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A Gene Expression Classifier from Whole Blood Distinguishes Benign from Malignant Lung Nodules Detected by Low-Dose CT.

Kossenkov AV, Qureshi R, Dawany NB, Wickramasinghe J, Liu Q, Majumdar RS, Chang C, Widura S, Kumar T, Horng WH, Konnisto E, Criner G, Tsay JJ, Pass H, Yendamuri S, Vachani A, Bauer T, Nam B, Rom WN, Showe MK, Showe LC.

Cancer Res. 2019 Jan 1;79(1):263-273. doi: 10.1158/0008-5472.CAN-18-2032. Epub 2018 Nov 28.


Epigenetically regulated PAX6 drives cancer cells toward a stem-like state via GLI-SOX2 signaling axis in lung adenocarcinoma.

Ooki A, Dinalankara W, Marchionni L, Tsay JJ, Goparaju C, Maleki Z, Rom WN, Pass HI, Hoque MO.

Oncogene. 2018 Nov;37(45):5967-5981. doi: 10.1038/s41388-018-0373-2. Epub 2018 Jul 6.


Aldehydes are the predominant forces inducing DNA damage and inhibiting DNA repair in tobacco smoke carcinogenesis.

Weng MW, Lee HW, Park SH, Hu Y, Wang HT, Chen LC, Rom WN, Huang WC, Lepor H, Wu XR, Yang CS, Tang MS.

Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6152-E6161. doi: 10.1073/pnas.1804869115. Epub 2018 Jun 18.


Airway Microbiota Is Associated with Upregulation of the PI3K Pathway in Lung Cancer.

Tsay JJ, Wu BG, Badri MH, Clemente JC, Shen N, Meyn P, Li Y, Yie TA, Lhakhang T, Olsen E, Murthy V, Michaud G, Sulaiman I, Tsirigos A, Heguy A, Pass H, Weiden MD, Rom WN, Sterman DH, Bonneau R, Blaser MJ, Segal LN.

Am J Respir Crit Care Med. 2018 Nov 1;198(9):1188-1198. doi: 10.1164/rccm.201710-2118OC.


Whole blood FPR1 mRNA expression predicts both non-small cell and small cell lung cancer.

Morris S, Vachani A, Pass HI, Rom WN, Ryden K, Weiss GJ, Hogarth DK, Runger G, Richards D, Shelton T, Mallery DW.

Int J Cancer. 2018 Jun 1;142(11):2355-2362. doi: 10.1002/ijc.31245. Epub 2018 Jan 30.


A Panel of Novel Detection and Prognostic Methylated DNA Markers in Primary Non-Small Cell Lung Cancer and Serum DNA.

Ooki A, Maleki Z, Tsay JJ, Goparaju C, Brait M, Turaga N, Nam HS, Rom WN, Pass HI, Sidransky D, Guerrero-Preston R, Hoque MO.

Clin Cancer Res. 2017 Nov 15;23(22):7141-7152. doi: 10.1158/1078-0432.CCR-17-1222. Epub 2017 Aug 29.


Clinical validation of a blood-based classifier for diagnostic evaluation of asymptomatic individuals with pulmonary nodules.

Birse CE, Tomic JL, Pass HI, Rom WN, Lagier RJ.

Clin Proteomics. 2017 Jul 5;14:25. doi: 10.1186/s12014-017-9158-9. eCollection 2017.


Identification of autoantibodies to ECH1 and HNRNPA2B1 as potential biomarkers in the early detection of lung cancer.

Dai L, Li J, Tsay JJ, Yie TA, Munger JS, Pass H, Rom WN, Tan EM, Zhang JY.

Oncoimmunology. 2017 Mar 31;6(5):e1310359. doi: 10.1080/2162402X.2017.1310359. eCollection 2017.


Anaerobic Bacterial Fermentation Products Increase Tuberculosis Risk in Antiretroviral-Drug-Treated HIV Patients.

Segal LN, Clemente JC, Li Y, Ruan C, Cao J, Danckers M, Morris A, Tapyrik S, Wu BG, Diaz P, Calligaro G, Dawson R, van Zyl-Smit RN, Dheda K, Rom WN, Weiden MD.

