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Items: 9

1.

Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells.

Sarkar S, Rokad D, Malovic E, Luo J, Harischandra DS, Jin H, Anantharam V, Huang X, Lewis M, Kanthasamy A, Kanthasamy AG.

Sci Signal. 2019 Jan 8;12(563). pii: eaat9900. doi: 10.1126/scisignal.aat9900.

PMID:
30622196
2.

Organophosphate pesticide chlorpyrifos impairs STAT1 signaling to induce dopaminergic neurotoxicity: Implications for mitochondria mediated oxidative stress signaling events.

Singh N, Lawana V, Luo J, Phong P, Abdalla A, Palanisamy B, Rokad D, Sarkar S, Jin H, Anantharam V, Kanthasamy AG, Kanthasamy A.

Neurobiol Dis. 2018 Sep;117:82-113. doi: 10.1016/j.nbd.2018.05.019. Epub 2018 May 31.

PMID:
29859868
3.

Characterization and comparative analysis of a new mouse microglial cell model for studying neuroinflammatory mechanisms during neurotoxic insults.

Sarkar S, Malovic E, Sarda D, Lawana V, Rokad D, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG.

Neurotoxicology. 2018 Jul;67:129-140. doi: 10.1016/j.neuro.2018.05.002. Epub 2018 May 30.

PMID:
29775624
4.

Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease.

Sarkar S, Malovic E, Harishchandra DS, Ghaisas S, Panicker N, Charli A, Palanisamy BN, Rokad D, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG.

NPJ Parkinsons Dis. 2017 Oct 17;3:30. doi: 10.1038/s41531-017-0032-2. eCollection 2017.

5.

Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes.

Sarkar S, Malovic E, Harischandra DS, Ngwa HA, Ghosh A, Hogan C, Rokad D, Zenitsky G, Jin H, Anantharam V, Kanthasamy AG, Kanthasamy A.

Neurotoxicology. 2018 Jan;64:204-218. doi: 10.1016/j.neuro.2017.05.009. Epub 2017 May 21.

6.

Exosomes in Toxicology: Relevance to Chemical Exposure and Pathogenesis of Environmentally Linked Diseases.

Harischandra DS, Ghaisas S, Rokad D, Kanthasamy AG.

Toxicol Sci. 2017 Jul 1;158(1):3-13. doi: 10.1093/toxsci/kfx074. Review.

7.

Environmental neurotoxicant manganese regulates exosome-mediated extracellular miRNAs in cell culture model of Parkinson's disease: Relevance to α-synuclein misfolding in metal neurotoxicity.

Harischandra DS, Ghaisas S, Rokad D, Zamanian M, Jin H, Anantharam V, Kimber M, Kanthasamy A, Kanthasamy AG.

Neurotoxicology. 2018 Jan;64:267-277. doi: 10.1016/j.neuro.2017.04.007. Epub 2017 Apr 24.

8.

Role of neurotoxicants and traumatic brain injury in α-synuclein protein misfolding and aggregation.

Rokad D, Ghaisas S, Harischandra DS, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG.

Brain Res Bull. 2017 Jul;133:60-70. doi: 10.1016/j.brainresbull.2016.12.003. Epub 2016 Dec 16.

9.

Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease.

Gordon R, Singh N, Lawana V, Ghosh A, Harischandra DS, Jin H, Hogan C, Sarkar S, Rokad D, Panicker N, Anantharam V, Kanthasamy AG, Kanthasamy A.

Neurobiol Dis. 2016 Sep;93:96-114. doi: 10.1016/j.nbd.2016.04.008. Epub 2016 May 2.

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