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Items: 1 to 50 of 68

1.

Design of a Gene Panel to Expose the Versatile Role of Hepatic Stellate Cells in Human Liver Fibrosis.

van Dijk F, Hazelhoff CM, Post E, Prins GGH, Rombouts K, Poelstra K, Olinga P, Beljaars L.

Pharmaceutics. 2020 Mar 20;12(3). pii: E278. doi: 10.3390/pharmaceutics12030278.

2.

A Microphysiological System for Studying Nonalcoholic Steatohepatitis.

Kostrzewski T, Maraver P, Ouro-Gnao L, Levi A, Snow S, Miedzik A, Rombouts K, Hughes D.

Hepatol Commun. 2019 Nov 13;4(1):77-91. doi: 10.1002/hep4.1450. eCollection 2020 Jan.

3.

Cirrhotic Human Liver Extracellular Matrix 3D Scaffolds Promote Smad-Dependent TGF-β1 Epithelial Mesenchymal Transition.

Mazza G, Telese A, Al-Akkad W, Frenguelli L, Levi A, Marrali M, Longato L, Thanapirom K, Vilia MG, Lombardi B, Crowley C, Crawford M, Karsdal MA, Leeming DJ, Marrone G, Bottcher K, Robinson B, Del Rio Hernandez A, Tamburrino D, Spoletini G, Malago M, Hall AR, Godovac-Zimmermann J, Luong TV, De Coppi P, Pinzani M, Rombouts K.

Cells. 2019 Dec 28;9(1). pii: E83. doi: 10.3390/cells9010083.

4.

Evaluation of NV556, a Novel Cyclophilin Inhibitor, as a Potential Antifibrotic Compound for Liver Fibrosis.

Simón Serrano S, Grönberg A, Longato L, Rombouts K, Kuo J, Gregory M, Moss S, Elmér E, Mazza G, Gallay P, Pinzani M, Hansson MJ, Massoumi R.

Cells. 2019 Nov 8;8(11). pii: E1409. doi: 10.3390/cells8111409.

5.

Clinicopathological correlations of mesenteric fibrosis and evaluation of a novel biomarker for fibrosis detection in small bowel neuroendocrine neoplasms.

Laskaratos FM, Mandair D, Hall A, Alexander S, von Stempel C, Bretherton J, Luong T, Watkins J, Ogunbiyi O, Rombouts K, Caplin M, Toumpanakis C.

Endocrine. 2020 Mar;67(3):718-726. doi: 10.1007/s12020-019-02107-4. Epub 2019 Oct 9.

6.

Ammonia Scavenging Prevents Progression of Fibrosis in Experimental Nonalcoholic Fatty Liver Disease.

De Chiara F, Thomsen KL, Habtesion A, Jones H, Davies N, Gracia-Sancho J, Manicardi N, Hall A, Andreola F, Paish HL, Reed LH, Watson AA, Leslie J, Oakley F, Rombouts K, Mookerjee RP, Mann J, Jalan R.

Hepatology. 2020 Mar;71(3):874-892. doi: 10.1002/hep.30890. Epub 2019 Oct 15.

PMID:
31378982
7.

Decellularized Human Gut as a Natural 3D Platform for Research in Intestinal Fibrosis.

Giuffrida P, Curti M, Al-Akkad W, Biel C, Crowley C, Frenguelli L, Telese A, Hall A, Tamburrino D, Spoletini G, Fusai G, Tinozzi FP, Pietrabissa A, Corazza GR, De Coppi P, Pinzani M, Di Sabatino A, Rombouts K, Mazza G.

Inflamm Bowel Dis. 2019 Oct 18;25(11):1740-1750. doi: 10.1093/ibd/izz115.

PMID:
31199863
8.

Matrix stiffness modulates the activity of MMP-9 and TIMP-1 in hepatic stellate cells to perpetuate fibrosis.

Lachowski D, Cortes E, Rice A, Pinato D, Rombouts K, Del Rio Hernandez A.

Sci Rep. 2019 May 13;9(1):7299. doi: 10.1038/s41598-019-43759-6.

9.

CXCR7 contributes to the aggressive phenotype of cholangiocarcinoma cells.

Gentilini A, Caligiuri A, Raggi C, Rombouts K, Pinzani M, Lori G, Correnti M, Invernizzi P, Rovida E, Navari N, Di Matteo S, Alvaro D, Banales JM, Rodrigues P, Raschioni C, Donadon M, Di Tommaso L, Marra F.

Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1;1865(9):2246-2256. doi: 10.1016/j.bbadis.2019.04.020. Epub 2019 May 3.

