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Growth Factors and Alcohol Use Disorder.

Liran M, Rahamim N, Ron D, Barak S.

Cold Spring Harb Perspect Med. 2020 Jan 21. pii: a039271. doi: 10.1101/cshperspect.a039271. [Epub ahead of print]


Maintenance treatment in metastatic colorectal cancer: in search of the best strategy.

Ron DA, Vera R, Labandeira CM, Manrique MCA, Núñez MÁ, Cid NG, Mata JG, Montes AF.

Clin Transl Oncol. 2020 Jan 2. doi: 10.1007/s12094-019-02267-9. [Epub ahead of print] Review.


De Novo Mutations in EIF2B1 Affecting eIF2 Signaling Cause Neonatal/Early Onset Diabetes and Transient Hepatic Dysfunction.

De Franco E, Caswell R, Johnson MB, Wakeling MN, Zung A, Dũng VC, Bích Ngọc CT, Goonetilleke R, Jury MV, El-Khateeb M, Ellard S, Flanagan SE, Ron D, Hattersley AT.

Diabetes. 2019 Dec 27. pii: db191029. doi: 10.2337/db19-1029. [Epub ahead of print]


GDF15 mediates the effects of metformin on body weight and energy balance.

Coll AP, Chen M, Taskar P, Rimmington D, Patel S, Tadross J, Cimino I, Yang M, Welsh P, Virtue S, Goldspink DA, Miedzybrodzka EL, Konopka AR, Esponda RR, Huang JT, Tung YCL, Rodriguez-Cuenca S, Tomaz RA, Harding HP, Melvin A, Yeo GSH, Preiss D, Vidal-Puig A, Vallier L, Nair KS, Wareham NJ, Ron D, Gribble FM, Reimann F, Sattar N, Savage DB, Allan BB, O'Rahilly S.

Nature. 2019 Dec 25. doi: 10.1038/s41586-019-1911-y. [Epub ahead of print]


Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR.

Amin-Wetzel N, Neidhardt L, Yan Y, Mayer MP, Ron D.

Elife. 2019 Dec 24;8. pii: e50793. doi: 10.7554/eLife.50793. [Epub ahead of print]


mTORC1 in the orbitofrontal cortex promotes habitual alcohol seeking.

Morisot N, Phamluong K, Ehinger Y, Berger AL, Moffat JJ, Ron D.

Elife. 2019 Dec 11;8. pii: e51333. doi: 10.7554/eLife.51333.


The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells.

Harding HP, Ordonez A, Allen F, Parts L, Inglis AJ, Williams RL, Ron D.

Elife. 2019 Nov 21;8. pii: e50149. doi: 10.7554/eLife.50149.


An oligomeric state-dependent switch in the ER enzyme FICD regulates AMPylation and deAMPylation of BiP.

Perera LA, Rato C, Yan Y, Neidhardt L, McLaughlin SH, Read RJ, Preissler S, Ron D.

EMBO J. 2019 Oct 4;38(21):e102177. doi: 10.15252/embj.2019102177. Epub 2019 Sep 18.


Protein Translation and Psychiatric Disorders.

Laguesse S, Ron D.

Neuroscientist. 2019 Jul 4:1073858419853236. doi: 10.1177/1073858419853236. [Epub ahead of print]


The tumor suppressor Sef is a scaffold for the classical NF-κB/RELA:P50 signaling module.

Korsensky L, Haif S, Heller R, Rabinovitz S, Haddad-Halloun J, Dahan N, Ron D.

Cell Signal. 2019 Jul;59:110-121. doi: 10.1016/j.cellsig.2019.01.009. Epub 2019 Mar 9.


MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP.

Yan Y, Rato C, Rohland L, Preissler S, Ron D.

Nat Commun. 2019 Feb 1;10(1):541. doi: 10.1038/s41467-019-08450-4.


GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans.

Patel S, Alvarez-Guaita A, Melvin A, Rimmington D, Dattilo A, Miedzybrodzka EL, Cimino I, Maurin AC, Roberts GP, Meek CL, Virtue S, Sparks LM, Parsons SA, Redman LM, Bray GA, Liou AP, Woods RM, Parry SA, Jeppesen PB, Kolnes AJ, Harding HP, Ron D, Vidal-Puig A, Reimann F, Gribble FM, Hulston CJ, Farooqi IS, Fafournoux P, Smith SR, Jensen J, Breen D, Wu Z, Zhang BB, Coll AP, Savage DB, O'Rahilly S.

