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Items: 1 to 50 of 117

1.

Studies of Structure-Function and Subunit Composition of Orai/STIM Channel.

Fahrner M, Schindl R, Romanin C.

In: Kozak JA, Putney JW Jr., editors. Calcium Entry Channels in Non-Excitable Cells. Boca Raton (FL): CRC Press/Taylor & Francis; 2018. Chapter 2.

2.

An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel.

Lichtenegger M, Tiapko O, Svobodova B, Stockner T, Glasnov TN, Schreibmayer W, Platzer D, de la Cruz GG, Krenn S, Schober R, Shrestha N, Schindl R, Romanin C, Groschner K.

Nat Chem Biol. 2018 Apr;14(4):396-404. doi: 10.1038/s41589-018-0015-6. Epub 2018 Mar 19.

PMID:
29556099
3.

A dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state.

Fahrner M, Stadlbauer M, Muik M, Rathner P, Stathopulos P, Ikura M, Müller N, Romanin C.

Nat Commun. 2018 Feb 26;9(1):825. doi: 10.1038/s41467-018-03062-w.

4.

Rapid NMR-scale purification of 15N,13C isotope-labeled recombinant human STIM1 coiled coil fragments.

Rathner P, Stadlbauer M, Romanin C, Fahrner M, Derler I, Müller N.

Protein Expr Purif. 2018 Jun;146:45-50. doi: 10.1016/j.pep.2018.01.013.

5.

Authentic CRAC channel activity requires STIM1 and the conserved portion of the Orai N terminus.

Derler I, Butorac C, Krizova A, Stadlbauer M, Muik M, Fahrner M, Frischauf I, Romanin C.

J Biol Chem. 2018 Jan 26;293(4):1259-1270. doi: 10.1074/jbc.M117.812206. Epub 2017 Dec 13.

6.

Communication between N terminus and loop2 tunes Orai activation.

Fahrner M, Pandey SK, Muik M, Traxler L, Butorac C, Stadlbauer M, Zayats V, Krizova A, Plenk P, Frischauf I, Schindl R, Gruber HJ, Hinterdorfer P, Ettrich R, Romanin C, Derler I.

J Biol Chem. 2018 Jan 26;293(4):1271-1285. doi: 10.1074/jbc.M117.812693. Epub 2017 Dec 13.

7.

Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription.

Frischauf I, Litviňuková M, Schober R, Zayats V, Svobodová B, Bonhenry D, Lunz V, Cappello S, Tociu L, Reha D, Stallinger A, Hochreiter A, Pammer T, Butorac C, Muik M, Groschner K, Bogeski I, Ettrich RH, Romanin C, Schindl R.

Sci Signal. 2017 Nov 28;10(507). pii: eaao0358. doi: 10.1126/scisignal.aao0358.

PMID:
29184031
8.

Detailed Evidence for an Unparalleled Interaction Mode between Calmodulin and Orai Proteins.

Traxler L, Rathner P, Fahrner M, Stadlbauer M, Faschinger F, Charnavets T, Müller N, Romanin C, Hinterdorfer P, Gruber HJ.

Angew Chem Int Ed Engl. 2017 Dec 4;56(49):15755-15759. doi: 10.1002/anie.201708667. Epub 2017 Nov 6.

PMID:
29024298
9.

The STIM-Orai Pathway: The Interactions Between STIM and Orai.

Fahrner M, Schindl R, Muik M, Derler I, Romanin C.

Adv Exp Med Biol. 2017;993:59-81. doi: 10.1007/978-3-319-57732-6_4. Review.

PMID:
28900909
10.

Live-cell imaging of ER-PM contact architecture by a novel TIRFM approach reveals extension of junctions in response to store-operated Ca2+-entry.

Poteser M, Leitinger G, Pritz E, Platzer D, Frischauf I, Romanin C, Groschner K.

Sci Rep. 2016 Oct 19;6:35656. doi: 10.1038/srep35656.

11.

The STIM1: Orai Interaction.

Frischauf I, Fahrner M, Jardín I, Romanin C.

Adv Exp Med Biol. 2016;898:25-46. doi: 10.1007/978-3-319-26974-0_2. Review.

PMID:
27161223
12.

Molecular mechanisms of STIM/Orai communication.

Derler I, Jardin I, Romanin C.

Am J Physiol Cell Physiol. 2016 Apr 15;310(8):C643-62. doi: 10.1152/ajpcell.00007.2016. Epub 2016 Jan 28. Review.

13.

Cholesterol modulates Orai1 channel function.

Derler I, Jardin I, Stathopulos PB, Muik M, Fahrner M, Zayats V, Pandey SK, Poteser M, Lackner B, Absolonova M, Schindl R, Groschner K, Ettrich R, Ikura M, Romanin C.