PMID:
31059778
10.

Impaired LXRα Phosphorylation Attenuates Progression of Fatty Liver Disease.

Becares N, Gage MC, Voisin M, Shrestha E, Martin-Gutierrez L, Liang N, Louie R, Pourcet B, Pello OM, Luong TV, Goñi S, Pichardo-Almarza C, Røberg-Larsen H, Diaz-Zuccarini V, Steffensen KR, O'Brien A, Garabedian MJ, Rombouts K, Treuter E, Pineda-Torra I.

Cell Rep. 2019 Jan 22;26(4):984-995.e6. doi: 10.1016/j.celrep.2018.12.094.

11.

Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor.

Cortes E, Lachowski D, Rice A, Thorpe SD, Robinson B, Yeldag G, Lee DA, Ghemtio L, Rombouts K, Del Río Hernández AE.

Oncogene. 2019 Apr;38(16):2910-2922. doi: 10.1038/s41388-018-0631-3. Epub 2018 Dec 21.

12.

Dual Targeting of Histone Methyltransferase G9a and DNA-Methyltransferase 1 for the Treatment of Experimental Hepatocellular Carcinoma.

Bárcena-Varela M, Caruso S, Llerena S, Álvarez-Sola G, Uriarte I, Latasa MU, Urtasun R, Rebouissou S, Alvarez L, Jimenez M, Santamaría E, Rodriguez-Ortigosa C, Mazza G, Rombouts K, San José-Eneriz E, Rabal O, Agirre X, Iraburu M, Santos-Laso A, Banales JM, Zucman-Rossi J, Prósper F, Oyarzabal J, Berasain C, Ávila MA, Fernández-Barrena MG.

Hepatology. 2019 Feb;69(2):587-603. doi: 10.1002/hep.30168. Epub 2019 Jan 4.

PMID:
30014490
13.

Urea cycle dysregulation in non-alcoholic fatty liver disease.

De Chiara F, Heebøll S, Marrone G, Montoliu C, Hamilton-Dutoit S, Ferrandez A, Andreola F, Rombouts K, Grønbæk H, Felipo V, Gracia-Sancho J, Mookerjee RP, Vilstrup H, Jalan R, Thomsen KL.

J Hepatol. 2018 Oct;69(4):905-915. doi: 10.1016/j.jhep.2018.06.023. Epub 2018 Jul 5.

PMID:
29981428
14.

The adenosine monophosphate-activated protein kinase-vacuolar adenosine triphosphatase-pH axis: A key regulator of the profibrogenic phenotype of human hepatic stellate cells.

Marrone G, De Chiara F, Böttcher K, Levi A, Dhar D, Longato L, Mazza G, Zhang Z, Marrali M, Fernández-Iglesias A, Hall A, Luong TV, Viollet B, Pinzani M, Rombouts K.

Hepatology. 2018 Sep;68(3):1140-1153. doi: 10.1002/hep.30029. Epub 2018 Jul 16.

PMID:
29663481
15.

Ammonia: A novel target for the treatment of non-alcoholic steatohepatitis.

Thomsen KL, De Chiara F, Rombouts K, Vilstrup H, Andreola F, Mookerjee RP, Jalan R.

Med Hypotheses. 2018 Apr;113:91-97. doi: 10.1016/j.mehy.2018.02.010. Epub 2018 Feb 15.

PMID:
29523305
16.

Liver tissue engineering: From implantable tissue to whole organ engineering.

Mazza G, Al-Akkad W, Rombouts K, Pinzani M.

Hepatol Commun. 2017 Dec 21;2(2):131-141. doi: 10.1002/hep4.1136. eCollection 2018 Feb. Review.

17.

MAIT cells are chronically activated in patients with autoimmune liver disease and promote profibrogenic hepatic stellate cell activation.

Böttcher K, Rombouts K, Saffioti F, Roccarina D, Rosselli M, Hall A, Luong T, Tsochatzis EA, Thorburn D, Pinzani M.

Hepatology. 2018 Jul;68(1):172-186. doi: 10.1002/hep.29782. Epub 2018 May 9.

PMID:
29328499
18.

Neuroendocrine tumors and fibrosis: An unsolved mystery?

Laskaratos FM, Rombouts K, Caplin M, Toumpanakis C, Thirlwell C, Mandair D.

Cancer. 2017 Dec 15;123(24):4770-4790. doi: 10.1002/cncr.31079. Epub 2017 Nov 7. Review.

19.

FAK controls the mechanical activation of YAP, a transcriptional regulator required for durotaxis.

Lachowski D, Cortes E, Robinson B, Rice A, Rombouts K, Del Río Hernández AE.

