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Items: 37


Functional Expression of Organic Anion Transporting Polypeptide 1a4 (Oatp1a4) is Regulated by Transforming Growth Factor-/Activin Receptor-like Kinase 1 (TGF-/ALK1) Signaling at the Blood-Brain Barrier.

Abdullahi W, Brzica H, Hirsch NA, Reilly BG, Ronaldson PT.

Mol Pharmacol. 2018 Sep 27. pii: mol.118.112912. doi: 10.1124/mol.118.112912. [Epub ahead of print]


Sex-specific differences in organic anion transporting polypeptide 1a4 (Oatp1a4) functional expression at the blood-brain barrier in Sprague-Dawley rats.

Brzica H, Abdullahi W, Reilly BG, Ronaldson PT.

Fluids Barriers CNS. 2018 Sep 13;15(1):25. doi: 10.1186/s12987-018-0110-9.


Blood-brain barrier dysfunction in ischemic stroke: targeting tight junctions and transporters for vascular protection.

Abdullahi W, Tripathi D, Ronaldson PT.

Am J Physiol Cell Physiol. 2018 Sep 1;315(3):C343-C356. doi: 10.1152/ajpcell.00095.2018. Epub 2018 Jun 27.


A Simple and Reproducible Method to Prepare Membrane Samples from Freshly Isolated Rat Brain Microvessels.

Brzica H, Abdullahi W, Reilly BG, Ronaldson PT.

J Vis Exp. 2018 May 7;(135). doi: 10.3791/57698.


Role of Transporters in Central Nervous System Drug Delivery and Blood-Brain Barrier Protection: Relevance to Treatment of Stroke.

Brzica H, Abdullahi W, Ibbotson K, Ronaldson PT.

J Cent Nerv Syst Dis. 2017 Apr 6;9:1179573517693802. doi: 10.1177/1179573517693802. eCollection 2017. Review.


Functional Expression of P-glycoprotein and Organic Anion Transporting Polypeptides at the Blood-Brain Barrier: Understanding Transport Mechanisms for Improved CNS Drug Delivery?

Abdullahi W, Davis TP, Ronaldson PT.

AAPS J. 2017 Jul;19(4):931-939. doi: 10.1208/s12248-017-0081-9. Epub 2017 Apr 26. Review.


Bone morphogenetic protein-9 increases the functional expression of organic anion transporting polypeptide 1a4 at the blood-brain barrier via the activin receptor-like kinase-1 receptor.

Abdullahi W, Brzica H, Ibbotson K, Davis TP, Ronaldson PT.

J Cereb Blood Flow Metab. 2017 Jul;37(7):2340-2345. doi: 10.1177/0271678X17702916. Epub 2017 Apr 7.


Hypoxic Stress and Inflammatory Pain Disrupt Blood-Brain Barrier Tight Junctions: Implications for Drug Delivery to the Central Nervous System.

Lochhead JJ, Ronaldson PT, Davis TP.

AAPS J. 2017 Jul;19(4):910-920. doi: 10.1208/s12248-017-0076-6. Epub 2017 Mar 28. Review.


Targeting transporters: promoting blood-brain barrier repair in response to oxidative stress injury.

Ronaldson PT, Davis TP.

Brain Res. 2015 Oct 14;1623:39-52. doi: 10.1016/j.brainres.2015.03.018. Epub 2015 Mar 18. Review.


Drug delivery to the ischemic brain.

Thompson BJ, Ronaldson PT.

Adv Pharmacol. 2014;71:165-202. doi: 10.1016/bs.apha.2014.06.013. Epub 2014 Aug 22. Review.


P-glycoprotein modulates morphine uptake into the CNS: a role for the non-steroidal anti-inflammatory drug diclofenac.

Sanchez-Covarrubias L, Slosky LM, Thompson BJ, Zhang Y, Laracuente ML, DeMarco KM, Ronaldson PT, Davis TP.

PLoS One. 2014 Feb 10;9(2):e88516. doi: 10.1371/journal.pone.0088516. eCollection 2014.


Hypoxia/reoxygenation stress signals an increase in organic anion transporting polypeptide 1a4 (Oatp1a4) at the blood-brain barrier: relevance to CNS drug delivery.

Thompson BJ, Sanchez-Covarrubias L, Slosky LM, Zhang Y, Laracuente ML, Ronaldson PT.

J Cereb Blood Flow Metab. 2014 Apr;34(4):699-707. doi: 10.1038/jcbfm.2014.4. Epub 2014 Jan 29.


Gabapentin and diclofenac reduce opioid consumption in patients undergoing tonsillectomy: a result of altered CNS drug delivery?

Ronaldson PT, Davis TP.

Arch Trauma Res. 2013 Aug;2(2):97-8. doi: 10.5812/atr.11011. Epub 2013 Aug 1. No abstract available.


Acetaminophen modulates P-glycoprotein functional expression at the blood-brain barrier by a constitutive androstane receptor-dependent mechanism.

Slosky LM, Thompson BJ, Sanchez-Covarrubias L, Zhang Y, Laracuente ML, Vanderah TW, Ronaldson PT, Davis TP.

Mol Pharmacol. 2013 Nov;84(5):774-86. doi: 10.1124/mol.113.086298. Epub 2013 Sep 9.


