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How the Membrane Attack Complex Damages the Bacterial Cell Envelope and Kills Gram-Negative Bacteria.

Doorduijn DJ, Rooijakkers SHM, Heesterbeek DAC.

Bioessays. 2019 Oct;41(10):e1900074. doi: 10.1002/bies.201900074. Epub 2019 Aug 26. Review.


Publisher Correction: Complement-dependent outer membrane perturbation sensitizes Gram-negative bacteria to Gram-positive specific antibiotics.

Heesterbeek DAC, Martin NI, Velthuizen A, Duijst M, Ruyken M, Wubbolts R, Rooijakkers SHM, Bardoel BW.

Sci Rep. 2019 May 21;9(1):7841. doi: 10.1038/s41598-019-43208-4.


Complement-dependent outer membrane perturbation sensitizes Gram-negative bacteria to Gram-positive specific antibiotics.

Heesterbeek DAC, Martin NI, Velthuizen A, Duijst M, Ruyken M, Wubbolts R, Rooijakkers SHM, Bardoel BW.

Sci Rep. 2019 Feb 28;9(1):3074. doi: 10.1038/s41598-019-38577-9. Erratum in: Sci Rep. 2019 May 21;9(1):7841.


Bacterial killing by complement requires membrane attack complex formation via surface-bound C5 convertases.

Heesterbeek DA, Bardoel BW, Parsons ES, Bennett I, Ruyken M, Doorduijn DJ, Gorham RD Jr, Berends ET, Pyne AL, Hoogenboom BW, Rooijakkers SH.

EMBO J. 2019 Feb 15;38(4). pii: e99852. doi: 10.15252/embj.201899852. Epub 2019 Jan 14.


Complement and Bacterial Infections: From Molecular Mechanisms to Therapeutic Applications.

Heesterbeek DAC, Angelier ML, Harrison RA, Rooijakkers SHM.

J Innate Immun. 2018;10(5-6):455-464. doi: 10.1159/000491439. Epub 2018 Aug 27. Review.


Functional Characterization of Alternative and Classical Pathway C3/C5 Convertase Activity and Inhibition Using Purified Models.

Zwarthoff SA, Berends ETM, Mol S, Ruyken M, Aerts PC, Józsi M, de Haas CJC, Rooijakkers SHM, Gorham RD Jr.

Front Immunol. 2018 Jul 23;9:1691. doi: 10.3389/fimmu.2018.01691. eCollection 2018.


Differential antibacterial control by neutrophil subsets.

Leliefeld PHC, Pillay J, Vrisekoop N, Heeres M, Tak T, Kox M, Rooijakkers SHM, Kuijpers TW, Pickkers P, Leenen LPH, Koenderman L.

Blood Adv. 2018 Jun 12;2(11):1344-1355. doi: 10.1182/bloodadvances.2017015578.


Group IIA-Secreted Phospholipase A2 in Human Serum Kills Commensal but Not Clinical Enterococcus faecium Isolates.

Paganelli FL, Leavis HL, He S, van Sorge NM, Payré C, Lambeau G, Willems RJL, Rooijakkers SHM.

Infect Immun. 2018 Jul 23;86(8). pii: e00180-18. doi: 10.1128/IAI.00180-18. Print 2018 Aug.


Identification of a staphylococcal complement inhibitor with broad host specificity in equid Staphylococcus aureus strains.

de Jong NWM, Vrieling M, Garcia BL, Koop G, Brettmann M, Aerts PC, Ruyken M, van Strijp JAG, Holmes M, Harrison EM, Geisbrecht BV, Rooijakkers SHM.

J Biol Chem. 2018 Mar 23;293(12):4468-4477. doi: 10.1074/jbc.RA117.000599. Epub 2018 Feb 5.


Evidence for multiple modes of neutrophil serine protease recognition by the EAP family of Staphylococcal innate immune evasion proteins.

