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Items: 41

1.

Human hematopoietic stem cell maintenance and myeloid cell development in next-generation humanized mouse models.

Sippel TR, Radtke S, Olsen TM, Kiem HP, Rongvaux A.

Blood Adv. 2019 Feb 12;3(3):268-274. doi: 10.1182/bloodadvances.2018023887. No abstract available.

2.

A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies.

Song Y, Rongvaux A, Taylor A, Jiang T, Tebaldi T, Balasubramanian K, Bagale A, Terzi YK, Gbyli R, Wang X, Fu X, Gao Y, Zhao J, Podoltsev N, Xu M, Neparidze N, Wong E, Torres R, Bruscia EM, Kluger Y, Manz MG, Flavell RA, Halene S.

Nat Commun. 2019 Jan 21;10(1):366. doi: 10.1038/s41467-018-08166-x.

3.

MISTRG mice support engraftment and assessment of nonhuman primate hematopoietic stem and progenitor cells.

Radtke S, Chan YY, Sippel TR, Kiem HP, Rongvaux A.

Exp Hematol. 2019 Feb;70:31-41.e1. doi: 10.1016/j.exphem.2018.12.003. Epub 2018 Dec 25.

PMID:
30590092
4.

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection.

Sarhan J, Liu BC, Muendlein HI, Li P, Nilson R, Tang AY, Rongvaux A, Bunnell SC, Shao F, Green DR, Poltorak A.

Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10888-E10897. doi: 10.1073/pnas.1809548115. Epub 2018 Oct 31.

5.

Corrigendum: Development and function of human innate immune cells in a humanized mouse model.

Rongvaux A, Willinger T, Martinek J, Strowig T, Gearty SV, Teichmann LL, Saito Y, Marches F, Halene S, Palucka AK, Manz MG, Flavell RA.

Nat Biotechnol. 2017 Dec 8;35(12):1211. doi: 10.1038/nbt1217-1211c. No abstract available.

PMID:
29220023
6.

Innate immunity and tolerance toward mitochondria.

Rongvaux A.

Mitochondrion. 2018 Jul;41:14-20. doi: 10.1016/j.mito.2017.10.007. Epub 2017 Oct 17. Review.

PMID:
29054471
7.

The fate and lifespan of human monocyte subsets in steady state and systemic inflammation.

Patel AA, Zhang Y, Fullerton JN, Boelen L, Rongvaux A, Maini AA, Bigley V, Flavell RA, Gilroy DW, Asquith B, Macallan D, Yona S.

J Exp Med. 2017 Jul 3;214(7):1913-1923. doi: 10.1084/jem.20170355. Epub 2017 Jun 12.

8.

Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype.

Shen X, Burguillos MA, Osman AM, Frijhoff J, Carrillo-Jiménez A, Kanatani S, Augsten M, Saidi D, Rodhe J, Kavanagh E, Rongvaux A, Rraklli V, Nyman U, Holmberg J, Östman A, Flavell RA, Barragan A, Venero JL, Blomgren K, Joseph B.

Nat Immunol. 2016 Nov;17(11):1282-1290. doi: 10.1038/ni.3545. Epub 2016 Sep 12.

PMID:
27618552
9.

Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death.

Philip NH, DeLaney A, Peterson LW, Santos-Marrero M, Grier JT, Sun Y, Wynosky-Dolfi MA, Zwack EE, Hu B, Olsen TM, Rongvaux A, Pope SD, López CB, Oberst A, Beiting DP, Henao-Mejia J, Brodsky IE.

PLoS Pathog. 2016 Oct 13;12(10):e1005910. doi: 10.1371/journal.ppat.1005910. eCollection 2016 Oct.

10.

Peripheral blood CD34+ cells efficiently engraft human cytokine knock-in mice.

Saito Y, Ellegast JM, Rafiei A, Song Y, Kull D, Heikenwalder M, Rongvaux A, Halene S, Flavell RA, Manz MG.