FASEB J. 2018 Feb;32(2):1099-1107. doi: 10.1096/fj.201700721R. Epub 2018 Jan 3.

PMID:
29070586
20.

Fibroblast growth factor 2 (FGF2) regulates cytoglobin expression and activation of human hepatic stellate cells via JNK signaling.

Sato-Matsubara M, Matsubara T, Daikoku A, Okina Y, Longato L, Rombouts K, Thuy LTT, Adachi J, Tomonaga T, Ikeda K, Yoshizato K, Pinzani M, Kawada N.

J Biol Chem. 2017 Nov 17;292(46):18961-18972. doi: 10.1074/jbc.M117.793794. Epub 2017 Sep 15.

21.

Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis.

Alberts R, de Vries EMG, Goode EC, Jiang X, Sampaziotis F, Rombouts K, Böttcher K, Folseraas T, Weismüller TJ, Mason AL, Wang W, Alexander G, Alvaro D, Bergquist A, Björkström NK, Beuers U, Björnsson E, Boberg KM, Bowlus CL, Bragazzi MC, Carbone M, Chazouillères O, Cheung A, Dalekos G, Eaton J, Eksteen B, Ellinghaus D, Färkkilä M, Festen EAM, Floreani A, Franceschet I, Gotthardt DN, Hirschfield GM, Hoek BV, Holm K, Hohenester S, Hov JR, Imhann F, Invernizzi P, Juran BD, Lenzen H, Lieb W, Liu JZ, Marschall HU, Marzioni M, Melum E, Milkiewicz P, Müller T, Pares A, Rupp C, Rust C, Sandford RN, Schramm C, Schreiber S, Schrumpf E, Silverberg MS, Srivastava B, Sterneck M, Teufel A, Vallier L, Verheij J, Vila AV, Vries B, Zachou K; International PSC Study Group, The UK PSC Consortium, Chapman RW, Manns MP, Pinzani M, Rushbrook SM, Lazaridis KN, Franke A, Anderson CA, Karlsen TH, Ponsioen CY, Weersma RK.

Gut. 2018 Aug;67(8):1517-1524. doi: 10.1136/gutjnl-2016-313598. Epub 2017 Aug 4.

22.

TRAIL regulatory receptors constrain human hepatic stellate cell apoptosis.

Singh HD, Otano I, Rombouts K, Singh KP, Peppa D, Gill US, Böttcher K, Kennedy PTF, Oben J, Pinzani M, Walczak H, Fusai G, Rosenberg WMC, Maini MK.

Sci Rep. 2017 Jul 17;7(1):5514. doi: 10.1038/s41598-017-05845-5.

23.

Rapid production of human liver scaffolds for functional tissue engineering by high shear stress oscillation-decellularization.

Mazza G, Al-Akkad W, Telese A, Longato L, Urbani L, Robinson B, Hall A, Kong K, Frenguelli L, Marrone G, Willacy O, Shaeri M, Burns A, Malago M, Gilbertson J, Rendell N, Moore K, Hughes D, Notingher I, Jell G, Del Rio Hernandez A, De Coppi P, Rombouts K, Pinzani M.

Sci Rep. 2017 Jul 17;7(1):5534. doi: 10.1038/s41598-017-05134-1.

24.

Engineering in vitro models of hepatofibrogenesis.

Mazza G, Al-Akkad W, Rombouts K.

Adv Drug Deliv Rev. 2017 Nov 1;121:147-157. doi: 10.1016/j.addr.2017.05.018. Epub 2017 May 31. Review.

PMID:
28578016
25.

CHK2 overexpression and mislocalisation within mitotic structures enhances chromosomal instability and hepatocellular carcinoma progression.

Carloni V, Lulli M, Madiai S, Mello T, Hall A, Luong TV, Pinzani M, Rombouts K, Galli A.

Gut. 2018 Feb;67(2):348-361. doi: 10.1136/gutjnl-2016-313114. Epub 2017 Mar 30.

PMID:
28360097
26.

Reactive gamma-ketoaldehydes as novel activators of hepatic stellate cells in vitro.

Longato L, Andreola F, Davies SS, Roberts JL, Fusai G, Pinzani M, Moore K, Rombouts K.

Free Radic Biol Med. 2017 Jan;102:162-173. doi: 10.1016/j.freeradbiomed.2016.11.036. Epub 2016 Nov 24.

PMID:
27890721
27.

Targeting the muscle for the treatment and prevention of hepatic encephalopathy.

Rombouts K, Bémeur C, Rose CF.

