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Items: 1 to 50 of 87

1.

PARP1 rs1805407 Increases Sensitivity to PARP1 Inhibitors in Cancer Cells Suggesting an Improved Therapeutic Strategy.

Abecassis I, Sedgewick AJ, Romkes M, Buch S, Nukui T, Kapetanaki MG, Vogt A, Kirkwood JM, Benos PV, Tawbi H.

Sci Rep. 2019 Mar 1;9(1):3309. doi: 10.1038/s41598-019-39542-2.

2.

Expression of PAM50 Genes in Lung Cancer: Evidence that Interactions between Hormone Receptors and HER2/HER3 Contribute to Poor Outcome.

Siegfried JM, Lin Y, Diergaarde B, Lin HM, Dacic S, Pennathur A, Weissfeld JL, Romkes M, Nukui T, Stabile LP.

Neoplasia. 2015 Nov;17(11):817-25. doi: 10.1016/j.neo.2015.11.002.

3.

Lung Cancer Risk Prediction Using Common SNPs Located in GWAS-Identified Susceptibility Regions.

Weissfeld JL, Lin Y, Lin HM, Kurland BF, Wilson DO, Fuhrman CR, Pennathur A, Romkes M, Nukui T, Yuan JM, Siegfried JM, Diergaarde B.

J Thorac Oncol. 2015 Nov;10(11):1538-45. doi: 10.1097/JTO.0000000000000666.

4.

MicroRNA expression profiling predicts clinical outcome of carboplatin/paclitaxel-based therapy in metastatic melanoma treated on the ECOG-ACRIN trial E2603.

Villaruz LC, Huang G, Romkes M, Kirkwood JM, Buch SC, Nukui T, Flaherty KT, Lee SJ, Wilson MA, Nathanson KL, Benos PV, Tawbi HA.

Clin Epigenetics. 2015 Jun 4;7:58. doi: 10.1186/s13148-015-0092-2. eCollection 2015.

5.

15q12 variants, sputum gene promoter hypermethylation, and lung cancer risk: a GWAS in smokers.

Leng S, Liu Y, Weissfeld JL, Thomas CL, Han Y, Picchi MA, Edlund CK, Willink RP, Gaither Davis AL, Do KC, Nukui T, Zhang X, Burki EA, Van Den Berg D, Romkes M, Gauderman WJ, Crowell RE, Tesfaigzi Y, Stidley CA, Amos CI, Siegfried JM, Gilliland FD, Belinsky SA.

J Natl Cancer Inst. 2015 Feb 23;107(5). pii: djv035. doi: 10.1093/jnci/djv035.

6.

Identification of epidermal growth factor receptor (EGFR) genetic variants that modify risk for head and neck squamous cell carcinoma.

Fung C, Zhou P, Joyce S, Trent K, Yuan JM, Grandis JR, Weissfeld JL, Romkes M, Weeks DE, Egloff AM.

Cancer Lett. 2015 Feb 28;357(2):549-56. doi: 10.1016/j.canlet.2014.12.008. Epub 2014 Dec 12.

7.

Matrix metalloproteinase-19 promotes metastatic behavior in vitro and is associated with increased mortality in non-small cell lung cancer.

Yu G, Herazo-Maya JD, Nukui T, Romkes M, Parwani A, Juan-Guardela BM, Robertson J, Gauldie J, Siegfried JM, Kaminski N, Kass DJ.

Am J Respir Crit Care Med. 2014 Oct 1;190(7):780-90. doi: 10.1164/rccm.201310-1903OC.

8.

Inherited variation in the ATP-binding cassette transporter ABCB1 and survival after chemotherapy for stage III-IV lung cancer.

Weissfeld JL, Diergaarde B, Nukui T, Buch S, Pennathur A, Socinski MA, Siegfried JM, Romkes M.

J Thorac Oncol. 2014 Sep;9(9):1264-71. doi: 10.1097/JTO.0000000000000262.

9.

Genotyping technologies: application to biotransformation enzyme genetic polymorphism screening.

Romkes M, Buch SC.

Methods Mol Biol. 2014;1105:99-115. doi: 10.1007/978-1-62703-739-6_8.

