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Best matches for Romão MJ[au]:

Structural basis for the role of mammalian aldehyde oxidases in the metabolism of drugs and xenobiotics. Romão MJ et al. Curr Opin Chem Biol. (2017)

X-ray crystallography in drug discovery. Carvalho AL et al. Methods Mol Biol. (2009)

Structure and function of mammalian aldehyde oxidases. Terao M et al. Arch Toxicol. (2016)

Search results

Items: 1 to 50 of 115

1.

SLMP53-1 interacts with wild-type and mutant p53 DNA-binding domain and reactivates multiple hotspot mutations.

Gomes AS, Ramos H, Gomes S, Loureiro JB, Soares J, Barcherini V, Monti P, Fronza G, Oliveira C, Domingues L, Bastos M, Dourado DFAR, Carvalho AL, Romão MJ, Pinheiro B, Marcelo F, Carvalho A, Santos MMM, Saraiva L.

Biochim Biophys Acta Gen Subj. 2020 Jan;1864(1):129440. doi: 10.1016/j.bbagen.2019.129440. Epub 2019 Sep 16.

PMID:
31536751
2.

New insights about the monomer and homodimer structures of the human AOX1.

Ferreira P, Cerqueira NMFSA, Coelho C, Fernandes PA, Romão MJ, Ramos MJ.

Phys Chem Chem Phys. 2019 Jul 7;21(25):13545-13554. doi: 10.1039/c9cp01040h. Epub 2019 Jun 7.

PMID:
31172995
3.

Human aldehyde oxidase (hAOX1): structure determination of the Moco-free form of the natural variant G1269R and biophysical studies of single nucleotide polymorphisms.

Mota C, Esmaeeli M, Coelho C, Santos-Silva T, Wolff M, Foti A, Leimkühler S, Romão MJ.

FEBS Open Bio. 2019 May;9(5):925-934. doi: 10.1002/2211-5463.12617. Epub 2019 Apr 15.

4.

The Crystal Structure of the R280K Mutant of Human p53 Explains the Loss of DNA Binding.

Gomes AS, Trovão F, Andrade Pinheiro B, Freire F, Gomes S, Oliveira C, Domingues L, Romão MJ, Saraiva L, Carvalho AL.

Int J Mol Sci. 2018 Apr 13;19(4). pii: E1184. doi: 10.3390/ijms19041184.

5.

First insights of peptidoglycan amidation in Gram-positive bacteria - the high-resolution crystal structure of Staphylococcus aureus glutamine amidotransferase GatD.

Leisico F, V Vieira D, Figueiredo TA, Silva M, Cabrita EJ, Sobral RG, Ludovice AM, Trincão J, Romão MJ, de Lencastre H, Santos-Silva T.

Sci Rep. 2018 Mar 28;8(1):5313. doi: 10.1038/s41598-018-22986-3.

6.

Electron transfer through arsenite oxidase: Insights into Rieske interaction with cytochrome c.

Watson C, Niks D, Hille R, Vieira M, Schoepp-Cothenet B, Marques AT, Romão MJ, Santos-Silva T, Santini JM.

Biochim Biophys Acta Bioenerg. 2017 Oct;1858(10):865-872. doi: 10.1016/j.bbabio.2017.08.003. Epub 2017 Aug 8.

7.

Stability and Ligand Promiscuity of Type A Carbohydrate-binding Modules Are Illustrated by the Structure of Spirochaeta thermophila StCBM64C.

Pires VM, Pereira PM, Brás JL, Correia M, Cardoso V, Bule P, Alves VD, Najmudin S, Venditto I, Ferreira LM, Romão MJ, Carvalho AL, Fontes CM, Prazeres DM.

J Biol Chem. 2017 Mar 24;292(12):4847-4860. doi: 10.1074/jbc.M116.767541. Epub 2017 Feb 8.

8.

Structural basis for the role of mammalian aldehyde oxidases in the metabolism of drugs and xenobiotics.

Romão MJ, Coelho C, Santos-Silva T, Foti A, Terao M, Garattini E, Leimkühler S.

Curr Opin Chem Biol. 2017 Apr;37:39-47. doi: 10.1016/j.cbpa.2017.01.005. Epub 2017 Jan 24. Review.

PMID:
28126656
9.

Diverse specificity of cellulosome attachment to the bacterial cell surface.

