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Phytochrome-Based Extracellular Matrix with Reversibly Tunable Mechanical Properties.

Hörner M, Raute K, Hummel B, Madl J, Creusen G, Thomas OS, Christen EH, Hotz N, Gübeli RJ, Engesser R, Rebmann B, Lauer J, Rolauffs B, Timmer J, Schamel WWA, Pruszak J, Römer W, Zurbriggen MD, Friedrich C, Walther A, Minguet S, Sawarkar R, Weber W.

Adv Mater. 2019 Mar;31(12):e1806727. doi: 10.1002/adma.201806727. Epub 2019 Jan 27.


Chondrocyte death after mechanically overloading degenerated human intervertebral disk explants is associated with a structurally impaired pericellular matrix.

Hofmann UK, Steidle J, Danalache M, Bonnaire F, Walter C, Rolauffs B.

J Tissue Eng Regen Med. 2018 Sep;12(9):2000-2010. doi: 10.1002/term.2735. Epub 2018 Aug 9.


Chondrosarcoma: A Rare Misfortune in Aging Human Cartilage? The Role of Stem and Progenitor Cells in Proliferation, Malignant Degeneration and Therapeutic Resistance.

Boehme KA, Schleicher SB, Traub F, Rolauffs B.

Int J Mol Sci. 2018 Jan 21;19(1). pii: E311. doi: 10.3390/ijms19010311. Review.


Chondrogenic potential of IL-10 in mechanically injured cartilage and cellularized collagen ACI grafts.

Behrendt P, Feldheim M, Preusse-Prange A, Weitkamp JT, Haake M, Eglin D, Rolauffs B, Fay J, Seekamp A, Grodzinsky AJ, Kurz B.

Osteoarthritis Cartilage. 2018 Feb;26(2):264-275. doi: 10.1016/j.joca.2017.11.007. Epub 2017 Nov 21.


The Potential for Synovium-derived Stem Cells in Cartilage Repair.

Kubosch EJ, Lang G, Furst D, Kubosch D, Izadpanah K, Rolauffs B, Sudkamp NP, Schmal H.

Curr Stem Cell Res Ther. 2018 Feb 23;13(3):174-184. doi: 10.2174/1574888X12666171002111026. Review.


Tissue engineering-relevant characteristics of ex vivo and monolayer-expanded chondrocytes from the notch versus trochlea of human knee joints.

Aurich M, Hofmann GO, Rolauffs B.

Int Orthop. 2017 Nov;41(11):2327-2335. doi: 10.1007/s00264-017-3615-y. Epub 2017 Aug 21.


Engineering the geometrical shape of mesenchymal stromal cells through defined cyclic stretch regimens.

Walters B, Uynuk-Ool T, Rothdiener M, Palm J, Hart ML, Stegemann JP, Rolauffs B.

Sci Rep. 2017 Jul 26;7(1):6640. doi: 10.1038/s41598-017-06794-9.


Human osteoarthritic chondrons outnumber patient- and joint-matched chondrocytes in hydrogel culture-Future application in autologous cell-based OA cartilage repair?

Rothdiener M, Uynuk-Ool T, Südkamp N, Aurich M, Grodzinsky AJ, Kurz B, Rolauffs B.

J Tissue Eng Regen Med. 2018 Feb;12(2):e1206-e1220. doi: 10.1002/term.2516. Epub 2017 Nov 8.


Induced Redifferentiation of Human Chondrocytes from Articular Cartilage Lesion in Alginate Bead Culture After Monolayer Dedifferentiation: An Alternative Cell Source for Cell-Based Therapies?

Aurich M, Hofmann GO, Best N, Rolauffs B.

Tissue Eng Part A. 2018 Feb;24(3-4):275-286. doi: 10.1089/ten.TEA.2016.0505. Epub 2017 Jul 19.


The geometrical shape of mesenchymal stromal cells measured by quantitative shape descriptors is determined by the stiffness of the biomaterial and by cyclic tensile forces.

Uynuk-Ool T, Rothdiener M, Walters B, Hegemann M, Palm J, Nguyen P, Seeger T, Stöckle U, Stegemann JP, Aicher WK, Kurz B, Hart ML, Klein G, Rolauffs B.