Sci Signal. 2016 Jan 26;9(412):ra10. doi: 10.1126/scisignal.aad7808.

14.

A calcium-accumulating region, CAR, in the channel Orai1 enhances Ca(2+) permeation and SOCE-induced gene transcription.

Frischauf I, Zayats V, Deix M, Hochreiter A, Jardin I, Muik M, Lackner B, Svobodová B, Pammer T, Litviňuková M, Sridhar AA, Derler I, Bogeski I, Romanin C, Ettrich RH, Schindl R.

Sci Signal. 2015 Dec 22;8(408):ra131. doi: 10.1126/scisignal.aab1901.

15.

Missense mutation in immunodeficient patients shows the multifunctional roles of coiled-coil domain 3 (CC3) in STIM1 activation.

Maus M, Jairaman A, Stathopulos PB, Muik M, Fahrner M, Weidinger C, Benson M, Fuchs S, Ehl S, Romanin C, Ikura M, Prakriya M, Feske S.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):6206-11. doi: 10.1073/pnas.1418852112. Epub 2015 Apr 27.

16.

A coiled-coil clamp controls both conformation and clustering of stromal interaction molecule 1 (STIM1).

Fahrner M, Muik M, Schindl R, Butorac C, Stathopulos P, Zheng L, Jardin I, Ikura M, Romanin C.

J Biol Chem. 2014 Nov 28;289(48):33231-44. doi: 10.1074/jbc.M114.610022. Epub 2014 Oct 23.

17.

TRPV6 calcium channel translocates to the plasma membrane via Orai1-mediated mechanism and controls cancer cell survival.

Raphaël M, Lehen'kyi V, Vandenberghe M, Beck B, Khalimonchyk S, Vanden Abeele F, Farsetti L, Germain E, Bokhobza A, Mihalache A, Gosset P, Romanin C, Clézardin P, Skryma R, Prevarskaya N.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):E3870-9. doi: 10.1073/pnas.1413409111. Epub 2014 Aug 29.

18.

Complex role of STIM1 in the activation of store-independent Orai1/3 channels.

Zhang X, Zhang W, González-Cobos JC, Jardin I, Romanin C, Matrougui K, Trebak M.

J Gen Physiol. 2014 Mar;143(3):345-59. doi: 10.1085/jgp.201311084.

19.

STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry.

Stathopulos PB, Schindl R, Fahrner M, Zheng L, Gasmi-Seabrook GM, Muik M, Romanin C, Ikura M.

Nat Commun. 2013;4:2963. doi: 10.1038/ncomms3963.

20.

In this issue of Channels: Special issue on STIM and Orai.

Romanin C.

Channels (Austin). 2013 Sep-Oct;7(5):329. doi: 10.4161/chan.27137. Epub 2013 Nov 8. No abstract available.

21.

The STIM1/Orai signaling machinery.

Fahrner M, Derler I, Jardin I, Romanin C.

Channels (Austin). 2013 Sep-Oct;7(5):330-43. doi: 10.4161/chan.26742. Epub 2013 Oct 9. Review.

22.

Inhibition of Orai1-mediated Ca(2+) entry is a key mechanism of the antiproliferative action of sirolimus in human arterial smooth muscle.

König S, Browne S, Doleschal B, Schernthaner M, Poteser M, Mächler H, Wittchow E, Braune M, Muik M, Romanin C, Groschner K.

Am J Physiol Heart Circ Physiol. 2013 Dec 1;305(11):H1646-57. doi: 10.1152/ajpheart.00365.2013. Epub 2013 Sep 20.

23.

The extended transmembrane Orai1 N-terminal (ETON) region combines binding interface and gate for Orai1 activation by STIM1.

Derler I, Plenk P, Fahrner M, Muik M, Jardin I, Schindl R, Gruber HJ, Groschner K, Romanin C.

J Biol Chem. 2013 Oct 4;288(40):29025-34. doi: 10.1074/jbc.M113.501510. Epub 2013 Aug 13.

24.

Mechanisms of STIM1 activation of store-independent leukotriene C4-regulated Ca2+ channels.

Zhang X, González-Cobos JC, Schindl R, Muik M, Ruhle B, Motiani RK, Bisaillon JM, Zhang W, Fahrner M, Barroso M, Matrougui K, Romanin C, Trebak M.

Mol Cell Biol. 2013 Sep;33(18):3715-23. doi: 10.1128/MCB.00554-13. Epub 2013 Jul 22.

25.

A novel homology model of TRPC3 reveals allosteric coupling between gate and selectivity filter.

Lichtenegger M, Stockner T, Poteser M, Schleifer H, Platzer D, Romanin C, Groschner K.