Cell Metab. 2019 Mar 5;29(3):707-718.e8. doi: 10.1016/j.cmet.2018.12.016. Epub 2019 Jan 10.


The Fyn kinase inhibitor, AZD0530, suppresses mouse alcohol self-administration and seeking.

Morisot N, Berger AL, Phamluong K, Cross A, Ron D.

Addict Biol. 2019 Nov;24(6):1227-1234. doi: 10.1111/adb.12699. Epub 2018 Dec 7.


D1 receptor hypersensitivity in mice with low striatal D2 receptors facilitates select cocaine behaviors.

Dobbs LK, Kaplan AR, Bock R, Phamluong K, Shin JH, Bocarsly ME, Eberhart L, Ron D, Alvarez VA.

Neuropsychopharmacology. 2019 Mar;44(4):805-816. doi: 10.1038/s41386-018-0286-3. Epub 2018 Dec 1.


Erratum: Early Events in the Endoplasmic Reticulum Unfolded Protein Response.

Preissler S, Ron D.

Cold Spring Harb Perspect Biol. 2018 Dec 3;10(12). pii: a037309. doi: 10.1101/cshperspect.a037309. No abstract available.


Special issue on new technologies for alcohol research and treatment.

Ron D, Weiner J.

Alcohol. 2019 Feb;74:1-2. doi: 10.1016/j.alcohol.2018.06.003. Epub 2018 Jun 14. No abstract available.


Early Events in the Endoplasmic Reticulum Unfolded Protein Response.

Preissler S, Ron D.

Cold Spring Harb Perspect Biol. 2019 Apr 1;11(4). pii: a033894. doi: 10.1101/cshperspect.a033894. Review. Erratum in: Cold Spring Harb Perspect Biol. 2018 Dec 3;10(12):.


Challenges in Lung Cancer Screening in Latin America.

Raez LE, Nogueira A, Santos ES, Dos Santos RS, Franceschini J, Ron DA, Block M, Yamaguchi N, Rolfo C.

J Glob Oncol. 2018 Sep;4:1-10. doi: 10.1200/JGO.17.00040. Review.


Single particle trajectories reveal active endoplasmic reticulum luminal flow.

Holcman D, Parutto P, Chambers JE, Fantham M, Young LJ, Marciniak SJ, Kaminski CF, Ron D, Avezov E.

Nat Cell Biol. 2018 Oct;20(10):1118-1125. doi: 10.1038/s41556-018-0192-2. Epub 2018 Sep 17.


Author Correction: The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation.

Aprile FA, Källstig E, Limorenko G, Vendruscolo M, Ron D, Hansen C.

Sci Rep. 2018 Aug 2;8(1):11848. doi: 10.1038/s41598-018-29893-7.


Increasing Brain-Derived Neurotrophic Factor (BDNF) in medial prefrontal cortex selectively reduces excessive drinking in ethanol dependent mice.

Haun HL, Griffin WC, Lopez MF, Solomon MG, Mulholland PJ, Woodward JJ, McGinty JF, Ron D, Becker HC.

Neuropharmacology. 2018 Sep 15;140:35-42. doi: 10.1016/j.neuropharm.2018.07.031. Epub 2018 Jul 26.


Mammalian target of rapamycin complex 1 and its downstream effector collapsin response mediator protein-2 drive reinstatement of alcohol reward seeking.

Ben Hamida S, Laguesse S, Morisot N, Park JH, Phuamluong K, Berger AL, Park KD, Ron D.

Addict Biol. 2019 Sep;24(5):908-920. doi: 10.1111/adb.12653. Epub 2018 Jul 18.


Mice engineered to mimic a common Val66Met polymorphism in the BDNF gene show greater sensitivity to reversal in environmental contingencies.

Vandenberg A, Lin WC, Tai LH, Ron D, Wilbrecht L.

Dev Cogn Neurosci. 2018 Nov;34:34-41. doi: 10.1016/j.dcn.2018.05.009. Epub 2018 May 30.


GDNF and alcohol use disorder.

Barak S, Ahmadiantehrani S, Logrip ML, Ron D.

Addict Biol. 2019 May;24(3):335-343. doi: 10.1111/adb.12628. Epub 2018 May 4.


The brain-derived neurotrophic factor VAL68MET polymorphism modulates how developmental ethanol exposure impacts the hippocampus.

Bird CW, Baculis BC, Mayfield JJ, Chavez GJ, Ontiveros T, Paine DJ, Marks AJ, Gonzales AL, Ron D, Valenzuela CF.

