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Items: 1 to 50 of 73

1.

One-Atom Substitution Enables Direct and Continuous Monitoring of Histone Deacylase Activity.

Zessin M, Kutil Z, Meleshin M, Nováková Z, Ghazy E, Kalbas D, Marek M, Romier C, Sippl W, Bařinka C, Schutkowski M.

Biochemistry. 2019 Nov 14. doi: 10.1021/acs.biochem.9b00786. [Epub ahead of print]

PMID:
31682411
2.

Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma mansoni (SmSirt2).

Monaldi D, Rotili D, Lancelot J, Marek M, Wössner N, Lucidi A, Tomaselli D, Ramos-Morales E, Romier C, Pierce RJ, Mai A, Jung M.

J Med Chem. 2019 Oct 10;62(19):8733-8759. doi: 10.1021/acs.jmedchem.9b00638. Epub 2019 Sep 20.

PMID:
31496251
3.

Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors.

Vögerl K, Ong N, Senger J, Herp D, Schmidtkunz K, Marek M, Müller M, Bartel K, Shaik TB, Porter NJ, Robaa D, Christianson DW, Romier C, Sippl W, Jung M, Bracher F.

J Med Chem. 2019 Feb 14;62(3):1138-1166. doi: 10.1021/acs.jmedchem.8b01090. Epub 2019 Feb 1.

PMID:
30645113
4.

Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.

Marek M, Shaik TB, Heimburg T, Chakrabarti A, Lancelot J, Ramos-Morales E, Da Veiga C, Kalinin D, Melesina J, Robaa D, Schmidtkunz K, Suzuki T, Holl R, Ennifar E, Pierce RJ, Jung M, Sippl W, Romier C.

J Med Chem. 2018 Nov 21;61(22):10000-10016. doi: 10.1021/acs.jmedchem.8b01087. Epub 2018 Nov 8.

PMID:
30347148
5.

Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies.

Brindisi M, Senger J, Cavella C, Grillo A, Chemi G, Gemma S, Cucinella DM, Lamponi S, Sarno F, Iside C, Nebbioso A, Novellino E, Shaik TB, Romier C, Herp D, Jung M, Butini S, Campiani G, Altucci L, Brogi S.

Eur J Med Chem. 2018 Sep 5;157:127-138. doi: 10.1016/j.ejmech.2018.07.069. Epub 2018 Jul 31.

PMID:
30092367
6.

Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as SmHDAC8 Inhibitors for the Treatment of Schistosomiasis.

Bayer T, Chakrabarti A, Lancelot J, Shaik TB, Hausmann K, Melesina J, Schmidtkunz K, Marek M, Erdmann F, Schmidt M, Robaa D, Romier C, Pierce RJ, Jung M, Sippl W.

ChemMedChem. 2018 Aug 10;13(15):1517-1529. doi: 10.1002/cmdc.201800238. Epub 2018 Jul 4.

PMID:
29806110
7.

Isoform-selective HDAC1/6/8 inhibitors with an imidazo-ketopiperazine cap containing stereochemical diversity.

Lecointre B, Narozny R, Borrello MT, Senger J, Chakrabarti A, Jung M, Marek M, Romier C, Melesina J, Sippl W, Bischoff L, Ganesan A.

Philos Trans R Soc Lond B Biol Sci. 2018 Jun 5;373(1748). pii: 20170364. doi: 10.1098/rstb.2017.0364.

8.

A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing.

Simoben CV, Robaa D, Chakrabarti A, Schmidtkunz K, Marek M, Lancelot J, Kannan S, Melesina J, Shaik TB, Pierce RJ, Romier C, Jung M, Sippl W.

Molecules. 2018 Mar 2;23(3). pii: E566. doi: 10.3390/molecules23030566.

9.

Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity.

Heimburg T, Kolbinger FR, Zeyen P, Ghazy E, Herp D, Schmidtkunz K, Melesina J, Shaik TB, Erdmann F, Schmidt M, Romier C, Robaa D, Witt O, Oehme I, Jung M, Sippl W.

J Med Chem. 2017 Dec 28;60(24):10188-10204. doi: 10.1021/acs.jmedchem.7b01447. Epub 2017 Dec 15.

