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Dysregulation of Gap Junction Function and Cytokine Production in Response to Non-Genotoxic Polycyclic Aromatic Hydrocarbons in an In Vitro Lung Cell Model.

Romo D, Velmurugan K, Upham BL, Dwyer-Nield LD, Bauer AK.

Cancers (Basel). 2019 Apr 23;11(4). pii: E572. doi: 10.3390/cancers11040572.


Simplified immunosuppressive and neuroprotective agents based on gracilin A.

Abbasov ME, Alvariño R, Chaheine CM, Alonso E, Sánchez JA, Conner ML, Alfonso A, Jaspars M, Botana LM, Romo D.

Nat Chem. 2019 Apr;11(4):342-350. doi: 10.1038/s41557-019-0230-0. Epub 2019 Mar 22.


An Educational Intervention to Improve Provider Screening for Syphilis Among Men Who Have Sex with Men Utilizing an Urban Urgent Care Center.

Romo D, Nagendra G, Schechter S, Pavlish A, Cohall A, Neu N.

J Community Health. 2019 Mar 14. doi: 10.1007/s10900-019-00647-4. [Epub ahead of print]


Creating novel translation inhibitors to target pro-survival proteins in chronic lymphocytic leukemia.

Chen R, Zhu M, Chaudhari RR, Robles O, Chen Y, Skillern W, Qin Q, Wierda WG, Zhang S, Hull KG, Romo D, Plunkett W.

Leukemia. 2019 Jan 30. doi: 10.1038/s41375-018-0364-x. [Epub ahead of print]


Early Mechanistic Events Induced by Low Molecular Weight Polycyclic Aromatic Hydrocarbons in Mouse Lung Epithelial Cells: A Role for Eicosanoid Signaling.

Siegrist KJ, Romo D, Upham BL, Armstrong M, Quinn K, Vanderlinden L, Osgood RS, Velmurugan K, Elie M, Manke J, Reinhold D, Reisdorph N, Saba L, Bauer AK.

Toxicol Sci. 2019 May 1;169(1):180-193. doi: 10.1093/toxsci/kfz030.


Total Synthesis and Anticancer Activity of (+)-Hypercalin C and Congeners.

Tao Y, Reisenauer K, Taube JH, Romo D.

Angew Chem Int Ed Engl. 2019 Feb 25;58(9):2734-2738. doi: 10.1002/anie.201812909. Epub 2019 Feb 1.


A Novel Actin Binding Drug with In Vivo Efficacy.

Ravichandran A, Geng M, Hull KG, Li J, Romo D, Lu SE, Albee A, Nutter C, Gordon DM, Ghannoum MA, Lockless SW, Smith L.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01585-18. doi: 10.1128/AAC.01585-18. Print 2019 Jan.


(-)-Homosalinosporamide A and Its Mode of Proteasome Inhibition: An X-ray Crystallographic Study.

Groll M, Nguyen H, Vellalath S, Romo D.

Mar Drugs. 2018 Jul 19;16(7). pii: E240. doi: 10.3390/md16070240.


Comparison of Alicyclobacillus acidocaldarius o-Succinylbenzoate Synthase to Its Promiscuous N-Succinylamino Acid Racemase/ o-Succinylbenzoate Synthase Relatives.

Odokonyero D, McMillan AW, Ramagopal UA, Toro R, Truong DP, Zhu M, Lopez MS, Somiari B, Herman M, Aziz A, Bonanno JB, Hull KG, Burley SK, Romo D, Almo SC, Glasner ME.

Biochemistry. 2018 Jul 3;57(26):3676-3689. doi: 10.1021/acs.biochem.8b00088. Epub 2018 May 30.


Enantioselective Synthesis of Medium-Sized Lactams via Chiral α,β-Unsaturated Acylammonium Salts.

Kang G, Yamagami M, Vellalath S, Romo D.

Angew Chem Int Ed Engl. 2018 May 28;57(22):6527-6531. doi: 10.1002/anie.201802483. Epub 2018 May 2.


Isolation, Derivative Synthesis, and Structure-Activity Relationships of Antiparasitic Bromopyrrole Alkaloids from the Marine Sponge Tedania brasiliensis.

Parra LLL, Bertonha AF, Severo IRM, Aguiar ACC, de Souza GE, Oliva G, Guido RVC, Grazzia N, Costa TR, Miguel DC, Gadelha FR, Ferreira AG, Hajdu E, Romo D, Berlinck RGS.

J Nat Prod. 2018 Jan 26;81(1):188-202. doi: 10.1021/acs.jnatprod.7b00876. Epub 2018 Jan 3.


Multicomponent, Enantioselective Michael-Michael-Aldol-β-Lactonizations Delivering Complex β-Lactones.

Van KN, Romo D.