Blood. 2016 Oct 6;128(14):1829-1833. doi: 10.1182/blood-2015-10-676452. Epub 2016 Aug 19.

11.

Generation of Genetically Modified Mice Using the CRISPR-Cas9 Genome-Editing System.

Henao-Mejia J, Williams A, Rongvaux A, Stein J, Hughes C, Flavell RA.

Cold Spring Harb Protoc. 2016 Feb 1;2016(2):pdb.prot090704. doi: 10.1101/pdb.prot090704.

12.

Humanized hemato-lymphoid system mice.

Theocharides AP, Rongvaux A, Fritsch K, Flavell RA, Manz MG.

Haematologica. 2016 Jan;101(1):5-19. doi: 10.3324/haematol.2014.115212. Review.

13.

Corrigendum: NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells.

Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz LA, Haberman AM, Elinav E, Kleinstein SH, Sutterwala FS, Flavell RA.

Nature. 2016 Feb 25;530(7591):504. doi: 10.1038/nature16074. Epub 2015 Nov 25. No abstract available.

PMID:
26605525
14.

Nlrp6 regulates intestinal antiviral innate immunity.

Wang P, Zhu S, Yang L, Cui S, Pan W, Jackson R, Zheng Y, Rongvaux A, Sun Q, Yang G, Gao S, Lin R, You F, Flavell R, Fikrig E.

Science. 2015 Nov 13;350(6262):826-30. doi: 10.1126/science.aab3145. Epub 2015 Oct 22.

15.

Executioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing Mouse Heart.

Cardona M, López JA, Serafín A, Rongvaux A, Inserte J, García-Dorado D, Flavell R, Llovera M, Cañas X, Vázquez J, Sanchis D.

PLoS One. 2015 Jun 29;10(6):e0131411. doi: 10.1371/journal.pone.0131411. eCollection 2015.

16.

Intracellular nicotinamide adenine dinucleotide promotes TNF-induced necroptosis in a sirtuin-dependent manner.

Preyat N, Rossi M, Kers J, Chen L, Bertin J, Gough PJ, Le Moine A, Rongvaux A, Van Gool F, Leo O.

Cell Death Differ. 2016 Jan;23(1):29-40. doi: 10.1038/cdd.2015.60. Epub 2015 May 22.

17.

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations.

Deng K, Pertea M, Rongvaux A, Wang L, Durand CM, Ghiaur G, Lai J, McHugh HL, Hao H, Zhang H, Margolick JB, Gurer C, Murphy AJ, Valenzuela DM, Yancopoulos GD, Deeks SG, Strowig T, Kumar P, Siliciano JD, Salzberg SL, Flavell RA, Shan L, Siliciano RF.

Nature. 2015 Jan 15;517(7534):381-5. doi: 10.1038/nature14053. Epub 2015 Jan 7.

18.

Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA.

Rongvaux A, Jackson R, Harman CC, Li T, West AP, de Zoete MR, Wu Y, Yordy B, Lakhani SA, Kuan CY, Taniguchi T, Shadel GS, Chen ZJ, Iwasaki A, Flavell RA.

Cell. 2014 Dec 18;159(7):1563-77. doi: 10.1016/j.cell.2014.11.037.

19.

PARP12, an interferon-stimulated gene involved in the control of protein translation and inflammation.

Welsby I, Hutin D, Gueydan C, Kruys V, Rongvaux A, Leo O.

J Biol Chem. 2014 Sep 19;289(38):26642-57. doi: 10.1074/jbc.M114.589515. Epub 2014 Aug 1.

20.

Development and function of human innate immune cells in a humanized mouse model.

Rongvaux A, Willinger T, Martinek J, Strowig T, Gearty SV, Teichmann LL, Saito Y, Marches F, Halene S, Palucka AK, Manz MG, Flavell RA.