PMID:
29190092
10.

[History of the Strasbourg Society of Biology].

Antony P, Romier C, Mantz JM.

Biol Aujourdhui. 2017;211(1):117-125. doi: 10.1051/jbio/2017003. Epub 2017 Jul 6. French.

PMID:
28682233
11.

Isophthalic Acid-Based HDAC Inhibitors as Potent Inhibitors of HDAC8 from Schistosoma mansoni.

Stenzel K, Chakrabarti A, Melesina J, Hansen FK, Lancelot J, Herkenhöhner S, Lungerich B, Marek M, Romier C, Pierce RJ, Sippl W, Jung M, Kurz T.

Arch Pharm (Weinheim). 2017 Aug;350(8). doi: 10.1002/ardp.201700096. Epub 2017 Jun 22.

PMID:
28639720
12.

Alkoxyurea-Based Histone Deacetylase Inhibitors Increase Cisplatin Potency in Chemoresistant Cancer Cell Lines.

Stenzel K, Hamacher A, Hansen FK, Gertzen CGW, Senger J, Marquardt V, Marek L, Marek M, Romier C, Remke M, Jung M, Gohlke H, Kassack MU, Kurz T.

J Med Chem. 2017 Jul 13;60(13):5334-5348. doi: 10.1021/acs.jmedchem.6b01538. Epub 2017 Jun 19.

PMID:
28581289
13.

Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups.

Krieger V, Hamacher A, Gertzen CGW, Senger J, Zwinderman MRH, Marek M, Romier C, Dekker FJ, Kurz T, Jung M, Gohlke H, Kassack MU, Hansen FK.

J Med Chem. 2017 Jul 13;60(13):5493-5506. doi: 10.1021/acs.jmedchem.7b00197. Epub 2017 Jun 16.

PMID:
28574690
14.

Photochromic histone deacetylase inhibitors based on dithienylethenes and fulgimides.

Wutz D, Gluhacevic D, Chakrabarti A, Schmidtkunz K, Robaa D, Erdmann F, Romier C, Sippl W, Jung M, König B.

Org Biomol Chem. 2017 Jun 7;15(22):4882-4896. doi: 10.1039/c7ob00976c.

PMID:
28537315
15.

Histone deacetylase inhibition modulates histone acetylation at gene promoter regions and affects genome-wide gene transcription in Schistosoma mansoni.

Anderson L, Gomes MR, daSilva LF, Pereira ADSA, Mourão MM, Romier C, Pierce R, Verjovski-Almeida S.

PLoS Negl Trop Dis. 2017 Apr 13;11(4):e0005539. doi: 10.1371/journal.pntd.0005539. eCollection 2017 Apr.

16.

Large-Scale Overproduction and Purification of Recombinant Histone Deacetylase 8 (HDAC8) from the Human-Pathogenic Flatworm Schistosoma mansoni.

Marek M, Shaik TB, Duclaud S, Pierce RJ, Romier C.

Methods Mol Biol. 2016;1436:109-18. doi: 10.1007/978-1-4939-3667-0_8.

PMID:
27246211
17.

Complex Reconstitution and Characterization by Combining Co-expression Techniques in Escherichia coli with High-Throughput.

Vincentelli R, Romier C.

Adv Exp Med Biol. 2016;896:43-58. doi: 10.1007/978-3-319-27216-0_4. Review.

PMID:
27165318
18.

Molecular basis and specificity of H2A.Z-H2B recognition and deposition by the histone chaperone YL1.

Latrick CM, Marek M, Ouararhni K, Papin C, Stoll I, Ignatyeva M, Obri A, Ennifar E, Dimitrov S, Romier C, Hamiche A.

Nat Struct Mol Biol. 2016 Apr;23(4):309-16. doi: 10.1038/nsmb.3189. Epub 2016 Mar 14.

PMID:
26974126
19.

Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis.

Heimburg T, Chakrabarti A, Lancelot J, Marek M, Melesina J, Hauser AT, Shaik TB, Duclaud S, Robaa D, Erdmann F, Schmidt M, Romier C, Pierce RJ, Jung M, Sippl W.

