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Items: 1 to 50 of 72

1.

In vivo investigation of hyperpolarized [1,3-13C2]acetoacetate as a metabolic probe in normal brain and in glioma.

Najac C, Radoul M, Le Page LM, Batsios G, Subramani E, Viswanath P, Gillespie AM, Ronen SM.

Sci Rep. 2019 Mar 4;9(1):3402. doi: 10.1038/s41598-019-39677-2.

2.

HDAC inhibition in glioblastoma monitored by hyperpolarized 13 C MRSI.

Radoul M, Najac C, Viswanath P, Mukherjee J, Kelly M, Gillespie AM, Chaumeil MM, Eriksson P, Delos Santos R, Pieper RO, Ronen SM.

NMR Biomed. 2019 Feb;32(2):e4044. doi: 10.1002/nbm.4044. Epub 2018 Dec 18.

PMID:
30561869
3.

Late-stage deuteration of 13C-enriched substrates for T1 prolongation in hyperpolarized 13C MRI.

Taglang C, Korenchan DE, von Morze C, Yu J, Najac C, Wang S, Blecha JE, Subramaniam S, Bok R, VanBrocklin HF, Vigneron DB, Ronen SM, Sriram R, Kurhanewicz J, Wilson DM, Flavell RR.

Chem Commun (Camb). 2018 May 17;54(41):5233-5236. doi: 10.1039/c8cc02246a.

PMID:
29726563
4.

Mutant IDH1 gliomas downregulate phosphocholine and phosphoethanolamine synthesis in a 2-hydroxyglutarate-dependent manner.

Viswanath P, Radoul M, Izquierdo-Garcia JL, Luchman HA, Gregory Cairncross J, Pieper RO, Phillips JJ, Ronen SM.

Cancer Metab. 2018 Apr 3;6:3. doi: 10.1186/s40170-018-0178-3. eCollection 2018.

5.

2-Hydroxyglutarate-Mediated Autophagy of the Endoplasmic Reticulum Leads to an Unusual Downregulation of Phospholipid Biosynthesis in Mutant IDH1 Gliomas.

Viswanath P, Radoul M, Izquierdo-Garcia JL, Ong WQ, Luchman HA, Cairncross JG, Huang B, Pieper RO, Phillips JJ, Ronen SM.

Cancer Res. 2018 May 1;78(9):2290-2304. doi: 10.1158/0008-5472.CAN-17-2926. Epub 2018 Jan 22.

PMID:
29358170
6.

Clonal expansion and epigenetic reprogramming following deletion or amplification of mutant IDH1.

Mazor T, Chesnelong C, Pankov A, Jalbert LE, Hong C, Hayes J, Smirnov IV, Marshall R, Souza CF, Shen Y, Viswanath P, Noushmehr H, Ronen SM, Jones SJM, Marra MA, Cairncross JG, Perry A, Nelson SJ, Chang SM, Bollen AW, Molinaro AM, Bengtsson H, Olshen AB, Weiss S, Phillips JJ, Luchman HA, Costello JF.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10743-10748. doi: 10.1073/pnas.1708914114. Epub 2017 Sep 15.

7.

Hyperpolarized 13C MR metabolic imaging can detect neuroinflammation in vivo in a multiple sclerosis murine model.

Guglielmetti C, Najac C, Didonna A, Van der Linden A, Ronen SM, Chaumeil MM.

Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):E6982-E6991. doi: 10.1073/pnas.1613345114. Epub 2017 Jul 31.

8.

Autophagy-Dependent Shuttling of TBC1D5 Controls Plasma Membrane Translocation of GLUT1 and Glucose Uptake.

Roy S, Leidal AM, Ye J, Ronen SM, Debnath J.

Mol Cell. 2017 Jul 6;67(1):84-95.e5. doi: 10.1016/j.molcel.2017.05.020. Epub 2017 Jun 8.

9.

Metabolic Profiling of IDH Mutation and Malignant Progression in Infiltrating Glioma.

Jalbert LE, Elkhaled A, Phillips JJ, Neill E, Williams A, Crane JC, Olson MP, Molinaro AM, Berger MS, Kurhanewicz J, Ronen SM, Chang SM, Nelson SJ.

Sci Rep. 2017 Mar 22;7:44792. doi: 10.1038/srep44792.

10.

Mutant IDH1 Expression Drives TERT Promoter Reactivation as Part of the Cellular Transformation Process.

Ohba S, Mukherjee J, Johannessen TC, Mancini A, Chow TT, Wood M, Jones L, Mazor T, Marshall RE, Viswanath P, Walsh KM, Perry A, Bell RJ, Phillips JJ, Costello JF, Ronen SM, Pieper RO.

