Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 158

1.

Structure and Dynamics of Stacking Interactions in an Antibody Binding Site.

Adhikary R, Zimmermann J, Stanfield RL, Wilson IA, Yu W, Oda M, Romesberg FE.

Biochemistry. 2019 Jul 9;58(27):2987-2995. doi: 10.1021/acs.biochem.9b00119. Epub 2019 Jun 19.

PMID:
31243995
2.

Optimization of Replication, Transcription, and Translation in a Semi-Synthetic Organism.

Feldman AW, Dien VT, Karadeema RJ, Fischer EC, You Y, Anderson BA, Krishnamurthy R, Chen JS, Li L, Romesberg FE.

J Am Chem Soc. 2019 Jul 10;141(27):10644-10653. doi: 10.1021/jacs.9b02075. Epub 2019 Jun 26.

PMID:
31241334
3.

Eight-Letter DNA.

Dien VT, Holcomb M, Romesberg FE.

Biochemistry. 2019 Jun 4;58(22):2581-2583. doi: 10.1021/acs.biochem.9b00274. Epub 2019 May 22.

PMID:
31117391
4.

Site-Specific Labeling of DNA via PCR with an Expanded Genetic Alphabet.

Ledbetter MP, Malyshev DA, Romesberg FE.

Methods Mol Biol. 2019;1973:193-212. doi: 10.1007/978-1-4939-9216-4_13.

PMID:
31016704
5.

Inhibition of Protein Secretion in Escherichia coli and Sub-MIC Effects of Arylomycin Antibiotics.

Walsh SI, Peters DS, Smith PA, Craney A, Dix MM, Cravatt BF, Romesberg FE.

Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e01253-18. doi: 10.1128/AAC.01253-18. Print 2019 Feb.

PMID:
30420476
6.

Progress Toward a Semi-Synthetic Organism with an Unrestricted Expanded Genetic Alphabet.

Dien VT, Holcomb M, Feldman AW, Fischer EC, Dwyer TJ, Romesberg FE.

J Am Chem Soc. 2018 Nov 28;140(47):16115-16123. doi: 10.1021/jacs.8b08416. Epub 2018 Nov 12.

PMID:
30418780
7.

Editorial overview: Expanding the genetic alphabet and code.

Ledbetter MP, Romesberg FE.

Curr Opin Chem Biol. 2018 Oct;46:A1-A2. doi: 10.1016/j.cbpa.2018.09.007. Epub 2018 Sep 27. No abstract available.

PMID:
30270151
8.

Expansion of the genetic code via expansion of the genetic alphabet.

Dien VT, Morris SE, Karadeema RJ, Romesberg FE.

Curr Opin Chem Biol. 2018 Oct;46:196-202. doi: 10.1016/j.cbpa.2018.08.009. Epub 2018 Sep 8. Review.

PMID:
30205312
9.

Optimization of a β-Lactam Scaffold for Antibacterial Activity via the Inhibition of Bacterial Type I Signal Peptidase.

Yeh CH, Walsh SI, Craney A, Tabor MG, Voica AF, Adhikary R, Morris SE, Romesberg FE.

ACS Med Chem Lett. 2018 Mar 15;9(4):376-380. doi: 10.1021/acsmedchemlett.8b00064. eCollection 2018 Apr 12.

10.

Semisynthetic Organisms with Expanded Genetic Codes.

Zhang Y, Romesberg FE.

Biochemistry. 2018 Apr 17;57(15):2177-2178. doi: 10.1021/acs.biochem.8b00013. Epub 2018 Apr 6. Review. No abstract available.

11.

Evolved polymerases facilitate selection of fully 2'-OMe-modified aptamers.

Liu Z, Chen T, Romesberg FE.

Chem Sci. 2017 Dec 1;8(12):8179-8182. doi: 10.1039/c7sc03747c. Epub 2017 Oct 16.

12.

Scalable Access to Arylomycins via C-H Functionalization Logic.

Peters DS, Romesberg FE, Baran PS.

J Am Chem Soc. 2018 Feb 14;140(6):2072-2075. doi: 10.1021/jacs.8b00087. Epub 2018 Feb 6.

13.

A Tool for the Import of Natural and Unnatural Nucleoside Triphosphates into Bacteria.