Transporters at CNS barrier sites: obstacles or opportunities for drug delivery?

Sanchez-Covarrubias L, Slosky LM, Thompson BJ, Davis TP, Ronaldson PT.

Curr Pharm Des. 2014;20(10):1422-49. Review.


Targeting transporters for CNS drug delivery.

Ronaldson PT.

Curr Pharm Des. 2014;20(10):1419-21. No abstract available.


Microglial activation decreases retention of the protease inhibitor saquinavir: implications for HIV treatment.

Dallas S, Block ML, Thompson DM, Bonini MG, Ronaldson PT, Bendayan R, Miller DS.

J Neuroinflammation. 2013 May 4;10:58. doi: 10.1186/1742-2094-10-58.


Targeted drug delivery to treat pain and cerebral hypoxia.

Ronaldson PT, Davis TP.

Pharmacol Rev. 2013 Jan 23;65(1):291-314. doi: 10.1124/pr.112.005991. Print 2013 Jan. Review.


P-glycoprotein trafficking at the blood-brain barrier altered by peripheral inflammatory hyperalgesia.

McCaffrey G, Staatz WD, Sanchez-Covarrubias L, Finch JD, Demarco K, Laracuente ML, Ronaldson PT, Davis TP.

J Neurochem. 2012 Sep;122(5):962-75. doi: 10.1111/j.1471-4159.2012.07831.x. Epub 2012 Jul 10.


Targeting blood-brain barrier changes during inflammatory pain: an opportunity for optimizing CNS drug delivery.

Ronaldson PT, Davis TP.

Ther Deliv. 2011 Aug;2(8):1015-41. doi: 10.4155/tde.11.67. Review.


Tempol modulates changes in xenobiotic permeability and occludin oligomeric assemblies at the blood-brain barrier during inflammatory pain.

Lochhead JJ, McCaffrey G, Sanchez-Covarrubias L, Finch JD, Demarco KM, Quigley CE, Davis TP, Ronaldson PT.

Am J Physiol Heart Circ Physiol. 2012 Feb 1;302(3):H582-93. doi: 10.1152/ajpheart.00889.2011. Epub 2011 Nov 11.


Regulation of P-glycoprotein by human immunodeficiency virus-1 in primary cultures of human fetal astrocytes.

Ashraf T, Ronaldson PT, Persidsky Y, Bendayan R.

J Neurosci Res. 2011 Nov;89(11):1773-82. doi: 10.1002/jnr.22720. Epub 2011 Aug 8.


Inflammatory pain signals an increase in functional expression of organic anion transporting polypeptide 1a4 at the blood-brain barrier.

Ronaldson PT, Finch JD, Demarco KM, Quigley CE, Davis TP.

J Pharmacol Exp Ther. 2011 Mar;336(3):827-39. doi: 10.1124/jpet.110.174151. Epub 2010 Dec 2.


Transforming growth factor-beta signaling alters substrate permeability and tight junction protein expression at the blood-brain barrier during inflammatory pain.

Ronaldson PT, Demarco KM, Sanchez-Covarrubias L, Solinsky CM, Davis TP.

J Cereb Blood Flow Metab. 2009 Jun;29(6):1084-98. doi: 10.1038/jcbfm.2009.32. Epub 2009 Mar 25.


Up-regulation of P-glycoprotein by HIV protease inhibitors in a human brain microvessel endothelial cell line.

Zastre JA, Chan GN, Ronaldson PT, Ramaswamy M, Couraud PO, Romero IA, Weksler B, Bendayan M, Bendayan R.

J Neurosci Res. 2009 Mar;87(4):1023-36. doi: 10.1002/jnr.21898.


Regulation of ABC membrane transporters in glial cells: relevance to the pharmacotherapy of brain HIV-1 infection.

Ronaldson PT, Persidsky Y, Bendayan R.

Glia. 2008 Dec;56(16):1711-35. doi: 10.1002/glia.20725. Review.


HIV-1 viral envelope glycoprotein gp120 produces oxidative stress and regulates the functional expression of multidrug resistance protein-1 (Mrp1) in glial cells.

Ronaldson PT, Bendayan R.

J Neurochem. 2008 Aug;106(3):1298-313. doi: 10.1111/j.1471-4159.2008.05479.x. Epub 2008 May 12.


In situ localization of P-glycoprotein (ABCB1) in human and rat brain.

Bendayan R, Ronaldson PT, Gingras D, Bendayan M.

J Histochem Cytochem. 2006 Oct;54(10):1159-67. Epub 2006 Jun 26.


In vitro toxicity to breast cancer cells of microsphere-delivered mitomycin C and its combination with doxorubicin.

Cheung RY, Rauth AM, Ronaldson PT, Bendayan R, Wu XY.

Eur J Pharm Biopharm. 2006 Apr;62(3):321-31. Epub 2005 Dec 5.


Multidrug resistance protein 1-mediated transport of saquinavir by microglia.

Dallas S, Ronaldson PT, Bendayan M, Bendayan R.

Neuroreport. 2004 May 19;15(7):1183-6.


Cellular localization and functional expression of P-glycoprotein in rat astrocyte cultures.

Ronaldson PT, Bendayan M, Gingras D, Piquette-Miller M, Bendayan R.

J Neurochem. 2004 May;89(3):788-800.

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