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Long Pentraxin 3-Mediated Fibroblast Growth Factor Trapping Impairs Fibrosarcoma Growth.

Rodrigues PF, Matarazzo S, Maccarinelli F, Foglio E, Giacomini A, Silva Nunes JP, Presta M, Dias AAM, Ronca R.

Front Oncol. 2018 Nov 1;8:472. doi: 10.3389/fonc.2018.00472. eCollection 2018.


Choline Kinase Alpha Inhibition by EB-3D Triggers Cellular Senescence, Reduces Tumor Growth and Metastatic Dissemination in Breast Cancer.

Mariotto E, Viola G, Ronca R, Persano L, Aveic S, Bhujwalla ZM, Mori N, Accordi B, Serafin V, López-Cara LC, Bortolozzi R.

Cancers (Basel). 2018 Oct 22;10(10). pii: E391. doi: 10.3390/cancers10100391.


Long Pentraxin-3 Modulates the Angiogenic Activity of Fibroblast Growth Factor-2.

Presta M, Foglio E, Churruca Schuind A, Ronca R.

Front Immunol. 2018 Oct 8;9:2327. doi: 10.3389/fimmu.2018.02327. eCollection 2018. Review.


Improvement and extension of anti-EGFR targeting in breast cancer therapy by integration with the Avidin-Nucleic-Acid-Nano-Assemblies.

Roncato F, Rruga F, Porcù E, Casarin E, Ronca R, Maccarinelli F, Realdon N, Basso G, Alon R, Viola G, Morpurgo M.

Nat Commun. 2018 Oct 4;9(1):4070. doi: 10.1038/s41467-018-06602-6.


Future applications of FGF/FGFR inhibitors in cancer.

Ghedini GC, Ronca R, Presta M, Giacomini A.

Expert Rev Anticancer Ther. 2018 Sep;18(9):861-872. doi: 10.1080/14737140.2018.1491795. Epub 2018 Jul 2.


Dendritic cells in inflammatory angiogenesis and lymphangiogenesis.

Bosisio D, Ronca R, Salvi V, Presta M, Sozzani S.

Curr Opin Immunol. 2018 Aug;53:180-186. doi: 10.1016/j.coi.2018.05.011. Epub 2018 Jun 4. Review.


Uptake Profiles of Human Serum Exosomes by Murine and Human Tumor Cells through Combined Use of Colloidal Nanoplasmonics and Flow Cytofluorimetric Analysis.

Busatto S, Giacomini A, Montis C, Ronca R, Bergese P.

Anal Chem. 2018 Jul 3;90(13):7855-7861. doi: 10.1021/acs.analchem.7b04374. Epub 2018 Jun 15.


Biochemical characterization of a thermostable endomannanase/endoglucanase from Dictyoglomus turgidum.

Fusco FA, Ronca R, Fiorentino G, Pedone E, Contursi P, Bartolucci S, Limauro D.

Extremophiles. 2018 Jan;22(1):131-140. doi: 10.1007/s00792-017-0983-6. Epub 2017 Nov 25.


Long pentraxin 3: A novel multifaceted player in cancer.

Giacomini A, Ghedini GC, Presta M, Ronca R.

Biochim Biophys Acta Rev Cancer. 2018 Jan;1869(1):53-63. doi: 10.1016/j.bbcan.2017.11.004. Epub 2017 Nov 23. Review.


Specific Effects of Chronic Dietary Exposure to Chlorpyrifos on Brain Gene Expression-A Mouse Study.

Pallotta MM, Ronca R, Carotenuto R, Porreca I, Turano M, Ambrosino C, Capriglione T.

Int J Mol Sci. 2017 Nov 20;18(11). pii: E2467. doi: 10.3390/ijms18112467.


Fibroblast growth factor modulates mast cell recruitment in a murine model of prostate cancer.

Ronca R, Tamma R, Coltrini D, Ruggieri S, Presta M, Ribatti D.

Oncotarget. 2017 Aug 1;8(47):82583-82592. doi: 10.18632/oncotarget.19773. eCollection 2017 Oct 10.


Utilizing CT with Maximum Intensity Projection Reconstruction Bypassing CTA Improves Time to Groin Puncture in Large Vessel Occlusion Stroke Thrombectomy.