Stapels DAC, Woehl JL, Milder FJ, Tromp AT, van Batenburg AA, de Graaf WC, Broll SC, White NM, Rooijakkers SHM, Geisbrecht BV.

Protein Sci. 2018 Feb;27(2):509-522. doi: 10.1002/pro.3342. Epub 2017 Nov 21.


Acquisition of C1 inhibitor by Bordetella pertussis virulence associated gene 8 results in C2 and C4 consumption away from the bacterial surface.

Hovingh ES, van den Broek B, Kuipers B, Pinelli E, Rooijakkers SHM, Jongerius I.

PLoS Pathog. 2017 Jul 24;13(7):e1006531. doi: 10.1371/journal.ppat.1006531. eCollection 2017 Jul.


Let's Tie the Knot: Marriage of Complement and Adaptive Immunity in Pathogen Evasion, for Better or Worse.

Bennett KM, Rooijakkers SH, Gorham RD Jr.

Front Microbiol. 2017 Jan 31;8:89. doi: 10.3389/fmicb.2017.00089. eCollection 2017. Review.


Excretions/secretions from medicinal larvae (Lucilia sericata) inhibit complement activation by two mechanisms.

Tamura T, Cazander G, Rooijakkers SH, Trouw LA, Nibbering PH.

Wound Repair Regen. 2017 Jan;25(1):41-50. doi: 10.1111/wrr.12504. Epub 2017 Mar 6.


Novel Evasion Mechanisms of the Classical Complement Pathway.

Garcia BL, Zwarthoff SA, Rooijakkers SH, Geisbrecht BV.

J Immunol. 2016 Sep 15;197(6):2051-60. doi: 10.4049/jimmunol.1600863. Review.


Complement resistance mechanisms of Klebsiella pneumoniae.

Doorduijn DJ, Rooijakkers SH, van Schaik W, Bardoel BW.

Immunobiology. 2016 Oct;221(10):1102-9. doi: 10.1016/j.imbio.2016.06.014. Epub 2016 Jun 16. Review.


The Staphylococcus aureus polysaccharide capsule and Efb-dependent fibrinogen shield act in concert to protect against phagocytosis.

Kuipers A, Stapels DAC, Weerwind LT, Ko YP, Ruyken M, Lee JC, van Kessel KPM, Rooijakkers SHM.

Microbiology. 2016 Jul;162(7):1185-1194. doi: 10.1099/mic.0.000293. Epub 2016 Apr 25.


Discovery of Small Molecules for Fluorescent Detection of Complement Activation Product C3d.

Gorham RD Jr, Nuñez V, Lin JH, Rooijakkers SH, Vullev VI, Morikis D.

J Med Chem. 2015 Dec 24;58(24):9535-45. doi: 10.1021/acs.jmedchem.5b01062. Epub 2015 Dec 9.


Molecular insights into the surface-specific arrangement of complement C5 convertase enzymes.

Berends ET, Gorham RD Jr, Ruyken M, Soppe JA, Orhan H, Aerts PC, de Haas CJ, Gros P, Rooijakkers SH.

BMC Biol. 2015 Nov 9;13:93. doi: 10.1186/s12915-015-0203-8.


Staphylococcus aureus protects its immune-evasion proteins against degradation by neutrophil serine proteases.

Stapels DA, Kuipers A, von Köckritz-Blickwede M, Ruyken M, Tromp AT, Horsburgh MJ, de Haas CJ, van Strijp JA, van Kessel KP, Rooijakkers SH.

Cell Microbiol. 2016 Apr;18(4):536-45. doi: 10.1111/cmi.12528. Epub 2015 Oct 23.


Complement activity is associated with disease severity in multifocal motor neuropathy.

Vlam L, Cats EA, Harschnitz O, Jansen MD, Piepers S, Veldink JH, Franssen H, Stork AC, Heezius E, Rooijakkers SH, Herpers BL, van Strijp JA, van den Berg LH, van der Pol WL.

Neurol Neuroimmunol Neuroinflamm. 2015 Jun 25;2(4):e119. doi: 10.1212/NXI.0000000000000119. eCollection 2015 Aug.