Cancer Res. 2016 Nov 15;76(22):6680-6689. doi: 10.1158/0008-5472.CAN-16-0696. Epub 2016 Oct 6.

11.
12.

Imaging Renal Urea Handling in Rats at Millimeter Resolution using Hyperpolarized Magnetic Resonance Relaxometry.

Reed GD, von Morze C, Verkman AS, Koelsch BL, Chaumeil MM, Lustig M, Ronen SM, Bok RA, Sands JM, Larson PE, Wang ZJ, Larsen JH, Kurhanewicz J, Vigneron DB.

Tomography. 2016 Jun;2(2):125-135.

13.

Detection of inflammatory cell function using (13)C magnetic resonance spectroscopy of hyperpolarized [6-(13)C]-arginine.

Najac C, Chaumeil MM, Kohanbash G, Guglielmetti C, Gordon JW, Okada H, Ronen SM.

Sci Rep. 2016 Aug 10;6:31397. doi: 10.1038/srep31397.

14.

Hyperpolarized (13)C MR imaging detects no lactate production in mutant IDH1 gliomas: Implications for diagnosis and response monitoring.

Chaumeil MM, Radoul M, Najac C, Eriksson P, Viswanath P, Blough MD, Chesnelong C, Luchman HA, Cairncross JG, Ronen SM.

Neuroimage Clin. 2016 Jun 23;12:180-9. doi: 10.1016/j.nicl.2016.06.018. eCollection 2016.

15.

Rapid Conversion of Mutant IDH1 from Driver to Passenger in a Model of Human Gliomagenesis.

Johannessen TA, Mukherjee J, Viswanath P, Ohba S, Ronen SM, Bjerkvig R, Pieper RO.

Mol Cancer Res. 2016 Oct;14(10):976-983. Epub 2016 Jul 18.

16.

Accelerated high-bandwidth MR spectroscopic imaging using compressed sensing.

Cao P, Shin PJ, Park I, Najac C, Marco-Rius I, Vigneron DB, Nelson SJ, Ronen SM, Larson PE.

Magn Reson Med. 2016 Aug;76(2):369-79. doi: 10.1002/mrm.26272. Epub 2016 May 26.

17.

Mutant IDH1 expression is associated with down-regulation of monocarboxylate transporters.

Viswanath P, Najac C, Izquierdo-Garcia JL, Pankov A, Hong C, Eriksson P, Costello JF, Pieper RO, Ronen SM.

Oncotarget. 2016 Jun 7;7(23):34942-55. doi: 10.18632/oncotarget.9006.

18.

Molecular Imaging of Metabolic Reprograming in Mutant IDH Cells.

Viswanath P, Chaumeil MM, Ronen SM.

Front Oncol. 2016 Mar 14;6:60. doi: 10.3389/fonc.2016.00060. eCollection 2016. Review.

19.
20.

MR Studies of Glioblastoma Models Treated with Dual PI3K/mTOR Inhibitor and Temozolomide:Metabolic Changes Are Associated with Enhanced Survival.

Radoul M, Chaumeil MM, Eriksson P, Wang AS, Phillips JJ, Ronen SM.

Mol Cancer Ther. 2016 May;15(5):1113-22. doi: 10.1158/1535-7163.MCT-15-0769. Epub 2016 Feb 16.

21.

Magnetic Resonance (MR) Metabolic Imaging in Glioma.

Chaumeil MM, Lupo JM, Ronen SM.

Brain Pathol. 2015 Nov;25(6):769-80. doi: 10.1111/bpa.12310. Review.

PMID:
26526945
22.

Studies of Metabolism Using (13)C MRS of Hyperpolarized Probes.

Chaumeil MM, Najac C, Ronen SM.

Methods Enzymol. 2015;561:1-71. doi: 10.1016/bs.mie.2015.04.001. Epub 2015 Jun 19. Review.

PMID:
26358901
23.

IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism.

Izquierdo-Garcia JL, Viswanath P, Eriksson P, Cai L, Radoul M, Chaumeil MM, Blough M, Luchman HA, Weiss S, Cairncross JG, Phillips JJ, Pieper RO, Ronen SM.

Cancer Res. 2015 Aug 1;75(15):2999-3009. doi: 10.1158/0008-5472.CAN-15-0840. Epub 2015 Jun 4.

24.

Metabolic reprogramming in mutant IDH1 glioma cells.

Izquierdo-Garcia JL, Viswanath P, Eriksson P, Chaumeil MM, Pieper RO, Phillips JJ, Ronen SM.

PLoS One. 2015 Feb 23;10(2):e0118781. doi: 10.1371/journal.pone.0118781. eCollection 2015.

25.

Changes in pyruvate metabolism detected by magnetic resonance imaging are linked to DNA damage and serve as a sensor of temozolomide response in glioblastoma cells.

