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Items: 15

1.

Revisiting the pharmacodynamics uroselectivity of Alpha1-Adrenergic Receptor Antagonists.

Quaresma BMCS, Pimenta AR, da Silva ACS, Pupo AS, Romeiro LAS, Silva CLM, Noel F.

J Pharmacol Exp Ther. 2019 Jul 8. pii: jpet.119.260216. doi: 10.1124/jpet.119.260216. [Epub ahead of print]

2.

Molecular evaluation of anti-inflammatory activity of phenolic lipid extracted from cashew nut shell liquid (CNSL).

de Souza MQ, Teotônio IMSN, de Almeida FC, Heyn GS, Alves PS, Romeiro LAS, Pratesi R, de Medeiros Nóbrega YK, Pratesi CB.

BMC Complement Altern Med. 2018 Jun 11;18(1):181. doi: 10.1186/s12906-018-2247-0.

3.

The novel piperazine-containing compound LQFM018: Necroptosis cell death mechanisms, dopamine D4 receptor binding and toxicological assessment.

Costa FB, Cortez AP, de Ávila RI, de Carvalho FS, Andrade WM, da Cruz AF, Reis KB, Menegatti R, Lião LM, Romeiro LAS, Noël F, Fraga CAM, Barreiro EJ, Sanz G, Rodrigues MF, Vaz BG, Valadares MC.

Biomed Pharmacother. 2018 Jun;102:481-493. doi: 10.1016/j.biopha.2018.02.120. Epub 2018 Apr 5.

PMID:
29579709
4.

Effect of piplartine and cinnamides on Leishmania amazonensis, Plasmodium falciparum and on peritoneal cells of Swiss mice.

Araújo-Vilges KM, Oliveira SV, Couto SCP, Fokoue HH, Romero GAS, Kato MJ, Romeiro LAS, Leite JRSA, Kuckelhaus SAS.

Pharm Biol. 2017 Dec;55(1):1601-1607. doi: 10.1080/13880209.2017.1313870.

5.

Potential acetylcholinesterase inhibitors: molecular docking, molecular dynamics, and in silico prediction.

Kiametis AS, Silva MA, Romeiro LA, Martins JB, Gargano R.

J Mol Model. 2017 Feb;23(2):67. doi: 10.1007/s00894-017-3228-9. Epub 2017 Feb 9.

PMID:
28185116
6.

ADME studies and preliminary safety pharmacology of LDT5, a lead compound for the treatment of benign prostatic hyperplasia.

Noël F, Nascimento-Viana JB, Romeiro LA, Silva RO, Lemes LF, Oliveira AS, Giorno TB, Fernandes PD, Silva CL.

Braz J Med Biol Res. 2016;49(12):e5542. doi: 10.1590/1414-431X20165542.

7.

Synthesis and structure-activity relationships of novel arylpiperazines as potent antagonists of α1-adrenoceptor.

Silva RO, de Oliveira AS, Nunes Lemes LF, de Camargo Nascente L, Coelho do Nascimento Nogueira P, Silveira ER, Brand GD, Vistoli G, Cilia A, Poggesi E, Buccioni M, Marucci G, Bolognesi ML, Romeiro LAS.

Eur J Med Chem. 2016 Oct 21;122:601-610. doi: 10.1016/j.ejmech.2016.06.052. Epub 2016 Jun 30.

PMID:
27448917
8.

Induction of apoptosis in Ehrlich ascites tumour cells via p53 activation by a novel small-molecule MDM2 inhibitor - LQFM030.

da Mota MF, Cortez AP, Benfica PL, Rodrigues Bdos S, Castro TF, Macedo LM, Castro CH, Lião LM, de Carvalho FS, Romeiro LA, Menegatti R, Verli H, Villavicencio B, Valadares MC.

J Pharm Pharmacol. 2016 Sep;68(9):1143-59. doi: 10.1111/jphp.12573. Epub 2016 Jun 28.

PMID:
27350017
9.

Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease.

Lemes LFN, de Andrade Ramos G, de Oliveira AS, da Silva FMR, de Castro Couto G, da Silva Boni M, Guimarães MJR, Souza INO, Bartolini M, Andrisano V, do Nascimento Nogueira PC, Silveira ER, Brand GD, Soukup O, Korábečný J, Romeiro NC, Castro NG, Bolognesi ML, Romeiro LAS.

Eur J Med Chem. 2016 Jan 27;108:687-700. doi: 10.1016/j.ejmech.2015.12.024. Epub 2015 Dec 17.

PMID:
26735910
10.

New Multi-target Antagonists of α1A-, α1D-Adrenoceptors and 5-HT1A Receptors Reduce Human Hyperplastic Prostate Cell Growth and the Increase of Intraurethral Pressure.

Nascimento-Viana JB, Carvalho AR, Nasciutti LE, Alcántara-Hernández R, Chagas-Silva F, Souza PA, Romeiro LA, García-Sáinz JA, Noël F, Silva CL.

J Pharmacol Exp Ther. 2016 Jan;356(1):212-22. doi: 10.1124/jpet.115.227066. Epub 2015 Oct 22.

PMID:
26493747
11.

Pharmacological characterization of N1-(2-methoxyphenyl)-N4-hexylpiperazine as a multi-target antagonist of α1A/α1D-adrenoceptors and 5-HT1A receptors that blocks prostate contraction and cell growth.

Chagas-Silva F, Nascimento-Viana JB, Romeiro LA, Barberato LC, Noël F, Silva CL.

Naunyn Schmiedebergs Arch Pharmacol. 2014 Mar;387(3):225-34. doi: 10.1007/s00210-013-0935-3. Epub 2013 Nov 10.

PMID:
24213881
12.

Discovery of LASSBio-772, a 1,3-benzodioxole N-phenylpiperazine derivative with potent alpha 1A/D-adrenergic receptor blocking properties.

Romeiro LA, da Silva Ferreira M, da Silva LL, Castro HC, Miranda AL, Silva CL, Noël F, Nascimento JB, Araújo CV, Tibiriçá E, Barreiro EJ, Fraga CA.

Eur J Med Chem. 2011 Jul;46(7):3000-12. doi: 10.1016/j.ejmech.2011.04.032. Epub 2011 Apr 16.

PMID:
21549456
13.

Synthesis and cytotoxicity screening of substituted isobenzofuranones designed from anacardic acids.

Logrado LP, Santos CO, Romeiro LA, Costa AM, Ferreira JR, Cavalcanti BC, Manoel de Moraes O, Costa-Lotufo LV, Pessoa C, Dos Santos ML.

Eur J Med Chem. 2010 Aug;45(8):3480-9. doi: 10.1016/j.ejmech.2010.05.015. Epub 2010 May 12.

PMID:
20537433
14.

New potential AChE inhibitor candidates.

de Paula AA, Martins JB, dos Santos ML, Nascente Lde C, Romeiro LA, Areas TF, Vieira KS, Gambôa NF, Castro NG, Gargano R.

Eur J Med Chem. 2009 Sep;44(9):3754-9. doi: 10.1016/j.ejmech.2009.03.045. Epub 2009 Apr 16.

PMID:
19446931
15.

Structure and enzyme properties of Zabrotes subfasciatus alpha-amylase.

Pelegrini PB, Murad AM, Grossi-de-Sá MF, Mello LV, Romeiro LA, Noronha EF, Caldas RA, Franco OL.

Arch Insect Biochem Physiol. 2006 Feb;61(2):77-86.

PMID:
16416448

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