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Items: 38


High-resolution structure of RGS17 suggests a role for Ca2+ in promoting the GTPase-activating protein activity by RZ subfamily members.

Sieng M, Hayes MP, O'Brien JB, Andrew Fowler C, Houtman JC, Roman DL, Lyon AM.

J Biol Chem. 2019 May 17;294(20):8148-8160. doi: 10.1074/jbc.RA118.006059. Epub 2019 Apr 2.


Assessment of the properties of chitin deacetylases showing different enzymatic action patterns.

Roman DL, Roman M, Sletta H, Ostafe V, Isvoran A.

J Mol Graph Model. 2019 May;88:41-48. doi: 10.1016/j.jmgm.2019.01.002. Epub 2019 Jan 9.


Computational Assessment of Pharmacokinetics and Biological Effects of Some Anabolic and Androgen Steroids.

Roman M, Roman DL, Ostafe V, Ciorsac A, Isvoran A.

Pharm Res. 2018 Feb 5;35(2):41. doi: 10.1007/s11095-018-2353-1.


Screen Targeting Lung and Prostate Cancer Oncogene Identifies Novel Inhibitors of RGS17 and Problematic Chemical Substructures.

Bodle CR, Schamp JH, O'Brien JB, Hayes MP, Wu M, Doorn JA, Roman DL.

SLAS Discov. 2018 Apr;23(4):363-374. doi: 10.1177/2472555217752301. Epub 2018 Jan 19.


Evaluation of the Selectivity and Cysteine Dependence of Inhibitors across the Regulator of G Protein-Signaling Family.

Hayes MP, Bodle CR, Roman DL.

Mol Pharmacol. 2018 Jan;93(1):25-35. doi: 10.1124/mol.117.109843. Epub 2017 Oct 19.


Identification of FDA-Approved Small Molecules Capable of Disrupting the Calmodulin-Adenylyl Cyclase 8 Interaction through Direct Binding to Calmodulin.

Hayes MP, Soto-Velasquez M, Fowler CA, Watts VJ, Roman DL.

ACS Chem Neurosci. 2018 Feb 21;9(2):346-357. doi: 10.1021/acschemneuro.7b00349. Epub 2017 Oct 16.


Natural Products Discovered in a High-Throughput Screen Identified as Inhibitors of RGS17 and as Cytostatic and Cytotoxic Agents for Lung and Prostate Cancer Cell Lines.

Bodle CR, Mackie DI, Hayes MP, Schamp JH, Miller MR, Henry MD, Doorn JA, Houtman JCD, James MA, Roman DL.

J Nat Prod. 2017 Jul 28;80(7):1992-2000. doi: 10.1021/acs.jnatprod.7b00112. Epub 2017 Jun 16.


Development of a bimolecular luminescence complementation assay for RGS: G protein interactions in cells.

Bodle CR, Hayes MP, O'Brien JB, Roman DL.

Anal Biochem. 2017 Apr 1;522:10-17. doi: 10.1016/j.ab.2017.01.013. Epub 2017 Jan 20.


Potential Obstacles in the Acquisition of Oral Anticancer Medications.

Niccolai JL, Roman DL, Julius JM, Nadour RW.

J Oncol Pract. 2017 Jan;13(1):e29-e36. doi: 10.1200/JOP.2016.012302. Epub 2016 Dec 6.


Regulator of G Protein Signaling 17 as a Negative Modulator of GPCR Signaling in Multiple Human Cancers.

Hayes MP, Roman DL.

AAPS J. 2016 May;18(3):550-9. doi: 10.1208/s12248-016-9894-1. Epub 2016 Feb 29. Review.


Bias analyses of preclinical and clinical D2 dopamine ligands: studies with immediate and complex signaling pathways.

Brust TF, Hayes MP, Roman DL, Burris KD, Watts VJ.

J Pharmacol Exp Ther. 2015 Mar;352(3):480-93. doi: 10.1124/jpet.114.220293. Epub 2014 Dec 24.