Atchaneeyasakul K, Tipirneni A, Khandelwal P, Saini V, Ronca R, Lord S, Sur S, Guada L, Ramdas K, Peterson E, Yavagal D.

Interv Neurol. 2017 Oct;6(3-4):147-152. doi: 10.1159/000464300. Epub 2017 Mar 29.


Paracrine interactions of cancer-associated fibroblasts, macrophages and endothelial cells: tumor allies and foes.

Ronca R, Van Ginderachter JA, Turtoi A.

Curr Opin Oncol. 2018 Jan;30(1):45-53. doi: 10.1097/CCO.0000000000000420. Review.


Contribution of vascular endothelial growth factor receptor-2 sialylation to the process of angiogenesis.

Chiodelli P, Rezzola S, Urbinati C, Federici Signori F, Monti E, Ronca R, Presta M, Rusnati M.

Oncogene. 2017 Nov 23;36(47):6531-6541. doi: 10.1038/onc.2017.243. Epub 2017 Aug 7.


Tumor angiogenesis revisited: Regulators and clinical implications.

Ronca R, Benkheil M, Mitola S, Struyf S, Liekens S.

Med Res Rev. 2017 Nov;37(6):1231-1274. doi: 10.1002/med.21452. Epub 2017 Jun 23. Review.


Functional analyses yield detailed insight into the mechanism of thrombin inhibition by the antihemostatic salivary protein cE5 from Anopheles gambiae.

Pirone L, Ripoll-Rozada J, Leone M, Ronca R, Lombardo F, Fiorentino G, Andersen JF, Pereira PJB, Arcà B, Pedone E.

J Biol Chem. 2017 Jul 28;292(30):12632-12642. doi: 10.1074/jbc.M117.788042. Epub 2017 Jun 7.


Fibroblast growth factors (FGFs) in cancer: FGF traps as a new therapeutic approach.

Presta M, Chiodelli P, Giacomini A, Rusnati M, Ronca R.

Pharmacol Ther. 2017 Nov;179:171-187. doi: 10.1016/j.pharmthera.2017.05.013. Epub 2017 May 28. Review.


U94 of human herpesvirus 6 down-modulates Src, promotes a partial mesenchymal-to-epithelial transition and inhibits tumor cell growth, invasion and metastasis.

Caccuri F, Ronca R, Laimbacher AS, Berenzi A, Steimberg N, Campilongo F, Mazzuca P, Giacomini A, Mazzoleni G, Benetti A, Caselli E, Presta M, Di Luca D, Fraefel C, Caruso A.

Oncotarget. 2017 Jul 4;8(27):44533-44549. doi: 10.18632/oncotarget.17817.


Eukaryotic initiation factor eIF6 modulates the expression of Kermit 2/XGIPC in IGF- regulated eye development.

De Marco N, Tussellino M, Carotenuto R, Ronca R, Rizzolio S, Biffo S, Campanella C.

Dev Biol. 2017 Jul 1;427(1):148-154. doi: 10.1016/j.ydbio.2017.04.017. Epub 2017 May 1.


Synthesis and Biological Evaluation of 2-Methyl-4,5-Disubstituted Oxazoles as a Novel Class of Highly Potent Antitubulin Agents.

Romagnoli R, Baraldi PG, Prencipe F, Oliva P, Baraldi S, Salvador MK, Lopez-Cara LC, Brancale A, Ferla S, Hamel E, Ronca R, Bortolozzi R, Mariotto E, Porcù E, Basso G, Viola G.

Sci Rep. 2017 Apr 13;7:46356. doi: 10.1038/srep46356.


Brain Gene Expression is Influenced by Incubation Temperature During Leopard Gecko (Eublepharis macularius) Development.

Pallotta MM, Turano M, Ronca R, Mezzasalma M, Petraccioli A, Odierna G, Capriglione T.

J Exp Zool B Mol Dev Evol. 2017 Jun;328(4):360-370. doi: 10.1002/jez.b.22736. Epub 2017 Mar 20.


Inflammation and N-formyl peptide receptors mediate the angiogenic activity of human vitreous humour in proliferative diabetic retinopathy.