Brás JL, Pinheiro BA, Cameron K, Cuskin F, Viegas A, Najmudin S, Bule P, Pires VM, Romão MJ, Bayer EA, Spencer HL, Smith S, Gilbert HJ, Alves VD, Carvalho AL, Fontes CM.

Sci Rep. 2016 Dec 7;6:38292. doi: 10.1038/srep38292.

10.

The Escherichia coli Periplasmic Aldehyde Oxidoreductase Is an Exceptional Member of the Xanthine Oxidase Family of Molybdoenzymes.

Correia MA, Otrelo-Cardoso AR, Schwuchow V, Sigfridsson Clauss KG, Haumann M, Romão MJ, Leimkühler S, Santos-Silva T.

ACS Chem Biol. 2016 Oct 21;11(10):2923-2935. Epub 2016 Sep 13.

PMID:
27622978
11.

Structure and function of mammalian aldehyde oxidases.

Terao M, Romão MJ, Leimkühler S, Bolis M, Fratelli M, Coelho C, Santos-Silva T, Garattini E.

Arch Toxicol. 2016 Apr;90(4):753-80. doi: 10.1007/s00204-016-1683-1. Epub 2016 Feb 26. Review.

PMID:
26920149
12.

Optimization of the Expression of Human Aldehyde Oxidase for Investigations of Single-Nucleotide Polymorphisms.

Foti A, Hartmann T, Coelho C, Santos-Silva T, Romão MJ, Leimkühler S.

Drug Metab Dispos. 2016 Aug;44(8):1277-85. doi: 10.1124/dmd.115.068395. Epub 2016 Feb 3.

PMID:
26842593
13.

Structural and mechanistic insights on nitrate reductases.

Coelho C, Romão MJ.

Protein Sci. 2015 Dec;24(12):1901-11. doi: 10.1002/pro.2801. Epub 2015 Sep 22. Review.

14.

Structural insights into xenobiotic and inhibitor binding to human aldehyde oxidase.

Coelho C, Foti A, Hartmann T, Santos-Silva T, Leimkühler S, Romão MJ.

Nat Chem Biol. 2015 Oct;11(10):779-83. doi: 10.1038/nchembio.1895. Epub 2015 Aug 31.

PMID:
26322824
15.

A contribution to the rational design of Ru(CO)3Cl2L complexes for in vivo delivery of CO.

Seixas JD, Santos MF, Mukhopadhyay A, Coelho AC, Reis PM, Veiros LF, Marques AR, Penacho N, Gonçalves AM, Romão MJ, Bernardes GJ, Santos-Silva T, Romão CC.

Dalton Trans. 2015 Mar 21;44(11):5058-75. doi: 10.1039/c4dt02966f.

PMID:
25427784
16.

Erratum to: Aromatic aldehydes at the active site of aldehyde oxidoreductase from Desulfovibrio gigas: reactivity and molecular details of the enzyme-substrate and enzyme-product interaction.

Correia HD, Marangon J, Brondino CD, Moura JJ, Romão MJ, González PJ, Santos-Silva T.

J Biol Inorg Chem. 2015 Mar;20(2):231. doi: 10.1007/s00775-014-1205-7. No abstract available.

PMID:
25349044
17.

Insights into the structural determinants of substrate specificity and activity in mouse aldehyde oxidases.

Cerqueira NM, Coelho C, Brás NF, Fernandes PA, Garattini E, Terao M, Romão MJ, Ramos MJ.

J Biol Inorg Chem. 2015 Mar;20(2):209-17. doi: 10.1007/s00775-014-1198-2. Epub 2014 Oct 7.

PMID:
25287365
18.

Aromatic aldehydes at the active site of aldehyde oxidoreductase from Desulfovibrio gigas: reactivity and molecular details of the enzyme-substrate and enzyme-product interaction.

Correia HD, Marangon J, Brondino CD, Moura JJ, Romão MJ, González PJ, Santos-Silva T.

J Biol Inorg Chem. 2015 Mar;20(2):219-29. doi: 10.1007/s00775-014-1196-4. Epub 2014 Sep 27. Erratum in: J Biol Inorg Chem. 2015 Mar;20(2):231.

PMID:
25261288
19.

Biochemical, stabilization and crystallization studies on a molecular chaperone (PaoD) involved in the maturation of molybdoenzymes.

Otrelo-Cardoso AR, Schwuchow V, Rodrigues D, Cabrita EJ, Leimkühler S, Romão MJ, Santos-Silva T.

PLoS One. 2014 Jan 31;9(1):e87295. doi: 10.1371/journal.pone.0087295. eCollection 2014.

