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Items: 40

1.

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases.

Cuadrado A, Rojo AI, Wells G, Hayes JD, Cousin SP, Rumsey WL, Attucks OC, Franklin S, Levonen AL, Kensler TW, Dinkova-Kostova AT.

Nat Rev Drug Discov. 2019 Apr;18(4):295-317. doi: 10.1038/s41573-018-0008-x. Review.

PMID:
30610225
2.

A role for APP in Wnt signalling links synapse loss with β-amyloid production.

Elliott C, Rojo AI, Ribe E, Broadstock M, Xia W, Morin P, Semenov M, Baillie G, Cuadrado A, Al-Shawi R, Ballard CG, Simons P, Killick R.

Transl Psychiatry. 2018 Sep 20;8(1):179. doi: 10.1038/s41398-018-0231-6.

3.

Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy.

Rojo AI, Pajares M, García-Yagüe AJ, Buendia I, Van Leuven F, Yamamoto M, López MG, Cuadrado A.

Redox Biol. 2018 Sep;18:173-180. doi: 10.1016/j.redox.2018.07.006. Epub 2018 Jul 11.

4.

Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A.

Pajares M, Rojo AI, Arias E, Díaz-Carretero A, Cuervo AM, Cuadrado A.

Autophagy. 2018;14(8):1310-1322. doi: 10.1080/15548627.2018.1474992. Epub 2018 Jul 26.

5.

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach.

Cuadrado A, Manda G, Hassan A, Alcaraz MJ, Barbas C, Daiber A, Ghezzi P, León R, López MG, Oliva B, Pajares M, Rojo AI, Robledinos-Antón N, Valverde AM, Guney E, Schmidt HHHW.

Pharmacol Rev. 2018 Apr;70(2):348-383. doi: 10.1124/pr.117.014753. Review.

6.

Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil.

Sellers KJ, Elliott C, Jackson J, Ghosh A, Ribe E, Rojo AI, Jarosz-Griffiths HH, Watson IA, Xia W, Semenov M, Morin P, Hooper NM, Porter R, Preston J, Al-Shawi R, Baillie G, Lovestone S, Cuadrado A, Harte M, Simons P, Srivastava DP, Killick R.

Alzheimers Dement. 2018 Mar;14(3):306-317. doi: 10.1016/j.jalz.2017.09.008. Epub 2017 Oct 19.

7.

NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology.

Rojo AI, Pajares M, Rada P, Nuñez A, Nevado-Holgado AJ, Killik R, Van Leuven F, Ribe E, Lovestone S, Yamamoto M, Cuadrado A.

Redox Biol. 2017 Oct;13:444-451. doi: 10.1016/j.redox.2017.07.006. Epub 2017 Jul 5.

8.

Transcription factor NRF2 controls the fate of neural stem cells in the subgranular zone of the hippocampus.

Robledinos-Antón N, Rojo AI, Ferreiro E, Núñez Á, Krause KH, Jaquet V, Cuadrado A.

Redox Biol. 2017 Oct;13:393-401. doi: 10.1016/j.redox.2017.06.010. Epub 2017 Jun 27.

9.

Discovery of the first dual GSK3β inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer's disease.

Gameiro I, Michalska P, Tenti G, Cores Á, Buendia I, Rojo AI, Georgakopoulos ND, Hernández-Guijo JM, Teresa Ramos M, Wells G, López MG, Cuadrado A, Menéndez JC, León R.

Sci Rep. 2017 Mar 31;7:45701. doi: 10.1038/srep45701.

10.

Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases.

Pajares M, Cuadrado A, Rojo AI.

Redox Biol. 2017 Apr;11:543-553. doi: 10.1016/j.redox.2017.01.006. Epub 2017 Jan 10. Review.

11.

Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes.

Pajares M, Jiménez-Moreno N, García-Yagüe ÁJ, Escoll M, de Ceballos ML, Van Leuven F, Rábano A, Yamamoto M, Rojo AI, Cuadrado A.

Autophagy. 2016 Oct 2;12(10):1902-1916. Epub 2016 Jul 18.

12.

WNT-3A regulates an Axin1/NRF2 complex that regulates antioxidant metabolism in hepatocytes.

Rada P, Rojo AI, Offergeld A, Feng GJ, Velasco-Martín JP, González-Sancho JM, Valverde ÁM, Dale T, Regadera J, Cuadrado A.

Antioxid Redox Signal. 2015 Mar 1;22(7):555-71. doi: 10.1089/ars.2014.6040. Epub 2014 Dec 9.

13.

The PTEN/NRF2 axis promotes human carcinogenesis.

Rojo AI, Rada P, Mendiola M, Ortega-Molina A, Wojdyla K, Rogowska-Wrzesinska A, Hardisson D, Serrano M, Cuadrado A.