Genes Brain Behav. 2019 Mar;18(3):e12484. doi: 10.1111/gbb.12484. Epub 2018 May 28.


Targeting the intracellular signaling "STOP" and "GO" pathways for the treatment of alcohol use disorders.

Ron D, Berger A.

Psychopharmacology (Berl). 2018 Jun;235(6):1727-1743. doi: 10.1007/s00213-018-4882-z. Epub 2018 Apr 14. Review.


Retraction Notice to: The Unfolded Protein Response Element IRE1α Senses Bacterial Proteins Invading the ER to Activate RIG-I and Innate Immune Signaling.

Cho JA, Lee AH, Platzer B, Cross BCS, Gardner BM, De Luca H, Luong P, Harding HP, Glimcher LH, Walter P, Fiebiger E, Ron D, Kagan JC, Lencer WI.

Cell Host Microbe. 2018 Apr 11;23(4):571. doi: 10.1016/j.chom.2018.03.005. No abstract available.


A Sephin1-insensitive tripartite holophosphatase dephosphorylates translation initiation factor 2α.

Crespillo-Casado A, Claes Z, Choy MS, Peti W, Bollen M, Ron D.

J Biol Chem. 2018 May 18;293(20):7766-7776. doi: 10.1074/jbc.RA118.002325. Epub 2018 Apr 4.


Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B.

Zyryanova AF, Weis F, Faille A, Alard AA, Crespillo-Casado A, Sekine Y, Harding HP, Allen F, Parts L, Fromont C, Fischer PM, Warren AJ, Ron D.

Science. 2018 Mar 30;359(6383):1533-1536. doi: 10.1126/science.aar5129.


mTORC2 in the dorsomedial striatum of mice contributes to alcohol-dependent F-Actin polymerization, structural modifications, and consumption.

Laguesse S, Morisot N, Phamluong K, Sakhai SA, Ron D.

Neuropsychopharmacology. 2018 Jun;43(7):1539-1547. doi: 10.1038/s41386-018-0012-1. Epub 2018 Feb 7.


Alcohol operant self-administration: Investigating how alcohol-seeking behaviors predict drinking in mice using two operant approaches.

Blegen MB, da Silva E Silva D, Bock R, Morisot N, Ron D, Alvarez VA.

Alcohol. 2018 Mar;67:23-36. doi: 10.1016/j.alcohol.2017.08.008. Epub 2017 Aug 19.


A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response.

Amin-Wetzel N, Saunders RA, Kamphuis MJ, Rato C, Preissler S, Harding HP, Ron D.

Cell. 2017 Dec 14;171(7):1625-1637.e13. doi: 10.1016/j.cell.2017.10.040. Epub 2017 Nov 30.


mTORC1-dependent translation of collapsin response mediator protein-2 drives neuroadaptations underlying excessive alcohol-drinking behaviors.

Liu F, Laguesse S, Legastelois R, Morisot N, Ben Hamida S, Ron D.

Mol Psychiatry. 2018 Jan;23(1):164. doi: 10.1038/mp.2017.252. Epub 2017 Nov 14.


Delivery of the gene encoding the tumor suppressor Sef into prostate tumors by therapeutic-ultrasound inhibits both tumor angiogenesis and growth.

Mishel S, Shneyer B, Korsensky L, Goldshmidt-Tran O, Haber T, Machluf M, Ron D.

Sci Rep. 2017 Nov 8;7(1):15060. doi: 10.1038/s41598-017-12408-1.


AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation.

Preissler S, Rohland L, Yan Y, Chen R, Read RJ, Ron D.

Elife. 2017 Oct 24;6. pii: e29428. doi: 10.7554/eLife.29428.


Fyn Signaling Is Compartmentalized to Dopamine D1 Receptor Expressing Neurons in the Dorsal Medial Striatum.

Phamluong K, Darcq E, Wu S, Sakhai SA, Ron D.

Front Mol Neurosci. 2017 Aug 31;10:273. doi: 10.3389/fnmol.2017.00273. eCollection 2017.


Prosapip1-Dependent Synaptic Adaptations in the Nucleus Accumbens Drive Alcohol Intake, Seeking, and Reward.

Laguesse S, Morisot N, Shin JH, Liu F, Adrover MF, Sakhai SA, Lopez MF, Phamluong K, Griffin WC 3rd, Becker HC, Bender KJ, Alvarez VA, Ron D.