Rezzola S, Corsini M, Chiodelli P, Cancarini A, Nawaz IM, Coltrini D, Mitola S, Ronca R, Belleri M, Lista L, Rusciano D, De Rosa M, Pavone V, Semeraro F, Presta M.

Diabetologia. 2017 Apr;60(4):719-728. doi: 10.1007/s00125-016-4204-0. Epub 2017 Jan 13.


Chlorpyrifos exposure affects fgf8, sox9, and bmp4 expression required for cranial neural crest morphogenesis and chondrogenesis in Xenopus laevis embryos.

Tussellino M, Ronca R, Carotenuto R, Pallotta MM, Furia M, Capriglione T.

Environ Mol Mutagen. 2016 Oct;57(8):630-640. doi: 10.1002/em.22057. Epub 2016 Sep 27.


The Novel Antitubulin Agent TR-764 Strongly Reduces Tumor Vasculature and Inhibits HIF-1α Activation.

Porcù E, Persano L, Ronca R, Mitola S, Bortolozzi R, Romagnoli R, Oliva P, Basso G, Viola G.

Sci Rep. 2016 Jun 13;6:27886. doi: 10.1038/srep27886.


Vascular disrupting activity of combretastatin analogues.

Porcù E, Salvador A, Primac I, Mitola S, Ronca R, Ravelli C, Bortolozzi R, Vedaldi D, Romagnoli R, Basso G, Viola G.

Vascul Pharmacol. 2016 Aug;83:78-89. doi: 10.1016/j.vph.2016.05.006. Epub 2016 May 25.


Design and Synthesis of Potent in Vitro and in Vivo Anticancer Agents Based on 1-(3',4',5'-Trimethoxyphenyl)-2-Aryl-1H-Imidazole.

Romagnoli R, Baraldi PG, Prencipe F, Oliva P, Baraldi S, Tabrizi MA, Lopez-Cara LC, Ferla S, Brancale A, Hamel E, Ronca R, Bortolozzi R, Mariotto E, Basso G, Viola G.

Sci Rep. 2016 May 24;6:26602. doi: 10.1038/srep26602.


Monomeric gremlin is a novel vascular endothelial growth factor receptor-2 antagonist.

Grillo E, Ravelli C, Corsini M, Ballmer-Hofer K, Zammataro L, Oreste P, Zoppetti G, Tobia C, Ronca R, Presta M, Mitola S.

Oncotarget. 2016 Jun 7;7(23):35353-68. doi: 10.18632/oncotarget.9286.


Synthesis, Structural Elucidation, and Biological Evaluation of NSC12, an Orally Available Fibroblast Growth Factor (FGF) Ligand Trap for the Treatment of FGF-Dependent Lung Tumors.

Castelli R, Giacomini A, Anselmi M, Bozza N, Vacondio F, Rivara S, Matarazzo S, Presta M, Mor M, Ronca R.

J Med Chem. 2016 May 26;59(10):4651-63. doi: 10.1021/acs.jmedchem.5b02021. Epub 2016 May 3.


Blocking the FGF/FGFR system as a "two-compartment" antiangiogenic/antitumor approach in cancer therapy.

Giacomini A, Chiodelli P, Matarazzo S, Rusnati M, Presta M, Ronca R.

Pharmacol Res. 2016 May;107:172-185. doi: 10.1016/j.phrs.2016.03.024. Epub 2016 Mar 22. Review.


HDAC7 inhibition resets STAT3 tumorigenic activity in human glioblastoma independently of EGFR and PTEN: new opportunities for selected targeted therapies.

Peixoto P, Blomme A, Costanza B, Ronca R, Rezzola S, Palacios AP, Schoysman L, Boutry S, Goffart N, Peulen O, Maris P, Di Valentin E, Hennequière V, Bianchi E, Henry A, Meunier P, Rogister B, Muller RN, Delvenne P, Bellahcène A, Castronovo V, Turtoi A.

Oncogene. 2016 Aug 25;35(34):4481-94. doi: 10.1038/onc.2015.506. Epub 2016 Feb 8.


Antibody acquisition models: A new tool for serological surveillance of malaria transmission intensity.

Yman V, White MT, Rono J, Arcà B, Osier FH, Troye-Blomberg M, Boström S, Ronca R, Rooth I, Färnert A.

