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Items: 1 to 50 of 161

2.

Synthesis of New Thiosemicarbazones and Semicarbazones Containing the 1,2,3-1H-triazole-isatin Scaffold: Trypanocidal, Cytotoxicity, Electrochemical Assays, and Molecular Docking.

Silva BNM, Sales Junior PA, Romanha AJ, Murta SMF, Lima CHS, Albuquerque MG, D'Elia E, Rodrigues JGA, Ferreira VF, Silva FC, Pinto AC, Silva BV.

Med Chem. 2019;15(3):240-256. doi: 10.2174/1573406414666180912120502.

PMID:
30332972
3.

Overexpression of eukaryotic initiation factor 5A (eIF5A) affects susceptibility to benznidazole in Trypanosoma cruzi populations.

Moreira DS, Duarte AP, Pais FSM, Silva-Pereira RAD, Romanha AJ, Schenkman S, Murta SMF.

Mem Inst Oswaldo Cruz. 2018 Jul 26;113(9):e180162. doi: 10.1590/0074-02760180162.

4.

Knockdown of Host Antioxidant Defense Genes Enhances the Effect of Glucantime on Intracellular Leishmania braziliensis in Human Macrophages.

Téllez J, Romero I, Soares MJ, Steindel M, Romanha AJ.

Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e02099-16. doi: 10.1128/AAC.02099-16. Print 2017 Jul.

5.

Synthesis and biological evaluation of potential inhibitors of the cysteine proteases cruzain and rhodesain designed by molecular simplification.

Braga SF, Martins LC, da Silva EB, Sales Júnior PA, Murta SM, Romanha AJ, Soh WT, Brandstetter H, Ferreira RS, de Oliveira RB.

Bioorg Med Chem. 2017 Mar 15;25(6):1889-1900. doi: 10.1016/j.bmc.2017.02.009. Epub 2017 Feb 9.

PMID:
28215783
6.

Constituents from stem barks of Luehea ochrophylla Mart and evaluation of their antiparasitic, antimicrobial, and antioxidant activities.

Araújo CRR, Silva RR, Silva TM, Takahashi JA, Sales-Junior PA, Dessimoni-Pinto NAV, Souza-Fagundes EM, Romanha AJ, Murta SMF, Alcântara AFC.

Nat Prod Res. 2017 Aug;31(16):1948-1953. doi: 10.1080/14786419.2016.1266346. Epub 2016 Dec 14.

PMID:
27966397
7.

Molecular characterization of lipoamide dehydrogenase gene in Trypanosoma cruzi populations susceptible and resistant to benznidazole.

Dos Santos PF, Moreira DS, Baba EH, Volpe CMO, Ruiz JC, Romanha AJ, Murta SMF.

Exp Parasitol. 2016 Nov;170:1-9. doi: 10.1016/j.exppara.2016.08.006. Epub 2016 Aug 25.

PMID:
27567984
8.

Synthesis of Xylitan Derivatives and Preliminary Evaluation of in Vitro Trypanocidal Activity.

Elias PR, Coelho GS, Xavier VF, Sales Junior PA, Romanha AJ, Murta SM, Carneiro CM, Camilo NS, Hilário FF, Taylor JG.

Molecules. 2016 Oct 10;21(10). pii: E1342.

9.

Unlocking the in vitro anti-Trypanosoma cruzi activity of halophyte plants from the southern Portugal.

Oliveira M, Sales Junior PA, Rodrigues MJ, DellaGreca M, Barreira L, Murta SM, Romanha AJ, Custódio L.

Asian Pac J Trop Med. 2016 Aug;9(8):735-41. doi: 10.1016/j.apjtm.2016.06.015. Epub 2016 Jun 29.

10.

Fungi associated with rocks of the Atacama Desert: taxonomy, distribution, diversity, ecology and bioprospection for bioactive compounds.

Gonçalves VN, Cantrell CL, Wedge DE, Ferreira MC, Soares MA, Jacob MR, Oliveira FS, Galante D, Rodrigues F, Alves TM, Zani CL, Junior PA, Murta S, Romanha AJ, Barbosa EC, Kroon EG, Oliveira JG, Gomez-Silva B, Galetovic A, Rosa CA, Rosa LH.

Environ Microbiol. 2016 Jan;18(1):232-45. doi: 10.1111/1462-2920.13005. Epub 2015 Sep 28.

PMID:
26235221
11.

Synthesis and structure-activity relationship study of a new series of antiparasitic aryloxyl thiosemicarbazones inhibiting Trypanosoma cruzi cruzain.

