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Items: 1 to 50 of 358


Conflicting Roles of 20-HETE in Hypertension and Stroke.

Shekhar S, Varghese K, Li M, Fan L, Booz GW, Roman RJ, Fan F.

Int J Mol Sci. 2019 Sep 11;20(18). pii: E4500. doi: 10.3390/ijms20184500. Review.


Knockout of Dual-Specificity Protein Phosphatase 5 Protects Against Hypertension-Induced Renal Injury.

Zhang C, He X, Murphy SR, Zhang H, Wang S, Ge Y, Gao W, Williams JM, Geurts AM, Roman RJ, Fan F.

J Pharmacol Exp Ther. 2019 Aug;370(2):206-217. doi: 10.1124/jpet.119.258954. Epub 2019 May 22.


Visualization of the intrarenal distribution of capillary blood flow.

Fan L, Wang S, He X, Gonzalez-Fernandez E, Lechene C, Fan F, Roman RJ.

Physiol Rep. 2019 Apr;7(8):e14065. doi: 10.14814/phy2.14065.


Enhanced renal ischemia-reperfusion injury in aging and diabetes.

Muroya Y, He X, Fan L, Wang S, Xu R, Fan F, Roman RJ.

Am J Physiol Renal Physiol. 2018 Dec 1;315(6):F1843-F1854. doi: 10.1152/ajprenal.00184.2018. Epub 2018 Sep 12.


Inhibition of prolyl hydroxylases alters cell metabolism and reverses pre-existing diastolic dysfunction in mice.

He X, Zeng H, Roman RJ, Chen JX.

Int J Cardiol. 2018 Dec 1;272:281-287. doi: 10.1016/j.ijcard.2018.08.065. Epub 2018 Aug 24.


20-HETE: Hypertension and Beyond.

Roman RJ, Fan F.

Hypertension. 2018 Jul;72(1):12-18. doi: 10.1161/HYPERTENSIONAHA.118.10269. Epub 2018 May 14. Review. No abstract available.


Oxidative Stress and Renal Fibrosis: Recent Insights for the Development of Novel Therapeutic Strategies.

Lv W, Booz GW, Fan F, Wang Y, Roman RJ.

Front Physiol. 2018 Feb 16;9:105. doi: 10.3389/fphys.2018.00105. eCollection 2018. Review.


Genetic Susceptibility to Hypertension-Induced Renal Injury.

Roman RJ, Fan F.

Hypertension. 2018 Apr;71(4):559-560. doi: 10.1161/HYPERTENSIONAHA.118.10773. Epub 2018 Feb 5. No abstract available.


Cerebral Autoregulation in Hypertension and Ischemic Stroke: A Mini Review.

Shekhar S, Liu R, Travis OK, Roman RJ, Fan F.

J Pharm Sci Exp Pharmacol. 2017;2017(1):21-27. Epub 2017 Oct 27.


Diffusion-weighted 7.0T Magnetic Resonance Imaging in Assessment of Intervertebral Disc Degeneration in Rats.

Li LY, Wu XL, Roman RJ, Fan F, Qiu CS, Chen BH.

Chin Med J (Engl). 2018 Jan 5;131(1):63-68. doi: 10.4103/0366-6999.221261.


Inflammation and renal fibrosis: Recent developments on key signaling molecules as potential therapeutic targets.

Lv W, Booz GW, Wang Y, Fan F, Roman RJ.

Eur J Pharmacol. 2018 Feb 5;820:65-76. doi: 10.1016/j.ejphar.2017.12.016. Epub 2017 Dec 8. Review.


Therapeutic potential of microRNAs for the treatment of renal fibrosis and CKD.

Lv W, Fan F, Wang Y, Gonzalez-Fernandez E, Wang C, Yang L, Booz GW, Roman RJ.

Physiol Genomics. 2018 Jan 1;50(1):20-34. doi: 10.1152/physiolgenomics.00039.2017. Epub 2017 Nov 10. Review.


Menopause and Ischemic Stroke: A Brief Review.

Shekhar S, Travis OK, He X, Roman RJ, Fan F.

MOJ Toxicol. 2017;3(4). pii: 00059. doi: 10.15406/mojt.2017.03.00059. Epub 2017 Aug 10.


Endothelial specific SIRT3 deletion impairs glycolysis and angiogenesis and causes diastolic dysfunction.