PMID:
24623222
10.

Strategies for measurement of biotransformation enzyme gene expression.

Romkes M, Buch SC.

Methods Mol Biol. 2014;1105:85-97. doi: 10.1007/978-1-62703-739-6_7. Review.

PMID:
24623221
11.

An empirical workflow for genome-wide single nucleotide polymorphism-based predictive modeling.

Floudas CS, Balasubramanian JB, Romkes M, Gopalakrishnan V.

AMIA Jt Summits Transl Sci Proc. 2013 Mar 18;2013:53-7. eCollection 2013.

12.

Pathologic and gene expression features of metastatic melanomas to the brain.

Hamilton R, Krauze M, Romkes M, Omolo B, Konstantinopoulos P, Reinhart T, Harasymczuk M, Wang Y, Lin Y, Ferrone S, Whiteside T, Bortoluzzi S, Werley J, Nukui T, Fallert-Junecko B, Kondziolka D, Ibrahim J, Becker D, Kirkwood J, Moschos S.

Cancer. 2013 Aug 1;119(15):2737-46. doi: 10.1002/cncr.28029. Epub 2013 May 21.

13.

Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers.

Lui VW, Hedberg ML, Li H, Vangara BS, Pendleton K, Zeng Y, Lu Y, Zhang Q, Du Y, Gilbert BR, Freilino M, Sauerwein S, Peyser ND, Xiao D, Diergaarde B, Wang L, Chiosea S, Seethala R, Johnson JT, Kim S, Duvvuri U, Ferris RL, Romkes M, Nukui T, Kwok-Shing Ng P, Garraway LA, Hammerman PS, Mills GB, Grandis JR.

Cancer Discov. 2013 Jul;3(7):761-9. doi: 10.1158/2159-8290.CD-13-0103. Epub 2013 Apr 25.

14.

Childhood passive smoke exposure is associated with adult head and neck cancer.

Troy JD, Grandis JR, Youk AO, Diergaarde B, Romkes M, Weissfeld JL.

Cancer Epidemiol. 2013 Aug;37(4):417-23. doi: 10.1016/j.canep.2013.03.011. Epub 2013 Apr 22.

15.

Genetic variation in ESR2 and estrogen receptor-beta expression in lung tumors.

Song JY, Siegfried JM, Diergaarde B, Land SR, Bowser R, Stabile LP, Dacic S, Dhir R, Nukui T, Romkes M, Weissfeld JL.

Cancer Epidemiol. 2013 Aug;37(4):518-22. doi: 10.1016/j.canep.2013.03.020. Epub 2013 Apr 23.

16.

CYP2A6 genotype and smoking behavior in current smokers screened for lung cancer.

Styn MA, Nukui T, Romkes M, Perkins KA, Land SR, Weissfeld JL.

Subst Use Misuse. 2013 May;48(7):490-4. doi: 10.3109/10826084.2013.778280. Epub 2013 Mar 25.

17.

Polymorphisms in NAT2 and GSTP1 are associated with survival in oral and oropharyngeal cancer.

Troy JD, Weissfeld JL, Diergaarde B, Youk AO, Buch SC, Romkes M, Grandis JR.

Cancer Epidemiol. 2013 Aug;37(4):505-11. doi: 10.1016/j.canep.2013.02.009. Epub 2013 Mar 21.

18.

Regulation of the human hydroxysteroid sulfotransferase (SULT2A1) by RORα and RORγ and its potential relevance to human liver diseases.

Ou Z, Shi X, Gilroy RK, Kirisci L, Romkes M, Lynch C, Wang H, Xu M, Jiang M, Ren S, Gramignoli R, Strom SC, Huang M, Xie W.

Mol Endocrinol. 2013 Jan;27(1):106-15. doi: 10.1210/me.2012-1145. Epub 2012 Dec 4.

19.

Pharmacologic evidence to support clinical decision making for peripartum methadone treatment.

Bogen DL, Perel JM, Helsel JC, Hanusa BH, Romkes M, Nukui T, Friedman CR, Wisner KL.

Psychopharmacology (Berl). 2013 Jan;225(2):441-51. doi: 10.1007/s00213-012-2833-7. Epub 2012 Aug 25.