Espíndola JW, Cardoso MV, Filho GB, Oliveira E Silva DA, Moreira DR, Bastos TM, Simone CA, Soares MB, Villela FS, Ferreira RS, Castro MC, Pereira VR, Murta SM, Sales Junior PA, Romanha AJ, Leite AC.

Eur J Med Chem. 2015 Aug 28;101:818-35. doi: 10.1016/j.ejmech.2015.06.048. Epub 2015 Jul 3.

PMID:
26231082
12.

In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures.

Lavorato SN, Sales Júnior PA, Murta SM, Romanha AJ, Alves RJ.

Mem Inst Oswaldo Cruz. 2015 Jun;110(4):566-8. doi: 10.1590/0074-02760150007. Epub 2015 May 29.

13.

Upregulation of Cysteine Synthase and Cystathionine β-Synthase Contributes to Leishmania braziliensis Survival under Oxidative Stress.

Romero I, Téllez J, Romanha AJ, Steindel M, Grisard EC.

Antimicrob Agents Chemother. 2015 Aug;59(8):4770-81. doi: 10.1128/AAC.04880-14. Epub 2015 Jun 1.

14.

Biological activities of ophiobolin K and 6-epi-ophiobolin K produced by the endophytic fungus Aspergillus calidoustus.

de Carvalho CR, Vieira Mde L, Cantrell CL, Wedge DE, Alves TM, Zani CL, Pimenta RS, Sales Junior PA, Murta SM, Romanha AJ, Rosa CA, Rosa LH.

Nat Prod Res. 2016;30(4):478-81. doi: 10.1080/14786419.2015.1022777. Epub 2015 Mar 27.

PMID:
25812930
15.

Diversity and bioprospection of fungal community present in oligotrophic soil of continental Antarctica.

Godinho VM, Gonçalves VN, Santiago IF, Figueredo HM, Vitoreli GA, Schaefer CE, Barbosa EC, Oliveira JG, Alves TM, Zani CL, Junior PA, Murta SM, Romanha AJ, Kroon EG, Cantrell CL, Wedge DE, Duke SO, Ali A, Rosa CA, Rosa LH.

Extremophiles. 2015 May;19(3):585-96. doi: 10.1007/s00792-015-0741-6. Epub 2015 Mar 26.

PMID:
25809294
16.

Bioactive endophytic fungi isolated from Caesalpinia echinata Lam. (Brazilwood) and identification of beauvericin as a trypanocidal metabolite from Fusarium sp.

Campos FF, Sales Junior PA, Romanha AJ, Araújo MS, Siqueira EP, Resende JM, Alves TM, Martins-Filho OA, Santos VL, Rosa CA, Zani CL, Cota BB.

Mem Inst Oswaldo Cruz. 2015 Feb;110(1):65-74. doi: 10.1590/0074-02760140243. Epub 2015 Jan 16.

17.

Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1.

Fonseca NC, da Cruz LF, da Silva Villela F, do Nascimento Pereira GA, de Siqueira-Neto JL, Kellar D, Suzuki BM, Ray D, de Souza TB, Alves RJ, Sales Júnior PA, Romanha AJ, Murta SM, McKerrow JH, Caffrey CR, de Oliveira RB, Ferreira RS.

Antimicrob Agents Chemother. 2015 May;59(5):2666-77. doi: 10.1128/AAC.04601-14. Epub 2015 Feb 23.

18.

Molecular characterization of Cyclophilin (TcCyP19) in Trypanosoma cruzi populations susceptible and resistant to benznidazole.

Rêgo JV, Duarte AP, Liarte DB, de Carvalho Sousa F, Barreto HM, Bua J, Romanha AJ, Rádis-Baptista G, Murta SM.

Exp Parasitol. 2015 Jan;148:73-80. doi: 10.1016/j.exppara.2014.11.007. Epub 2014 Nov 20.

PMID:
25450774
19.

Genome of the avirulent human-infective trypanosome--Trypanosoma rangeli.

Stoco PH, Wagner G, Talavera-Lopez C, Gerber A, Zaha A, Thompson CE, Bartholomeu DC, Lückemeyer DD, Bahia D, Loreto E, Prestes EB, Lima FM, Rodrigues-Luiz G, Vallejo GA, Filho JF, Schenkman S, Monteiro KM, Tyler KM, de Almeida LG, Ortiz MF, Chiurillo MA, de Moraes MH, Cunha Ode L, Mendonça-Neto R, Silva R, Teixeira SM, Murta SM, Sincero TC, Mendes TA, Urmenyi TP, Silva VG, DaRocha WD, Andersson B, Romanha AJ, Steindel M, de Vasconcelos AT, Grisard EC.