He X, Zeng H, Chen ST, Roman RJ, Aschner JL, Didion S, Chen JX.

J Mol Cell Cardiol. 2017 Nov;112:104-113. doi: 10.1016/j.yjmcc.2017.09.007. Epub 2017 Sep 19.


Effect of Cytochrome P450 Metabolites of Arachidonic Acid in Nephrology.

Fan F, Roman RJ.

J Am Soc Nephrol. 2017 Oct;28(10):2845-2855. doi: 10.1681/ASN.2017030252. Epub 2017 Jul 12. Review.


GPR75 Identified as the First 20-HETE Receptor: A Chemokine Receptor Adopted by a New Family.

Fan F, Roman RJ.

Circ Res. 2017 May 26;120(11):1696-1698. doi: 10.1161/CIRCRESAHA.117.311022. No abstract available.


Upregulation of 20-HETE Synthetic Cytochrome P450 Isoforms by Oxygen-Glucose Deprivation in Cortical Neurons.

Zhang H, Falck JR, Roman RJ, Harder DR, Koehler RC, Yang ZJ.

Cell Mol Neurobiol. 2017 Oct;37(7):1279-1286. doi: 10.1007/s10571-017-0462-8. Epub 2017 Jan 21.


Knockdown of Add3 impairs the myogenic response of renal afferent arterioles and middle cerebral arteries.

Fan F, Pabbidi MR, Ge Y, Li L, Wang S, Mims PN, Roman RJ.

Am J Physiol Renal Physiol. 2017 Jun 1;312(6):F971-F981. doi: 10.1152/ajprenal.00529.2016. Epub 2016 Dec 7.


Elevated K+ channel activity opposes vasoconstrictor response to serotonin in cerebral arteries of the Fawn Hooded Hypertensive rat.

Pabbidi MR, Roman RJ.

Physiol Genomics. 2017 Jan 1;49(1):27-36. doi: 10.1152/physiolgenomics.00072.2016. Epub 2016 Oct 27.


Loss of prolyl hydroxylase domain protein 2 in vascular endothelium increases pericyte coverage and promotes pulmonary arterial remodeling.

Wang S, Zeng H, Xie XJ, Tao YK, He X, Roman RJ, Aschner JL, Chen JX.

Oncotarget. 2016 Sep 13;7(37):58848-58861. doi: 10.18632/oncotarget.11585.


p66Shc regulates renal vascular tone in hypertension-induced nephropathy.

Miller B, Palygin O, Rufanova VA, Chong A, Lazar J, Jacob HJ, Mattson D, Roman RJ, Williams JM, Cowley AW Jr, Geurts AM, Staruschenko A, Imig JD, Sorokin A.

J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6.


Expression of CYP 4A ω-hydroxylase and formation of 20-hydroxyeicosatetreanoic acid (20-HETE) in cultured rat brain astrocytes.

Gebremedhin D, Zhang DX, Carver KA, Rau N, Rarick KR, Roman RJ, Harder DR.

Prostaglandins Other Lipid Mediat. 2016 Jul;124:16-26. doi: 10.1016/j.prostaglandins.2016.04.003. Epub 2016 May 9.


Molecular mechanisms and cell signaling of 20-hydroxyeicosatetraenoic acid in vascular pathophysiology.

Fan F, Ge Y, Lv W, Elliott MR, Muroya Y, Hirata T, Booz GW, Roman RJ.

Front Biosci (Landmark Ed). 2016 Jun 1;21:1427-63. Review.


Intrarenal Renin-Angiotensin System: Locally Synthesized or Taken up Via Endocytosis?

Roman RJ, Fan F, Zhuo JL.

Hypertension. 2016 May;67(5):831-3. doi: 10.1161/HYPERTENSIONAHA.116.07103. Epub 2016 Feb 29. No abstract available.


Is Beta-Amyloid Accumulation a Cause or Consequence of Alzheimer's Disease?

Wang S, Mims PN, Roman RJ, Fan F.

J Alzheimers Parkinsonism Dement. 2016;1(2). pii: 007. Epub 2016 Nov 17.


Elevated Aminopeptidase P Attenuates Cerebral Arterial Responses to Bradykinin in Fawn-Hooded Hypertensive Rats.

Hye Khan MA, Sharma A, Rarick KR, Roman RJ, Harder DR, Imig JD.

PLoS One. 2015 Dec 18;10(12):e0145335. doi: 10.1371/journal.pone.0145335. eCollection 2015.