New functional activity of aripiprazole revealed: Robust antagonism of D2 dopamine receptor-stimulated Gβγ signaling.

Brust TF, Hayes MP, Roman DL, Watts VJ.

Biochem Pharmacol. 2015 Jan 1;93(1):85-91. doi: 10.1016/j.bcp.2014.10.014. Epub 2014 Nov 7.


RABL6A, a novel RAB-like protein, controls centrosome amplification and chromosome instability in primary fibroblasts.

Zhang X, Hagen J, Muniz VP, Smith T, Coombs GS, Eischen CM, Mackie DI, Roman DL, Van Rheeden R, Darbro B, Tompkins VS, Quelle DE.

PLoS One. 2013 Nov 25;8(11):e80228. doi: 10.1371/journal.pone.0080228. eCollection 2013.


Modification and functional inhibition of regulator of G-protein signaling 4 (RGS4) by 4-hydroxy-2-nonenal.

Monroy CA, Doorn JA, Roman DL.

Chem Res Toxicol. 2013 Dec 16;26(12):1832-9. doi: 10.1021/tx400212q. Epub 2013 Nov 14.


RGS17: an emerging therapeutic target for lung and prostate cancers.

Bodle CR, Mackie DI, Roman DL.

Future Med Chem. 2013 Jun;5(9):995-1007. doi: 10.4155/fmc.13.91.


A high throughput screen for RGS proteins using steady state monitoring of free phosphate formation.

Monroy CA, Mackie DI, Roman DL.

PLoS One. 2013 Apr 23;8(4):e62247. doi: 10.1371/journal.pone.0062247. Print 2013.


Real-time monitoring of tyrosine hydroxylase activity using a plate reader assay.

Vermeer LM, Higgins CA, Roman DL, Doorn JA.

Anal Biochem. 2013 Jan 1;432(1):11-5. doi: 10.1016/j.ab.2012.09.005. Epub 2012 Sep 23.


Expression and purification of recombinant human tyrosine hydroxylase as a fusion protein in Escherichia coli.

Higgins CA, Vermeer LM, Doorn JA, Roman DL.

Protein Expr Purif. 2012 Aug;84(2):219-23. doi: 10.1016/j.pep.2012.05.007. Epub 2012 Jun 1.


Regulators of G protein signaling (RGS) proteins as drug targets: modulating G-protein-coupled receptor (GPCR) signal transduction.

Roman DL, Traynor JR.

J Med Chem. 2011 Nov 10;54(21):7433-40. doi: 10.1021/jm101572n. Epub 2011 Sep 29. No abstract available.


Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins.

Blazer LL, Roman DL, Chung A, Larsen MJ, Greedy BM, Husbands SM, Neubig RR.

Mol Pharmacol. 2010 Sep;78(3):524-33. doi: 10.1124/mol.110.065128. Epub 2010 Jun 22.


Allosteric inhibition of the regulator of G protein signaling-Galpha protein-protein interaction by CCG-4986.

Roman DL, Blazer LL, Monroy CA, Neubig RR.

Mol Pharmacol. 2010 Sep;78(3):360-5. doi: 10.1124/mol.109.063388. Epub 2010 Jun 7.


Use of flow cytometric methods to quantify protein-protein interactions.

Blazer LL, Roman DL, Muxlow MR, Neubig RR.

Curr Protoc Cytom. 2010 Jan;Chapter 13:Unit 13.11.1-15. doi: 10.1002/0471142956.cy1311s51.


Differential modulation of mu-opioid receptor signaling to adenylyl cyclase by regulators of G protein signaling proteins 4 or 8 and 7 in permeabilised C6 cells is Galpha subtype dependent.

Talbot JN, Roman DL, Clark MJ, Roof RA, Tesmer JJ, Neubig RR, Traynor JR.

J Neurochem. 2010 Feb;112(4):1026-34. doi: 10.1111/j.1471-4159.2009.06519.x. Epub 2009 Nov 30.


Polyplexed flow cytometry protein interaction assay: a novel high-throughput screening paradigm for RGS protein inhibitors.