J Tissue Eng Regen Med. 2017 Dec;11(12):3508-3522. doi: 10.1002/term.2263. Epub 2017 Mar 29.


Differences in type II collagen turnover of osteoarthritic human knee and ankle joints.

Aurich M, Hofmann GO, Rolauffs B.

Int Orthop. 2017 May;41(5):999-1005. doi: 10.1007/s00264-017-3414-5. Epub 2017 Feb 6.


Stretching human mesenchymal stromal cells on stiffness-customized collagen type I generates a smooth muscle marker profile without growth factor addition.

Rothdiener M, Hegemann M, Uynuk-Ool T, Walters B, Papugy P, Nguyen P, Claus V, Seeger T, Stoeckle U, Boehme KA, Aicher WK, Stegemann JP, Hart ML, Kurz B, Klein G, Rolauffs B.

Sci Rep. 2016 Oct 24;6:35840. doi: 10.1038/srep35840.


IL-10 reduces apoptosis and extracellular matrix degradation after injurious compression of mature articular cartilage.

Behrendt P, Preusse-Prange A, Klüter T, Haake M, Rolauffs B, Grodzinsky AJ, Lippross S, Kurz B.

Osteoarthritis Cartilage. 2016 Nov;24(11):1981-1988. doi: 10.1016/j.joca.2016.06.016. Epub 2016 Jun 24.


Autologous chondrocyte implantation (ACI) for cartilage defects of the knee: A guideline by the working group "Clinical Tissue Regeneration" of the German Society of Orthopaedics and Trauma (DGOU).

Niemeyer P, Albrecht D, Andereya S, Angele P, Ateschrang A, Aurich M, Baumann M, Bosch U, Erggelet C, Fickert S, Gebhard H, Gelse K, Günther D, Hoburg A, Kasten P, Kolombe T, Madry H, Marlovits S, Meenen NM, Müller PE, Nöth U, Petersen JP, Pietschmann M, Richter W, Rolauffs B, Rhunau K, Schewe B, Steinert A, Steinwachs MR, Welsch GH, Zinser W, Fritz J.

Knee. 2016 Jun;23(3):426-35. doi: 10.1016/j.knee.2016.02.001. Epub 2016 Mar 3. Review.


[Early Diagnosis of Osteoarthritis: Clinical Reality and Promising Experimental Techniques].

Arnscheidt C, Meder A, Rolauffs B.

Z Orthop Unfall. 2016 Jun;154(3):254-68. doi: 10.1055/s-0042-100478. Epub 2016 Feb 19. Review. German.


Loss of spatial organization and destruction of the pericellular matrix in early osteoarthritis in vivo and in a novel in vitro methodology.

Felka T, Rothdiener M, Bast S, Uynuk-Ool T, Zouhair S, Ochs BG, De Zwart P, Stoeckle U, Aicher WK, Hart ML, Shiozawa T, Grodzinsky AJ, Schenke-Layland K, Venkatesan JK, Cucchiarini M, Madry H, Kurz B, Rolauffs B.

Osteoarthritis Cartilage. 2016 Jul;24(7):1200-9. doi: 10.1016/j.joca.2016.02.001. Epub 2016 Feb 12.


Bone marrow-derived mesenchymal stromal cells differ in their attachment to fibronectin-derived peptides from term placenta-derived mesenchymal stromal cells.

Maerz JK, Roncoroni LP, Goldeck D, Abruzzese T, Kalbacher H, Rolauffs B, DeZwart P, Nieselt K, Hart ML, Klein G, Aicher WK.

Stem Cell Res Ther. 2016 Feb 11;7:29. doi: 10.1186/s13287-015-0243-6.


Choice of xenogenic-free expansion media significantly influences the myogenic differentiation potential of human bone marrow-derived mesenchymal stromal cells.

Brun J, Abruzzese T, Rolauffs B, Aicher WK, Hart ML.

Cytotherapy. 2016 Mar;18(3):344-59. doi: 10.1016/j.jcyt.2015.11.019.


