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The transcription factor Duxbl mediates elimination of pre-T cells that fail β-selection.

Klein F, Mitrovic M, Roux J, Engdahl C, von Muenchow L, Alberti-Servera L, Fehling HJ, Pelczar P, Rolink A, Tsapogas P.

J Exp Med. 2019 Mar 4;216(3):638-655. doi: 10.1084/jem.20181444. Epub 2019 Feb 14.


Accumulation of Multipotent Hematopoietic Progenitors in Peripheral Lymphoid Organs of Mice Over-expressing Interleukin-7 and Flt3-Ligand.

Klein F, von Muenchow L, Capoferri G, Heiler S, Alberti-Servera L, Rolink H, Engdahl C, Rolink M, Mitrovic M, Cvijetic G, Andersson J, Ceredig R, Tsapogas P, Rolink A.

Front Immunol. 2018 Oct 10;9:2258. doi: 10.3389/fimmu.2018.02258. eCollection 2018.


DN2 Thymocytes Activate a Specific Robust DNA Damage Response to Ionizing Radiation-Induced DNA Double-Strand Breaks.

Calvo-Asensio I, Sugrue T, Bosco N, Rolink A, Ceredig R.

Front Immunol. 2018 Jun 11;9:1312. doi: 10.3389/fimmu.2018.01312. eCollection 2018.


Testosterone is an endogenous regulator of BAFF and splenic B cell number.

Wilhelmson AS, Lantero Rodriguez M, Stubelius A, Fogelstrand P, Johansson I, Buechler MB, Lianoglou S, Kapoor VN, Johansson ME, Fagman JB, Duhlin A, Tripathi P, Camponeschi A, Porse BT, Rolink AG, Nissbrandt H, Turley SJ, Carlsten H, Mårtensson IL, Karlsson MCI, Tivesten Å.

Nat Commun. 2018 May 25;9(1):2067. doi: 10.1038/s41467-018-04408-0.


DPP9 enzymatic activity in hematopoietic cells is dispensable for mouse hematopoiesis.

Kim M, von Muenchow L, Le Meur T, Kueng B, Gapp B, Weber D, Dietrich W, Kovarik J, Rolink AG, Ksiazek I.

Immunol Lett. 2018 Jun;198:60-65. doi: 10.1016/j.imlet.2018.04.008. Epub 2018 Apr 27.


Prophylactic and Therapeutic Effects of Interleukin-2 (IL-2)/Anti-IL-2 Complexes in Systemic Lupus Erythematosus-Like Chronic Graft-Versus-Host Disease.

Heiler S, Lötscher J, Kreuzaler M, Rolink J, Rolink A.

Front Immunol. 2018 Apr 4;9:656. doi: 10.3389/fimmu.2018.00656. eCollection 2018.


A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors.

Vigolo M, Chambers MG, Willen L, Chevalley D, Maskos K, Lammens A, Tardivel A, Das D, Kowalczyk-Quintas C, Schuepbach-Mallepell S, Smulski CR, Eslami M, Rolink A, Hummler E, Samy E, Fomekong Nanfack Y, Mackay F, Liao M, Hess H, Jiang X, Schneider P.

Nat Commun. 2018 Mar 23;9(1):1199. doi: 10.1038/s41467-018-03323-8.


Two Distinct Pathways in Mice Generate Antinuclear Antigen-Reactive B Cell Repertoires.

Faderl M, Klein F, Wirz OF, Heiler S, Albertí-Servera L, Engdahl C, Andersson J, Rolink A.

Front Immunol. 2018 Jan 22;9:16. doi: 10.3389/fimmu.2018.00016. eCollection 2018.


Single-cell RNA sequencing reveals developmental heterogeneity among early lymphoid progenitors.

Alberti-Servera L, von Muenchow L, Tsapogas P, Capoferri G, Eschbach K, Beisel C, Ceredig R, Ivanek R, Rolink A.

EMBO J. 2017 Dec 15;36(24):3619-3633. doi: 10.15252/embj.201797105. Epub 2017 Oct 13.