Roman DL, Ota S, Neubig RR.

J Biomol Screen. 2009 Jul;14(6):610-9. doi: 10.1177/1087057109336590. Epub 2009 Jun 16.


A covalent peptide inhibitor of RGS4 identified in a focused one-bead, one compound library screen.

Roof RA, Roman DL, Clements ST, Sobczyk-Kojiro K, Blazer LL, Ota S, Mosberg HI, Neubig RR.

BMC Pharmacol. 2009 May 22;9:9. doi: 10.1186/1471-2210-9-9.


Identification of ligands targeting RGS proteins high-throughput screening and therapeutic potential.

Roman DL.

Prog Mol Biol Transl Sci. 2009;86:335-56. doi: 10.1016/S1877-1173(09)86011-0. Epub 2009 Oct 7. Review.


Assembly of high order G alpha q-effector complexes with RGS proteins.

Shankaranarayanan A, Thal DM, Tesmer VM, Roman DL, Neubig RR, Kozasa T, Tesmer JJ.

J Biol Chem. 2008 Dec 12;283(50):34923-34. doi: 10.1074/jbc.M805860200. Epub 2008 Oct 20.


In vitro protein kinase activity measurement by flow cytometry.

Bernsteel DJ, Roman DL, Neubig RR.

Anal Biochem. 2008 Dec 15;383(2):180-5. doi: 10.1016/j.ab.2008.08.026. Epub 2008 Sep 3.


Novel peptide ligands of RGS4 from a focused one-bead, one-compound library.

Roof RA, Sobczyk-Kojiro K, Turbiak AJ, Roman DL, Pogozheva ID, Blazer LL, Neubig RR, Mosberg HI.

Chem Biol Drug Des. 2008 Aug;72(2):111-9. doi: 10.1111/j.1747-0285.2008.00687.x. Epub 2008 Jul 15.


Microfabricated channel array electrophoresis for characterization and screening of enzymes using RGS-G protein interactions as a model system.

Pei J, Dishinger JF, Roman DL, Rungwanitcha C, Neubig RR, Kennedy RT.

Anal Chem. 2008 Jul 1;80(13):5225-31. doi: 10.1021/ac800553g. Epub 2008 May 9.


Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay.

Roman DL, Talbot JN, Roof RA, Sunahara RK, Traynor JR, Neubig RR.

Mol Pharmacol. 2007 Jan;71(1):169-75. Epub 2006 Sep 29.


Mechanism of action and structural requirements of constrained peptide inhibitors of RGS proteins.

Roof RA, Jin Y, Roman DL, Sunahara RK, Ishii M, Mosberg HI, Neubig RR.

Chem Biol Drug Des. 2006 Apr;67(4):266-74.


Interactions of antidepressants with the serotonin transporter: a contemporary molecular analysis.

Roman DL, Walline CC, Rodriguez GJ, Barker EL.

Eur J Pharmacol. 2003 Oct 31;479(1-3):53-63.


Distinct molecular recognition of psychostimulants by human and Drosophila serotonin transporters.

Roman DL, Saldaña SN, Nichols DE, Carroll FI, Barker EL.

J Pharmacol Exp Ther. 2004 Feb;308(2):679-87. Epub 2003 Oct 30.


Distinct recognition of substrates by the human and Drosophila serotonin transporters.

Rodríguez GJ, Roman DL, White KJ, Nichols DE, Barker EL.

J Pharmacol Exp Ther. 2003 Jul;306(1):338-46. Epub 2003 Apr 7.


Streptococcal necrotizing fasciitis ("flesh-eating strep infection").

Schwartz SN, Roman DL, Grosserode MH, Rowland MD.

J Okla State Med Assoc. 1995 Nov;88(11):472-4.


[Ultrasonic therapy of chronic prostatitis].

Karpukhin VT, Nesterov NI, Roman DL.

Vopr Kurortol Fizioter Lech Fiz Kult. 1977 May-Jun;(3):75-7. Russian. No abstract available.


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