Contribution of the complement Membrane Attack Complex to the bactericidal activity of human serum.

Berends ET, Mohan S, Miellet WR, Ruyken M, Rooijakkers SH.

Mol Immunol. 2015 Jun;65(2):328-35. doi: 10.1016/j.molimm.2015.01.020. Epub 2015 Feb 26.


Effective Neutrophil Phagocytosis of Aspergillus fumigatus Is Mediated by Classical Pathway Complement Activation.

Braem SG, Rooijakkers SH, van Kessel KP, de Cock H, Wösten HA, van Strijp JA, Haas PJ.

J Innate Immun. 2015;7(4):364-74. doi: 10.1159/000369493. Epub 2015 Feb 10.


Neutrophil serine proteases in antibacterial defense.

Stapels DA, Geisbrecht BV, Rooijakkers SH.

Curr Opin Microbiol. 2015 Feb;23:42-8. doi: 10.1016/j.mib.2014.11.002. Epub 2014 Nov 18. Review.


The extracellular adherence protein from Staphylococcus aureus inhibits the classical and lectin pathways of complement by blocking formation of the C3 proconvertase.

Woehl JL, Stapels DAC, Garcia BL, Ramyar KX, Keightley A, Ruyken M, Syriga M, Sfyroera G, Weber AB, Zolkiewski M, Ricklin D, Lambris JD, Rooijakkers SHM, Geisbrecht BV.

J Immunol. 2014 Dec 15;193(12):6161-6171. doi: 10.4049/jimmunol.1401600. Epub 2014 Nov 7.


Staphylococcus aureus secretes a unique class of neutrophil serine protease inhibitors.

Stapels DA, Ramyar KX, Bischoff M, von Köckritz-Blickwede M, Milder FJ, Ruyken M, Eisenbeis J, McWhorter WJ, Herrmann M, van Kessel KP, Geisbrecht BV, Rooijakkers SH.

Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13187-92. doi: 10.1073/pnas.1407616111. Epub 2014 Aug 26.


Bacteria under stress by complement and coagulation.

Berends ET, Kuipers A, Ravesloot MM, Urbanus RT, Rooijakkers SH.

FEMS Microbiol Rev. 2014 Nov;38(6):1146-71. doi: 10.1111/1574-6976.12080. Epub 2014 Sep 3. Review.


Novel role of the antimicrobial peptide LL-37 in the protection of neutrophil extracellular traps against degradation by bacterial nucleases.

Neumann A, Völlger L, Berends ET, Molhoek EM, Stapels DA, Midon M, Friães A, Pingoud A, Rooijakkers SH, Gallo RL, Mörgelin M, Nizet V, Naim HY, von Köckritz-Blickwede M.

J Innate Immun. 2014;6(6):860-8. doi: 10.1159/000363699. Epub 2014 Jul 8.


The classical lancefield antigen of group a Streptococcus is a virulence determinant with implications for vaccine design.

van Sorge NM, Cole JN, Kuipers K, Henningham A, Aziz RK, Kasirer-Friede A, Lin L, Berends ETM, Davies MR, Dougan G, Zhang F, Dahesh S, Shaw L, Gin J, Cunningham M, Merriman JA, Hütter J, Lepenies B, Rooijakkers SHM, Malley R, Walker MJ, Shattil SJ, Schlievert PM, Choudhury B, Nizet V.

Cell Host Microbe. 2014 Jun 11;15(6):729-740. doi: 10.1016/j.chom.2014.05.009.


Entrapment exploited.

van Strijp JA, Rooijakkers SH.

Trends Microbiol. 2014 Feb;22(2):55-7. doi: 10.1016/j.tim.2013.12.010. Epub 2013 Dec 31.


Phagocytosis escape by a Staphylococcus aureus protein that connects complement and coagulation proteins at the bacterial surface.