20.

Genetic variability in DNA repair and cell cycle control pathway genes and risk of smoking-related lung cancer.

Buch SC, Diergaarde B, Nukui T, Day RS, Siegfried JM, Romkes M, Weissfeld JL.

Mol Carcinog. 2012 Oct;51 Suppl 1:E11-20. doi: 10.1002/mc.20858. Epub 2011 Oct 4.

21.

Effects of ERCC2 Lys751Gln (A35931C) and CCND1 (G870A) polymorphism on outcome of advanced-stage squamous cell carcinoma of the head and neck are treatment dependent.

Zhong S, Nukui T, Buch S, Diergaarde B, Weissfeld LA, Grandis J, Romkes M, Weissfeld JL.

Cancer Epidemiol Biomarkers Prev. 2011 Nov;20(11):2429-37. doi: 10.1158/1055-9965.EPI-11-0520. Epub 2011 Sep 2.

22.

The mutational landscape of head and neck squamous cell carcinoma.

Stransky N, Egloff AM, Tward AD, Kostic AD, Cibulskis K, Sivachenko A, Kryukov GV, Lawrence MS, Sougnez C, McKenna A, Shefler E, Ramos AH, Stojanov P, Carter SL, Voet D, Cortés ML, Auclair D, Berger MF, Saksena G, Guiducci C, Onofrio RC, Parkin M, Romkes M, Weissfeld JL, Seethala RR, Wang L, Rangel-Escareño C, Fernandez-Lopez JC, Hidalgo-Miranda A, Melendez-Zajgla J, Winckler W, Ardlie K, Gabriel SB, Meyerson M, Lander ES, Getz G, Golub TR, Garraway LA, Grandis JR.

Science. 2011 Aug 26;333(6046):1157-60. doi: 10.1126/science.1208130. Epub 2011 Jul 28.

23.

XPF expression correlates with clinical outcome in squamous cell carcinoma of the head and neck.

Vaezi A, Wang X, Buch S, Gooding W, Wang L, Seethala RR, Weaver DT, D'Andrea AD, Argiris A, Romkes M, Niedernhofer LJ, Grandis JR.

Clin Cancer Res. 2011 Aug 15;17(16):5513-22. doi: 10.1158/1078-0432.CCR-11-0086. Epub 2011 Jul 7.

24.

Genome-wide association study of survival in non-small cell lung cancer patients receiving platinum-based chemotherapy.

Wu X, Ye Y, Rosell R, Amos CI, Stewart DJ, Hildebrandt MA, Roth JA, Minna JD, Gu J, Lin J, Buch SC, Nukui T, Ramirez Serrano JL, Taron M, Cassidy A, Lu C, Chang JY, Lippman SM, Hong WK, Spitz MR, Romkes M, Yang P.

J Natl Cancer Inst. 2011 May 18;103(10):817-25. doi: 10.1093/jnci/djr075. Epub 2011 Apr 11.

25.

A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.

McKay JD, Truong T, Gaborieau V, Chabrier A, Chuang SC, Byrnes G, Zaridze D, Shangina O, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Bucur A, Bencko V, Holcatova I, Janout V, Foretova L, Lagiou P, Trichopoulos D, Benhamou S, Bouchardy C, Ahrens W, Merletti F, Richiardi L, Talamini R, Barzan L, Kjaerheim K, Macfarlane GJ, Macfarlane TV, Simonato L, Canova C, Agudo A, Castellsagué X, Lowry R, Conway DI, McKinney PA, Healy CM, Toner ME, Znaor A, Curado MP, Koifman S, Menezes A, Wünsch-Filho V, Neto JE, Garrote LF, Boccia S, Cadoni G, Arzani D, Olshan AF, Weissler MC, Funkhouser WK, Luo J, Lubiński J, Trubicka J, Lener M, Oszutowska D, Schwartz SM, Chen C, Fish S, Doody DR, Muscat JE, Lazarus P, Gallagher CJ, Chang SC, Zhang ZF, Wei Q, Sturgis EM, Wang LE, Franceschi S, Herrero R, Kelsey KT, McClean MD, Marsit CJ, Nelson HH, Romkes M, Buch S, Nukui T, Zhong S, Lacko M, Manni JJ, Peters WH, Hung RJ, McLaughlin J, Vatten L, Njølstad I, Goodman GE, Field JK, Liloglou T, Vineis P, Clavel-Chapelon F, Palli D, Tumino R, Krogh V, Panico S, González CA, Quirós JR, Martínez C, Navarro C, Ardanaz E, Larrañaga N, Khaw KT, Key T, Bueno-de-Mesquita HB, Peeters PH, Trichopoulou A, Linseisen J, Boeing H, Hallmans G, Overvad K, Tjønneland A, Kumle M, Riboli E, Välk K, Vooder T, Metspalu A, Zelenika D, Boland A, Delepine M, Foglio M, Lechner D, Blanché H, Gut IG, Galan P, Heath S, Hashibe M, Hayes RB, Boffetta P, Lathrop M, Brennan P.