Antioxid Redox Signal. 2014 Dec 20;21(18):2498-514. doi: 10.1089/ars.2014.5843. Epub 2014 Jul 31.

14.

Redox control of microglial function: molecular mechanisms and functional significance.

Rojo AI, McBean G, Cindric M, Egea J, López MG, Rada P, Zarkovic N, Cuadrado A.

Antioxid Redox Signal. 2014 Oct 20;21(12):1766-801. doi: 10.1089/ars.2013.5745. Epub 2014 May 5. Review.

15.

Dysfunction of the PI3K-Akt-GSK-3 pathway is a common feature in cell culture and in vivo models of prion disease.

Simon D, Herva ME, Benitez MJ, Garrido JJ, Rojo AI, Cuadrado A, Torres JM, Wandosell F.

Neuropathol Appl Neurobiol. 2014 Apr;40(3):311-26. doi: 10.1111/nan.12066.

PMID:
23741998
16.

Nuclear import and export signals control the subcellular localization of Nurr1 protein in response to oxidative stress.

García-Yagüe ÁJ, Rada P, Rojo AI, Lastres-Becker I, Cuadrado A.

J Biol Chem. 2013 Feb 22;288(8):5506-17. doi: 10.1074/jbc.M112.439190. Epub 2013 Jan 2.

17.

Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis.

Rada P, Rojo AI, Evrard-Todeschi N, Innamorato NG, Cotte A, Jaworski T, Tobón-Velasco JC, Devijver H, García-Mayoral MF, Van Leuven F, Hayes JD, Bertho G, Cuadrado A.

Mol Cell Biol. 2012 Sep;32(17):3486-99. doi: 10.1128/MCB.00180-12. Epub 2012 Jul 2.

18.

Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3.

Rojo AI, Medina-Campos ON, Rada P, Zúñiga-Toalá A, López-Gazcón A, Espada S, Pedraza-Chaverri J, Cuadrado A.

Free Radic Biol Med. 2012 Jan 15;52(2):473-87. doi: 10.1016/j.freeradbiomed.2011.11.003. Epub 2011 Nov 12.

PMID:
22142471
19.

Pharmacological targeting of the transcription factor Nrf2 at the basal ganglia provides disease modifying therapy for experimental parkinsonism.

Jazwa A, Rojo AI, Innamorato NG, Hesse M, Fernández-Ruiz J, Cuadrado A.

Antioxid Redox Signal. 2011 Jun 15;14(12):2347-60. doi: 10.1089/ars.2010.3731. Epub 2011 Mar 28.

20.

SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner.

Rada P, Rojo AI, Chowdhry S, McMahon M, Hayes JD, Cuadrado A.

Mol Cell Biol. 2011 Mar;31(6):1121-33. doi: 10.1128/MCB.01204-10. Epub 2011 Jan 18.

21.

Different susceptibility to the Parkinson's toxin MPTP in mice lacking the redox master regulator Nrf2 or its target gene heme oxygenase-1.

Innamorato NG, Jazwa A, Rojo AI, García C, Fernández-Ruiz J, Grochot-Przeczek A, Stachurska A, Jozkowicz A, Dulak J, Cuadrado A.

PLoS One. 2010 Jul 28;5(7):e11838. doi: 10.1371/journal.pone.0011838.

22.

The purinergic P2Y(13) receptor activates the Nrf2/HO-1 axis and protects against oxidative stress-induced neuronal death.

Espada S, Ortega F, Molina-Jijón E, Rojo AI, Pérez-Sen R, Pedraza-Chaverri J, Miras-Portugal MT, Cuadrado A.

Free Radic Biol Med. 2010 Aug 1;49(3):416-26. doi: 10.1016/j.freeradbiomed.2010.04.031. Epub 2010 May 4.

PMID:
20447456
23.

Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease.

Rojo AI, Innamorato NG, Martín-Moreno AM, De Ceballos ML, Yamamoto M, Cuadrado A.

Glia. 2010 Apr;58(5):588-98. doi: 10.1002/glia.20947.

PMID:
19908287
24.

Fibroblast growth factor-1 within the ventral tegmental area participates in motor sensitizing effects of morphine.

Flores JA, Galan-Rodriguez B, Rojo AI, Ramiro-Fuentes S, Cuadrado A, Fernandez-Espejo E.

Neuroscience. 2010 Jan 13;165(1):198-211. doi: 10.1016/j.neuroscience.2009.10.009. Epub 2009 Oct 9.

PMID:
19819303
25.

The muscarinic M1 receptor activates Nrf2 through a signaling cascade that involves protein kinase C and inhibition of GSK-3beta: connecting neurotransmission with neuroprotection.

Espada S, Rojo AI, Salinas M, Cuadrado A.

J Neurochem. 2009 Aug;110(3):1107-19. doi: 10.1111/j.1471-4159.2009.06208.x. Epub 2009 Jun 12.