Sci Rep. 2016 Feb 5;6:19472. doi: 10.1038/srep19472.


Long-Pentraxin 3 Derivative as a Small-Molecule FGF Trap for Cancer Therapy.

Ronca R, Giacomini A, Di Salle E, Coltrini D, Pagano K, Ragona L, Matarazzo S, Rezzola S, Maiolo D, Torrella R, Moroni E, Mazzieri R, Escobar G, Mor M, Colombo G, Presta M.

Cancer Cell. 2015 Aug 10;28(2):225-39. doi: 10.1016/j.ccell.2015.07.002.


The potential of fibroblast growth factor/fibroblast growth factor receptor signaling as a therapeutic target in tumor angiogenesis.

Ronca R, Giacomini A, Rusnati M, Presta M.

Expert Opin Ther Targets. 2015;19(10):1361-77. doi: 10.1517/14728222.2015.1062475. Epub 2015 Jun 30. Review.


A selective cannabinoid CB2 agonist attenuates damage and improves memory retention following stroke in mice.

Ronca RD, Myers AM, Ganea D, Tuma RF, Walker EA, Ward SJ.

Life Sci. 2015 Oct 1;138:72-7. doi: 10.1016/j.lfs.2015.05.005. Epub 2015 May 30.


A long pentraxin-3-derived pentapeptide for the therapy of FGF8b-driven steroid hormone-regulated cancers.

Giacomini A, Matarazzo S, Pagano K, Ragona L, Rezzola S, Corsini M, Di Salle E, Presta M, Ronca R.

Oncotarget. 2015 May 30;6(15):13790-802.


Cavin-1 and Caveolin-1 are both required to support cell proliferation, migration and anchorage-independent cell growth in rhabdomyosarcoma.

Faggi F, Chiarelli N, Colombi M, Mitola S, Ronca R, Madaro L, Bouche M, Poliani PL, Vezzoli M, Longhena F, Monti E, Salani B, Maggi D, Keller C, Fanzani A.

Lab Invest. 2015 Jun;95(6):585-602. doi: 10.1038/labinvest.2015.45. Epub 2015 Mar 30.


Design, synthesis, in vitro, and in vivo anticancer and antiangiogenic activity of novel 3-arylaminobenzofuran derivatives targeting the colchicine site on tubulin.

Romagnoli R, Baraldi PG, Salvador MK, Prencipe F, Lopez-Cara C, Schiaffino Ortega S, Brancale A, Hamel E, Castagliuolo I, Mitola S, Ronca R, Bortolozzi R, Porcù E, Basso G, Viola G.

J Med Chem. 2015 Apr 9;58(7):3209-22. doi: 10.1021/acs.jmedchem.5b00155. Epub 2015 Mar 26.


The Anopheles gambiae cE5 salivary protein: a sensitive biomarker to evaluate the efficacy of insecticide-treated nets in malaria vector control.

Marie A, Ronca R, Poinsignon A, Lombardo F, Drame PM, Cornelie S, Besnard P, Le Mire J, Fiorentino G, Fortes F, Carnevale P, Remoue F, Arcà B.

Microbes Infect. 2015 Jun;17(6):409-16. doi: 10.1016/j.micinf.2015.01.002. Epub 2015 Jan 28.


The broad-spectrum anti-DNA virus agent cidofovir inhibits lung metastasis of virus-independent, FGF2-driven tumors.

Liekens S, Noppen S, Gijsbers S, Sienaert R, Ronca R, Tobia C, Presta M.

Oncotarget. 2015 Mar 10;6(7):4633-48.


Differential antibody response to the Anopheles gambiae gSG6 and cE5 salivary proteins in individuals naturally exposed to bites of malaria vectors.

Rizzo C, Lombardo F, Ronca R, Mangano V, Sirima SB, Nèbiè I, Fiorentino G, Modiano D, Arcà B.

Parasit Vectors. 2014 Nov 28;7:549. doi: 10.1186/s13071-014-0549-8.


IgG1 and IgG4 antibody responses to the Anopheles gambiae salivary protein gSG6 in the sympatric ethnic groups Mossi and Fulani in a malaria hyperhendemic area of Burkina Faso.