Cell Host Microbe. 2017 Apr 12;21(4):530-537.e4. doi: 10.1016/j.chom.2017.03.003. Epub 2017 Mar 30.


Integrated Metabolomics and Proteomics Highlight Altered Nicotinamide- and Polyamine Pathways in Lung Adenocarcinoma.

Fahrmann JF, Grapov DD, Wanichthanarak K, DeFelice BC, Salemi MR, Rom WN, Gandara DR, Phinney BS, Fiehn O, Pass H, Miyamoto S.

Carcinogenesis. 2017 Jan 3. pii: bgw205. doi: 10.1093/carcin/bgw205. [Epub ahead of print] Review.


Distal airway dysfunction identifies pulmonary inflammation in asymptomatic smokers.

Berger KI, Pradhan DR, Goldring RM, Oppenheimer BW, Rom WN, Segal LN.

ERJ Open Res. 2016 Nov 29;2(4). pii: 00066-2016. eCollection 2016 Oct.


Enrichment of the lung microbiome with oral taxa is associated with lung inflammation of a Th17 phenotype.

Segal LN, Clemente JC, Tsay JC, Koralov SB, Keller BC, Wu BG, Li Y, Shen N, Ghedin E, Morris A, Diaz P, Huang L, Wikoff WR, Ubeda C, Artacho A, Rom WN, Sterman DH, Collman RG, Blaser MJ, Weiden MD.

Nat Microbiol. 2016 Apr 4;1:16031. doi: 10.1038/nmicrobiol.2016.31.


Autoantibodies against tumor-associated antigens in the early detection of lung cancer.

Dai L, Tsay JC, Li J, Yie TA, Munger JS, Pass H, Rom WN, Zhang Y, Tan EM, Zhang JY.

Lung Cancer. 2016 Sep;99:172-9. doi: 10.1016/j.lungcan.2016.07.018. Epub 2016 Jul 18.


Randomised, double-blind, placebo-controlled trial with azithromycin selects for anti-inflammatory microbial metabolites in the emphysematous lung.

Segal LN, Clemente JC, Wu BG, Wikoff WR, Gao Z, Li Y, Ko JP, Rom WN, Blaser MJ, Weiden MD.

Thorax. 2017 Jan;72(1):13-22. doi: 10.1136/thoraxjnl-2016-208599. Epub 2016 Aug 2.


Progression from respiratory dysfunction to failure in late-onset Pompe disease.

Berger KI, Chan Y, Rom WN, Oppenheimer BW, Goldring RM.

Neuromuscul Disord. 2016 Aug;26(8):481-9. doi: 10.1016/j.nmd.2016.05.018. Epub 2016 May 30.


Erratum to "reduced lung function in smokers in a lung cancer screening cohort with asbestos exposure and pleural plaques".

Lopatin S, Tsay JC, Addrizzo-Harris D, Munger JS, Pass H, Rom WN.

Am J Ind Med. 2016 May;59(5):424. doi: 10.1002/ajim.22583. No abstract available.


Serum phosphatidylethanolamine levels distinguish benign from malignant solitary pulmonary nodules and represent a potential diagnostic biomarker for lung cancer.

Fahrmann JF, Grapov D, DeFelice BC, Taylor S, Kim K, Kelly K, Wikoff WR, Pass H, Rom WN, Fiehn O, Miyamoto S.

Cancer Biomark. 2016 Mar 11;16(4):609-17. doi: 10.3233/CBM-160602.


Risk Factors Associated With Quantitative Evidence of Lung Emphysema and Fibrosis in an HIV-Infected Cohort.

Leader JK, Crothers K, Huang L, King MA, Morris A, Thompson BW, Flores SC, Drummond MB, Rom WN, Diaz PT.

J Acquir Immune Defic Syndr. 2016 Apr 1;71(4):420-7. doi: 10.1097/QAI.0000000000000894.


Comparative Study of Autoantibody Responses between Lung Adenocarcinoma and Benign Pulmonary Nodules.