J Med Chem. 2016 Mar 24;59(6):2423-35. doi: 10.1021/acs.jmedchem.5b01478. Epub 2016 Mar 14.

PMID:
26937828
20.

Combattre les maladies négligées en ciblant sélectivement leurs enzymes épigénétiques : le cas de la désacétylase 8 (HDAC8) de Schistosoma mansoni.

Marek M, Shaik TB, Jung M, Sippl W, Pierce RJ, Romier C.

Biol Aujourdhui. 2016;210(4):311-320. doi: 10.1051/jbio/2017001. Epub 2017 Mar 22. French.

PMID:
28327287
21.

Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors.

Senger J, Melesina J, Marek M, Romier C, Oehme I, Witt O, Sippl W, Jung M.

J Med Chem. 2016 Feb 25;59(4):1545-55. doi: 10.1021/acs.jmedchem.5b01493. Epub 2015 Dec 22.

PMID:
26653328
22.

Homology modeling of parasite histone deacetylases to guide the structure-based design of selective inhibitors.

Melesina J, Robaa D, Pierce RJ, Romier C, Sippl W.

J Mol Graph Model. 2015 Nov;62:342-361. doi: 10.1016/j.jmgm.2015.10.006. Epub 2015 Oct 19.

PMID:
26595183
23.

HDAC8: a multifaceted target for therapeutic interventions.

Chakrabarti A, Oehme I, Witt O, Oliveira G, Sippl W, Romier C, Pierce RJ, Jung M.

Trends Pharmacol Sci. 2015 Jul;36(7):481-92. doi: 10.1016/j.tips.2015.04.013. Epub 2015 May 23. Review.

24.

Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives.

Marek M, Oliveira G, Pierce RJ, Jung M, Sippl W, Romier C.

Future Med Chem. 2015;7(6):783-800. doi: 10.4155/fmc.15.25. Review.

25.

Schistosome sirtuins as drug targets.

Lancelot J, Cabezas-Cruz A, Caby S, Marek M, Schultz J, Romier C, Sippl W, Jung M, Pierce RJ.

Future Med Chem. 2015;7(6):765-82. doi: 10.4155/fmc.15.24. Review.

26.

Characterization and production of protein complexes by co-expression in Escherichia coli.

Haffke M, Marek M, Pelosse M, Diebold ML, Schlattner U, Berger I, Romier C.

Methods Mol Biol. 2015;1261:63-89. doi: 10.1007/978-1-4939-2230-7_4.

PMID:
25502194
27.

Hydroxamates of para-aminobenzoic acid as selective inhibitors of HDAC8.

Kulandaivelu U, Chilakamari LM, Jadav SS, Rao TR, Jayaveera KN, Shireesha B, Hauser AT, Senger J, Marek M, Romier C, Jung M, Jayaprakash V.

Bioorg Chem. 2014 Dec;57:116-20. doi: 10.1016/j.bioorg.2014.08.005. Epub 2014 Sep 3.

PMID:
25462986
28.

Fluorescence-based screening assays for the NAD⁺-dependent histone deacetylase smSirt2 from Schistosoma mansoni.

Schiedel M, Marek M, Lancelot J, Karaman B, Almlöf I, Schultz J, Sippl W, Pierce RJ, Romier C, Jung M.

J Biomol Screen. 2015 Jan;20(1):112-21. doi: 10.1177/1087057114555307. Epub 2014 Oct 16.

PMID:
25325257
29.

Discovery of inhibitors of Schistosoma mansoni HDAC8 by combining homology modeling, virtual screening, and in vitro validation.

Kannan S, Melesina J, Hauser AT, Chakrabarti A, Heimburg T, Schmidtkunz K, Walter A, Marek M, Pierce RJ, Romier C, Jung M, Sippl W.

J Chem Inf Model. 2014 Oct 27;54(10):3005-19. doi: 10.1021/ci5004653. Epub 2014 Oct 2.

PMID:
25243797
30.

TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation.

Alpern D, Langer D, Ballester B, Le Gras S, Romier C, Mengus G, Davidson I.