Engineered T cells towards TNFRSF13C (BAFFR): a novel strategy to efficiently target B-cell acute lymphoblastic leukaemia.

Turazzi N, Fazio G, Rossi V, Rolink A, Cazzaniga G, Biondi A, Magnani CF, Biagi E.

Br J Haematol. 2018 Sep;182(6):939-943. doi: 10.1111/bjh.14899. Epub 2017 Aug 18. No abstract available.


TNFRSF13C (BAFFR) positive blasts persist after early treatment and at relapse in childhood B-cell precursor acute lymphoblastic leukaemia.

Fazio G, Turazzi N, Cazzaniga V, Kreuzaler M, Maglia O, Magnani CF, Biagi E, Rolink A, Biondi A, Cazzaniga G.

Br J Haematol. 2018 Aug;182(3):434-436. doi: 10.1111/bjh.14794. Epub 2017 Jun 1. No abstract available.


The Cytokine Flt3-Ligand in Normal and Malignant Hematopoiesis.

Tsapogas P, Mooney CJ, Brown G, Rolink A.

Int J Mol Sci. 2017 May 24;18(6). pii: E1115. doi: 10.3390/ijms18061115. Review.


BAFF- and TACI-Dependent Processing of BAFFR by ADAM Proteases Regulates the Survival of B Cells.

Smulski CR, Kury P, Seidel LM, Staiger HS, Edinger AK, Willen L, Seidl M, Hess H, Salzer U, Rolink AG, Rizzi M, Schneider P, Eibel H.

Cell Rep. 2017 Feb 28;18(9):2189-2202. doi: 10.1016/j.celrep.2017.02.005.


Pro-B cells propagated in stromal cell-free cultures reconstitute functional B-cell compartments in immunodeficient mice.

von Muenchow L, Tsapogas P, Albertí-Servera L, Capoferri G, Doelz M, Rolink H, Bosco N, Ceredig R, Rolink AG.

Eur J Immunol. 2017 Feb;47(2):394-405. doi: 10.1002/eji.201646638. Epub 2016 Dec 28.


Permissive roles of cytokines interleukin-7 and Flt3 ligand in mouse B-cell lineage commitment.

von Muenchow L, Alberti-Servera L, Klein F, Capoferri G, Finke D, Ceredig R, Rolink A, Tsapogas P.

Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):E8122-E8130. Epub 2016 Nov 29.


Flt3 Ligand Regulates the Development of Innate Lymphoid Cells in Fetal and Adult Mice.

Baerenwaldt A, von Burg N, Kreuzaler M, Sitte S, Horvath E, Peter A, Voehringer D, Rolink AG, Finke D.

J Immunol. 2016 Mar 15;196(6):2561-71. doi: 10.4049/jimmunol.1501380. Epub 2016 Feb 5.


Enhancer repertoires are reshaped independently of early priming and heterochromatin dynamics during B cell differentiation.

Choukrallah MA, Song S, Rolink AG, Burger L, Matthias P.

Nat Commun. 2015 Oct 19;6:8324. doi: 10.1038/ncomms9324.


PI3-Kinase-γ Has a Distinct and Essential Role in Lung-Specific Dendritic Cell Development.

Nobs SP, Schneider C, Dietrich MG, Brocker T, Rolink A, Hirsch E, Kopf M.

Immunity. 2015 Oct 20;43(4):674-89. doi: 10.1016/j.immuni.2015.09.006. Epub 2015 Oct 6.


Trace amine-associated receptor 1 activation silences GSK3β signaling of TAAR1 and D2R heteromers.

Harmeier A, Obermueller S, Meyer CA, Revel FG, Buchy D, Chaboz S, Dernick G, Wettstein JG, Iglesias A, Rolink A, Bettler B, Hoener MC.

Eur Neuropsychopharmacol. 2015 Nov;25(11):2049-61. doi: 10.1016/j.euroneuro.2015.08.011. Epub 2015 Aug 20.


Versatility of stem and progenitor cells and the instructive actions of cytokines on hematopoiesis.