Wang J, Shivakumar S, Barker K, Tang Y, Wallstrom G, Park JG, Tsay JC, Pass HI, Rom WN, LaBaer J, Qiu J.

J Thorac Oncol. 2016 Mar;11(3):334-45. doi: 10.1016/j.jtho.2015.11.011. Epub 2016 Feb 16.


Reduced lung function in smokers in a lung cancer screening cohort with asbestos exposure and pleural plaques.

Lopatin S, Tsay JC, Addrizzo-Harris D, Munger JS, Pass H, Rom WN.

Am J Ind Med. 2016 Mar;59(3):178-85. doi: 10.1002/ajim.22571. Epub 2016 Jan 27. Erratum in: Am J Ind Med. 2016 May;59(5):424.


Inflammatory cytokines and non-small cell lung cancer in a CT-scan screening cohort: Background review of the literature.

DeCotiis C, Hu Y, Greenberg AK, Huie M, Tsay JC, Pass H, Goldberg JD, Rom WN.

Cancer Biomark. 2016;16(2):219-33. doi: 10.3233/CBM-150559. Review.


Blinded Validation of Breath Biomarkers of Lung Cancer, a Potential Ancillary to Chest CT Screening.

Phillips M, Bauer TL, Cataneo RN, Lebauer C, Mundada M, Pass HI, Ramakrishna N, Rom WN, Vallières E.

PLoS One. 2015 Dec 23;10(12):e0142484. doi: 10.1371/journal.pone.0142484. eCollection 2015.


Cigarette side-stream smoke lung and bladder carcinogenesis: inducing mutagenic acrolein-DNA adducts, inhibiting DNA repair and enhancing anchorage-independent-growth cell transformation.

Lee HW, Wang HT, Weng MW, Chin C, Huang W, Lepor H, Wu XR, Rom WN, Chen LC, Tang MS.

Oncotarget. 2015 Oct 20;6(32):33226-36. doi: 10.18632/oncotarget.5429.


The History of the Bellevue Hospital Chest Service (1903-2015).

Rom WN, Reibman J.

Ann Am Thorac Soc. 2015 Oct;12(10):1438-46. doi: 10.1513/AnnalsATS.201506-370PS.


Role of GLI1 and NDRG1 in Increased Resistance to Apoptosis Induction.

Wu F, Rom WN, Koshiji M, Mo Y, Hosomi Y, Tchou-Wong KM.

J Environ Pathol Toxicol Oncol. 2015;34(3):213-25.


Differential N-Glycosylation Patterns in Lung Adenocarcinoma Tissue.

Ruhaak LR, Taylor SL, Stroble C, Nguyen UT, Parker EA, Song T, Lebrilla CB, Rom WN, Pass H, Kim K, Kelly K, Miyamoto S.

J Proteome Res. 2015 Nov 6;14(11):4538-49. doi: 10.1021/acs.jproteome.5b00255. Epub 2015 Sep 30.


Blood-based lung cancer biomarkers identified through proteomic discovery in cancer tissues, cell lines and conditioned medium.

Birse CE, Lagier RJ, FitzHugh W, Pass HI, Rom WN, Edell ES, Bungum AO, Maldonado F, Jett JR, Mesri M, Sult E, Joseloff E, Li A, Heidbrink J, Dhariwal G, Danis C, Tomic JL, Bruce RJ, Moore PA, He T, Lewis ME, Ruben SM.

Clin Proteomics. 2015 Jul 16;12(1):18. doi: 10.1186/s12014-015-9090-9. eCollection 2015.


Biomarkers of World Trade Center Particulate Matter Exposure: Physiology of Distal Airway and Blood Biomarkers that Predict FEV₁ Decline.

Weiden MD, Kwon S, Caraher E, Berger KI, Reibman J, Rom WN, Prezant DJ, Nolan A.

Semin Respir Crit Care Med. 2015 Jun;36(3):323-33. doi: 10.1055/s-0035-1547349. Epub 2015 May 29. Review.


Environmental lung diseases--2015.

Rom WN, Reibman J.