20.

Structural data on the periplasmic aldehyde oxidoreductase PaoABC from Escherichia coli: SAXS and preliminary X-ray crystallography analysis.

Otrelo-Cardoso AR, da Silva Correia MA, Schwuchow V, Svergun DI, Romão MJ, Leimkühler S, Santos-Silva T.

Int J Mol Sci. 2014 Jan 31;15(2):2223-36. doi: 10.3390/ijms15022223.

21.

Kinetic and structural studies of aldehyde oxidoreductase from Desulfovibrio gigas reveal a dithiolene-based chemistry for enzyme activation and inhibition by H(2)O(2).

Marangon J, Correia HD, Brondino CD, Moura JJ, Romão MJ, González PJ, Santos-Silva T.

PLoS One. 2013 Dec 31;8(12):e83234. doi: 10.1371/journal.pone.0083234. eCollection 2013.

22.

Identification of crucial amino acids in mouse aldehyde oxidase 3 that determine substrate specificity.

Mahro M, Brás NF, Cerqueira NM, Teutloff C, Coelho C, Romão MJ, Leimkühler S.

PLoS One. 2013 Dec 16;8(12):e82285. doi: 10.1371/journal.pone.0082285. eCollection 2013.

23.

Overexpression, crystallization and preliminary X-ray crystallographic analysis of glucuronoxylan xylanohydrolase (Xyn30A) from Clostridium thermocellum.

Verma AK, Goyal A, Freire F, Bule P, Venditto I, Brás JL, Santos H, Cardoso V, Bonifácio C, Thompson A, Romão MJ, Prates JA, Ferreira LM, Fontes CM, Najmudin S.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Dec;69(Pt 12):1440-2. doi: 10.1107/S1744309113025050. Epub 2013 Nov 30.

24.

Interaction of vanadium(IV) with human serum apo-transferrin.

Mehtab S, Gonçalves G, Roy S, Tomaz AI, Santos-Silva T, Santos MF, Romão MJ, Jakusch T, Kiss T, Pessoa JC.

J Inorg Biochem. 2013 Apr;121:187-95. doi: 10.1016/j.jinorgbio.2012.12.020. Epub 2013 Jan 17.

PMID:
23411030
25.

Solution structure, dynamics and binding studies of a family 11 carbohydrate-binding module from Clostridium thermocellum (CtCBM11).

Viegas A, Sardinha J, Freire F, Duarte DF, Carvalho AL, Fontes CM, Romão MJ, Macedo AL, Cabrita EJ.

Biochem J. 2013 Apr 15;451(2):289-300. doi: 10.1042/BJ20120627.

PMID:
23356867
26.

Characterization of a versatile organometallic pro-drug (CORM) for experimental CO based therapeutics.

Seixas JD, Mukhopadhyay A, Santos-Silva T, Otterbein LE, Gallo DJ, Rodrigues SS, Guerreiro BH, Gonçalves AM, Penacho N, Marques AR, Coelho AC, Reis PM, Romão MJ, Romão CC.

Dalton Trans. 2013 May 7;42(17):5985-98. doi: 10.1039/c2dt32174b.

27.

Novel Clostridium thermocellum type I cohesin-dockerin complexes reveal a single binding mode.

Brás JL, Alves VD, Carvalho AL, Najmudin S, Prates JA, Ferreira LM, Bolam DN, Romão MJ, Gilbert HJ, Fontes CM.

J Biol Chem. 2012 Dec 28;287(53):44394-405. doi: 10.1074/jbc.M112.407700. Epub 2012 Nov 1.

28.

The first mammalian aldehyde oxidase crystal structure: insights into substrate specificity.

Coelho C, Mahro M, Trincão J, Carvalho AT, Ramos MJ, Terao M, Garattini E, Leimkühler S, Romão MJ.

J Biol Chem. 2012 Nov 23;287(48):40690-702. doi: 10.1074/jbc.M112.390419. Epub 2012 Sep 27.

29.

New insights into the chemistry of fac-[Ru(CO)₃]²⁺ fragments in biologically relevant conditions: the CO releasing activity of [Ru(CO)₃Cl₂(1,3-thiazole)], and the X-ray crystal structure of its adduct with lysozyme.

Santos MF, Seixas JD, Coelho AC, Mukhopadhyay A, Reis PM, Romão MJ, Romão CC, Santos-Silva T.