Brown G, Mooney CJ, Alberti-Servera L, Muenchow Lv, Toellner KM, Ceredig R, Rolink A.

Crit Rev Clin Lab Sci. 2015;52(4):168-79. doi: 10.3109/10408363.2015.1021412. Epub 2015 Jul 27. Review.


Pillars Article: Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature. 1999. 401: 556-562.

Nutt SL, Heavey B, Rolink AG, Busslinger M.

J Immunol. 2015 Aug 1;195(3):766-72. No abstract available.


De novo DNA Methyltransferases Dnmt3a and Dnmt3b regulate the onset of Igκ light chain rearrangement during early B-cell development.

Manoharan A, Du Roure C, Rolink AG, Matthias P.

Eur J Immunol. 2015 Aug;45(8):2343-55. doi: 10.1002/eji.201445035. Epub 2015 Jun 16.


Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammation.

Bornancin F, Renner F, Touil R, Sic H, Kolb Y, Touil-Allaoui I, Rush JS, Smith PA, Bigaud M, Junker-Walker U, Burkhart C, Dawson J, Niwa S, Katopodis A, Nuesslein-Hildesheim B, Weckbecker G, Zenke G, Kinzel B, Traggiai E, Brenner D, Brüstle A, St Paul M, Zamurovic N, McCoy KD, Rolink A, Régnier CH, Mak TW, Ohashi PS, Patel DD, Calzascia T.

J Immunol. 2015 Apr 15;194(8):3723-34. doi: 10.4049/jimmunol.1402254. Epub 2015 Mar 11.


The immunogenicity of antibody aggregates in a novel transgenic mouse model.

Bessa J, Boeckle S, Beck H, Buckel T, Schlicht S, Ebeling M, Kiialainen A, Koulov A, Boll B, Weiser T, Singer T, Rolink AG, Iglesias A.

Pharm Res. 2015 Jul;32(7):2344-59. doi: 10.1007/s11095-015-1627-0. Epub 2015 Jan 29.


A stromal cell free culture system generates mouse pro-T cells that can reconstitute T-cell compartments in vivo.

Gehre N, Nusser A, von Muenchow L, Tussiwand R, Engdahl C, Capoferri G, Bosco N, Ceredig R, Rolink AG.

Eur J Immunol. 2015 Mar;45(3):932-42. doi: 10.1002/eji.201444681. Epub 2014 Dec 16.


Activated group 3 innate lymphoid cells promote T-cell-mediated immune responses.

von Burg N, Chappaz S, Baerenwaldt A, Horvath E, Bose Dasgupta S, Ashok D, Pieters J, Tacchini-Cottier F, Rolink A, Acha-Orbea H, Finke D.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12835-40. doi: 10.1073/pnas.1406908111. Epub 2014 Aug 18.


The development of autoimmune features in aging mice is closely associated with alterations of the peripheral CD4⁺ T-cell compartment.

Nusser A, Nuber N, Wirz OF, Rolink H, Andersson J, Rolink A.

Eur J Immunol. 2014 Oct;44(10):2893-902. doi: 10.1002/eji.201344408. Epub 2014 Aug 25.


A translocated effector required for Bartonella dissemination from derma to blood safeguards migratory host cells from damage by co-translocated effectors.

Okujava R, Guye P, Lu YY, Mistl C, Polus F, Vayssier-Taussat M, Halin C, Rolink AG, Dehio C.

PLoS Pathog. 2014 Jun 19;10(6):e1004187. doi: 10.1371/journal.ppat.1004187. eCollection 2014 Jun.


Reconstitution of the peripheral B lymphocyte compartment in patients with ANCA-associated vasculitides treated with rituximab for relapsing or refractory disease.

Venhoff N, Niessen L, Kreuzaler M, Rolink AG, Hässler F, Rizzi M, Voll RE, Thiel J.

Autoimmunity. 2014 Sep;47(6):401-8. doi: 10.3109/08916934.2014.914174. Epub 2014 May 6.


The amount of self-antigen determines the effector function of murine T cells escaping negative selection.