Feldman AW, Fischer EC, Ledbetter MP, Liao JY, Chaput JC, Romesberg FE.

J Am Chem Soc. 2018 Jan 31;140(4):1447-1454. doi: 10.1021/jacs.7b11404. Epub 2018 Jan 17.

14.

Reprograming the Replisome of a Semisynthetic Organism for the Expansion of the Genetic Alphabet.

Ledbetter MP, Karadeema RJ, Romesberg FE.

J Am Chem Soc. 2018 Jan 17;140(2):758-765. doi: 10.1021/jacs.7b11488. Epub 2018 Jan 8.

15.

Topological Evidence of Previously Overlooked Ni+1-H···Ni H-Bonds and Their Contribution to Protein Structure and Stability.

Holcomb M, Adhikary R, Zimmermann J, Romesberg FE.

J Phys Chem A. 2018 Jan 11;122(1):446-450. doi: 10.1021/acs.jpca.7b11013. Epub 2017 Dec 20.

PMID:
29260873
16.

Stable Signal Peptides and the Response to Secretion Stress in Staphylococcus aureus.

Craney A, Romesberg FE.

MBio. 2017 Dec 12;8(6). pii: e01507-17. doi: 10.1128/mBio.01507-17.

17.

Expansion of the Genetic Alphabet: A Chemist's Approach to Synthetic Biology.

Feldman AW, Romesberg FE.

Acc Chem Res. 2018 Feb 20;51(2):394-403. doi: 10.1021/acs.accounts.7b00403. Epub 2017 Dec 2.

18.

A semi-synthetic organism that stores and retrieves increased genetic information.

Zhang Y, Ptacin JL, Fischer EC, Aerni HR, Caffaro CE, San Jose K, Feldman AW, Turner CR, Romesberg FE.

Nature. 2017 Nov 29;551(7682):644-647. doi: 10.1038/nature24659.

19.

A Method for the Exponential Synthesis of RNA: Introducing the Polymerase Chain Transcription (PCT) Reaction.

Chen T, Romesberg FE.

Biochemistry. 2017 Oct 10;56(40):5227-5228. doi: 10.1021/acs.biochem.7b00846. Epub 2017 Sep 20. No abstract available.

PMID:
28930440
20.

Enzymatic Synthesis, Amplification, and Application of DNA with a Functionalized Backbone.

Chen T, Romesberg FE.

Angew Chem Int Ed Engl. 2017 Nov 6;56(45):14046-14051. doi: 10.1002/anie.201707367. Epub 2017 Oct 10.

PMID:
28914996
21.

In Vivo Structure-Activity Relationships and Optimization of an Unnatural Base Pair for Replication in a Semi-Synthetic Organism.

Feldman AW, Romesberg FE.

J Am Chem Soc. 2017 Aug 23;139(33):11427-11433. doi: 10.1021/jacs.7b03540. Epub 2017 Aug 10.

22.

Reply to Hettinger: Hydrophobic unnatural base pairs and the expansion of the genetic alphabet.

Feldman AW, Ledbetter MP, Zhang Y, Romesberg FE.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6478-E6479. doi: 10.1073/pnas.1708259114. Epub 2017 Aug 2. No abstract available.

23.

Polymerase Chain Transcription: Exponential Synthesis of RNA and Modified RNA.

Chen T, Romesberg FE.

J Am Chem Soc. 2017 Jul 26;139(29):9949-9954. doi: 10.1021/jacs.7b03981. Epub 2017 Jul 17.

PMID:
28715205
24.

Synthetic Biology Parts for the Storage of Increased Genetic Information in Cells.

Morris SE, Feldman AW, Romesberg FE.

ACS Synth Biol. 2017 Oct 20;6(10):1834-1840. doi: 10.1021/acssynbio.7b00115. Epub 2017 Jun 27.

25.

Conformational Heterogeneity and DNA Recognition by the Morphogen Bicoid.

Adhikary R, Tan YX, Liu J, Zimmermann J, Holcomb M, Yvellez C, Dawson PE, Romesberg FE.

Biochemistry. 2017 Jun 6;56(22):2787-2793. doi: 10.1021/acs.biochem.7b00255. Epub 2017 May 26.

PMID:
28547993
26.