PLoS Negl Trop Dis. 2014 Sep 18;8(9):e3176. doi: 10.1371/journal.pntd.0003176. eCollection 2014 Sep.

20.

In vitro cytotoxic, antifungal, trypanocidal and leishmanicidal activities of acetogenins isolated from Annona cornifolia A. St. -Hil. (Annonaceae).

Lima LARS, Alves TMA, Zani CL, Sales Júnior PA, Romanha AJ, Johann S, Cisalpino PS, Pimenta LPS, Boaventura MAD.

An Acad Bras Cienc. 2014 Jun;86(2):829-839.

21.

The in vitro activity of fatty diamines and amino alcohols against mixed amastigote and trypomastigote Trypanosoma cruzi forms.

Sales Júnior PA, Rezende Júnior CO, Le Hyaric M, Almeida MV, Romanha AJ.

Mem Inst Oswaldo Cruz. 2014 Jun;109(3):362-4. Epub 2014 Apr 25.

22.

Transsulfuration is an active pathway for cysteine biosynthesis in Trypanosoma rangeli.

Romero I, Téllez J, Yamanaka LE, Steindel M, Romanha AJ, Grisard EC.

Parasit Vectors. 2014 Apr 24;7:197. doi: 10.1186/1756-3305-7-197.

23.

Diversity patterns, ecology and biological activities of fungal communities associated with the endemic macroalgae across the Antarctic peninsula.

Furbino LE, Godinho VM, Santiago IF, Pellizari FM, Alves TM, Zani CL, Junior PA, Romanha AJ, Carvalho AG, Gil LH, Rosa CA, Minnis AM, Rosa LH.

Microb Ecol. 2014 May;67(4):775-87. doi: 10.1007/s00248-014-0374-9. Epub 2014 Feb 9.

PMID:
24509705
24.

Synthesis and evaluation of the antiparasitic activity of bis-(arylmethylidene) cycloalkanones.

Braga SF, Alves ÉV, Ferreira RS, Fradico JR, Lage PS, Duarte MC, Ribeiro TG, Júnior PA, Romanha AJ, Tonini ML, Steindel M, Coelho EF, de Oliveira RB.

Eur J Med Chem. 2014 Jan;71:282-9. doi: 10.1016/j.ejmech.2013.11.011. Epub 2013 Nov 16.

PMID:
24321832
25.

In vitro interaction between paromomycin sulphate and four drugs with leishmanicidal activity against three New World Leishmania species.

de Morais-Teixeira E, Gallupo MK, Rodrigues LF, Romanha AJ, Rabello A.

J Antimicrob Chemother. 2014 Jan;69(1):150-4. doi: 10.1093/jac/dkt318. Epub 2013 Aug 22.

PMID:
23970484
26.

Diversity and bioprospecting of fungal communities associated with endemic and cold-adapted macroalgae in Antarctica.

Godinho VM, Furbino LE, Santiago IF, Pellizzari FM, Yokoya NS, Pupo D, Alves TM, Junior PA, Romanha AJ, Zani CL, Cantrell CL, Rosa CA, Rosa LH.

ISME J. 2013 Jul;7(7):1434-51. doi: 10.1038/ismej.2013.77. Epub 2013 May 23.

27.

Molecular characterization of the hexose transporter gene in benznidazole resistant and susceptible populations of Trypanosoma cruzi.

dos Santos PF, Ruiz JC, Soares RP, Moreira DS, Rezende AM, Folador EL, Oliveira G, Romanha AJ, Murta SM.

Parasit Vectors. 2012 Aug 7;5:161. doi: 10.1186/1756-3305-5-161.

28.

Intraspecies variation in Trypanosoma cruzi GPI-mucins: biological activities and differential expression of α-galactosyl residues.

Soares RP, Torrecilhas AC, Assis RR, Rocha MN, Moura e Castro FA, Freitas GF, Murta SM, Santos SL, Marques AF, Almeida IC, Romanha AJ.

Am J Trop Med Hyg. 2012 Jul;87(1):87-96. doi: 10.4269/ajtmh.2012.12-0015.

29.
30.

Hb Stanleyville-II [α78(EF7)Asn→Lys (α2); HbA2: c.237C>A]: incidence of 1:11,500 in a newborn screening program in Brazil.

Silva MR, Sendin SM, Pimentel FS, Velloso-Rodrigues C, Romanha ÁJ, Viana MB.

Hemoglobin. 2012;36(4):388-94. doi: 10.3109/03630269.2012.686257. Epub 2012 May 24.