26.

Heme oxygenase-1 induction modulates microsomal prostaglandin E synthase-1 expression and prostaglandin E(2) production in osteoarthritic chondrocytes.

Megías J, Guillén MI, Clérigues V, Rojo AI, Cuadrado A, Castejón MA, Gomar F, Alcaraz MJ.

Biochem Pharmacol. 2009 Jun 15;77(12):1806-13. doi: 10.1016/j.bcp.2009.03.009. Epub 2009 Mar 21.

PMID:
19428335
27.

Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal cell death.

Rojo AI, Rada P, Egea J, Rosa AO, López MG, Cuadrado A.

Mol Cell Neurosci. 2008 Sep;39(1):125-32. doi: 10.1016/j.mcn.2008.06.007. Epub 2008 Jun 20.

PMID:
18619545
28.

The transcription factor Nrf2 is a therapeutic target against brain inflammation.

Innamorato NG, Rojo AI, García-Yagüe AJ, Yamamoto M, de Ceballos ML, Cuadrado A.

J Immunol. 2008 Jul 1;181(1):680-9.

29.

Heme oxygenase-1 as a therapeutic target in neurodegenerative diseases and brain infections.

Cuadrado A, Rojo AI.

Curr Pharm Des. 2008;14(5):429-42. Review.

PMID:
18289070
30.
31.

Nrf2-mediated haeme oxygenase-1 up-regulation induced by cobalt protoporphyrin has antinociceptive effects against inflammatory pain in the formalin test in mice.

Rosa AO, Egea J, Lorrio S, Rojo AI, Cuadrado A, López MG.

Pain. 2008 Jul 15;137(2):332-9. Epub 2007 Oct 26.

PMID:
17964723
32.

Chronic inhalation of rotenone or paraquat does not induce Parkinson's disease symptoms in mice or rats.

Rojo AI, Cavada C, de Sagarra MR, Cuadrado A.

Exp Neurol. 2007 Nov;208(1):120-6. Epub 2007 Aug 22.

PMID:
17880941
33.

Persistent penetration of MPTP through the nasal route induces Parkinson's disease in mice.

Rojo AI, Montero C, Salazar M, Close RM, Fernández-Ruiz J, Sánchez-González MA, de Sagarra MR, Jackson-Lewis V, Cavada C, Cuadrado A.

Eur J Neurosci. 2006 Oct;24(7):1874-84.

PMID:
17067291
34.

Regulation of heme oxygenase-1 gene expression through the phosphatidylinositol 3-kinase/PKC-zeta pathway and Sp1.

Rojo AI, Salina M, Salazar M, Takahashi S, Suske G, Calvo V, de Sagarra MR, Cuadrado A.

Free Radic Biol Med. 2006 Jul 15;41(2):247-61. Epub 2006 Apr 21.

PMID:
16814105
35.

Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2.

Salazar M, Rojo AI, Velasco D, de Sagarra RM, Cuadrado A.

J Biol Chem. 2006 May 26;281(21):14841-51. Epub 2006 Mar 21.

36.

Protein kinase Akt/PKB phosphorylates heme oxygenase-1 in vitro and in vivo.

Salinas M, Wang J, Rosa de Sagarra M, Martín D, Rojo AI, Martin-Perez J, Ortiz de Montellano PR, Cuadrado A.

FEBS Lett. 2004 Dec 3;578(1-2):90-4.

37.

Regulation of Cu/Zn-superoxide dismutase expression via the phosphatidylinositol 3 kinase/Akt pathway and nuclear factor-kappaB.

Rojo AI, Salinas M, Martín D, Perona R, Cuadrado A.

J Neurosci. 2004 Aug 18;24(33):7324-34.

38.

Signaling through the leukocyte integrin LFA-1 in T cells induces a transient activation of Rac-1 that is regulated by Vav and PI3K/Akt-1.

Sánchez-Martín L, Sánchez-Sánchez N, Gutiérrez-López MD, Rojo AI, Vicente-Manzanares M, Pérez-Alvarez MJ, Sánchez-Mateos P, Bustelo XR, Cuadrado A, Sánchez-Madrid F, Rodríguez-Fernández JL, Cabañas C.

J Biol Chem. 2004 Apr 16;279(16):16194-205. Epub 2004 Feb 11.

39.

Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol.

Martin D, Rojo AI, Salinas M, Diaz R, Gallardo G, Alam J, De Galarreta CM, Cuadrado A.

J Biol Chem. 2004 Mar 5;279(10):8919-29. Epub 2003 Dec 19.

40.

Prion peptide induces neuronal cell death through a pathway involving glycogen synthase kinase 3.

Pérez M, Rojo AI, Wandosell F, Díaz-Nido J, Avila J.

Biochem J. 2003 May 15;372(Pt 1):129-36.

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