Selection of 2'-Fluoro-Modified Aptamers with Optimized Properties.

Thirunavukarasu D, Chen T, Liu Z, Hongdilokkul N, Romesberg FE.

J Am Chem Soc. 2017 Mar 1;139(8):2892-2895. doi: 10.1021/jacs.6b13132. Epub 2017 Feb 20.

PMID:
28218835
27.

Chemical Stabilization of Unnatural Nucleotide Triphosphates for the in Vivo Expansion of the Genetic Alphabet.

Feldman AW, Dien VT, Romesberg FE.

J Am Chem Soc. 2017 Feb 15;139(6):2464-2467. doi: 10.1021/jacs.6b12731. Epub 2017 Feb 7.

28.

A semisynthetic organism engineered for the stable expansion of the genetic alphabet.

Zhang Y, Lamb BM, Feldman AW, Zhou AX, Lavergne T, Li L, Romesberg FE.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):1317-1322. doi: 10.1073/pnas.1616443114. Epub 2017 Jan 23.

29.

Transparent Window Vibrational Probes for the Characterization of Proteins With High Structural and Temporal Resolution.

Adhikary R, Zimmermann J, Romesberg FE.

Chem Rev. 2017 Feb 8;117(3):1927-1969. doi: 10.1021/acs.chemrev.6b00625. Epub 2017 Jan 20. Review.

PMID:
28106985
30.

Discovery of novel antibacterials.

Romesberg FE, Craney A.

Bioorg Med Chem. 2016 Dec 15;24(24):6225-6226. doi: 10.1016/j.bmc.2016.11.046. No abstract available.

PMID:
27932231
31.

Not just an antibiotic target: Exploring the role of type I signal peptidase in bacterial virulence.

Walsh SI, Craney A, Romesberg FE.

Bioorg Med Chem. 2016 Dec 15;24(24):6370-6378. doi: 10.1016/j.bmc.2016.09.048. Epub 2016 Sep 21.

32.

The expanding world of DNA and RNA.

Chen T, Hongdilokkul N, Liu Z, Thirunavukarasu D, Romesberg FE.

Curr Opin Chem Biol. 2016 Oct;34:80-87. doi: 10.1016/j.cbpa.2016.08.001. Epub 2016 Aug 24. Review.

33.

Evolution of thermophilic DNA polymerases for the recognition and amplification of C2'-modified DNA.

Chen T, Hongdilokkul N, Liu Z, Adhikary R, Tsuen SS, Romesberg FE.

Nat Chem. 2016 Jun;8(6):556-62. doi: 10.1038/nchem.2493. Epub 2016 Apr 18.

34.

FRET Characterization of Complex Conformational Changes in a Large 16S Ribosomal RNA Fragment Site-Specifically Labeled Using Unnatural Base Pairs.

Lavergne T, Lamichhane R, Malyshev DA, Li Z, Li L, Sperling E, Williamson JR, Millar DP, Romesberg FE.

ACS Chem Biol. 2016 May 20;11(5):1347-53. doi: 10.1021/acschembio.5b00952. Epub 2016 Mar 4.

35.

Temperature Dependence of CN and SCN IR Absorptions Facilitates Their Interpretation and Use as Probes of Proteins.

Adhikary R, Zimmermann J, Dawson PE, Romesberg FE.

Anal Chem. 2015 Nov 17;87(22):11561-7. doi: 10.1021/acs.analchem.5b03437. Epub 2015 Nov 2.

PMID:
26523838
36.

The expanded genetic alphabet.

Malyshev DA, Romesberg FE.

Angew Chem Int Ed Engl. 2015 Oct 5;54(41):11930-44. doi: 10.1002/anie.201502890. Epub 2015 Aug 25. Review.

37.

An Alternative Terminal Step of the General Secretory Pathway in Staphylococcus aureus.

Craney A, Dix MM, Adhikary R, Cravatt BF, Romesberg FE.

MBio. 2015 Aug 18;6(4). pii: e01178-15. doi: 10.1128/mBio.01178-15.

38.

The inhibition of type I bacterial signal peptidase: Biological consequences and therapeutic potential.

Craney A, Romesberg FE.

Bioorg Med Chem Lett. 2015 Nov 1;25(21):4761-4766. doi: 10.1016/j.bmcl.2015.07.072. Epub 2015 Jul 26. Review.