PMID:
22625430
31.

The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases - part II.

Schmidt TJ, Khalid SA, Romanha AJ, Alves TM, Biavatti MW, Brun R, Da Costa FB, de Castro SL, Ferreira VF, de Lacerda MV, Lago JH, Leon LL, Lopes NP, das Neves Amorim RC, Niehues M, Ogungbe IV, Pohlit AM, Scotti MT, Setzer WN, de N C Soeiro M, Steindel M, Tempone AG.

Curr Med Chem. 2012;19(14):2176-228. Review.

PMID:
22414104
32.

The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases - part I.

Schmidt TJ, Khalid SA, Romanha AJ, Alves TM, Biavatti MW, Brun R, Da Costa FB, de Castro SL, Ferreira VF, de Lacerda MV, Lago JH, Leon LL, Lopes NP, das Neves Amorim RC, Niehues M, Ogungbe IV, Pohlit AM, Scotti MT, Setzer WN, de N C Soeiro M, Steindel M, Tempone AG.

Curr Med Chem. 2012;19(14):2128-75. Review.

PMID:
22414103
33.

NADPH phagocyte oxidase knockout mice control Trypanosoma cruzi proliferation, but develop circulatory collapse and succumb to infection.

Santiago HC, Gonzalez Lombana CZ, Macedo JP, Utsch L, Tafuri WL, Campagnole-Santos MJ, Alves RO, Alves-Filho JC, Romanha AJ, Cunha FQ, Teixeira MM, Radi R, Vieira LQ.

PLoS Negl Trop Dis. 2012;6(2):e1492. doi: 10.1371/journal.pntd.0001492. Epub 2012 Feb 14.

34.

The activity of a metronidazole analogue and its β-cyclodextrin complex against Trypanosoma cruzi.

Lopes MS, Sales Júnior PA, Lopes AG, Yoshida MI, Silva TH, Romanha AJ, Alves RJ, Oliveira RB.

Mem Inst Oswaldo Cruz. 2011 Dec;106(8):1055-7.

35.

Leishmanicidal and antitumoral activities of endophytic fungi associated with the Antarctic angiosperms Deschampsia antarctica Desv. and Colobanthus quitensis (Kunth) Bartl.

Santiago IF, Alves TM, Rabello A, Sales Junior PA, Romanha AJ, Zani CL, Rosa CA, Rosa LH.

Extremophiles. 2012 Jan;16(1):95-103. doi: 10.1007/s00792-011-0409-9. Epub 2011 Nov 10.

PMID:
22072308
36.

Synthesis and evaluation of the anti parasitic activity of aromatic nitro compounds.

Lopes MS, de Souza Pietra RC, Borgati TF, Romeiro CF, Júnior PA, Romanha AJ, Alves RJ, Souza-Fagundes EM, Fernandes AP, de Oliveira RB.

Eur J Med Chem. 2011 Nov;46(11):5443-7. doi: 10.1016/j.ejmech.2011.09.002. Epub 2011 Sep 8.

PMID:
21940071
37.

The in vitro leishmanicidal activity of hexadecylphosphocholine (miltefosine) against four medically relevant Leishmania species of Brazil.

Morais-Teixeira Ed, Damasceno QS, Galuppo MK, Romanha AJ, Rabello A.

Mem Inst Oswaldo Cruz. 2011 Jun;106(4):475-8.

38.

In vitro trypanocidal activity of DB745B and other novel arylimidamides against Trypanosoma cruzi.

Da Silva CF, Junqueira A, Lima MM, Romanha AJ, Sales Junior PA, Stephens CE, Som P, Boykin DW, Soeiro Mde N.

J Antimicrob Chemother. 2011 Jun;66(6):1295-7. doi: 10.1093/jac/dkr140. Epub 2011 Apr 8.

PMID:
21478242
39.

Splenectomy increases mortality in murine Trypanosoma cruzi infection.

Maioli TU, Assis FA, Vieira PM, Borelli P, Santiago H, Alves R, Romanha AJ, Carneiro CM, Faria AM.

Scand J Immunol. 2011 Jan;73(1):36-45. doi: 10.1111/j.1365-3083.2010.02478.x.

40.

The anticancer drug tamoxifen is active against Trypanosoma cruzi in vitro but ineffective in the treatment of the acute phase of Chagas disease in mice.

Miguel DC, Ferraz ML, Alves Rde O, Yokoyama-Yasunaka JK, Torrecilhas AC, Romanha AJ, Uliana SR.