Nat Biotechnol. 2014 Apr;32(4):364-72. doi: 10.1038/nbt.2858. Epub 2014 Mar 16. Erratum in: Nat Biotechnol. 2017 Dec 8;35(12 ):1211.

21.

Procaspase-3 regulates fibronectin secretion and influences adhesion, migration and survival independently of catalytic function.

Brentnall M, Weir DB, Rongvaux A, Marcus AI, Boise LH.

J Cell Sci. 2014 May 15;127(Pt 10):2217-26. doi: 10.1242/jcs.135137. Epub 2014 Mar 7.

22.

A pathway involving HDAC5, cFLIP and caspases regulates expression of the splicing regulator polypyrimidine tract binding protein in the heart.

Ye J, Llorian M, Cardona M, Rongvaux A, Moubarak RS, Comella JX, Bassel-Duby R, Flavell RA, Olson EN, Smith CW, Sanchis D.

J Cell Sci. 2013 Apr 1;126(Pt 7):1682-91. doi: 10.1242/jcs.121384. Epub 2013 Feb 19.

23.

Human hemato-lymphoid system mice: current use and future potential for medicine.

Rongvaux A, Takizawa H, Strowig T, Willinger T, Eynon EE, Flavell RA, Manz MG.

Annu Rev Immunol. 2013;31:635-674. doi: 10.1146/annurev-immunol-032712-095921. Epub 2013 Jan 16. Review.

24.

NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells.

Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz LA, Haberman AM, Elinav E, Kleinstein SH, Sutterwala FS, Flavell RA.

Nature. 2012 Apr 25;484(7395):510-3. doi: 10.1038/nature11012. Erratum in: Nature. 2016 Feb 25;530(7591):504.

25.

Efficient differentiation and function of human macrophages in humanized CSF-1 mice.

Rathinam C, Poueymirou WT, Rojas J, Murphy AJ, Valenzuela DM, Yancopoulos GD, Rongvaux A, Eynon EE, Manz MG, Flavell RA.

Blood. 2011 Sep 15;118(11):3119-28. doi: 10.1182/blood-2010-12-326926. Epub 2011 Jul 25.

26.

Transgenic expression of human signal regulatory protein alpha in Rag2-/-gamma(c)-/- mice improves engraftment of human hematopoietic cells in humanized mice.

Strowig T, Rongvaux A, Rathinam C, Takizawa H, Borsotti C, Philbrick W, Eynon EE, Manz MG, Flavell RA.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13218-23. doi: 10.1073/pnas.1109769108. Epub 2011 Jul 25.

27.

Control of TH17 cells occurs in the small intestine.

Esplugues E, Huber S, Gagliani N, Hauser AE, Town T, Wan YY, O'Connor W Jr, Rongvaux A, Van Rooijen N, Haberman AM, Iwakura Y, Kuchroo VK, Kolls JK, Bluestone JA, Herold KC, Flavell RA.

Nature. 2011 Jul 17;475(7357):514-8. doi: 10.1038/nature10228.

28.

Improving human hemato-lymphoid-system mice by cytokine knock-in gene replacement.

Willinger T, Rongvaux A, Strowig T, Manz MG, Flavell RA.

Trends Immunol. 2011 Jul;32(7):321-7. doi: 10.1016/j.it.2011.04.005. Epub 2011 Jun 21. Review.

PMID:
21697012
29.

Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo.

Rongvaux A, Willinger T, Takizawa H, Rathinam C, Auerbach W, Murphy AJ, Valenzuela DM, Yancopoulos GD, Eynon EE, Stevens S, Manz MG, Flavell RA.

Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2378-83. doi: 10.1073/pnas.1019524108. Epub 2011 Jan 24.

30.

Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung.

Willinger T, Rongvaux A, Takizawa H, Yancopoulos GD, Valenzuela DM, Murphy AJ, Auerbach W, Eynon EE, Stevens S, Manz MG, Flavell RA.

Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2390-5. doi: 10.1073/pnas.1019682108. Epub 2011 Jan 24.

31.

Metabolic stress boosts humoral responses in vivo independently of inflammasome and inflammatory reaction.

Andris F, Denanglaire S, Baus E, Rongvaux A, Steuve J, Flavell RA, Leo O.

J Immunol. 2011 Feb 15;186(4):2245-53. doi: 10.4049/jimmunol.1002333. Epub 2011 Jan 19.

32.

A mouse model for the human pathogen Salmonella typhi.

Song J, Willinger T, Rongvaux A, Eynon EE, Stevens S, Manz MG, Flavell RA, Galán JE.

Cell Host Microbe. 2010 Oct 21;8(4):369-76. doi: 10.1016/j.chom.2010.09.003.

33.

The nicotinamide phosphoribosyltransferase: a molecular link between metabolism, inflammation, and cancer.

Gallí M, Van Gool F, Rongvaux A, Andris F, Leo O.

Cancer Res. 2010 Jan 1;70(1):8-11. doi: 10.1158/0008-5472.CAN-09-2465. Epub 2009 Dec 22. Review.

34.

Humanized mice for modeling human infectious disease: challenges, progress, and outlook.

Legrand N, Ploss A, Balling R, Becker PD, Borsotti C, Brezillon N, Debarry J, de Jong Y, Deng H, Di Santo JP, Eisenbarth S, Eynon E, Flavell RA, Guzman CA, Huntington ND, Kremsdorf D, Manns MP, Manz MG, Mention JJ, Ott M, Rathinam C, Rice CM, Rongvaux A, Stevens S, Spits H, Strick-Marchand H, Takizawa H, van Lent AU, Wang C, Weijer K, Willinger T, Ziegler P.

Cell Host Microbe. 2009 Jul 23;6(1):5-9. doi: 10.1016/j.chom.2009.06.006. Review.

35.

[A new inflammatory pathway linked to NAD].

Van Gool F, Galli M, Rongvaux A, Andris F, Leo O.

Med Sci (Paris). 2009 Jun-Jul;25(6-7):551-3. doi: 10.1051/medsci/2009256-7551. French. No abstract available.

36.

Apoptosis is not required for mammalian neural tube closure.

Massa V, Savery D, Ybot-Gonzalez P, Ferraro E, Rongvaux A, Cecconi F, Flavell R, Greene ND, Copp AJ.

Proc Natl Acad Sci U S A. 2009 May 19;106(20):8233-8. doi: 10.1073/pnas.0900333106. Epub 2009 May 6.

37.

Nicotinamide phosphoribosyl transferase/pre-B cell colony-enhancing factor/visfatin is required for lymphocyte development and cellular resistance to genotoxic stress.

Rongvaux A, Galli M, Denanglaire S, Van Gool F, Drèze PL, Szpirer C, Bureau F, Andris F, Leo O.

J Immunol. 2008 Oct 1;181(7):4685-95.

38.

Granzyme B-induced cell death exerted by ex vivo CTL: discriminating requirements for cell death and some of its signs.

Pardo J, Wallich R, Martin P, Urban C, Rongvaux A, Flavell RA, Müllbacher A, Borner C, Simon MM.

Cell Death Differ. 2008 Mar;15(3):567-79. Epub 2007 Dec 7.

39.

Pro-inflammatory properties for thiazolidinediones.

Desmet C, Warzée B, Gosset P, Mélotte D, Rongvaux A, Gillet L, Fiévez L, Seumois G, Vanderplasschen A, Staels B, Lekeux P, Bureau F.

Biochem Pharmacol. 2005 Jan 15;69(2):255-65. Epub 2004 Nov 13.

PMID:
15627478
40.

Reconstructing eukaryotic NAD metabolism.

Rongvaux A, Andris F, Van Gool F, Leo O.

Bioessays. 2003 Jul;25(7):683-90. Review.

PMID:
12815723
41.

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