Elife. 2014 Sep 10;3:e03613. doi: 10.7554/eLife.03613.

31.

Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoni.

Stolfa DA, Marek M, Lancelot J, Hauser AT, Walter A, Leproult E, Melesina J, Rumpf T, Wurtz JM, Cavarelli J, Sippl W, Pierce RJ, Romier C, Jung M.

J Mol Biol. 2014 Oct 9;426(20):3442-53. doi: 10.1016/j.jmb.2014.03.007. Epub 2014 Mar 20.

32.

DNA binding by Sgf11 protein affects histone H2B deubiquitination by Spt-Ada-Gcn5-acetyltransferase (SAGA).

Koehler C, Bonnet J, Stierle M, Romier C, Devys D, Kieffer B.

J Biol Chem. 2014 Mar 28;289(13):8989-99. doi: 10.1074/jbc.M113.500868. Epub 2014 Feb 7.

33.

ANP32E is a histone chaperone that removes H2A.Z from chromatin.

Obri A, Ouararhni K, Papin C, Diebold ML, Padmanabhan K, Marek M, Stoll I, Roy L, Reilly PT, Mak TW, Dimitrov S, Romier C, Hamiche A.

Nature. 2014 Jan 30;505(7485):648-53. doi: 10.1038/nature12922. Epub 2014 Jan 22.

PMID:
24463511
34.

Characterization of the interaction between protein Snu13p/15.5K and the Rsa1p/NUFIP factor and demonstration of its functional importance for snoRNP assembly.

Rothé B, Back R, Quinternet M, Bizarro J, Robert MC, Blaud M, Romier C, Manival X, Charpentier B, Bertrand E, Branlant C.

Nucleic Acids Res. 2014 Feb;42(3):2015-36. doi: 10.1093/nar/gkt1091. Epub 2013 Nov 13.

35.

Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni.

Marek M, Kannan S, Hauser AT, Moraes Mourão M, Caby S, Cura V, Stolfa DA, Schmidtkunz K, Lancelot J, Andrade L, Renaud JP, Oliveira G, Sippl W, Jung M, Cavarelli J, Pierce RJ, Romier C.

PLoS Pathog. 2013;9(9):e1003645. doi: 10.1371/journal.ppat.1003645. Epub 2013 Sep 26.

36.

Baculovirus VP1054 is an acquired cellular PURα, a nucleic acid-binding protein specific for GGN repeats.

Marek M, Romier C, Galibert L, Merten OW, van Oers MM.

J Virol. 2013 Aug;87(15):8465-80. doi: 10.1128/JVI.00068-13. Epub 2013 May 29.

37.

Expression in Escherichia coli: becoming faster and more complex.

Vincentelli R, Romier C.

Curr Opin Struct Biol. 2013 Jun;23(3):326-34. doi: 10.1016/j.sbi.2013.01.006. Epub 2013 Feb 17. Review.

PMID:
23422067
38.

Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination.

Nardini M, Gnesutta N, Donati G, Gatta R, Forni C, Fossati A, Vonrhein C, Moras D, Romier C, Bolognesi M, Mantovani R.

Cell. 2013 Jan 17;152(1-2):132-43. doi: 10.1016/j.cell.2012.11.047.

39.

Sequence and structure requirements for specific recognition of HIV-1 TAR and DIS RNA by the HIV-1 Vif protein.

Freisz S, Mezher J, Hafirassou L, Wolff P, Nominé Y, Romier C, Dumas P, Ennifar E.

RNA Biol. 2012 Jul;9(7):966-77. doi: 10.4161/rna.20483. Epub 2012 Jul 1.

PMID:
22767258
40.

TFIID TAF6-TAF9 complex formation involves the HEAT repeat-containing C-terminal domain of TAF6 and is modulated by TAF5 protein.

Scheer E, Delbac F, Tora L, Moras D, Romier C.

J Biol Chem. 2012 Aug 10;287(33):27580-92. doi: 10.1074/jbc.M112.379206. Epub 2012 Jun 13.

41.

Strategies for bacterial expression of protein-peptide complexes: application to solubilization of papillomavirus E6.