PLoS Genet. 2011 Mar;7(3):e1001333. doi: 10.1371/journal.pgen.1001333. Epub 2011 Mar 17. Erratum in: PLoS Genet. 2011 Apr;7(4). doi: 10.1371/annotation/9952526f-2f1f-47f3-af0f-1a7cf6f0abc1. Voodern, Tõnu [corrected to Vooder, Tõnu].

26.

Phase I trial of pemetrexed in combination with cetuximab and concurrent radiotherapy in patients with head and neck cancer.

Argiris A, Karamouzis MV, Smith R, Kotsakis A, Gibson MK, Lai SY, Kim S, Branstetter BF, Shuai Y, Romkes M, Wang L, Grandis JR, Ferris RL, Johnson JT, Heron DE.

Ann Oncol. 2011 Nov;22(11):2482-8. doi: 10.1093/annonc/mdr002. Epub 2011 Mar 1.

27.

Phase II trial of pemetrexed and bevacizumab in patients with recurrent or metastatic head and neck cancer.

Argiris A, Karamouzis MV, Gooding WE, Branstetter BF, Zhong S, Raez LE, Savvides P, Romkes M.

J Clin Oncol. 2011 Mar 20;29(9):1140-5. doi: 10.1200/JCO.2010.33.3591. Epub 2011 Feb 22.

28.

A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers.

Chen D, Truong T, Gaborieau V, Byrnes G, Chabrier A, Chuang SC, Olshan AF, Weissler MC, Luo J, Romkes M, Buch S, Nukui T, Franceschi S, Herrero R, Talamini R, Kelsey KT, Christensen B, McClean MD, Lacko M, Manni JJ, Peters WH, Lubiński J, Trubicka J, Lener M, Muscat JE, Lazarus P, Wei Q, Sturgis EM, Zhang ZF, Chang SC, Wang R, Schwartz SM, Chen C, Benhamou S, Lagiou P, Holcátová I, Richiardi L, Kjaerheim K, Agudo A, Castellsagué X, Macfarlane TV, Barzan L, Canova C, Thakker NS, Conway DI, Znaor A, Healy CM, Ahrens W, Zaridze D, Szeszenia-Dabrowska N, Lissowska J, Fabianova E, Bucur A, Bencko V, Foretova L, Janout V, Curado MP, Koifman S, Menezes A, Wünsch-Filho V, Eluf-Neto J, Fernandez L, Boccia S, Hashibe M, Hayes RB, Boffetta P, Brennan P, McKay JD.

Cancer Epidemiol Biomarkers Prev. 2011 Apr;20(4):658-64. doi: 10.1158/1055-9965.EPI-10-1008. Epub 2011 Feb 18.

29.

Genetic polymorphisms in the DNA repair genes XPD and XRCC1, p53 gene mutations and bladder cancer risk.

Gao W, Romkes M, Zhong S, Nukui T, Persad RA, Smith PJ, Branch R, Keohavong P.

Oncol Rep. 2010 Jul;24(1):257-62.

30.

Team building: electronic management-clinical translational research (eM-CTR) systems.