39.

Origins of Yersinia pestis sensitivity to the arylomycin antibiotics and the inhibition of type I signal peptidase.

Steed DB, Liu J, Wasbrough E, Miller L, Halasohoris S, Miller J, Somerville B, Hershfield JR, Romesberg FE.

Antimicrob Agents Chemother. 2015 Jul;59(7):3887-98. doi: 10.1128/AAC.00181-15. Epub 2015 Apr 20.

40.

Adaptive mutations alter antibody structure and dynamics during affinity maturation.

Adhikary R, Yu W, Oda M, Walker RC, Chen T, Stanfield RL, Wilson IA, Zimmermann J, Romesberg FE.

Biochemistry. 2015 Mar 24;54(11):2085-93. doi: 10.1021/bi501417q. Epub 2015 Mar 10.

41.

A putative cro-like repressor contributes to arylomycin resistance in Staphylococcus aureus.

Craney A, Romesberg FE.

Antimicrob Agents Chemother. 2015;59(6):3066-74. doi: 10.1128/AAC.04597-14. Epub 2015 Mar 9.

42.

Axinellamines as broad-spectrum antibacterial agents: scalable synthesis and biology.

Rodriguez RA, Barrios Steed D, Kawamata Y, Su S, Smith PA, Steed TC, Romesberg FE, Baran PS.

J Am Chem Soc. 2014 Oct 29;136(43):15403-13. doi: 10.1021/ja508632y. Epub 2014 Oct 20.

43.

Evidence of an unusual N-H···N hydrogen bond in proteins.

Adhikary R, Zimmermann J, Liu J, Forrest RP, Janicki TD, Dawson PE, Corcelli SA, Romesberg FE.

J Am Chem Soc. 2014 Oct 1;136(39):13474-7. doi: 10.1021/ja503107h. Epub 2014 Sep 16.

PMID:
25226114
44.

Systematic exploration of a class of hydrophobic unnatural base pairs yields multiple new candidates for the expansion of the genetic alphabet.

Dhami K, Malyshev DA, Ordoukhanian P, Kubelka T, Hocek M, Romesberg FE.

Nucleic Acids Res. 2014;42(16):10235-44. doi: 10.1093/nar/gku715. Epub 2014 Aug 13.

45.

A semi-synthetic organism with an expanded genetic alphabet.

Malyshev DA, Dhami K, Lavergne T, Chen T, Dai N, Foster JM, Corrêa IR Jr, Romesberg FE.

Nature. 2014 May 15;509(7500):385-8. doi: 10.1038/nature13314. Epub 2014 May 7.

46.

IR probes of protein microenvironments: utility and potential for perturbation.

Adhikary R, Zimmermann J, Dawson PE, Romesberg FE.

Chemphyschem. 2014 Apr 4;15(5):849-53. doi: 10.1002/cphc.201400017. Epub 2014 Feb 12.

PMID:
24519759
47.

Structural insights into DNA replication without hydrogen bonds.

Betz K, Malyshev DA, Lavergne T, Welte W, Diederichs K, Romesberg FE, Marx A.

J Am Chem Soc. 2013 Dec 11;135(49):18637-43. doi: 10.1021/ja409609j. Epub 2013 Nov 27.

48.

Directed polymerase evolution.

Chen T, Romesberg FE.

FEBS Lett. 2014 Jan 21;588(2):219-29. doi: 10.1016/j.febslet.2013.10.040. Epub 2013 Nov 5. Review.

49.

Natural-like replication of an unnatural base pair for the expansion of the genetic alphabet and biotechnology applications.

Li L, Degardin M, Lavergne T, Malyshev DA, Dhami K, Ordoukhanian P, Romesberg FE.

J Am Chem Soc. 2014 Jan 22;136(3):826-9. doi: 10.1021/ja408814g. Epub 2013 Oct 23.

50.

Carbon-deuterium bonds as non-perturbative infrared probes of protein dynamics, electrostatics, heterogeneity, and folding.

Zimmermann J, Romesberg FE.

Methods Mol Biol. 2014;1084:101-19. doi: 10.1007/978-1-62703-658-0_6.

PMID:
24061918

Supplemental Content

Loading ...
Support Center