Park I, Mukherjee J, Ito M, Chaumeil MM, Jalbert LE, Gaensler K, Ronen SM, Nelson SJ, Pieper RO.

Cancer Res. 2014 Dec 1;74(23):7115-24. doi: 10.1158/0008-5472.CAN-14-0849. Epub 2014 Oct 15.

26.

Glioma cells with the IDH1 mutation modulate metabolic fractional flux through pyruvate carboxylase.

Izquierdo-Garcia JL, Cai LM, Chaumeil MM, Eriksson P, Robinson AE, Pieper RO, Phillips JJ, Ronen SM.

PLoS One. 2014 Sep 22;9(9):e108289. doi: 10.1371/journal.pone.0108289. eCollection 2014.

27.

Rapid in vivo apparent diffusion coefficient mapping of hyperpolarized (13) C metabolites.

Koelsch BL, Reed GD, Keshari KR, Chaumeil MM, Bok R, Ronen SM, Vigneron DB, Kurhanewicz J, Larson PEZ.

Magn Reson Med. 2015 Sep;74(3):622-633. doi: 10.1002/mrm.25422. Epub 2014 Sep 11.

28.

HR-MAS MRS of the pancreas reveals reduced lipid and elevated lactate and taurine associated with early pancreatic cancer.

Wang AS, Lodi A, Rivera LB, Izquierdo-Garcia JL, Firpo MA, Mulvihill SJ, Tempero MA, Bergers G, Ronen SM.

NMR Biomed. 2014 Nov;27(11):1361-70. doi: 10.1002/nbm.3198. Epub 2014 Sep 9.

29.

Hyperpolarized [1-13C] glutamate: a metabolic imaging biomarker of IDH1 mutational status in glioma.

Chaumeil MM, Larson PE, Woods SM, Cai L, Eriksson P, Robinson AE, Lupo JM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM.

Cancer Res. 2014 Aug 15;74(16):4247-57. doi: 10.1158/0008-5472.CAN-14-0680. Epub 2014 May 29.

30.

Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer.

Cunningham JT, Moreno MV, Lodi A, Ronen SM, Ruggero D.

Cell. 2014 May 22;157(5):1088-103. doi: 10.1016/j.cell.2014.03.052. Erratum in: Cell. 2014 Jul 31;158(3):689.

31.

MR-detectable metabolic consequences of mitogen-activated protein kinase kinase (MEK) inhibition.

Lodi A, Woods SM, Ronen SM.

NMR Biomed. 2014 Jun;27(6):700-8. doi: 10.1002/nbm.3109. Epub 2014 Apr 2.

32.

Lactate dehydrogenase A silencing in IDH mutant gliomas.

Chesnelong C, Chaumeil MM, Blough MD, Al-Najjar M, Stechishin OD, Chan JA, Pieper RO, Ronen SM, Weiss S, Luchman HA, Cairncross JG.

Neuro Oncol. 2014 May;16(5):686-95. doi: 10.1093/neuonc/not243. Epub 2013 Dec 22.

33.

Non-invasive in vivo assessment of IDH1 mutational status in glioma.

Chaumeil MM, Larson PE, Yoshihara HA, Danforth OM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM.

Nat Commun. 2013;4:2429. doi: 10.1038/ncomms3429.

34.

Early Chk1 phosphorylation is driven by temozolomide-induced, DNA double strand break- and mismatch repair-independent DNA damage.

Ito M, Ohba S, Gaensler K, Ronen SM, Mukherjee J, Pieper RO.

PLoS One. 2013 May 7;8(5):e62351. doi: 10.1371/journal.pone.0062351. Print 2013.

35.

HDAC inhibition induces increased choline uptake and elevated phosphocholine levels in MCF7 breast cancer cells.

Ward CS, Eriksson P, Izquierdo-Garcia JL, Brandes AH, Ronen SM.

PLoS One. 2013 Apr 23;8(4):e62610. doi: 10.1371/journal.pone.0062610. Print 2013.

36.

Pyruvate kinase M2 expression, but not pyruvate kinase activity, is up-regulated in a grade-specific manner in human glioma.

Mukherjee J, Phillips JJ, Zheng S, Wiencke J, Ronen SM, Pieper RO.

PLoS One. 2013;8(2):e57610. doi: 10.1371/journal.pone.0057610. Epub 2013 Feb 25.

37.

Gene expression profile identifies tyrosine kinase c-Met as a targetable mediator of antiangiogenic therapy resistance.

Jahangiri A, De Lay M, Miller LM, Carbonell WS, Hu YL, Lu K, Tom MW, Paquette J, Tokuyasu TA, Tsao S, Marshall R, Perry A, Bjorgan KM, Chaumeil MM, Ronen SM, Bergers G, Aghi MK.