Cecchetti AA, Parmanto B, Vecchio ML, Ahmad S, Buch S, Zgheib NK, Groark SJ Jr, Vemuganti A, Romkes M, Sciurba F, Donahoe MP, Branch RA.

Clin Transl Sci. 2009 Dec;2(6):449-55. doi: 10.1111/j.1752-8062.2009.00157.x.

31.

Smoking behavior 1 year after computed tomography screening for lung cancer: Effect of physician referral for abnormal CT findings.

Styn MA, Land SR, Perkins KA, Wilson DO, Romkes M, Weissfeld JL.

Cancer Epidemiol Biomarkers Prev. 2009 Dec;18(12):3484-9. doi: 10.1158/1055-9965.EPI-09-0895.

32.

Voriconazole pharmacokinetics in liver transplant recipients.

Johnson HJ, Han K, Capitano B, Blisard D, Husain S, Linden PK, Marcos A, Kwak EJ, Potoski B, Paterson DL, Romkes M, Venkataramanan R.

Antimicrob Agents Chemother. 2010 Feb;54(2):852-9. doi: 10.1128/AAC.00429-09. Epub 2009 Nov 23.

33.

Pharmacogenomics.

Zhong S, Romkes M.

Methods Mol Biol. 2009;520:231-45. doi: 10.1007/978-1-60327-811-9_17. Review.

PMID:
19381959
34.

Case-control study of oral and oropharyngeal cancer in whites and genetic variation in eight metabolic enzymes.

Buch SC, Nazar-Stewart V, Weissfeld JL, Romkes M.

Head Neck. 2008 Sep;30(9):1139-47. doi: 10.1002/hed.20867.

35.

The impact of genetic variation in DRD2 and SLC6A3 on smoking cessation in a cohort of participants 1 year after enrollment in a lung cancer screening study.

Styn MA, Nukui T, Romkes M, Perkins K, Land SR, Weissfeld JL.

Am J Med Genet B Neuropsychiatr Genet. 2009 Mar 5;150B(2):254-61. doi: 10.1002/ajmg.b.30801.

36.

Exogenous and endogenous determinants of blood trihalomethane levels after showering.

Backer LC, Lan Q, Blount BC, Nuckols JR, Branch R, Lyu CW, Kieszak SM, Brinkman MC, Gordon SM, Flanders WD, Romkes M, Cantor KP.

Environ Health Perspect. 2008 Jan;116(1):57-63. doi: 10.1289/ehp.10049.

37.

Pharmacokinetics and metabolism of all-trans- and 13-cis-retinoic acid in pulmonary emphysema patients.

Muindi JR, Roth MD, Wise RA, Connett JE, O'Connor GT, Ramsdell JW, Schluger NW, Romkes M, Branch RA, Sciurba FC; FORTE Study Investigators.

J Clin Pharmacol. 2008 Jan;48(1):96-107.

PMID:
18094222
38.

Loss of distal 11q is associated with DNA repair deficiency and reduced sensitivity to ionizing radiation in head and neck squamous cell carcinoma.

Parikh RA, White JS, Huang X, Schoppy DW, Baysal BE, Baskaran R, Bakkenist CJ, Saunders WS, Hsu LC, Romkes M, Gollin SM.

Genes Chromosomes Cancer. 2007 Aug;46(8):761-75.

PMID:
17492757
39.

Mutation and polymorphism in the EGFR-TK domain associated with lung cancer.

Zhang W, Stabile LP, Keohavong P, Romkes M, Grandis JR, Traynor AM, Siegfried JM.

J Thorac Oncol. 2006 Sep;1(7):635-47.

40.

Association of the EGFR intron 1 CA repeat length with lung cancer risk.

Zhang W, Weissfeld JL, Romkes M, Land SR, Grandis JR, Siegfried JM.

Mol Carcinog. 2007 May;46(5):372-80.

PMID:
17219440
41.

Evaluation of flurbiprofen urinary ratios as in vivo indices for CYP2C9 activity.

Zgheib NK, Frye RF, Tracy TS, Romkes M, Branch RA.

Br J Clin Pharmacol. 2007 Apr;63(4):477-87. Epub 2006 Oct 19.

42.