Smooth Muscle-Like Cells Generated from Human Mesenchymal Stromal Cells Display Marker Gene Expression and Electrophysiological Competence Comparable to Bladder Smooth Muscle Cells.

Brun J, Lutz KA, Neumayer KM, Klein G, Seeger T, Uynuk-Ool T, Wörgötter K, Schmid S, Kraushaar U, Guenther E, Rolauffs B, Aicher WK, Hart ML.

PLoS One. 2015 Dec 16;10(12):e0145153. doi: 10.1371/journal.pone.0145153. eCollection 2015.


Mesenchymal Stromal Cells for Sphincter Regeneration: Role of Laminin Isoforms upon Myogenic Differentiation.

Seeger T, Hart M, Patarroyo M, Rolauffs B, Aicher WK, Klein G.

PLoS One. 2015 Sep 25;10(9):e0137419. doi: 10.1371/journal.pone.0137419. eCollection 2015.


Human Placenta-Derived CD146-Positive Mesenchymal Stromal Cells Display a Distinct Osteogenic Differentiation Potential.

Ulrich C, Abruzzese T, Maerz JK, Ruh M, Amend B, Benz K, Rolauffs B, Abele H, Hart ML, Aicher WK.

Stem Cells Dev. 2015 Jul 1;24(13):1558-69. doi: 10.1089/scd.2014.0465. Epub 2015 Apr 13.


Differences in injury pattern and prevalence of cartilage lesions in knee and ankle joints: a retrospective cohort study.

Aurich M, Hofmann GO, Rolauffs B, Gras F.

Orthop Rev (Pavia). 2014 Dec 16;6(4):5611. doi: 10.4081/or.2014.5611. eCollection 2014 Oct 27.


Mesenchymal stromal cells for sphincter regeneration.

Klein G, Hart ML, Brinchmann JE, Rolauffs B, Stenzl A, Sievert KD, Aicher WK.

Adv Drug Deliv Rev. 2015 Mar;82-83:123-36. doi: 10.1016/j.addr.2014.10.026. Epub 2014 Oct 27. Review.


Which parameters affect medium- to long-term results after angular stable plate fixation for proximal humeral fractures?

Bahrs C, Kühle L, Blumenstock G, Stöckle U, Rolauffs B, Freude T.

J Shoulder Elbow Surg. 2015 May;24(5):727-32. doi: 10.1016/j.jse.2014.08.009. Epub 2014 Oct 17.


Trends in epidemiology and patho-anatomical pattern of proximal humeral fractures.

Bahrs C, Stojicevic T, Blumenstock G, Brorson S, Badke A, Stöckle U, Rolauffs B, Freude T.

Int Orthop. 2014 Aug;38(8):1697-704. doi: 10.1007/s00264-014-2362-6. Epub 2014 May 25. Erratum in: Int Orthop. 2014 Aug;38(8):1755. Tanja, Stojicevic [corrected to Stojicevic, Tanja]; Gunnar, Blumenstock [corrected to Blumenstock, Gunnar]; Stig, Brorson [corrected to Brorson, Stig]; Ulrich, Stöckle [corrected to Stöckle, Ulrich]; Bernd, Rolauffs [corrected to Rolauffs, Bernd]; Thomas.


[Treatment of proximal humeral fractures in Germany: Influence of the level of hospital care and the frequency of treatment].

Tepass A, Weise K, Rolauffs B, Blumenstock G, Bahrs C.

Unfallchirurg. 2015 Sep;118(9):772-9. doi: 10.1007/s00113-013-2531-x. German.


The spatial organisation of joint surface chondrocytes: review of its potential roles in tissue functioning, disease and early, preclinical diagnosis of osteoarthritis.

Aicher WK, Rolauffs B.

Ann Rheum Dis. 2014 Apr;73(4):645-53. doi: 10.1136/annrheumdis-2013-204308. Epub 2013 Dec 20. Review.


Complication rates and outcomes stratified by treatment modalities in proximal humeral fractures: a systematic literature review from 1970-2009.