Ko YP, Kuipers A, Freitag CM, Jongerius I, Medina E, van Rooijen WJ, Spaan AN, van Kessel KP, Höök M, Rooijakkers SH.

PLoS Pathog. 2013;9(12):e1003816. doi: 10.1371/journal.ppat.1003816. Epub 2013 Dec 12.


Distinct localization of the complement C5b-9 complex on Gram-positive bacteria.

Berends ET, Dekkers JF, Nijland R, Kuipers A, Soppe JA, van Strijp JA, Rooijakkers SH.

Cell Microbiol. 2013 Dec;15(12):1955-68. doi: 10.1111/cmi.12170. Epub 2013 Aug 13.


Staphylococcal Ecb protein and host complement regulator factor H enhance functions of each other in bacterial immune evasion.

Amdahl H, Jongerius I, Meri T, Pasanen T, Hyvärinen S, Haapasalo K, van Strijp JA, Rooijakkers SH, Jokiranta TS.

J Immunol. 2013 Aug 15;191(4):1775-84. doi: 10.4049/jimmunol.1300638. Epub 2013 Jul 17.


Optimal complement-mediated phagocytosis of Pseudomonas aeruginosa by monocytes is cystic fibrosis transmembrane conductance regulator-dependent.

Van de Weert-van Leeuwen PB, Van Meegen MA, Speirs JJ, Pals DJ, Rooijakkers SH, Van der Ent CK, Terheggen-Lagro SW, Arets HG, Beekman JM.

Am J Respir Cell Mol Biol. 2013 Sep;49(3):463-70. doi: 10.1165/rcmb.2012-0502OC.


Intravital two-photon microscopy of host-pathogen interactions in a mouse model of Staphylococcus aureus skin abscess formation.

Liese J, Rooijakkers SH, van Strijp JA, Novick RP, Dustin ML.

Cell Microbiol. 2013 Jun;15(6):891-909. doi: 10.1111/cmi.12085. Epub 2012 Dec 24.


Yersinia enterocolitica YadA mediates complement evasion by recruitment and inactivation of C3 products.

Schindler MK, Schütz MS, Mühlenkamp MC, Rooijakkers SH, Hallström T, Zipfel PF, Autenrieth IB.

J Immunol. 2012 Nov 15;189(10):4900-8. doi: 10.4049/jimmunol.1201383. Epub 2012 Oct 15.


Secondary cell wall polymers of Enterococcus faecalis are critical for resistance to complement activation via mannose-binding lectin.

Geiss-Liebisch S, Rooijakkers SH, Beczala A, Sanchez-Carballo P, Kruszynska K, Repp C, Sakinc T, Vinogradov E, Holst O, Huebner J, Theilacker C.

J Biol Chem. 2012 Nov 2;287(45):37769-77. doi: 10.1074/jbc.M112.358283. Epub 2012 Aug 20.


Staphylococcus aureus Staphopain A inhibits CXCR2-dependent neutrophil activation and chemotaxis.

Laarman AJ, Mijnheer G, Mootz JM, van Rooijen WJ, Ruyken M, Malone CL, Heezius EC, Ward R, Milligan G, van Strijp JA, de Haas CJ, Horswill AR, van Kessel KP, Rooijakkers SH.

EMBO J. 2012 Aug 29;31(17):3607-19. doi: 10.1038/emboj.2012.212. Epub 2012 Jul 31.


Staphylococcus aureus virulence is enhanced by secreted factors that block innate immune defenses.

Jongerius I, von Köckritz-Blickwede M, Horsburgh MJ, Ruyken M, Nizet V, Rooijakkers SH.

J Innate Immun. 2012;4(3):301-11. doi: 10.1159/000334604. Epub 2012 Feb 7.


Pseudomonas aeruginosa alkaline protease blocks complement activation via the classical and lectin pathways.

Laarman AJ, Bardoel BW, Ruyken M, Fernie J, Milder FJ, van Strijp JA, Rooijakkers SH.

