol. 2005 May 20;107(3-4):307-12.


The Brucella abortus Cu,Zn superoxide dismutase is required for optimal resistance to oxidative killing by murine macrophages and wild-type virulence in experimentally infected mice.

Gee JM, Valderas MW, Kovach ME, Grippe VK, Robertson GT, Ng WL, Richardson JM, Winkler ME, Roop RM 2nd.

Infect Immun. 2005 May;73(5):2873-80.


Role of catalase in the virulence of Brucella melitensis in pregnant goats.

Gee JM, Kovach ME, Grippe VK, Hagius S, Walker JV, Elzer PH, Roop RM 2nd.

Vet Microbiol. 2004 Aug 19;102(1-2):111-5.


Intact purine biosynthesis pathways are required for wild-type virulence of Brucella abortus 2308 in the BALB/c mouse model.

Alcantara RB, Read RD, Valderas MW, Brown TD, Roop RM 2nd.

Infect Immun. 2004 Aug;72(8):4911-7.


Adaptation of the Brucellae to their intracellular niche.

Roop RM 2nd, Bellaire BH, Valderas MW, Cardelli JA.

Mol Microbiol. 2004 May;52(3):621-30. Review.


Similarity to peroxisomal-membrane protein family reveals that Sinorhizobium and Brucella BacA affect lipid-A fatty acids.

Ferguson GP, Datta A, Baumgartner J, Roop RM 2nd, Carlson RW, Walker GC.

Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):5012-7. Epub 2004 Mar 24.


Brucella stationary-phase gene expression and virulence.

Roop RM 2nd, Gee JM, Robertson GT, Richardson JM, Ng WL, Winkler ME.

Annu Rev Microbiol. 2003;57:57-76. Epub 2003 May 1. Review.


Interactions between Brucella melitensis and human phagocytes: bacterial surface O-Polysaccharide inhibits phagocytosis, bacterial killing, and subsequent host cell apoptosis.

Fernandez-Prada CM, Zelazowska EB, Nikolich M, Hadfield TL, Roop RM 2nd, Robertson GL, Hoover DL.

Infect Immun. 2003 Apr;71(4):2110-9.


Seeking a niche: putative contributions of the hfq and bacA gene products to the successful adaptation of the brucellae to their intracellular home.

Roop RM 2nd, Robertson GT, Ferguson GP, Milford LE, Winkler ME, Walker GC.

Vet Microbiol. 2002 Dec 20;90(1-4):349-63. Review.


Brucella abortus siderophore 2,3-dihydroxybenzoic acid (DHBA) facilitates intracellular survival of the bacteria.

Parent MA, Bellaire BH, Murphy EA, Roop RM 2nd, Elzer PH, Baldwin CL.

Microb Pathog. 2002 May;32(5):239-48.


Re-examination of the role of the Brucella melitensis HtrA stress response protease in virulence in pregnant goats.

Roop RM 2nd, Phillips RW, Hagius S, Walker JV, Booth NJ, Fulton WT, Edmonds MD, Elzer PH.

Vet Microbiol. 2001 Sep 3;82(1):91-5.


Attenuation and immunogenicity of a Brucella abortus htrA cycL double mutant in cattle.

Edmonds M, Booth N, Hagius S, Walker J, Enright F, Roop RM 2nd, Elzer P.

Vet Microbiol. 2000 Sep 15;76(1):81-90.


The Brucella abortus CcrM DNA methyltransferase is essential for viability, and its overexpression attenuates intracellular replication in murine macrophages.

Robertson GT, Reisenauer A, Wright R, Jensen RB, Jensen A, Shapiro L, Roop RM 2nd.

J Bacteriol. 2000 Jun;182(12):3482-9.


Similar requirements of a plant symbiont and a mammalian pathogen for prolonged intracellular survival.

LeVier K, Phillips RW, Grippe VK, Roop RM 2nd, Walker GC.

Science. 2000 Mar 31;287(5462):2492-3.

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