Neuron. 2017 Sep 27;96(1):145-159.e8. doi: 10.1016/j.neuron.2017.08.037. Epub 2017 Sep 8.


The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation.

Aprile FA, Källstig E, Limorenko G, Vendruscolo M, Ron D, Hansen C.

Sci Rep. 2017 Aug 22;7(1):9039. doi: 10.1038/s41598-017-08324-z. Erratum in: Sci Rep. 2018 Aug 2;8(1):11848.


The requirement of IRE1 and XBP1 in resolving physiological stress during Drosophila development.

Huang HW, Zeng X, Rhim T, Ron D, Ryoo HD.

J Cell Sci. 2017 Sep 15;130(18):3040-3049. doi: 10.1242/jcs.203612. Epub 2017 Aug 3.


Periadolescent Maturation of GABAergic Hyperpolarization at the Axon Initial Segment.

Rinetti-Vargas G, Phamluong K, Ron D, Bender KJ.

Cell Rep. 2017 Jul 5;20(1):21-29. doi: 10.1016/j.celrep.2017.06.030.


A new generation of mTORC1 inhibitor attenuates alcohol intake and reward in mice.

Morisot N, Novotny CJ, Shokat KM, Ron D.

Addict Biol. 2018 Mar;23(2):713-722. doi: 10.1111/adb.12528. Epub 2017 Jul 6.


Surprising convergence of the Monte Carlo renormalization group for the three-dimensional Ising model.

Ron D, Brandt A, Swendsen RH.

Phys Rev E. 2017 May;95(5-1):053305. doi: 10.1103/PhysRevE.95.053305. Epub 2017 May 16.


Generic membrane-spanning features endow IRE1α with responsiveness to membrane aberrancy.

Kono N, Amin-Wetzel N, Ron D.

Mol Biol Cell. 2017 Aug 15;28(17):2318-2332. doi: 10.1091/mbc.E17-03-0144. Epub 2017 Jun 14.


PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz.

Crespillo-Casado A, Chambers JE, Fischer PM, Marciniak SJ, Ron D.

Elife. 2017 Apr 27;6. pii: e26109. doi: 10.7554/eLife.26109.


TriPer, an optical probe tuned to the endoplasmic reticulum tracks changes in luminal H2O2.

Melo EP, Lopes C, Gollwitzer P, Lortz S, Lenzen S, Mehmeti I, Kaminski CF, Ron D, Avezov E.

BMC Biol. 2017 Mar 27;15(1):24. doi: 10.1186/s12915-017-0367-5.


Limited Excessive Voluntary Alcohol Drinking Leads to Liver Dysfunction in Mice.

Wegner SA, Pollard KA, Kharazia V, Darevsky D, Perez L, Roychowdhury S, Xu A, Ron D, Nagy LE, Hopf FW.

Alcohol Clin Exp Res. 2017 Feb;41(2):345-358. doi: 10.1111/acer.13303. Epub 2017 Jan 19.


Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis.

Tschurtschenthaler M, Adolph TE, Ashcroft JW, Niederreiter L, Bharti R, Saveljeva S, Bhattacharyya J, Flak MB, Shih DQ, Fuhler GM, Parkes M, Kohno K, Iwawaki T, Janneke van der Woude C, Harding HP, Smith AM, Peppelenbosch MP, Targan SR, Ron D, Rosenstiel P, Blumberg RS, Kaser A.

J Exp Med. 2017 Feb;214(2):401-422. doi: 10.1084/jem.20160791. Epub 2017 Jan 12.


FICD acts bifunctionally to AMPylate and de-AMPylate the endoplasmic reticulum chaperone BiP.

Preissler S, Rato C, Perera L, Saudek V, Ron D.

Nat Struct Mol Biol. 2017 Jan;24(1):23-29. doi: 10.1038/nsmb.3337. Epub 2016 Dec 5.


Alcohol-dependent molecular adaptations of the NMDA receptor system.

Morisot N, Ron D.

Genes Brain Behav. 2017 Jan;16(1):139-148. doi: 10.1111/gbb.12363. Review.


Paradoxical Sensitivity to an Integrated Stress Response Blocking Mutation in Vanishing White Matter Cells.

Sekine Y, Zyryanova A, Crespillo-Casado A, Amin-Wetzel N, Harding HP, Ron D.

PLoS One. 2016 Nov 3;11(11):e0166278. doi: 10.1371/journal.pone.0166278. eCollection 2016.

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