J Org Chem. 2018 Jan 19;83(2):632-643. doi: 10.1021/acs.joc.7b02543. Epub 2018 Jan 4.


Environmentally prevalent polycyclic aromatic hydrocarbons can elicit co-carcinogenic properties in an in vitro murine lung epithelial cell model.

Bauer AK, Velmurugan K, Plöttner S, Siegrist KJ, Romo D, Welge P, Brüning T, Xiong KN, Käfferlein HU.

Arch Toxicol. 2018 Mar;92(3):1311-1322. doi: 10.1007/s00204-017-2124-5. Epub 2017 Nov 23.


Quantitative chemoproteomic profiling reveals multiple target interactions of spongiolactone derivatives in leukemia cells.

Wright MH, Tao Y, Drechsel J, Krysiak J, Chamni S, Weigert-Munoz A, Harvey NL, Romo D, Sieber SA.

Chem Commun (Camb). 2017 Nov 28;53(95):12818-12821. doi: 10.1039/c7cc04990k.


Diastereo- and Enantioselective Synthesis of Bi- and Tricyclic N-Heterocycle-Fused β-Lactones.

Kong W, Romo D.

J Org Chem. 2017 Dec 15;82(24):13161-13170. doi: 10.1021/acs.joc.7b02235. Epub 2017 Dec 4.


Bioactive Seco-Lanostane-Type Triterpenoids from the Roots of Leplaea mayombensis.

Sidjui LS, Eyong KO, Hull KG, Folefoc GN, Leddet VM, Herbette G, Ollivier E, Taube J, Klausmeyer K, Romo D.

J Nat Prod. 2017 Oct 27;80(10):2644-2651. doi: 10.1021/acs.jnatprod.7b00210. Epub 2017 Sep 25.


Stereodivergent, Diels-Alder-initiated organocascades employing α,β-unsaturated acylammonium salts: scope, mechanism, and application.

Abbasov ME, Hudson BM, Tantillo DJ, Romo D.

Chem Sci. 2017 Feb 1;8(2):1511-1524. doi: 10.1039/c6sc04273b. Epub 2016 Oct 21.


Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A.

McClary B, Zinshteyn B, Meyer M, Jouanneau M, Pellegrino S, Yusupova G, Schuller A, Reyes JCP, Lu J, Guo Z, Ayinde S, Luo C, Dang Y, Romo D, Yusupov M, Green R, Liu JO.

Cell Chem Biol. 2017 May 18;24(5):605-613.e5. doi: 10.1016/j.chembiol.2017.04.006. Epub 2017 Apr 27.


Enantioselective Diels-Alder-lactamization organocascades employing a furan-based diene.

Abbasov ME, Hudson BM, Kong W, Tantillo DJ, Romo D.

Org Biomol Chem. 2017 Apr 11;15(15):3179-3183. doi: 10.1039/c6ob02738e.


Antiretroviral therapy in HIV-infected adolescents: clinical and pharmacologic challenges.

Dobroszycki J, Lee P, Romo DL, Rosenberg MG, Wiznia A, Abadi J.

Expert Rev Clin Pharmacol. 2017 May;10(5):509-516. doi: 10.1080/17512433.2017.1301205. Epub 2017 Mar 14. Review.


Approach to Human Immunodeficiency Virus/Sexually Transmitted Infection Testing for Men at an Urban Urgent Care Center.

Schechter SB, Romo DL, Cohall AT, Neu NM.

Sex Transm Dis. 2017 Apr;44(4):255-259. doi: 10.1097/OLQ.0000000000000571.


A strategy for dual inhibition of the proteasome and fatty acid synthase with belactosin C-orlistat hybrids.

Zhu M, Harshbarger WD, Robles O, Krysiak J, Hull KG, Cho SW, Richardson RD, Yang Y, Garcia A, Spiegelman L, Ramirez B, Wilson CT, Yau JA, Moore JT, Walker CB, Sacchettini JC, Liu WR, Sieber SA, Smith JW, Romo D.

Bioorg Med Chem. 2017 Jun 1;25(11):2901-2916. doi: 10.1016/j.bmc.2017.01.020. Epub 2017 Jan 19.


Social Media Use and its Association with Sexual Risk and Parental Monitoring among a Primarily Hispanic Adolescent Population.

Romo DL, Garnett C, Younger AP, Stockwell MS, Soren K, Catallozzi M, Neu N.

J Pediatr Adolesc Gynecol. 2017 Aug;30(4):466-473. doi: 10.1016/j.jpag.2017.02.004. Epub 2017 Feb 17.


Xylem Surfactants Introduce a New Element to the Cohesion-Tension Theory.

Schenk HJ, Espino S, Romo DM, Nima N, Do AY, Michaud JM, Papahadjopoulos-Sternberg B, Yang J, Zuo YY, Steppe K, Jansen S.