J Hepatol. 2016 Nov;65(5):876-878. doi: 10.1016/j.jhep.2016.08.014. Epub 2016 Aug 31. No abstract available.

PMID:
27590353
28.

Endoplasmic reticulum stress enhances fibrosis through IRE1α-mediated degradation of miR-150 and XBP-1 splicing.

Heindryckx F, Binet F, Ponticos M, Rombouts K, Lau J, Kreuger J, Gerwins P.

EMBO Mol Med. 2016 Jul 1;8(7):729-44. doi: 10.15252/emmm.201505925. Print 2016 Jul.

29.

Fluorescent Labeling of Plasmid DNA and mRNA: Gains and Losses of Current Labeling Strategies.

Rombouts K, Braeckmans K, Remaut K.

Bioconjug Chem. 2016 Feb 17;27(2):280-97. doi: 10.1021/acs.bioconjchem.5b00579. Epub 2015 Dec 28. Review.

PMID:
26670733
30.

Ammonia produces pathological changes in human hepatic stellate cells and is a target for therapy of portal hypertension.

Jalan R, De Chiara F, Balasubramaniyan V, Andreola F, Khetan V, Malago M, Pinzani M, Mookerjee RP, Rombouts K.

J Hepatol. 2016 Apr;64(4):823-33. doi: 10.1016/j.jhep.2015.11.019. Epub 2015 Dec 2.

PMID:
26654994
31.

Determination and Characterization of Tetraspanin-Associated Phosphoinositide-4 Kinases in Primary and Neoplastic Liver Cells.

Rombouts K, Carloni V.

Methods Mol Biol. 2016;1376:203-12. doi: 10.1007/978-1-4939-3170-5_17.

PMID:
26552686
32.

Aerosolized Non-viral Nucleic Acid Delivery in the Vaginal Tract of Pigs.

Remaut K, De Clercq E, Andries O, Rombouts K, Van Gils M, Cicchelero L, Vandenbussche I, Van Praet S, Benito JM, Fernandéz JM, Sanders N, Vanrompay D.

Pharm Res. 2016 Feb;33(2):384-94. doi: 10.1007/s11095-015-1796-x. Epub 2015 Oct 30.

PMID:
26514579
33.

Decellularized human liver as a natural 3D-scaffold for liver bioengineering and transplantation.

Mazza G, Rombouts K, Rennie Hall A, Urbani L, Vinh Luong T, Al-Akkad W, Longato L, Brown D, Maghsoudlou P, Dhillon AP, Fuller B, Davidson B, Moore K, Dhar D, De Coppi P, Malago M, Pinzani M.

Sci Rep. 2015 Aug 7;5:13079. doi: 10.1038/srep13079.

34.

Stealth monoolein-based nanocarriers for delivery of siRNA to cancer cells.

Oliveira AC, Raemdonck K, Martens T, Rombouts K, Simón-Vázquez R, Botelho C, Lopes I, Lúcio M, González-Fernández Á, Real Oliveira ME, Gomes AC, Braeckmans K.

Acta Biomater. 2015 Oct;25:216-29. doi: 10.1016/j.actbio.2015.07.032. Epub 2015 Jul 29.

PMID:
26225736
35.

Boosting pigment epithelial-derived factor: a promising approach for the treatment of early portal hypertension.

Vespasiani-Gentilucci U, Rombouts K.

Gut. 2015 Apr;64(4):523-4. doi: 10.1136/gutjnl-2014-307583. Epub 2014 Jun 25. No abstract available.

36.

Effect of covalent fluorescence labeling of plasmid DNA on its intracellular processing and transfection with lipid-based carriers.

Rombouts K, Martens TF, Zagato E, Demeester J, De Smedt SC, Braeckmans K, Remaut K.

Mol Pharm. 2014 May 5;11(5):1359-68. doi: 10.1021/mp4003078. Epub 2014 Apr 10.

PMID:
24678563
37.

DNA counterstaining for methylation and hydroxymethylation immunostaining in bovine zygotes.

Heras S, Forier K, Rombouts K, Braeckmans K, Van Soom A.

Anal Biochem. 2014 Jun 1;454:14-6. doi: 10.1016/j.ab.2014.03.002. Epub 2014 Mar 11.

PMID:
24631518
38.

Hepatic stellate cells and extracellular matrix in hepatocellular carcinoma: more complicated than ever.

Carloni V, Luong TV, Rombouts K.

Liver Int. 2014 Jul;34(6):834-43. doi: 10.1111/liv.12465. Epub 2014 Feb 12. Review.

PMID:
24397349
39.

The fibrotic microenvironment as a heterogeneity facet of hepatocellular carcinoma.

