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HIV-1 Vpr mediates the depletion of the cellular repressor CTIP2 to counteract viral gene silencing.

Forouzanfar F, Ali S, Wallet C, De Rovere M, Ducloy C, El Mekdad H, El Maassarani M, Aït-Ammar A, Van Assche J, Boutant E, Daouad F, Margottin-Goguet F, Moog C, Van Lint C, Schwartz C, Rohr O.

Sci Rep. 2019 Sep 11;9(1):13154. doi: 10.1038/s41598-019-48689-x.


Toxoplasma gondii ROP16 kinase silences the cyclin B1 gene promoter by hijacking host cell UHRF1-dependent epigenetic pathways.

Sabou M, Doderer-Lang C, Leyer C, Konjic A, Kubina S, Lennon S, Rohr O, Viville S, Cianférani S, Candolfi E, Pfaff AW, Brunet J.

Cell Mol Life Sci. 2019 Sep 6. doi: 10.1007/s00018-019-03267-2. [Epub ahead of print]


Heterogeneous HIV-1 Reactivation Patterns of Disulfiram and Combined Disulfiram+Romidepsin Treatments.

Kula A, Delacourt N, Bouchat S, Darcis G, Avettand-Fenoel V, Verdikt R, Corazza F, Necsoi C, Vanhulle C, Bendoumou M, Burny A, De Wit S, Rouzioux C, Rohr O, Van Lint C.

J Acquir Immune Defic Syndr. 2019 Apr 15;80(5):605-613. doi: 10.1097/QAI.0000000000001958.


Targeting the DNA-PK complex: Its rationale use in cancer and HIV-1 infection.

Schwartz C, Rohr O, Wallet C.

Biochem Pharmacol. 2019 Feb;160:80-91. doi: 10.1016/j.bcp.2018.12.002. Epub 2018 Dec 6. Review.


In Trauma Patients, the Occurrence of Early-Onset Nosocomial Infections is Associated With Increased Plasma Concentrations of Chromogranin A.

Schneider F, Marban C, Ajob G, Helle S, Guillot M, Launoy A, Maestraggi Q, Scavello F, Rohr O, Metz-Boutigue MH.

Shock. 2018 May;49(5):522-528. doi: 10.1097/SHK.0000000000001000.


On the way to find a cure: Purging latent HIV-1 reservoirs.

Schwartz C, Bouchat S, Marban C, Gautier V, Van Lint C, Rohr O, Le Douce V.

Biochem Pharmacol. 2017 Dec 15;146:10-22. doi: 10.1016/j.bcp.2017.07.001. Epub 2017 Jul 4. Review.


Repression of Human T-lymphotropic virus type 1 Long Terminal Repeat sense transcription by Sp1 recruitment to novel Sp1 binding sites.

Fauquenoy S, Robette G, Kula A, Vanhulle C, Bouchat S, Delacourt N, Rodari A, Marban C, Schwartz C, Burny A, Rohr O, Van Driessche B, Van Lint C.

Sci Rep. 2017 Mar 3;7:43221. doi: 10.1038/srep43221.


Corrigendum: HIC1 controls cellular- and HIV-1- gene transcription via interactions with CTIP2 and HMGA1.

Le Douce V, Forouzanfar F, Eilebrecht S, Van Driessche B, Ait-Ammar A, Verdikt R, Kurashige Y, Marban C, Gautier V, Candolfi E, Benecke AG, Van Lint C, Rohr O, Schwartz C.

Sci Rep. 2017 Feb 10;7:39569. doi: 10.1038/srep39569. No abstract available.


Reactivation capacity by latency-reversing agents ex vivo correlates with the size of the HIV-1 reservoir.

Darcis G, Bouchat S, Kula A, Van Driessche B, Delacourt N, Vanhulle C, Avettand-Fenoel V, De Wit S, Rohr O, Rouzioux C, Van Lint C.

AIDS. 2017 Jan 14;31(2):181-189. doi: 10.1097/QAD.0000000000001290.


Targeting the Brain Reservoirs: Toward an HIV Cure.

Marban C, Forouzanfar F, Ait-Ammar A, Fahmi F, El Mekdad H, Daouad F, Rohr O, Schwartz C.

Front Immunol. 2016 Sep 30;7:397. eCollection 2016. Review.


HIC1 controls cellular- and HIV-1- gene transcription via interactions with CTIP2 and HMGA1.

Le Douce V, Forouzanfar F, Eilebrecht S, Van Driessche B, Ait-Ammar A, Verdikt R, Kurashige Y, Marban C, Gautier V, Candolfi E, Benecke AG, Van Lint C, Rohr O, Schwartz C.

Sci Rep. 2016 Oct 11;6:34920. doi: 10.1038/srep34920. Erratum in: Sci Rep. 2017 Feb 10;7:39569.


Characterization of new RNA polymerase III and RNA polymerase II transcriptional promoters in the Bovine Leukemia Virus genome.