Semin Respir Crit Care Med. 2015 Jun;36(3):321-2. doi: 10.1055/s-0035-1551541. Epub 2015 May 29. No abstract available.


YKL-40 is a Protective Biomarker for Fatty Liver in World Trade Center Particulate Matter-Exposed Firefighters.

Cho SJ, Echevarria GC, Lee YI, Kwon S, Park KY, Tsukiji J, Rom WN, Prezant DJ, Nolan A, Weiden MD.

J Mol Biomark Diagn. 2014;5. pii: 1000174.


From closing the atmospheric ozone hole to reducing climate change. Lessons learned.

Ewart GW, Rom WN, Braman SS, Pinkerton KE.

Ann Am Thorac Soc. 2015 Feb;12(2):247-51. doi: 10.1513/AnnalsATS.201411-537PS.


Molecular characterization of the peripheral airway field of cancerization in lung adenocarcinoma.

Tsay JC, Li Z, Yie TA, Wu F, Segal L, Greenberg AK, Leibert E, Weiden MD, Pass H, Munger J, Statnikov A, Tchou-Wong KM, Rom WN.

PLoS One. 2015 Feb 23;10(2):e0118132. doi: 10.1371/journal.pone.0118132. eCollection 2015.


Metabolomic markers of altered nucleotide metabolism in early stage adenocarcinoma.

Wikoff WR, Grapov D, Fahrmann JF, DeFelice B, Rom WN, Pass HI, Kim K, Nguyen U, Taylor SL, Gandara DR, Kelly K, Fiehn O, Miyamoto S.

Cancer Prev Res (Phila). 2015 May;8(5):410-8. doi: 10.1158/1940-6207.CAPR-14-0329. Epub 2015 Feb 5.


Validation of a multiprotein plasma classifier to identify benign lung nodules.

Vachani A, Pass HI, Rom WN, Midthun DE, Edell ES, Laviolette M, Li XJ, Fong PY, Hunsucker SW, Hayward C, Mazzone PJ, Madtes DK, Miller YE, Walker MG, Shi J, Kearney P, Fang KC, Massion PP.

J Thorac Oncol. 2015 Apr;10(4):629-37. doi: 10.1097/JTO.0000000000000447.


Adenosine deaminase acting on RNA-1 (ADAR1) inhibits HIV-1 replication in human alveolar macrophages.

Weiden MD, Hoshino S, Levy DN, Li Y, Kumar R, Burke SA, Dawson R, Hioe CE, Borkowsky W, Rom WN, Hoshino Y.

PLoS One. 2014 Oct 1;9(10):e108476. doi: 10.1371/journal.pone.0108476. eCollection 2014.


Enlarged pulmonary artery is predicted by vascular injury biomarkers and is associated with WTC-Lung Injury in exposed fire fighters: a case-control study.

Schenck EJ, Echevarria GC, Girvin FG, Kwon S, Comfort AL, Rom WN, Prezant DJ, Weiden MD, Nolan A.

BMJ Open. 2014 Sep 29;4(9):e005575. doi: 10.1136/bmjopen-2014-005575.


Biomarkers for lung cancer.

Rom WN.

Respir Investig. 2014 Sep;52(5):277-8. doi: 10.1016/j.resinv.2014.06.002. Epub 2014 Jul 11. No abstract available.


Validation of a blood protein signature for non-small cell lung cancer.

Mehan MR, Williams SA, Siegfried JM, Bigbee WL, Weissfeld JL, Wilson DO, Pass HI, Rom WN, Muley T, Meister M, Franklin W, Miller YE, Brody EN, Ostroff RM.

Clin Proteomics. 2014 Aug 1;11(1):32. doi: 10.1186/1559-0275-11-32. eCollection 2014.


New drugs to treat multidrug-resistant tuberculosis: the case for bedaquiline.

Leibert E, Danckers M, Rom WN.

Ther Clin Risk Manag. 2014 Jul 29;10:597-602. doi: 10.2147/TCRM.S37743. eCollection 2014. Review.


Obliterative bronchiolitis.