Tepass A, Rolauffs B, Weise K, Bahrs SD, Dietz K, Bahrs C.

Patient Saf Surg. 2013 Nov 24;7(1):34. doi: 10.1186/1754-9493-7-34.


Early evaluation and value-based pricing of regenerative medicine technologies.

Koerber F, Rolauffs B, Rogowski W.

Regen Med. 2013 Nov;8(6):747-58. doi: 10.2217/rme.13.69.


Estrogen reduces mechanical injury-related cell death and proteoglycan degradation in mature articular cartilage independent of the presence of the superficial zone tissue.

Imgenberg J, Rolauffs B, Grodzinsky AJ, Schünke M, Kurz B.

Osteoarthritis Cartilage. 2013 Nov;21(11):1738-45. doi: 10.1016/j.joca.2013.07.007. Epub 2013 Jul 14.


Stress-vs-time signals allow the prediction of structurally catastrophic events during fracturing of immature cartilage and predetermine the biomechanical, biochemical, and structural impairment.

Rolauffs B, Kurz B, Felka T, Rothdiener M, Uynuk-Ool T, Aurich M, Frank E, Bahrs C, Badke A, Stöckle U, Aicher WK, Grodzinsky AJ.

J Struct Biol. 2013 Sep;183(3):501-511. doi: 10.1016/j.jsb.2013.06.011. Epub 2013 Jun 28.


Low osteogenic differentiation potential of placenta-derived mesenchymal stromal cells correlates with low expression of the transcription factors Runx2 and Twist2.

Ulrich C, Rolauffs B, Abele H, Bonin M, Nieselt K, Hart ML, Aicher WK.

Stem Cells Dev. 2013 Nov 1;22(21):2859-72. doi: 10.1089/scd.2012.0693. Epub 2013 Jul 20.


Translation between the Neer- and the AO/OTA-classification for proximal humeral fractures: do we need to be bilingual to interpret the scientific literature?

Brorson S, Eckardt H, Audigé L, Rolauffs B, Bahrs C.

BMC Res Notes. 2013 Feb 25;6:69. doi: 10.1186/1756-0500-6-69.


[Autologous chondrocyte implantation (ACI) for cartilage defects of the knee: a guideline by the working group "Tissue Regeneration" of the German Society of Orthopaedic Surgery and Traumatology (DGOU)].

Niemeyer P, Andereya S, Angele P, Ateschrang A, Aurich M, Baumann M, Behrens P, Bosch U, Erggelet C, Fickert S, Fritz J, Gebhard H, Gelse K, Günther D, Hoburg A, Kasten P, Kolombe T, Madry H, Marlovits S, Meenen NM, Müller PE, Nöth U, Petersen JP, Pietschmann M, Richter W, Rolauffs B, Rhunau K, Schewe B, Steinert A, Steinwachs MR, Welsch GH, Zinser W, Albrecht D.

Z Orthop Unfall. 2013 Feb;151(1):38-47. doi: 10.1055/s-0032-1328207. Epub 2013 Feb 19. German.


The complexity of proximal humeral fractures is age and gender specific.

Bahrs C, Bauer M, Blumenstock G, Eingartner C, Bahrs SD, Tepass A, Weise K, Rolauffs B.

J Orthop Sci. 2013 May;18(3):465-70. doi: 10.1007/s00776-013-0361-x. Epub 2013 Feb 19.


Current strategies for the treatment of proximal humeral fractures: an analysis of a survey carried out at 348 hospitals in Germany, Austria, and Switzerland.

Tepass A, Blumenstock G, Weise K, Rolauffs B, Bahrs C.

J Shoulder Elbow Surg. 2013 Jan;22(1):e8-14. doi: 10.1016/j.jse.2012.04.002. Epub 2012 Jul 20.


In vitro phenotypic modulation of chondrocytes from knees of patients with osteochondritis dissecans: implications for chondrocyte implantation procedures.

Aurich M, Hofmann GO, Mückley T, Mollenhauer J, Rolauffs B.

J Bone Joint Surg Br. 2012 Jan;94(1):62-7. doi: 10.1302/0301-620X.94B1.27528.