Swee LK, Nusser A, Curti M, Kreuzaler M, Rolink H, Terracciano L, Melchers F, Andersson J, Rolink A.

Eur J Immunol. 2014 May;44(5):1299-312. doi: 10.1002/eji.201343840. Epub 2014 Mar 7.


The selection of mature B cells is critically dependent on the expression level of the co-receptor CD19.

von Muenchow L, Engdahl C, Karjalainen K, Rolink AG.

Immunol Lett. 2014 Aug;160(2):113-9. doi: 10.1016/j.imlet.2014.01.011. Epub 2014 Jan 25.


In vivo evidence for an instructive role of fms-like tyrosine kinase-3 (FLT3) ligand in hematopoietic development.

Tsapogas P, Swee LK, Nusser A, Nuber N, Kreuzaler M, Capoferri G, Rolink H, Ceredig R, Rolink A.

Haematologica. 2014 Apr;99(4):638-46. doi: 10.3324/haematol.2013.089482. Epub 2014 Jan 24.


A common single nucleotide polymorphism impairs B-cell activating factor receptor's multimerization, contributing to common variable immunodeficiency.

Pieper K, Rizzi M, Speletas M, Smulski CR, Sic H, Kraus H, Salzer U, Fiala GJ, Schamel WW, Lougaris V, Plebani A, Hammarstrom L, Recher M, Germenis AE, Grimbacher B, Warnatz K, Rolink AG, Schneider P, Notarangelo LD, Eibel H.

J Allergy Clin Immunol. 2014 Apr;133(4):1222-5. doi: 10.1016/j.jaci.2013.11.021. Epub 2014 Jan 7. No abstract available. Erratum in: J Allergy Clin Immunol. 2014 Aug;134(2):495.


A feeder-free differentiation system identifies autonomously proliferating B cell precursors in human bone marrow.

Kraus H, Kaiser S, Aumann K, Bönelt P, Salzer U, Vestweber D, Erlacher M, Kunze M, Burger M, Pieper K, Sic H, Rolink A, Eibel H, Rizzi M.

J Immunol. 2014 Feb 1;192(3):1044-54. doi: 10.4049/jimmunol.1301815. Epub 2013 Dec 30.


An epigenetic profile of early T-cell development from multipotent progenitors to committed T-cell descendants.

Vigano MA, Ivanek R, Balwierz P, Berninger P, van Nimwegen E, Karjalainen K, Rolink A.

Eur J Immunol. 2014 Apr;44(4):1181-93. doi: 10.1002/eji.201344022. Epub 2014 Feb 1.


BAFF receptor mAb treatment ameliorates development and progression of atherosclerosis in hyperlipidemic ApoE(-/-) mice.

Kyaw T, Cui P, Tay C, Kanellakis P, Hosseini H, Liu E, Rolink AG, Tipping P, Bobik A, Toh BH.

PLoS One. 2013;8(4):e60430. doi: 10.1371/journal.pone.0060430. Epub 2013 Apr 3.


PAX5/ETV6 alters the gene expression profile of precursor B cells with opposite dominant effect on endogenous PAX5.

Fazio G, Cazzaniga V, Palmi C, Galbiati M, Giordan M, te Kronnie G, Rolink A, Biondi A, Cazzaniga G.

Leukemia. 2013 Apr;27(4):992-5. doi: 10.1038/leu.2012.281. Epub 2012 Oct 1. No abstract available.


The key role of IL-7 in lymphopoiesis.

Ceredig R, Rolink AG.

Semin Immunol. 2012 Jun;24(3):159-64. doi: 10.1016/j.smim.2012.02.004. Epub 2012 Mar 14. Review.


Soluble BAFF levels inversely correlate with peripheral B cell numbers and the expression of BAFF receptors.

Kreuzaler M, Rauch M, Salzer U, Birmelin J, Rizzi M, Grimbacher B, Plebani A, Lougaris V, Quinti I, Thon V, Litzman J, Schlesier M, Warnatz K, Thiel J, Rolink AG, Eibel H.

