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Items: 17

1.

Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib).

Germann UA, Furey BF, Markland W, Hoover RR, Aronov AM, Roix JJ, Hale M, Boucher DM, Sorrell DA, Martinez-Botella G, Fitzgibbon M, Shapiro P, Wick MJ, Samadani R, Meshaw K, Groover A, DeCrescenzo G, Namchuk M, Emery CM, Saha S, Welsch DJ.

Mol Cancer Ther. 2017 Nov;16(11):2351-2363. doi: 10.1158/1535-7163.MCT-17-0456. Epub 2017 Sep 22.

2.

Intratumoral injection of Clostridium novyi-NT spores induces antitumor responses.

Roberts NJ, Zhang L, Janku F, Collins A, Bai RY, Staedtke V, Rusk AW, Tung D, Miller M, Roix J, Khanna KV, Murthy R, Benjamin RS, Helgason T, Szvalb AD, Bird JE, Roy-Chowdhuri S, Zhang HH, Qiao Y, Karim B, McDaniel J, Elpiner A, Sahora A, Lachowicz J, Phillips B, Turner A, Klein MK, Post G, Diaz LA Jr, Riggins GJ, Papadopoulos N, Kinzler KW, Vogelstein B, Bettegowda C, Huso DL, Varterasian M, Saha S, Zhou S.

Sci Transl Med. 2014 Aug 13;6(249):249ra111. doi: 10.1126/scitranslmed.3008982.

3.

Systematic repurposing screening in xenograft models identifies approved drugs with novel anti-cancer activity.

Roix JJ, Harrison SD, Rainbolt EA, Meshaw KR, McMurry AS, Cheung P, Saha S.

PLoS One. 2014 Aug 5;9(8):e101708. doi: 10.1371/journal.pone.0101708. eCollection 2014.

4.

TNF-α blockade is ineffective in animal models of established polycystic kidney disease.

Roix J, Saha S.

BMC Nephrol. 2013 Oct 25;14:233. doi: 10.1186/1471-2369-14-233.

5.

Effect of the antipsychotic agent amisulpride on glucose lowering and insulin secretion.

Roix JJ, DeCrescenzo GA, Cheung PH, Ciallella JR, Sulpice T, Saha S, Halse R.

Diabetes Obes Metab. 2012 Apr;14(4):329-34. doi: 10.1111/j.1463-1326.2011.01529.x. Epub 2011 Dec 27.

PMID:
22059694
6.

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.

Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, Hu T, de Bakker PI, Abecasis GR, Almgren P, Andersen G, Ardlie K, Boström KB, Bergman RN, Bonnycastle LL, Borch-Johnsen K, Burtt NP, Chen H, Chines PS, Daly MJ, Deodhar P, Ding CJ, Doney AS, Duren WL, Elliott KS, Erdos MR, Frayling TM, Freathy RM, Gianniny L, Grallert H, Grarup N, Groves CJ, Guiducci C, Hansen T, Herder C, Hitman GA, Hughes TE, Isomaa B, Jackson AU, Jørgensen T, Kong A, Kubalanza K, Kuruvilla FG, Kuusisto J, Langenberg C, Lango H, Lauritzen T, Li Y, Lindgren CM, Lyssenko V, Marvelle AF, Meisinger C, Midthjell K, Mohlke KL, Morken MA, Morris AD, Narisu N, Nilsson P, Owen KR, Palmer CN, Payne F, Perry JR, Pettersen E, Platou C, Prokopenko I, Qi L, Qin L, Rayner NW, Rees M, Roix JJ, Sandbaek A, Shields B, Sjögren M, Steinthorsdottir V, Stringham HM, Swift AJ, Thorleifsson G, Thorsteinsdottir U, Timpson NJ, Tuomi T, Tuomilehto J, Walker M, Watanabe RM, Weedon MN, Willer CJ; Wellcome Trust Case Control Consortium, Illig T, Hveem K, Hu FB, Laakso M, Stefansson K, Pedersen O, Wareham NJ, Barroso I, Hattersley AT, Collins FS, Groop L, McCarthy MI, Boehnke M, Altshuler D.