Sidi AO, Babah KO, Brimer N, Nominé Y, Romier C, Kieffer B, Pol SV, Travé G, Zanier K.

Protein Expr Purif. 2011 Nov;80(1):8-16. doi: 10.1016/j.pep.2011.06.013. Epub 2011 Jul 14.

42.

Robots, pipelines, polyproteins: enabling multiprotein expression in prokaryotic and eukaryotic cells.

Vijayachandran LS, Viola C, Garzoni F, Trowitzsch S, Bieniossek C, Chaillet M, Schaffitzel C, Busso D, Romier C, Poterszman A, Richmond TJ, Berger I.

J Struct Biol. 2011 Aug;175(2):198-208. doi: 10.1016/j.jsb.2011.03.007. Epub 2011 Mar 17. Review.

PMID:
21419851
43.

Expression of protein complexes using multiple Escherichia coli protein co-expression systems: a benchmarking study.

Busso D, Peleg Y, Heidebrecht T, Romier C, Jacobovitch Y, Dantes A, Salim L, Troesch E, Schuetz A, Heinemann U, Folkers GE, Geerlof A, Wilmanns M, Polewacz A, Quedenau C, Büssow K, Adamson R, Blagova E, Walton J, Cartwright JL, Bird LE, Owens RJ, Berrow NS, Wilson KS, Sussman JL, Perrakis A, Celie PH.

J Struct Biol. 2011 Aug;175(2):159-70. doi: 10.1016/j.jsb.2011.03.004. Epub 2011 Mar 5.

PMID:
21382497
44.

Deciphering correct strategies for multiprotein complex assembly by co-expression: application to complexes as large as the histone octamer.

Diebold ML, Fribourg S, Koch M, Metzger T, Romier C.

J Struct Biol. 2011 Aug;175(2):178-88. doi: 10.1016/j.jsb.2011.02.001. Epub 2011 Feb 12.

PMID:
21320604
45.

The structure of an Iws1/Spt6 complex reveals an interaction domain conserved in TFIIS, Elongin A and Med26.

Diebold ML, Koch M, Loeliger E, Cura V, Winston F, Cavarelli J, Romier C.

EMBO J. 2010 Dec 1;29(23):3979-91. doi: 10.1038/emboj.2010.272. Epub 2010 Nov 5.

46.

Noncanonical tandem SH2 enables interaction of elongation factor Spt6 with RNA polymerase II.

Diebold ML, Loeliger E, Koch M, Winston F, Cavarelli J, Romier C.

J Biol Chem. 2010 Dec 3;285(49):38389-98. doi: 10.1074/jbc.M110.146696. Epub 2010 Oct 6.

47.

The structural plasticity of SCA7 domains defines their differential nucleosome-binding properties.

Bonnet J, Wang YH, Spedale G, Atkinson RA, Romier C, Hamiche A, Pijnappel WW, Timmers HT, Tora L, Devys D, Kieffer B.

EMBO Rep. 2010 Aug;11(8):612-8. doi: 10.1038/embor.2010.98. Epub 2010 Jul 16.

48.

Crystallization and preliminary crystallographic analysis of eukaryotic transcription and mRNA export factor Iws1 from Encephalitozoon cuniculi.

Koch M, Diebold ML, Cavarelli J, Romier C.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Feb 1;66(Pt 2):207-10. doi: 10.1107/S1744309109052749. Epub 2010 Jan 28.

49.

Automated unrestricted multigene recombineering for multiprotein complex production.

Bieniossek C, Nie Y, Frey D, Olieric N, Schaffitzel C, Collinson I, Romier C, Berger P, Richmond TJ, Steinmetz MO, Berger I.

Nat Methods. 2009 Jun;6(6):447-50. doi: 10.1038/nmeth.1326. Epub 2009 May 3.

PMID:
19412171
50.

The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes.

Nagy Z, Riss A, Romier C, le Guezennec X, Dongre AR, Orpinell M, Han J, Stunnenberg H, Tora L.

Mol Cell Biol. 2009 Mar;29(6):1649-60. doi: 10.1128/MCB.01076-08. Epub 2008 Dec 29.

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