Macula Densa Nitric Oxide Synthase 1β Protects against Salt-Sensitive Hypertension.

Lu Y, Wei J, Stec DE, Roman RJ, Ge Y, Cheng L, Liu EY, Zhang J, Hansen PB, Fan F, Juncos LA, Wang L, Pollock J, Huang PL, Fu Y, Wang S, Liu R.

J Am Soc Nephrol. 2016 Aug;27(8):2346-56. doi: 10.1681/ASN.2015050515. Epub 2015 Dec 8.


Fluorescence dilution technique for measurement of albumin reflection coefficient in isolated glomeruli.

Fan F, Chen CC, Zhang J, Schreck CM, Roman EA, Williams JM, Hirata T, Sharma M, Beard DA, Savin VJ, Roman RJ.

Am J Physiol Renal Physiol. 2015 Dec 15;309(12):F1049-59. doi: 10.1152/ajprenal.00311.2015. Epub 2015 Oct 7.


Shear stress blunts tubuloglomerular feedback partially mediated by primary cilia and nitric oxide at the macula densa.

Wang L, Shen C, Liu H, Wang S, Chen X, Roman RJ, Juncos LA, Lu Y, Wei J, Zhang J, Yip KP, Liu R.

Am J Physiol Regul Integr Comp Physiol. 2015 Oct;309(7):R757-66. doi: 10.1152/ajpregu.00173.2015. Epub 2015 Aug 12.


Renoprotective effects of combined SGLT2 and ACE inhibitor therapy in diabetic Dahl S rats.

Kojima N, Williams JM, Slaughter TN, Kato S, Takahashi T, Miyata N, Roman RJ.

Physiol Rep. 2015 Jul;3(7). pii: e12436. doi: 10.14814/phy2.12436.


Deficiency in the Formation of 20-Hydroxyeicosatetraenoic Acid Enhances Renal Ischemia-Reperfusion Injury.

Muroya Y, Fan F, Regner KR, Falck JR, Garrett MR, Juncos LA, Roman RJ.

J Am Soc Nephrol. 2015 Oct;26(10):2460-9. doi: 10.1681/ASN.2014090868. Epub 2015 Feb 2.


Identification and function of adenosine A3 receptor in afferent arterioles.

Lu Y, Zhang R, Ge Y, Carlstrom M, Wang S, Fu Y, Cheng L, Wei J, Roman RJ, Wang L, Gao X, Liu R.

Am J Physiol Renal Physiol. 2015 May 1;308(9):F1020-5. doi: 10.1152/ajprenal.00422.2014. Epub 2015 Jan 21.


Impaired myogenic response and autoregulation of cerebral blood flow is rescued in CYP4A1 transgenic Dahl salt-sensitive rat.

Fan F, Geurts AM, Murphy SR, Pabbidi MR, Jacob HJ, Roman RJ.

Am J Physiol Regul Integr Comp Physiol. 2015 Mar 1;308(5):R379-90. doi: 10.1152/ajpregu.00256.2014. Epub 2014 Dec 24.


Cytochrome P450 eicosanoids in hypertension and renal disease.

Fan F, Muroya Y, Roman RJ.

Curr Opin Nephrol Hypertens. 2015 Jan;24(1):37-46. doi: 10.1097/MNH.0000000000000088. Review.


Zinc-finger nuclease knockout of dual-specificity protein phosphatase-5 enhances the myogenic response and autoregulation of cerebral blood flow in FHH.1BN rats.

Fan F, Geurts AM, Pabbidi MR, Smith SV, Harder DR, Jacob H, Roman RJ.

PLoS One. 2014 Nov 14;9(11):e112878. doi: 10.1371/journal.pone.0112878. eCollection 2014.


Nephron Deficiency and Predisposition to Renal Injury in a Novel One-Kidney Genetic Model.

Wang X, Johnson AC, Williams JM, White T, Chade AR, Zhang J, Liu R, Roman RJ, Lee JW, Kyle PB, Solberg-Woods L, Garrett MR.

J Am Soc Nephrol. 2015 Jul;26(7):1634-46. doi: 10.1681/ASN.2014040328. Epub 2014 Oct 27.


Placental ischemia in pregnant rats impairs cerebral blood flow autoregulation and increases blood-brain barrier permeability.