Barker AF, Bergeron A, Rom WN, Hertz MI.

N Engl J Med. 2014 May 8;370(19):1820-8. doi: 10.1056/NEJMra1204664. Review. No abstract available.


Lysophosphatidic acid and apolipoprotein A1 predict increased risk of developing World Trade Center-lung injury: a nested case-control study.

Tsukiji J, Cho SJ, Echevarria GC, Kwon S, Joseph P, Schenck EJ, Naveed B, Prezant DJ, Rom WN, Schmidt AM, Weiden MD, Nolan A.

Biomarkers. 2014 Mar;19(2):159-65. doi: 10.3109/1354750X.2014.891047. Epub 2014 Feb 19.


Lung microbiome for clinicians. New discoveries about bugs in healthy and diseased lungs.

Segal LN, Rom WN, Weiden MD.

Ann Am Thorac Soc. 2014 Jan;11(1):108-16. doi: 10.1513/AnnalsATS.201310-339FR. Review.


Enrichment of lung microbiome with supraglottic taxa is associated with increased pulmonary inflammation.

Segal LN, Alekseyenko AV, Clemente JC, Kulkarni R, Wu B, Gao Z, Chen H, Berger KI, Goldring RM, Rom WN, Blaser MJ, Weiden MD.

Microbiome. 2013 Jul 1;1(1):19. doi: 10.1186/2049-2618-1-19. Erratum in: Microbiome. 2014;2:21. Gao, Zhan [added].


MMP-2 and TIMP-1 predict healing of WTC-lung injury in New York City firefighters.

Nolan A, Kwon S, Cho SJ, Naveed B, Comfort AL, Prezant DJ, Rom WN, Weiden MD.

Respir Res. 2014 Jan 21;15:5. doi: 10.1186/1465-9921-15-5.


One airway: Biomarkers of protection from upper and lower airway injury after World Trade Center exposure.

Cho SJ, Echevarria GC, Kwon S, Naveed B, Schenck EJ, Tsukiji J, Rom WN, Prezant DJ, Nolan A, Weiden MD.

Respir Med. 2014 Jan;108(1):162-70. doi: 10.1016/j.rmed.2013.11.002. Epub 2013 Nov 13.


Chemoprevention of lung cancer: prospects and disappointments in human clinical trials.

Greenberg AK, Tsay JC, Tchou-Wong KM, Jorgensen A, Rom WN.

Cancers (Basel). 2013 Jan 24;5(1):131-48. doi: 10.3390/cancers5010131.


Early elevation of serum MMP-3 and MMP-12 predicts protection from World Trade Center-lung injury in New York City Firefighters: a nested case-control study.

Kwon S, Weiden MD, Echevarria GC, Comfort AL, Naveed B, Prezant DJ, Rom WN, Nolan A.

PLoS One. 2013 Oct 16;8(10):e76099. doi: 10.1371/journal.pone.0076099. eCollection 2013.


A blood-based proteomic classifier for the molecular characterization of pulmonary nodules.

Li XJ, Hayward C, Fong PY, Dominguez M, Hunsucker SW, Lee LW, McLean M, Law S, Butler H, Schirm M, Gingras O, Lamontagne J, Allard R, Chelsky D, Price ND, Lam S, Massion PP, Pass H, Rom WN, Vachani A, Fang KC, Hood L, Kearney P.

Sci Transl Med. 2013 Oct 16;5(207):207ra142. doi: 10.1126/scitranslmed.3007013.


Experimental human exposure to air pollutants is essential to understand adverse health effects.

Rom WN, Boushey H, Caplan A.

Am J Respir Cell Mol Biol. 2013 Nov;49(5):691-6. doi: 10.1165/rcmb.2013-0253PS.


microRNAs derived from circulating exosomes as noninvasive biomarkers for screening and diagnosing lung cancer.

Cazzoli R, Buttitta F, Di Nicola M, Malatesta S, Marchetti A, Rom WN, Pass HI.

J Thorac Oncol. 2013 Sep;8(9):1156-62. doi: 10.1097/JTO.0b013e318299ac32.

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