Cell Calcium. 2013 Sep;54(3):175-85. doi: 10.1016/j.ceca.2013.05.010. Epub 2013 Jun 22.

26.

Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons.

Kaya L, Meissner B, Riedl MC, Muik M, Schwarzer C, Ferraguti F, Sarg B, Lindner H, Schweigreiter R, Knaus HG, Romanin C, Bandtlow CE.

Biochim Biophys Acta. 2013 Jun;1833(6):1421-33. doi: 10.1016/j.bbamcr.2013.02.012. Epub 2013 Feb 27.

27.

Store-independent Orai1/3 channels activated by intracrine leukotriene C4: role in neointimal hyperplasia.

González-Cobos JC, Zhang X, Zhang W, Ruhle B, Motiani RK, Schindl R, Muik M, Spinelli AM, Bisaillon JM, Shinde AV, Fahrner M, Singer HA, Matrougui K, Barroso M, Romanin C, Trebak M.

Circ Res. 2013 Mar 29;112(7):1013-25. doi: 10.1161/CIRCRESAHA.111.300220. Epub 2013 Jan 24.

28.

The action of selective CRAC channel blockers is affected by the Orai pore geometry.

Derler I, Schindl R, Fritsch R, Heftberger P, Riedl MC, Begg M, House D, Romanin C.

Cell Calcium. 2013 Feb;53(2):139-51. doi: 10.1016/j.ceca.2012.11.005. Epub 2012 Dec 5.

29.

Canonical transient receptor potential (TRPC) 1 acts as a negative regulator for vanilloid TRPV6-mediated Ca2+ influx.

Schindl R, Fritsch R, Jardin I, Frischauf I, Kahr H, Muik M, Riedl MC, Groschner K, Romanin C.

J Biol Chem. 2012 Oct 12;287(42):35612-20. doi: 10.1074/jbc.M112.400952. Epub 2012 Aug 29.

30.

Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+) entry pathways.

Schleifer H, Doleschal B, Lichtenegger M, Oppenrieder R, Derler I, Frischauf I, Glasnov TN, Kappe CO, Romanin C, Groschner K.

Br J Pharmacol. 2012 Dec;167(8):1712-22. doi: 10.1111/j.1476-5381.2012.02126.x.

31.

Ca(2+) release-activated Ca(2+) (CRAC) current, structure, and function.

Muik M, Schindl R, Fahrner M, Romanin C.

Cell Mol Life Sci. 2012 Dec;69(24):4163-76. doi: 10.1007/s00018-012-1072-8. Epub 2012 Jul 17. Review.

32.

Nanopatterned polymer substrates promote endothelial proliferation by initiation of β-catenin transcriptional signaling.

Schernthaner M, Reisinger B, Wolinski H, Kohlwein SD, Trantina-Yates A, Fahrner M, Romanin C, Itani H, Stifter D, Leitinger G, Groschner K, Heitz J.

Acta Biomater. 2012 Aug;8(8):2953-62. doi: 10.1016/j.actbio.2012.04.018. Epub 2012 Apr 20.

PMID:
22522133
33.

Structure, regulation and biophysics of I(CRAC), STIM/Orai1.

Derler I, Madl J, Schütz G, Romanin C.

Adv Exp Med Biol. 2012;740:383-410. doi: 10.1007/978-94-007-2888-2_16. Review.

PMID:
22453951
34.

Gating and permeation of Orai channels.

Derler I, Schindl R, Fritsch R, Romanin C.

Front Biosci (Landmark Ed). 2012 Jan 1;17:1304-22. Review.

PMID:
22201805
35.

Laser microstructuring of photomodified fluorinated ethylene propylene surface for confined growth of Chinese hamster ovary cells and single cell isolation.

Yakunin S, Fahrner M, Reisinger B, Itani H, Romanin C, Heitz J.

J Biomed Mater Res B Appl Biomater. 2012 Jan;100(1):170-6. doi: 10.1002/jbm.b.31935. Epub 2011 Sep 21.

PMID:
21948557
36.

Extending optogenetics to a Ca(2+)-selective channel.

Romanin C.

Chem Biol. 2011 Jul 29;18(7):820-1. doi: 10.1016/j.chembiol.2011.07.004.

37.

Molecular determinants within N terminus of Orai3 protein that control channel activation and gating.

Bergsmann J, Derler I, Muik M, Frischauf I, Fahrner M, Pollheimer P, Schwarzinger C, Gruber HJ, Groschner K, Romanin C.

J Biol Chem. 2011 Sep 9;286(36):31565-75. doi: 10.1074/jbc.M111.227546. Epub 2011 Jul 1.

38.