Plant Physiol. 2017 Feb;173(2):1177-1196. doi: 10.1104/pp.16.01039. Epub 2016 Dec 7.


Re-focusing HIV prevention messages: a qualitative study in rural Uganda.

Mathur S, Romo D, Rasmussen M, Nakyanjo N, Nalugoda F, Santelli JS.

AIDS Res Ther. 2016 Nov 11;13:37. eCollection 2016.


Asymmetric Organocatalysis: The Emerging Utility of α,β-Unsaturated Acylammonium Salts.

Vellalath S, Romo D.

Angew Chem Int Ed Engl. 2016 Nov 2;55(45):13934-13943. doi: 10.1002/anie.201602217. Epub 2016 Sep 21. Review.


Herpes Simplex Virus 2 Virion Host Shutoff Endoribonuclease Activity Is Required To Disrupt Stress Granule Formation.

Finnen RL, Zhu M, Li J, Romo D, Banfield BW.

J Virol. 2016 Aug 12;90(17):7943-55. doi: 10.1128/JVI.00947-16. Print 2016 Sep 1.


Editorial: Strategies for cellular target identification of natural products.

Romo D, Liu JO.

Nat Prod Rep. 2016 May 4;33(5):592-4. doi: 10.1039/c6np90016j. No abstract available.


Derivatization of agelastatin A leading to bioactive analogs and a trifunctional probe.

Jouanneau M, McClary B, Reyes JC, Chen R, Chen Y, Plunkett W, Cheng X, Milinichik AZ, Albone EF, Liu JO, Romo D.

Bioorg Med Chem Lett. 2016 Apr 15;26(8):2092-7. doi: 10.1016/j.bmcl.2016.02.051. Epub 2016 Feb 23.


Chemical Mechanism of the Phosphotriesterase from Sphingobium sp. Strain TCM1, an Enzyme Capable of Hydrolyzing Organophosphate Flame Retardants.

Bigley AN, Xiang DF, Ren Z, Xue H, Hull KG, Romo D, Raushel FM.

J Am Chem Soc. 2016 Mar 9;138(9):2921-4. doi: 10.1021/jacs.5b12739. Epub 2016 Feb 26.


Correction: Piperlongumine Blocks JAK2-STAT3 to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species†.

Yuan H, Houck KL, Tian Y, Bharadwaj U, Hull K, Zhou Z, Zhu M, Wu X, Tweardy DJ, Romo D, Fu X, Zhang Y, Zhang J, Dong JF.

PLoS One. 2016 Jan 4;11(1):e0146626. doi: 10.1371/journal.pone.0146626. eCollection 2016. No abstract available.


Piperlongumine Blocks JAK2-STAT3 to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species.

Yuan H, Houck KL, Tian Y, Bharadwaj U, Hull K, Zhou Z, Zhu M, Wu X, Tweardy DJ, Romo D, Fu X, Zhang Y, Zhang J, Dong JF.

PLoS One. 2015 Dec 8;10(12):e0143964. doi: 10.1371/journal.pone.0143964. eCollection 2015. Erratum in: PLoS One. 2016;11(1):e0146626. Zhou, Mingzhao [corrected to Zhu, Mingzhao].


Interrogation of the Substrate Profile and Catalytic Properties of the Phosphotriesterase from Sphingobium sp. Strain TCM1: An Enzyme Capable of Hydrolyzing Organophosphate Flame Retardants and Plasticizers.

Xiang DF, Bigley AN, Ren Z, Xue H, Hull KG, Romo D, Raushel FM.

Biochemistry. 2015 Dec 29;54(51):7539-49. doi: 10.1021/acs.biochem.5b01144. Epub 2015 Dec 16.


Blind colour separation of H&E stained histological images by linearly transforming the colour space.

Celis R, Romo D, Romero E.

J Microsc. 2015 Dec;260(3):377-88. doi: 10.1111/jmi.12304. Epub 2015 Sep 10.


Covalent modification of a cysteine residue in the XPB subunit of the general transcription factor TFIIH through single epoxide cleavage of the transcription inhibitor triptolide.

He QL, Titov DV, Li J, Tan M, Ye Z, Zhao Y, Romo D, Liu JO.

Angew Chem Int Ed Engl. 2015 Feb 2;54(6):1859-63. doi: 10.1002/anie.201408817. Epub 2014 Dec 12.


Synthesis of (±)-spongiolactone enabling discovery of a more potent derivative.

Harvey NL, Krysiak J, Chamni S, Cho SW, Sieber SA, Romo D.

Chemistry. 2015 Jan 19;21(4):1425-8. doi: 10.1002/chem.201405980. Epub 2014 Dec 8.