Modeling chondrocyte patterns by elliptical cluster processes.

Meinhardt M, Lück S, Martin P, Felka T, Aicher W, Rolauffs B, Schmidt V.

J Struct Biol. 2012 Feb;177(2):447-58. doi: 10.1016/j.jsb.2011.11.023. Epub 2011 Dec 1.


Onset of preclinical osteoarthritis: the angular spatial organization permits early diagnosis.

Rolauffs B, Rothdiener M, Bahrs C, Badke A, Weise K, Kuettner KE, Kurz B, Aurich M, Grodzinsky AJ, Aicher WK.

Arthritis Rheum. 2011 Jun;63(6):1637-47. doi: 10.1002/art.30217.


Remodeling of articular cartilage and subchondral bone after bone grafting and matrix-associated autologous chondrocyte implantation for osteochondritis dissecans of the knee.

Ochs BG, Müller-Horvat C, Albrecht D, Schewe B, Weise K, Aicher WK, Rolauffs B.

Am J Sports Med. 2011 Apr;39(4):764-73. doi: 10.1177/0363546510388896. Epub 2010 Dec 30.


Regeneration of cartilage and bone by defined subsets of mesenchymal stromal cells--potential and pitfalls.

Aicher WK, Bühring HJ, Hart M, Rolauffs B, Badke A, Klein G.

Adv Drug Deliv Rev. 2011 Apr 30;63(4-5):342-51. doi: 10.1016/j.addr.2010.12.004. Epub 2010 Dec 22. Review.


Arthroscopic treatment of osteochondral lesions of the ankle with matrix-associated chondrocyte implantation: early clinical and magnetic resonance imaging results.

Aurich M, Bedi HS, Smith PJ, Rolauffs B, Mückley T, Clayton J, Blackney M.

Am J Sports Med. 2011 Feb;39(2):311-9. doi: 10.1177/0363546510381575. Epub 2010 Nov 10.


Human term placenta-derived mesenchymal stromal cells are less prone to osteogenic differentiation than bone marrow-derived mesenchymal stromal cells.

Pilz GA, Ulrich C, Ruh M, Abele H, Schäfer R, Kluba T, Bühring HJ, Rolauffs B, Aicher WK.

Stem Cells Dev. 2011 Apr;20(4):635-46. doi: 10.1089/scd.2010.0308. Epub 2011 Jan 27.


Computer-assisted periacetabular screw placement: Comparison of different fluoroscopy-based navigation procedures with conventional technique.

Ochs BG, Gonser C, Shiozawa T, Badke A, Weise K, Rolauffs B, Stuby FM.

Injury. 2010 Dec;41(12):1297-305. doi: 10.1016/j.injury.2010.07.502. Epub 2010 Aug 21.


Vulnerability of the superficial zone of immature articular cartilage to compressive injury.

Rolauffs B, Muehleman C, Li J, Kurz B, Kuettner KE, Frank E, Grodzinsky AJ.

Arthritis Rheum. 2010 Oct;62(10):3016-27. doi: 10.1002/art.27610.


Changes in the treatment of acetabular fractures over 15 years: Analysis of 1266 cases treated by the German Pelvic Multicentre Study Group (DAO/DGU).

Ochs BG, Marintschev I, Hoyer H, Rolauffs B, Culemann U, Pohlemann T, Stuby FM.

Injury. 2010 Aug;41(8):839-51. doi: 10.1016/j.injury.2010.04.010. Epub 2010 May 6.


Effect of proximal humeral fractures on the age-specific prevalence of rotator cuff tears.

Bahrs C, Rolauffs B, Stuby F, Dietz K, Weise K, Helwig P.

J Trauma. 2010 Oct;69(4):901-6. doi: 10.1097/TA.0b013e3181cda518.


Proliferative remodeling of the spatial organization of human superficial chondrocytes distant from focal early osteoarthritis.

Rolauffs B, Williams JM, Aurich M, Grodzinsky AJ, Kuettner KE, Cole AA.

Arthritis Rheum. 2010 Feb;62(2):489-98. doi: 10.1002/art.27217.

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