Rizzo C, Ronca R, Lombardo F, Mangano V, Sirima SB, Nèbiè I, Fiorentino G, Troye-Blomberg M, Modiano D, Arcà B.

PLoS One. 2014 Apr 23;9(4):e96130. doi: 10.1371/journal.pone.0096130. eCollection 2014.


Molecular cloning and knockdown of galactocerebrosidase in zebrafish: new insights into the pathogenesis of Krabbe's disease.

Zizioli D, Guarienti M, Tobia C, Gariano G, Borsani G, Bresciani R, Ronca R, Giacopuzzi E, Preti A, Gaudenzi G, Belleri M, Di Salle E, Fabrias G, Casas J, Ribatti D, Monti E, Presta M.

Biochim Biophys Acta. 2014 Apr;1842(4):665-75. doi: 10.1016/j.bbadis.2014.01.008. Epub 2014 Jan 24.


Antiangiogenic effects of N6-isopentenyladenosine, an endogenous isoprenoid end product, mediated by AMPK activation.

Pisanti S, Picardi P, Ciaglia E, Margarucci L, Ronca R, Giacomini A, Malfitano AM, Casapullo A, Laezza C, Gazzerro P, Bifulco M.

FASEB J. 2014 Mar;28(3):1132-44. doi: 10.1096/fj.13-238238. Epub 2013 Nov 21.


Long pentraxin-3 inhibits epithelial-mesenchymal transition in melanoma cells.

Ronca R, Di Salle E, Giacomini A, Leali D, Alessi P, Coltrini D, Ravelli C, Matarazzo S, Ribatti D, Vermi W, Presta M.

Mol Cancer Ther. 2013 Dec;12(12):2760-71. doi: 10.1158/1535-7163.MCT-13-0487. Epub 2013 Oct 15.


Inhibition of angiogenesis by β-galactosylceramidase deficiency in globoid cell leukodystrophy.

Belleri M, Ronca R, Coltrini D, Nico B, Ribatti D, Poliani PL, Giacomini A, Alessi P, Marchesini S, Santos MB, Bongarzone ER, Presta M.

Brain. 2013 Sep;136(Pt 9):2859-75. doi: 10.1093/brain/awt215.


Influence of infection on malaria-specific antibody dynamics in a cohort exposed to intense malaria transmission in northern Uganda.

Proietti C, Verra F, Bretscher MT, Stone W, Kanoi BN, Balikagala B, Egwang TG, Corran P, Ronca R, Arcà B, Riley EM, Crisanti A, Drakeley C, Bousema T.

Parasite Immunol. 2013 May-Jun;35(5-6):164-73. doi: 10.1111/pim.12031.


TR-644 a novel potent tubulin binding agent induces impairment of endothelial cells function and inhibits angiogenesis.

Porcù E, Viola G, Bortolozzi R, Persano L, Mitola S, Ronca R, Presta M, Romagnoli R, Baraldi PG, Basso G.

Angiogenesis. 2013 Jul;16(3):647-62. doi: 10.1007/s10456-013-9343-z. Epub 2013 Mar 2.


Long pentraxin-3 as an epithelial-stromal fibroblast growth factor-targeting inhibitor in prostate cancer.

Ronca R, Alessi P, Coltrini D, Di Salle E, Giacomini A, Leali D, Corsini M, Belleri M, Tobia C, Garlanda C, Bonomi E, Tardanico R, Vermi W, Presta M.

J Pathol. 2013 Jun;230(2):228-38. doi: 10.1002/path.4181.


Matrigel plug assay: evaluation of the angiogenic response by reverse transcription-quantitative PCR.

Coltrini D, Di Salle E, Ronca R, Belleri M, Testini C, Presta M.

Angiogenesis. 2013 Apr;16(2):469-77. doi: 10.1007/s10456-012-9324-7. Epub 2012 Nov 11.


IgG responses to Anopheles gambiae salivary antigen gSG6 detect variation in exposure to malaria vectors and disease risk.

Stone W, Bousema T, Jones S, Gesase S, Hashim R, Gosling R, Carneiro I, Chandramohan D, Theander T, Ronca R, Modiano D, Arcà B, Drakeley C.

PLoS One. 2012;7(6):e40170. doi: 10.1371/journal.pone.0040170. Epub 2012 Jun 29.

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