Meta- and pooled analysis of GSTT1 and lung cancer: a HuGE-GSEC review.

Raimondi S, Paracchini V, Autrup H, Barros-Dios JM, Benhamou S, Boffetta P, Cote ML, Dialyna IA, Dolzan V, Filiberti R, Garte S, Hirvonen A, Husgafvel-Pursiainen K, Imyanitov EN, Kalina I, Kang D, Kiyohara C, Kohno T, Kremers P, Lan Q, London S, Povey AC, Rannug A, Reszka E, Risch A, Romkes M, Schneider J, Seow A, Shields PG, Sobti RC, Sørensen M, Spinola M, Spitz MR, Strange RC, Stücker I, Sugimura H, To-Figueras J, Tokudome S, Yang P, Yuan JM, Warholm M, Taioli E.

Am J Epidemiol. 2006 Dec 1;164(11):1027-42. Epub 2006 Sep 25.

PMID:
17000715
43.

Relationship of glutathione S-transferase genotypes with side-effects of pulsed cyclophosphamide therapy in patients with systemic lupus erythematosus.

Zhong S, Huang M, Yang X, Liang L, Wang Y, Romkes M, Duan W, Chan E, Zhou SF.

Br J Clin Pharmacol. 2006 Oct;62(4):457-72.

44.

Validation of incorporating flurbiprofen into the Pittsburgh cocktail.

Zgheib NK, Frye RF, Tracy TS, Romkes M, Branch RA.

Clin Pharmacol Ther. 2006 Sep;80(3):257-63.

PMID:
16952492
45.

Polymorphisms in DNA repair genes XPD and XRCC1 and p53 mutations in lung carcinomas of never-smokers.

Gao WM, Romkes M, Siegfried JM, Luketich JD, Keohavong P.

Mol Carcinog. 2006 Nov;45(11):828-32.

PMID:
16865671
46.

CYP2D6 genotype and venlafaxine-XR concentrations in depressed elderly.

Whyte EM, Romkes M, Mulsant BH, Kirshne MA, Begley AE, Reynolds CF 3rd, Pollock BG.

Int J Geriatr Psychiatry. 2006 Jun;21(6):542-9.

PMID:
16642541
47.

The absence of interaction between drug metabolizing enzyme genotypes and maternal lifestyle factors on glycophorin A somatic mutation frequency levels in newborns.

Nukui T, Day RD, Gordish-Dressman HA, Harger G, Bigbee WL, Ness RB, Romkes M.

Pharmacogenet Genomics. 2006 Feb;16(2):129-38.

PMID:
16424825
48.

Metabolic gene polymorphisms and lung cancer risk in non-smokers. An update of the GSEC study.

Raimondi S, Boffetta P, Anttila S, Bröckmoller J, Butkiewicz D, Cascorbi I, Clapper ML, Dragani TA, Garte S, Gsur A, Haidinger G, Hirvonen A, Ingelman-Sundberg M, Kalina I, Lan Q, Leoni VP, Le Marchand L, London SJ, Neri M, Povey AC, Rannug A, Reszka E, Ryberg D, Risch A, Romkes M, Ruano-Ravina A, Schoket B, Spinola M, Sugimura H, Wu X, Taioli E.

Mutat Res. 2005 Dec 30;592(1-2):45-57. Epub 2005 Jul 11.

PMID:
16009381
49.

CYP1A1, GSTM1 and GSTT1 polymorphisms and lung cancer: a pooled analysis of gene-gene interactions.

Vineis P, Veglia F, Anttila S, Benhamou S, Clapper ML, Dolzan V, Ryberg D, Hirvonen A, Kremers P, Le Marchand L, Pastorelli R, Rannug A, Romkes M, Schoket B, Strange RC, Garte S, Taioli E.

Biomarkers. 2004 May-Jun;9(3):298-305.

PMID:
15764294
50.

Association of polymorphisms in the cyclin D1 and XPD genes and susceptibility to cancers of the upper aero-digestive tract.

Buch S, Zhu B, Davis AG, Odom D, Siegfried JM, Grandis JR, Romkes M.

Mol Carcinog. 2005 Apr;42(4):222-8.

PMID:
15754315

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