Clin Cancer Res. 2013 Apr 1;19(7):1773-83. doi: 10.1158/1078-0432.CCR-12-1281. Epub 2013 Jan 10.

38.

Treatment with the MEK inhibitor U0126 induces decreased hyperpolarized pyruvate to lactate conversion in breast, but not prostate, cancer cells.

Lodi A, Woods SM, Ronen SM.

NMR Biomed. 2013 Mar;26(3):299-306. doi: 10.1002/nbm.2848. Epub 2012 Sep 3.

39.

Evaluation of heterogeneous metabolic profile in an orthotopic human glioblastoma xenograft model using compressed sensing hyperpolarized 3D 13C magnetic resonance spectroscopic imaging.

Park I, Hu S, Bok R, Ozawa T, Ito M, Mukherjee J, Phillips JJ, James CD, Pieper RO, Ronen SM, Vigneron DB, Nelson SJ.

Magn Reson Med. 2013 Jul;70(1):33-9. doi: 10.1002/mrm.24434. Epub 2012 Jul 31.

40.

Longitudinal evaluation of MPIO-labeled stem cell biodistribution in glioblastoma using high resolution and contrast-enhanced MR imaging at 14.1 tesla.

Chaumeil MM, Gini B, Yang H, Iwanami A, Sukumar S, Ozawa T, Pieper RO, Mischel PS, James CD, Berger MS, Ronen SM.

Neuro Oncol. 2012 Aug;14(8):1050-61. doi: 10.1093/neuonc/nos126. Epub 2012 Jun 4.

41.

Metabolic consequences of treatment with AKT inhibitor perifosine in breast cancer cells.

Su JS, Woods SM, Ronen SM.

NMR Biomed. 2012 Feb;25(2):379-88. doi: 10.1002/nbm.1764. Epub 2011 Aug 23.

42.

Reduced phosphocholine and hyperpolarized lactate provide magnetic resonance biomarkers of PI3K/Akt/mTOR inhibition in glioblastoma.

Venkatesh HS, Chaumeil MM, Ward CS, Haas-Kogan DA, James CD, Ronen SM.

Neuro Oncol. 2012 Mar;14(3):315-25. doi: 10.1093/neuonc/nor209. Epub 2011 Dec 12.

43.

Vascular patterning and permeability in prostate cancer models with differing osteogenic properties.

Dafni H, Burghardt AJ, Majumdar S, Navone NM, Ronen SM.

NMR Biomed. 2012 Jun;25(6):843-51. doi: 10.1002/nbm.1800. Epub 2011 Dec 2.

PMID:
22134886
44.

Choline metabolism in malignant transformation.

Glunde K, Bhujwalla ZM, Ronen SM.

Nat Rev Cancer. 2011 Nov 17;11(12):835-48. doi: 10.1038/nrc3162. Review.

45.

Magnetic resonance spectroscopy detectable metabolomic fingerprint of response to antineoplastic treatment.

Lodi A, Ronen SM.

PLoS One. 2011;6(10):e26155. doi: 10.1371/journal.pone.0026155. Epub 2011 Oct 12.

46.

Hyperpolarized 13C MR spectroscopic imaging can be used to monitor Everolimus treatment in vivo in an orthotopic rodent model of glioblastoma.

Chaumeil MM, Ozawa T, Park I, Scott K, James CD, Nelson SJ, Ronen SM.

Neuroimage. 2012 Jan 2;59(1):193-201. doi: 10.1016/j.neuroimage.2011.07.034. Epub 2011 Jul 23.

47.

Detection of early response to temozolomide treatment in brain tumors using hyperpolarized 13C MR metabolic imaging.

Park I, Bok R, Ozawa T, Phillips JJ, James CD, Vigneron DB, Ronen SM, Nelson SJ.

J Magn Reson Imaging. 2011 Jun;33(6):1284-90. doi: 10.1002/jmri.22563.

48.

Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation.

Lock R, Roy S, Kenific CM, Su JS, Salas E, Ronen SM, Debnath J.

Mol Biol Cell. 2011 Jan 15;22(2):165-78. doi: 10.1091/mbc.E10-06-0500. Epub 2010 Nov 30.

50.

Hyperpolarized 13C spectroscopic imaging informs on hypoxia-inducible factor-1 and myc activity downstream of platelet-derived growth factor receptor.

Dafni H, Larson PE, Hu S, Yoshihara HA, Ward CS, Venkatesh HS, Wang C, Zhang X, Vigneron DB, Ronen SM.

Cancer Res. 2010 Oct 1;70(19):7400-10. doi: 10.1158/0008-5472.CAN-10-0883. Epub 2010 Sep 21.

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