PKC-dependent coupling of calcium permeation through transient receptor potential canonical 3 (TRPC3) to calcineurin signaling in HL-1 myocytes.

Poteser M, Schleifer H, Lichtenegger M, Schernthaner M, Stockner T, Kappe CO, Glasnov TN, Romanin C, Groschner K.

Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10556-61. doi: 10.1073/pnas.1106183108. Epub 2011 Jun 8. Erratum in: Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13876-8.

39.

STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation.

Muik M, Fahrner M, Schindl R, Stathopulos P, Frischauf I, Derler I, Plenk P, Lackner B, Groschner K, Ikura M, Romanin C.

EMBO J. 2011 May 4;30(9):1678-89. doi: 10.1038/emboj.2011.79. Epub 2011 Mar 22.

40.

Orai1 contributes to the establishment of an apoptosis-resistant phenotype in prostate cancer cells.

Flourakis M, Lehen'kyi V, Beck B, Raphaël M, Vandenberghe M, Abeele FV, Roudbaraki M, Lepage G, Mauroy B, Romanin C, Shuba Y, Skryma R, Prevarskaya N.

Cell Death Dis. 2010 Sep 16;1:e75. doi: 10.1038/cddis.2010.52.

41.

Cooperativeness of Orai cytosolic domains tunes subtype-specific gating.

Frischauf I, Schindl R, Bergsmann J, Derler I, Fahrner M, Muik M, Fritsch R, Lackner B, Groschner K, Romanin C.

J Biol Chem. 2011 Mar 11;286(10):8577-84. doi: 10.1074/jbc.M110.187179. Epub 2011 Jan 10.

42.

Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entry.

Zheng L, Stathopulos PB, Schindl R, Li GY, Romanin C, Ikura M.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1337-42. doi: 10.1073/pnas.1015125108. Epub 2011 Jan 7.

43.

Protein–Protein Interactions in TRPC Channel Complexes.

Eder P, Schindl R, Romanin C, Groschner K.

In: Liedtke WB, Heller S, editors. TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades. Boca Raton (FL): CRC Press/Taylor & Francis; 2007. Chapter 24.

44.

Resting state Orai1 diffuses as homotetramer in the plasma membrane of live mammalian cells.

Madl J, Weghuber J, Fritsch R, Derler I, Fahrner M, Frischauf I, Lackner B, Romanin C, Schütz GJ.

J Biol Chem. 2010 Dec 24;285(52):41135-42. doi: 10.1074/jbc.M110.177881. Epub 2010 Oct 20.

45.

Lpe10p modulates the activity of the Mrs2p-based yeast mitochondrial Mg2+ channel.

Sponder G, Svidova S, Schindl R, Wieser S, Schweyen RJ, Romanin C, Froschauer EM, Weghuber J.

FEBS J. 2010 Sep;277(17):3514-25. doi: 10.1111/j.1742-4658.2010.07761.x. Epub 2010 Jul 23.

46.

Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction.

Graziani A, Poteser M, Heupel WM, Schleifer H, Krenn M, Drenckhahn D, Romanin C, Baumgartner W, Groschner K.

J Biol Chem. 2010 Feb 5;285(6):4213-23. doi: 10.1074/jbc.M109.060301. Epub 2009 Dec 8.

47.

Plasticity in Ca2+ selectivity of Orai1/Orai3 heteromeric channel.

Schindl R, Frischauf I, Bergsmann J, Muik M, Derler I, Lackner B, Groschner K, Romanin C.

Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19623-8. doi: 10.1073/pnas.0907714106. Epub 2009 Nov 3.

48.

Mechanistic view on domains mediating STIM1-Orai coupling.

Fahrner M, Muik M, Derler I, Schindl R, Fritsch R, Frischauf I, Romanin C.

Immunol Rev. 2009 Sep;231(1):99-112. doi: 10.1111/j.1600-065X.2009.00815.x. Review.

PMID:
19754892
49.

Recent progress on STIM1 domains controlling Orai activation.

Schindl R, Muik M, Fahrner M, Derler I, Fritsch R, Bergsmann J, Romanin C.

Cell Calcium. 2009 Oct;46(4):227-32. doi: 10.1016/j.ceca.2009.08.003. Epub 2009 Sep 4. Review.

PMID:
19733393
50.

A Ca2(+ )release-activated Ca2(+) (CRAC) modulatory domain (CMD) within STIM1 mediates fast Ca2(+)-dependent inactivation of ORAI1 channels.

Derler I, Fahrner M, Muik M, Lackner B, Schindl R, Groschner K, Romanin C.

J Biol Chem. 2009 Sep 11;284(37):24933-8. doi: 10.1074/jbc.C109.024083. Epub 2009 Jul 21.

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