J Inorg Biochem. 2012 Dec;117:285-91. doi: 10.1016/j.jinorgbio.2012.06.018. Epub 2012 Jul 6.

PMID:
22883959
30.

Escherichia coli expression, purification, crystallization, and structure determination of bacterial cohesin-dockerin complexes.

Brás JL, Carvalho AL, Viegas A, Najmudin S, Alves VD, Prates JA, Ferreira LM, Romão MJ, Gilbert HJ, Fontes CM.

Methods Enzymol. 2012;510:395-415. doi: 10.1016/B978-0-12-415931-0.00021-5.

PMID:
22608738
31.

Purification, crystallization and preliminary X-ray characterization of the pentamodular arabinoxylanase CtXyl5A from Clostridium thermocellum.

Brás JL, Correia MA, Romão MJ, Prates JA, Fontes CM, Najmudin S.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jul 1;67(Pt 7):833-6. doi: 10.1107/S1744309111020823. Epub 2011 Jun 30.

32.

Towards improved therapeutic CORMs: understanding the reactivity of CORM-3 with proteins.

Santos-Silva T, Mukhopadhyay A, Seixas JD, Bernardes GJ, Romão CC, Romão MJ.

Curr Med Chem. 2011;18(22):3361-6. Review.

PMID:
21728965
33.

Characterization and crystallization of mouse aldehyde oxidase 3: from mouse liver to Escherichia coli heterologous protein expression.

Mahro M, Coelho C, Trincão J, Rodrigues D, Terao M, Garattini E, Saggu M, Lendzian F, Hildebrandt P, Romão MJ, Leimkühler S.

Drug Metab Dispos. 2011 Oct;39(10):1939-45. doi: 10.1124/dmd.111.040873. Epub 2011 Jun 24.

PMID:
21705476
34.

Overproduction, purification, crystallization and preliminary X-ray characterization of a novel carbohydrate-binding module of endoglucanase Cel5A from Eubacterium cellulosolvens.

Luís AS, Alves VD, Romão MJ, Prates JA, Fontes CM, Najmudin S.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Apr 1;67(Pt 4):491-3. doi: 10.1107/S1744309111004246. Epub 2011 Mar 25.

35.

Structural insights into a unique cellulase fold and mechanism of cellulose hydrolysis.

Brás JL, Cartmell A, Carvalho AL, Verzé G, Bayer EA, Vazana Y, Correia MA, Prates JA, Ratnaparkhe S, Boraston AB, Romão MJ, Fontes CM, Gilbert HJ.

Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5237-42. doi: 10.1073/pnas.1015006108. Epub 2011 Mar 10. Erratum in: Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):following 5242. Proc Natl Acad Sci U S A. 2011 May 17;108(20):8525.

36.

Molecular architecture and structural transitions of a Clostridium thermocellum mini-cellulosome.

García-Alvarez B, Melero R, Dias FM, Prates JA, Fontes CM, Smith SP, Romão MJ, Carvalho AL, Llorca O.

J Mol Biol. 2011 Apr 8;407(4):571-80. doi: 10.1016/j.jmb.2011.01.060. Epub 2011 Feb 15.

PMID:
21315080
37.

CORM-3 reactivity toward proteins: the crystal structure of a Ru(II) dicarbonyl-lysozyme complex.

Santos-Silva T, Mukhopadhyay A, Seixas JD, Bernardes GJ, Romão CC, Romão MJ.

J Am Chem Soc. 2011 Feb 9;133(5):1192-5. doi: 10.1021/ja108820s. Epub 2011 Jan 4.

PMID:
21204537
38.

Crystal structure of the zinc-, cobalt-, and iron-containing adenylate kinase from Desulfovibrio gigas: a novel metal-containing adenylate kinase from Gram-negative bacteria.

Mukhopadhyay A, Kladova AV, Bursakov SA, Gavel OY, Calvete JJ, Shnyrov VL, Moura I, Moura JJ, Romão MJ, Trincão J.

J Biol Inorg Chem. 2011 Jan;16(1):51-61. doi: 10.1007/s00775-010-0700-8. Epub 2010 Sep 7.

PMID:
20821240
39.

Putting an N-terminal end to the Clostridium thermocellum xylanase Xyn10B story: crystal structure of the CBM22-1-GH10 modules complexed with xylohexaose.

Najmudin S, Pinheiro BA, Prates JA, Gilbert HJ, Romão MJ, Fontes CM.

J Struct Biol. 2010 Dec;172(3):353-62. doi: 10.1016/j.jsb.2010.07.009. Epub 2010 Aug 1.