Mem Inst Oswaldo Cruz. 2010 Nov;105(7):945-8.

41.

In vitro activity of hypnophilin from Lentinus strigosus: a potential prototype for Chagas disease and leishmaniasis chemotherapy.

Souza-Fagundes EM, Cota BB, Rosa LH, Romanha AJ, Corrêa-Oliveira R, Rosa CA, Zani CL, Teixeira-Carvalho A, Martins-Filho OA.

Braz J Med Biol Res. 2010 Nov;43(11):1054-61. Epub 2010 Oct 14.

42.

Trypanocidal activity of lipophilic diamines and amino alcohols.

Júnior CO, Alves RO, Rezende CA, da Costa CF, Silva H, Le Hyaric M, Fontes AP, Alves RJ, Romanha AJ, de Almeida MV.

Biomed Pharmacother. 2010 Nov;64(9):624-6. doi: 10.1016/j.biopha.2010.06.002. Epub 2010 Jul 21.

PMID:
20888176
43.

CA88, a nuclear repetitive DNA sequence identified in Schistosoma mansoni, aids in the genotyping of nine Schistosoma species of medical and veterinary importance.

Bahia D, Rodrigues NB, Araújo FM, Romanha AJ, Ruiz JC, Johnston DA, Oliveira G.

Mem Inst Oswaldo Cruz. 2010 Jul;105(4):391-7.

44.

Susceptibility of Triatoma brasiliensis from state of Ceará, Northeastern Brazil, to the pyrethroid deltamethrin.

Sonoda IV, Dias LS, Bezerra CM, Dias JC, Romanha AJ, Diotaiuti L.

Mem Inst Oswaldo Cruz. 2010 May;105(3):348-52.

45.

Arylimidamide DB766, a potential chemotherapeutic candidate for Chagas' disease treatment.

Batista Dda G, Batista MM, de Oliveira GM, do Amaral PB, Lannes-Vieira J, Britto CC, Junqueira A, Lima MM, Romanha AJ, Sales Junior PA, Stephens CE, Boykin DW, Soeiro Mde N.

Antimicrob Agents Chemother. 2010 Jul;54(7):2940-52. doi: 10.1128/AAC.01617-09. Epub 2010 May 10.

46.

Role of CCL3/MIP-1alpha and CCL5/RANTES during acute Trypanosoma cruzi infection in rats.

Roffê E, Oliveira F, Souza AL, Pinho V, Souza DG, Souza PR, Russo RC, Santiago HC, Romanha AJ, Tanowitz HB, Valenzuela JG, Teixeira MM.

Microbes Infect. 2010 Aug;12(8-9):669-76. doi: 10.1016/j.micinf.2010.04.011. Epub 2010 May 7.

47.

In vitro and in vivo experimental models for drug screening and development for Chagas disease.

Romanha AJ, Castro SL, Soeiro Mde N, Lannes-Vieira J, Ribeiro I, Talvani A, Bourdin B, Blum B, Olivieri B, Zani C, Spadafora C, Chiari E, Chatelain E, Chaves G, Calzada JE, Bustamante JM, Freitas-Junior LH, Romero LI, Bahia MT, Lotrowska M, Soares M, Andrade SG, Armstrong T, Degrave W, Andrade Zde A.

Mem Inst Oswaldo Cruz. 2010 Mar;105(2):233-8.

48.

Leishmanicidal, trypanocidal, and cytotoxic activities of endophytic fungi associated with bioactive plants in Brazil.

Rosa LH, Gonçalves VN, Caligiorne RB, Alves TM, Rabello A, Sales PA, Romanha AJ, Sobral ME, Rosa CA, Zani CL.

Braz J Microbiol. 2010 Apr;41(2):420-30. doi: 10.1590/S1517-838220100002000024. Epub 2010 Jun 1.

49.

A new consensus for Trypanosoma cruzi intraspecific nomenclature: second revision meeting recommends TcI to TcVI.

Zingales B, Andrade SG, Briones MR, Campbell DA, Chiari E, Fernandes O, Guhl F, Lages-Silva E, Macedo AM, Machado CR, Miles MA, Romanha AJ, Sturm NR, Tibayrenc M, Schijman AG; Second Satellite Meeting.

Mem Inst Oswaldo Cruz. 2009 Nov;104(7):1051-4.

50.

Susceptibility of triatoma infestans to deltamethrin in Rio Grande do Sul, Brazil.

Sonoda IV, Pessoa GC, Cortez MR, Dias JC, Romanha AJ, Diotaiuti L.

Mem Inst Oswaldo Cruz. 2009 Jul;104(4):668-70.

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