J Immunol. 2012 Jan 1;188(1):497-503. doi: 10.4049/jimmunol.1102321. Epub 2011 Nov 28.


BAFF-R expression correlates with positive selection of immature B cells.

Tussiwand R, Rauch M, Flück LA, Rolink AG.

Eur J Immunol. 2012 Jan;42(1):206-16. doi: 10.1002/eji.201141957. Epub 2011 Dec 5.


The preTCR-dependent DN3 to DP transition requires Notch signaling, is improved by CXCL12 signaling and is inhibited by IL-7 signaling.

Tussiwand R, Engdahl C, Gehre N, Bosco N, Ceredig R, Rolink AG.

Eur J Immunol. 2011 Nov;41(11):3371-80. doi: 10.1002/eji.201141824. Epub 2011 Oct 4.


Mutation of the BAFF furin cleavage site impairs B-cell homeostasis and antibody responses.

Bossen C, Tardivel A, Willen L, Fletcher CA, Perroud M, Beermann F, Rolink AG, Scott ML, Mackay F, Schneider P.

Eur J Immunol. 2011 Mar;41(3):787-97. doi: 10.1002/eji.201040591. Epub 2011 Feb 1.


Homeostatic expansion of autoreactive immunoglobulin-secreting cells in the Rag2 mouse model of Omenn syndrome.

Cassani B, Poliani PL, Marrella V, Schena F, Sauer AV, Ravanini M, Strina D, Busse CE, Regenass S, Wardemann H, Martini A, Facchetti F, van der Burg M, Rolink AG, Vezzoni P, Grassi F, Traggiai E, Villa A.

J Exp Med. 2010 Jul 5;207(7):1525-40. doi: 10.1084/jem.20091928. Epub 2010 Jun 14.


Rescue of the mature B cell compartment in BAFF-deficient mice by treatment with recombinant Fc-BAFF.

Swee LK, Tardivel A, Schneider P, Rolink A.

Immunol Lett. 2010 Jun 15;131(1):40-8. doi: 10.1016/j.imlet.2010.03.007. Epub 2010 Mar 27.


Evidence that Yaa-induced loss of marginal zone B cells is a result of dendritic cell-mediated enhanced activation.

Santiago-Raber ML, Amano H, Amano E, Fossati-Jimack L, Swee LK, Rolink A, Izui S.

J Autoimmun. 2010 Jun;34(4):349-55. doi: 10.1016/j.jaut.2010.01.001. Epub 2010 Feb 10.


Auto-reconstitution of the T-cell compartment by radioresistant hematopoietic cells following lethal irradiation and bone marrow transplantation.

Bosco N, Swee LK, Bénard A, Ceredig R, Rolink A.

Exp Hematol. 2010 Mar;38(3):222-232.e2. doi: 10.1016/j.exphem.2009.12.006. Epub 2010 Jan 4.


Tolerance checkpoints in B-cell development: Johnny B good.

Tussiwand R, Bosco N, Ceredig R, Rolink AG.

Eur J Immunol. 2009 Sep;39(9):2317-24. doi: 10.1002/eji.200939633.


Cutting edge: IL-7 regulates the peripheral pool of adult ROR gamma+ lymphoid tissue inducer cells.

Schmutz S, Bosco N, Chappaz S, Boyman O, Acha-Orbea H, Ceredig R, Rolink AG, Finke D.

J Immunol. 2009 Aug 15;183(4):2217-21. doi: 10.4049/jimmunol.0802911. Epub 2009 Jul 27.


Crucial role for BAFF-BAFF-R signaling in the survival and maintenance of mature B cells.

Rauch M, Tussiwand R, Bosco N, Rolink AG.

PLoS One. 2009;4(5):e5456. doi: 10.1371/journal.pone.0005456. Epub 2009 May 6.


Models of haematopoiesis: seeing the wood for the trees.

Ceredig R, Rolink AG, Brown G.

Nat Rev Immunol. 2009 Apr;9(4):293-300. doi: 10.1038/nri2525. Review.


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