PMID:
20682344
40.

Family 42 carbohydrate-binding modules display multiple arabinoxylan-binding interfaces presenting different ligand affinities.

Ribeiro T, Santos-Silva T, Alves VD, Dias FM, Luís AS, Prates JA, Ferreira LM, Romão MJ, Fontes CM.

Biochim Biophys Acta. 2010 Oct;1804(10):2054-62. doi: 10.1016/j.bbapap.2010.07.006. Epub 2010 Jul 14.

PMID:
20637315
41.

The 1.4 A resolution structure of Paracoccus pantotrophus pseudoazurin.

Najmudin S, Pauleta SR, Moura I, Romão MJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jun 1;66(Pt 6):627-35. doi: 10.1107/S1744309110013989. Epub 2010 May 25.

42.

Real-time monitoring of molecular dynamics of ethylene glycol dimethacrylate glass former.

Viciosa MT, Correia NT, Salmerón Sanchez M, Carvalho AL, Romão MJ, Gómez Ribelles JL, Dionísio M.

J Phys Chem B. 2009 Oct 29;113(43):14209-17. doi: 10.1021/jp903212g.

PMID:
19803485
43.

Cobalt-, zinc- and iron-bound forms of adenylate kinase (AK) from the sulfate-reducing bacterium Desulfovibrio gigas: purification, crystallization and preliminary X-ray diffraction analysis.

Kladova AV, Gavel OY, Mukhopaadhyay A, Boer DR, Teixeira S, Shnyrov VL, Moura I, Moura JJ, Romão MJ, Trincão J, Bursakov SA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Sep 1;65(Pt 9):926-9. doi: 10.1107/S1744309109029157. Epub 2009 Aug 22.

44.

Crystallization and crystallographic analysis of the apo form of the orange protein (ORP) from Desulfovibrio gigas.

Najmudin S, Bonifácio C, Duarte AG, Pauleta SR, Moura I, Moura JJ, Romão MJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Jul 1;65(Pt 7):730-2. doi: 10.1107/S1744309109023392. Epub 2009 Jun 30. Erratum in: Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Aug 1;65(Pt 8):856. Pualeta, Sofia R [corrected to Pauleta, Sofia R].

45.

Preliminary structural characterization of human SOUL, a haem-binding protein.

Freire F, Romão MJ, Macedo AL, Aveiro SS, Goodfellow BJ, Carvalho AL.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Jul 1;65(Pt 7):723-6. doi: 10.1107/S174430910902291X. Epub 2009 Jun 27.

46.

Kinetic, structural, and EPR studies reveal that aldehyde oxidoreductase from Desulfovibrio gigas does not need a sulfido ligand for catalysis and give evidence for a direct Mo-C interaction in a biological system.

Santos-Silva T, Ferroni F, Thapper A, Marangon J, González PJ, Rizzi AC, Moura I, Moura JJ, Romão MJ, Brondino CD.

J Am Chem Soc. 2009 Jun 17;131(23):7990-8. doi: 10.1021/ja809448r.

PMID:
19459677
47.

Molybdenum and tungsten enzymes: a crystallographic and mechanistic overview.

Romão MJ.

Dalton Trans. 2009 Jun 7;(21):4053-68. doi: 10.1039/b821108f. Epub 2009 Mar 14. Review.

PMID:
19452052
48.

The effect of the sixth sulfur ligand in the catalytic mechanism of periplasmic nitrate reductase.

Cerqueira NM, Gonzalez PJ, Brondino CD, Romão MJ, Romão CC, Moura I, Moura JJ.

J Comput Chem. 2009 Nov 30;30(15):2466-84. doi: 10.1002/jcc.21280.

PMID:
19360810
49.

X-ray crystallography in drug discovery.

Carvalho AL, Trincão J, Romão MJ.

Methods Mol Biol. 2009;572:31-56. doi: 10.1007/978-1-60761-244-5_3. Review.

PMID:
20694684
50.

Ion jelly: a tailor-made conducting material for smart electrochemical devices.

Vidinha P, Lourenço NM, Pinheiro C, Brás AR, Carvalho T, Santos-Silva T, Mukhopadhyay A, Romão MJ, Parola J, Dionisio M, Cabral JM, Afonso CA, Barreiros S.

Chem Commun (Camb). 2008 Nov 30;(44):5842-4. doi: 10.1039/b811647d. Epub 2008 Oct 3.

PMID:
19009100

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