Warrington JP, Fan F, Murphy SR, Roman RJ, Drummond HA, Granger JP, Ryan MJ.

Physiol Rep. 2014 Aug 28;2(8). pii: e12134. doi: 10.14814/phy2.12134. Print 2014 Aug 1.


Urinary CYP eicosanoid excretion correlates with glomerular filtration in African-Americans with chronic kidney disease.

Dreisbach AW, Smith SV, Kyle PB, Ramaiah M, Amenuke M, Garrett MR, Lirette ST, Griswold ME, Roman RJ.

Prostaglandins Other Lipid Mediat. 2014 Oct;113-115:45-51. doi: 10.1016/j.prostaglandins.2014.08.002. Epub 2014 Aug 22.


Role of 20-HETE in the impaired myogenic and TGF responses of the Af-Art of Dahl salt-sensitive rats.

Ge Y, Murphy SR, Fan F, Williams JM, Falck JR, Liu R, Roman RJ.

Am J Physiol Renal Physiol. 2014 Sep 1;307(5):F509-15. doi: 10.1152/ajprenal.00273.2014. Epub 2014 Jul 9.


Cytochrome P4504A inhibitors attenuate the exaggerated natriuretic response to volume expansion in thyroidectomized rats.

Colombero C, Venara M, Gonzalez D, Roman RJ, Nowicki S.

Physiol Rep. 2014 Jun 11;2(6). pii: e12040. doi: 10.14814/phy2.12040. Print 2014 Jun 1.


Sex differences in blood pressure control in SHR: lack of a role for EETs.

Moulana M, Hosick K, Stanford J, Zhang H, Roman RJ, Reckelhoff JF.

Physiol Rep. 2014 May 20;2(5). pii: e12022. doi: 10.14814/phy2.12022. Print 2014 May 1.


Enhanced large conductance K+ channel activity contributes to the impaired myogenic response in the cerebral vasculature of Fawn Hooded Hypertensive rats.

Pabbidi MR, Mazur O, Fan F, Farley JM, Gebremedhin D, Harder DR, Roman RJ.

Am J Physiol Heart Circ Physiol. 2014 Apr 1;306(7):H989-H1000. doi: 10.1152/ajpheart.00636.2013. Epub 2014 Jan 24.


Postmenopausal hypertension: role of the sympathetic nervous system in an animal model.

Maranon RO, Lima R, Mathbout M, do Carmo JM, Hall JE, Roman RJ, Reckelhoff JF.

Am J Physiol Regul Integr Comp Physiol. 2014 Feb 15;306(4):R248-56. doi: 10.1152/ajpregu.00490.2013. Epub 2013 Dec 31.


20-Hydroxyeicosatetraenoic acid contributes to the inhibition of K+ channel activity and vasoconstrictor response to angiotensin II in rat renal microvessels.

Fan F, Sun CW, Maier KG, Williams JM, Pabbidi MR, Didion SP, Falck JR, Zhuo J, Roman RJ.

PLoS One. 2013 Dec 4;8(12):e82482. doi: 10.1371/journal.pone.0082482. eCollection 2013.


Comparison of the Development Diabetic Induced Renal Disease in Strains of Goto-Kakizaki Rats.

Kojima N, Slaughter TN, Paige A, Kato S, Roman RJ, Williams JM.

J Diabetes Metab. 2013 May 30;Suppl 9(5). pii: S9-005.


Molecular mechanisms of renal blood flow autoregulation.

Burke M, Pabbidi MR, Farley J, Roman RJ.

Curr Vasc Pharmacol. 2014;12(6):845-58. Review.


Characterization of the development of renal injury in Type-1 diabetic Dahl salt-sensitive rats.

Slaughter TN, Paige A, Spires D, Kojima N, Kyle PB, Garrett MR, Roman RJ, Williams JM.

Am J Physiol Regul Integr Comp Physiol. 2013 Oct 1;305(7):R727-34. doi: 10.1152/ajpregu.00382.2012. Epub 2013 Aug 7.


20-Hydroxyeicosatetraenoic acid inhibition attenuates balloon injury-induced neointima formation and vascular remodeling in rat carotid arteries.

Orozco LD, Liu H, Perkins E, Johnson DA, Chen BB, Fan F, Baker RC, Roman RJ.

J Pharmacol Exp Ther. 2013 Jul;346(1):67-74. doi: 10.1124/jpet.113.203844. Epub 2013 May 8.

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