J Immunol. 2012 Jan 1;188(1):386-93. doi: 10.4049/jimmunol.1102162. Epub 2011 Nov 30.


Staphylococcus aureus metalloprotease aureolysin cleaves complement C3 to mediate immune evasion.

Laarman AJ, Ruyken M, Malone CL, van Strijp JA, Horswill AR, Rooijakkers SH.

J Immunol. 2011 Jun 1;186(11):6445-53. doi: 10.4049/jimmunol.1002948. Epub 2011 Apr 18.


Streptococcal inhibitor of complement promotes innate immune resistance phenotypes of invasive M1T1 group A Streptococcus.

Pence MA, Rooijakkers SH, Cogen AL, Cole JN, Hollands A, Gallo RL, Nizet V.

J Innate Immun. 2010;2(6):587-95. doi: 10.1159/000317672. Epub 2010 Sep 1.


Human transferrin confers serum resistance against Bacillus anthracis.

Rooijakkers SH, Rasmussen SL, McGillivray SM, Bartnikas TB, Mason AB, Friedlander AM, Nizet V.

J Biol Chem. 2010 Sep 3;285(36):27609-13. doi: 10.1074/jbc.M110.154930. Epub 2010 Jul 8.


Functional basis for complement evasion by staphylococcal superantigen-like 7.

Bestebroer J, Aerts PC, Rooijakkers SH, Pandey MK, Köhl J, van Strijp JA, de Haas CJ.

Cell Microbiol. 2010 Oct;12(10):1506-16. doi: 10.1111/j.1462-5822.2010.01486.x.


Convertase inhibitory properties of Staphylococcal extracellular complement-binding protein.

Jongerius I, Garcia BL, Geisbrecht BV, van Strijp JA, Rooijakkers SH.

J Biol Chem. 2010 May 14;285(20):14973-9. doi: 10.1074/jbc.M109.091975. Epub 2010 Mar 19.


M1T1 group A streptococcal pili promote epithelial colonization but diminish systemic virulence through neutrophil extracellular entrapment.

Crotty Alexander LE, Maisey HC, Timmer AM, Rooijakkers SH, Gallo RL, von Köckritz-Blickwede M, Nizet V.

J Mol Med (Berl). 2010 Apr;88(4):371-81. doi: 10.1007/s00109-009-0566-9. Epub 2009 Dec 4.


Staphylococcal complement inhibitor modulates phagocyte responses by dimerization of convertases.

Jongerius I, Puister M, Wu J, Ruyken M, van Strijp JA, Rooijakkers SH.

J Immunol. 2010 Jan 1;184(1):420-5. doi: 10.4049/jimmunol.0902865. Epub 2009 Nov 30.


Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor.

Rooijakkers SH, Wu J, Ruyken M, van Domselaar R, Planken KL, Tzekou A, Ricklin D, Lambris JD, Janssen BJ, van Strijp JA, Gros P.

Nat Immunol. 2009 Jul;10(7):721-7. doi: 10.1038/ni.1756. Epub 2009 Jun 7.


Immune evasion by Staphylococcus aureus conferred by iron-regulated surface determinant protein IsdH.

Visai L, Yanagisawa N, Josefsson E, Tarkowski A, Pezzali I, Rooijakkers SH, Foster TJ, Speziale P.

Microbiology. 2009 Mar;155(Pt 3):667-79. doi: 10.1099/mic.0.025684-0.


Staphylococcal complement evasion by various convertase-blocking molecules.

Jongerius I, Köhl J, Pandey MK, Ruyken M, van Kessel KP, van Strijp JA, Rooijakkers SH.

J Exp Med. 2007 Oct 1;204(10):2461-71. Epub 2007 Sep 24.


Role of phosphatidylcholine saturation in preventing bile salt toxicity to gastrointestinal epithelia and membranes.

Dial EJ, Rooijakkers SH, Darling RL, Romero JJ, Lichtenberger LM.

J Gastroenterol Hepatol. 2008 Mar;23(3):430-6. Epub 2007 Sep 12.


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