Yasuní--a hotspot for jaguars Panthera onca (Carnivora: Felidae)? Camera-traps and jaguar activity at Tiputini Biodiversity Station, Ecuador.

Blake JG, Mosquera D, Guerra J, Loiselle BA, Romo D, Swing JK.

Rev Biol Trop. 2014 Jun;62(2):689-98.


The ever-expanding role of asymmetric covalent organocatalysis in scalable, natural product synthesis.

Abbasov ME, Romo D.

Nat Prod Rep. 2014 Oct;31(10):1318-27. doi: 10.1039/c4np00025k. Review.


Role of an active site loop in the promiscuous activities of Amycolatopsis sp. T-1-60 NSAR/OSBS.

McMillan AW, Lopez MS, Zhu M, Morse BC, Yeo IC, Amos J, Hull K, Romo D, Glasner ME.

Biochemistry. 2014 Jul 15;53(27):4434-44. doi: 10.1021/bi500573v. Epub 2014 Jul 3.


Promiscuity of Exiguobacterium sp. AT1b o-succinylbenzoate synthase illustrates evolutionary transitions in the OSBS family.

Brizendine AM, Odokonyero D, McMillan AW, Zhu M, Hull K, Romo D, Glasner ME.

Biochem Biophys Res Commun. 2014 Jul 18;450(1):679-84. doi: 10.1016/j.bbrc.2014.06.034. Epub 2014 Jun 14.


Acylammonium salts as dienophiles in Diels-Alder/lactonization organocascades.

Abbasov ME, Hudson BM, Tantillo DJ, Romo D.

J Am Chem Soc. 2014 Mar 26;136(12):4492-5. doi: 10.1021/ja501005g. Epub 2014 Mar 12.


Chemo- and site-selective derivatizations of natural products enabling biological studies.

Robles O, Romo D.

Nat Prod Rep. 2014 Mar;31(3):318-34. doi: 10.1039/c3np70087a. Review.


Second-generation derivatives of the eukaryotic translation initiation inhibitor pateamine A targeting eIF4A as potential anticancer agents.

Low WK, Li J, Zhu M, Kommaraju SS, Shah-Mittal J, Hull K, Liu JO, Romo D.

Bioorg Med Chem. 2014 Jan 1;22(1):116-25. doi: 10.1016/j.bmc.2013.11.046. Epub 2013 Dec 4.


Rapid assembly of complex cyclopentanes employing chiral, α,β-unsaturated acylammonium intermediates.

Liu G, Shirley ME, Van KN, McFarlin RL, Romo D.

Nat Chem. 2013 Dec;5(12):1049-57. doi: 10.1038/nchem.1788. Epub 2013 Nov 3.


Direct catalytic asymmetric synthesis of N-heterocycles from commodity acid chlorides by employing α,β-unsaturated acylammonium salts.

Vellalath S, Van KN, Romo D.

Angew Chem Int Ed Engl. 2013 Dec 16;52(51):13688-93. doi: 10.1002/anie.201306050. Epub 2013 Oct 31.


Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification.

Zhou P, Zhang Y, Ma Q, Gu F, Day DS, He A, Zhou B, Li J, Stevens SM, Romo D, Pu WT.

Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15395-400. doi: 10.1073/pnas.1304124110. Epub 2013 Sep 3.


Is it ok 2 txt? Reaching out to adolescents about sexual and reproductive health.

Malbon K, Romo D.

Postgrad Med J. 2013 Sep;89(1055):534-9. doi: 10.1136/postgradmedj-2012-131519. Epub 2013 Jul 10. Review.


Simultaneous structure-activity studies and arming of natural products by C-H amination reveal cellular targets of eupalmerin acetate.

Li J, Cisar JS, Zhou CY, Vera B, Williams H, Rodríguez AD, Cravatt BF, Romo D.

Nat Chem. 2013 Jun;5(6):510-7. doi: 10.1038/nchem.1653. Epub 2013 May 19. Erratum in: Nat Chem. 2013 Jul;5(7):634.


Concise synthesis of the isothiourea organocatalysts homobenzotetramisole and derivatives.

Ranieri B, Robles O, Romo D.

J Org Chem. 2013 Jun 21;78(12):6291-6. doi: 10.1021/jo400603n. Epub 2013 Jun 5. Erratum in: J Org Chem. 2013 Aug 16;78(16):8215.


Dyotropic rearrangements of fused tricyclic β-lactones: application to the synthesis of (-)-curcumanolide A and (-)-curcumalactone.

Leverett CA, Purohit VC, Johnson AG, Davis RL, Tantillo DJ, Romo D.

J Am Chem Soc. 2012 Aug 15;134(32):13348-56. doi: 10.1021/ja303414a. Epub 2012 Aug 1. Erratum in: J Am Chem Soc. 2013 Aug 21;135(33):12478.


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