Rombouts K, Carloni V.

Fibrogenesis Tissue Repair. 2013 Sep 16;6(1):17. doi: 10.1186/1755-1536-6-17.

40.

Myristoylated Alanine-Rich protein Kinase C Substrate (MARCKS) expression modulates the metastatic phenotype in human and murine colon carcinoma in vitro and in vivo.

Rombouts K, Carloni V, Mello T, Omenetti S, Galastri S, Madiai S, Galli A, Pinzani M.

Cancer Lett. 2013 Jun 10;333(2):244-52. doi: 10.1016/j.canlet.2013.01.040. Epub 2013 Jan 29.

PMID:
23376641
41.

Role of the stromal-derived factor-1 (SDF-1)-CXCR4 axis in the interaction between hepatic stellate cells and cholangiocarcinoma.

Gentilini A, Rombouts K, Galastri S, Caligiuri A, Mingarelli E, Mello T, Marra F, Mantero S, Roncalli M, Invernizzi P, Pinzani M.

J Hepatol. 2012 Oct;57(4):813-20. doi: 10.1016/j.jhep.2012.06.012. Epub 2012 Jun 19.

PMID:
22727731
42.

MARCKS actin-binding capacity mediates actin filament assembly during mitosis in human hepatic stellate cells.

Rombouts K, Mello T, Liotta F, Galli A, Caligiuri A, Annunziato F, Pinzani M.

Am J Physiol Cell Physiol. 2012 Aug 15;303(4):C357-67. doi: 10.1152/ajpcell.00093.2012. Epub 2012 May 2.

43.

What is new in the liver sinusoids? meeting report, 16th International Symposium on Cells of the Hepatic Sinusoid (ISCHS).

Rombouts K, Pinzani M.

Fibrogenesis Tissue Repair. 2011 Dec 13;4(1):27. doi: 10.1186/1755-1536-4-27.

44.

Fibrosis in alcoholic and nonalcoholic steatohepatitis.

Bataller R, Rombouts K, Altamirano J, Marra F.

Best Pract Res Clin Gastroenterol. 2011 Apr;25(2):231-44. doi: 10.1016/j.bpg.2011.02.010. Review.

PMID:
21497741
45.

Mammalian target of rapamycin mediates the angiogenic effects of leptin in human hepatic stellate cells.

Aleffi S, Navari N, Delogu W, Galastri S, Novo E, Rombouts K, Pinzani M, Parola M, Marra F.

Am J Physiol Gastrointest Liver Physiol. 2011 Aug;301(2):G210-9. doi: 10.1152/ajpgi.00047.2010. Epub 2011 Jan 20.

46.

Molecular mechanisms of hepatic fibrosis in non-alcoholic steatohepatitis.

Rombouts K, Marra F.

Dig Dis. 2010;28(1):229-35. doi: 10.1159/000282094. Epub 2010 May 7. Review.

PMID:
20460917
47.

MARCKS is a downstream effector in platelet-derived growth factor-induced cell motility in activated human hepatic stellate cells.

Rombouts K, Lottini B, Caligiuri A, Liotta F, Mello T, Carloni V, Marra F, Pinzani M.

Exp Cell Res. 2008 Apr 15;314(7):1444-54. doi: 10.1016/j.yexcr.2008.01.029. Epub 2008 Feb 12.

PMID:
18329017
48.

Activation of p38(MAPK) mediates the angiostatic effect of the chemokine receptor CXCR3-B.

Petrai I, Rombouts K, Lasagni L, Annunziato F, Cosmi L, Romanelli RG, Sagrinati C, Mazzinghi B, Pinzani M, Romagnani S, Romagnani P, Marra F.

Int J Biochem Cell Biol. 2008;40(9):1764-74. doi: 10.1016/j.biocel.2008.01.008. Epub 2008 Jan 16.

PMID:
18291705
49.

Nuclear localization of TRK-A in liver cells.

Bonacchi A, Taddei ML, Petrai I, Efsen E, Defranco R, Nosi D, Torcia M, Rosini P, Formigli L, Rombouts K, Zecchi S, Milani S, Pinzani M, Laffi G, Marra F.

Histol Histopathol. 2008 Mar;23(3):327-40. doi: 10.14670/HH-23.327.

PMID:
18072090
50.

Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells.

Aleffi S, Petrai I, Bertolani C, Parola M, Colombatto S, Novo E, Vizzutti F, Anania FA, Milani S, Rombouts K, Laffi G, Pinzani M, Marra F.

Hepatology. 2005 Dec;42(6):1339-48.

PMID:
16317688

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