Nat Genet. 2008 May;40(5):638-45. doi: 10.1038/ng.120. Epub 2008 Mar 30.

7.

The role of adipocyte insulin resistance in the pathogenesis of obesity-related elevations in endocannabinoids.

D'Eon TM, Pierce KA, Roix JJ, Tyler A, Chen H, Teixeira SR.

Diabetes. 2008 May;57(5):1262-8. doi: 10.2337/db07-1186. Epub 2008 Feb 14.

8.

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.

Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research, Saxena R, Voight BF, Lyssenko V, Burtt NP, de Bakker PI, Chen H, Roix JJ, Kathiresan S, Hirschhorn JN, Daly MJ, Hughes TE, Groop L, Altshuler D, Almgren P, Florez JC, Meyer J, Ardlie K, Bengtsson Boström K, Isomaa B, Lettre G, Lindblad U, Lyon HN, Melander O, Newton-Cheh C, Nilsson P, Orho-Melander M, Råstam L, Speliotes EK, Taskinen MR, Tuomi T, Guiducci C, Berglund A, Carlson J, Gianniny L, Hackett R, Hall L, Holmkvist J, Laurila E, Sjögren M, Sterner M, Surti A, Svensson M, Svensson M, Tewhey R, Blumenstiel B, Parkin M, Defelice M, Barry R, Brodeur W, Camarata J, Chia N, Fava M, Gibbons J, Handsaker B, Healy C, Nguyen K, Gates C, Sougnez C, Gage D, Nizzari M, Gabriel SB, Chirn GW, Ma Q, Parikh H, Richardson D, Ricke D, Purcell S.

Science. 2007 Jun 1;316(5829):1331-6. Epub 2007 Apr 26.

9.

Interaction with Grb14 results in site-specific regulation of tyrosine phosphorylation of the insulin receptor.

Nouaille S, Blanquart C, Zilberfarb V, Boute N, Perdereau D, Roix J, Burnol AF, Issad T.

EMBO Rep. 2006 May;7(5):512-8. Epub 2006 Mar 31.

10.

Neural induction promotes large-scale chromatin reorganisation of the Mash1 locus.

Williams RR, Azuara V, Perry P, Sauer S, Dvorkina M, Jørgensen H, Roix J, McQueen P, Misteli T, Merkenschlager M, Fisher AG.

J Cell Sci. 2006 Jan 1;119(Pt 1):132-40.

11.

An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis.

Sweet-Cordero A, Mukherjee S, Subramanian A, You H, Roix JJ, Ladd-Acosta C, Mesirov J, Golub TR, Jacks T.

Nat Genet. 2005 Jan;37(1):48-55. Epub 2004 Dec 19.

12.

Evidence for a conserved function in synapse formation reveals Phr1 as a candidate gene for respiratory failure in newborn mice.

Burgess RW, Peterson KA, Johnson MJ, Roix JJ, Welsh IC, O'Brien TP.

Mol Cell Biol. 2004 Feb;24(3):1096-105.

13.

An uncertainty principle in chromosome positioning.

Parada LA, Roix JJ, Misteli T.

Trends Cell Biol. 2003 Aug;13(8):393-6.

PMID:
12888289
14.

Spatial proximity of translocation-prone gene loci in human lymphomas.

Roix JJ, McQueen PG, Munson PJ, Parada LA, Misteli T.

Nat Genet. 2003 Jul;34(3):287-91.

PMID:
12808455
15.

Genomes, proteomes, and dynamic networks in the cell nucleus.

Roix J, Misteli T.

Histochem Cell Biol. 2002 Aug;118(2):105-16. Epub 2002 Jun 29.

PMID:
12189514
16.

Functional and comparative genomic analysis of the piebald deletion region of mouse chromosome 14.

Peterson KA, King BL, Hagge-Greenberg A, Roix JJ, Bult CJ, O'Brien TP.

Genomics. 2002 Aug;80(2):172-84.

PMID:
12160731
17.

Molecular and functional mapping of the piebald deletion complex on mouse chromosome 14.

Roix JJ, Hagge-Greenberg A, Bissonnette DM, Rodick S, Russell LB, O'Brien TP.

Genetics. 2001 Feb;157(2):803-15.

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