Van Driessche B, Rodari A, Delacourt N, Fauquenoy S, Vanhulle C, Burny A, Rohr O, Van Lint C.

Sci Rep. 2016 Aug 22;6:31125. doi: 10.1038/srep31125.


Improving combination antiretroviral therapy by targeting HIV-1 gene transcription.

Le Douce V, Ait-Amar A, Forouzan Far F, Fahmi F, Quiel J, El Mekdad H, Daouad F, Marban C, Rohr O, Schwartz C.

Expert Opin Ther Targets. 2016 Nov;20(11):1311-1324. Epub 2016 Jun 18. Review.


Protein Kinase C-Mediated Phosphorylation of BCL11B at Serine 2 Negatively Regulates Its Interaction with NuRD Complexes during CD4+ T-Cell Activation.

Dubuissez M, Loison I, Paget S, Vorng H, Ait-Yahia S, Rohr O, Tsicopoulos A, Leprince D.

Mol Cell Biol. 2016 Jun 15;36(13):1881-98. doi: 10.1128/MCB.00062-16. Print 2016 Jul 1.


Tuning of AKT-pathway by Nef and its blockade by protease inhibitors results in limited recovery in latently HIV infected T-cell line.

Kumar A, Abbas W, Colin L, Khan KA, Bouchat S, Varin A, Larbi A, Gatot JS, Kabeya K, Vanhulle C, Delacourt N, Pasquereau S, Coquard L, Borch A, König R, Clumeck N, De Wit S, Rohr O, Rouzioux C, Fulop T, Van Lint C, Herbein G.

Sci Rep. 2016 Apr 14;6:24090. doi: 10.1038/srep24090.


Sequential treatment with 5-aza-2'-deoxycytidine and deacetylase inhibitors reactivates HIV-1.

Bouchat S, Delacourt N, Kula A, Darcis G, Van Driessche B, Corazza F, Gatot JS, Melard A, Vanhulle C, Kabeya K, Pardons M, Avettand-Fenoel V, Clumeck N, De Wit S, Rohr O, Rouzioux C, Van Lint C.

EMBO Mol Med. 2016 Feb 1;8(2):117-38. doi: 10.15252/emmm.201505557.


An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression.

Darcis G, Kula A, Bouchat S, Fujinaga K, Corazza F, Ait-Ammar A, Delacourt N, Melard A, Kabeya K, Vanhulle C, Van Driessche B, Gatot JS, Cherrier T, Pianowski LF, Gama L, Schwartz C, Vila J, Burny A, Clumeck N, Moutschen M, De Wit S, Peterlin BM, Rouzioux C, Rohr O, Van Lint C.

PLoS Pathog. 2015 Jul 30;11(7):e1005063. doi: 10.1371/journal.ppat.1005063. eCollection 2015 Jul.


[CTIP2, a multifunctional protein: cellular physiopathology and therapeutic implications].

Le Douce V, Cherrier T, Riclet R, Rohr O, Schwartz C.

Med Sci (Paris). 2014 Aug-Sep;30(8-9):797-802. doi: 10.1051/medsci/20143008019. Epub 2014 Sep 1. Review. French.


HMGA1 recruits CTIP2-repressed P-TEFb to the HIV-1 and cellular target promoters.

Eilebrecht S, Le Douce V, Riclet R, Targat B, Hallay H, Van Driessche B, Schwartz C, Robette G, Van Lint C, Rohr O, Benecke AG.

Nucleic Acids Res. 2014 Apr;42(8):4962-71. doi: 10.1093/nar/gku168. Epub 2014 Mar 11.


Blockade of BFA-mediated apoptosis in macrophages by the HIV-1 Nef protein.

Abbas W, Khan KA, Kumar A, Tripathy MK, Dichamp I, Keita M, Mahlknecht U, Rohr O, Herbein G.

Cell Death Dis. 2014 Feb 20;5:e1080. doi: 10.1038/cddis.2014.16.


The many lives of CTIP2: from AIDS to cancer and cardiac hypertrophy.

Le Douce V, Cherrier T, Riclet R, Rohr O, Schwartz C.

J Cell Physiol. 2014 May;229(5):533-7. doi: 10.1002/jcp.24490. Review.


Pseudomonas DING proteins as human transcriptional regulators and HIV-1 antagonists.

Suh A, Le Douce V, Rohr O, Schwartz C, Scott K.

Virol J. 2013 Jul 15;10:234. doi: 10.1186/1743-422X-10-234.


CTIP2 is a negative regulator of P-TEFb.

Cherrier T, Le Douce V, Eilebrecht S, Riclet R, Marban C, Dequiedt F, Goumon Y, Paillart JC, Mericskay M, Parlakian A, Bausero P, Abbas W, Herbein G, Kurdistani SK, Grana X, Van Driessche B, Schwartz C, Candolfi E, Benecke AG, Van Lint C, Rohr O.

Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12655-60. doi: 10.1073/pnas.1220136110. Epub 2013 Jul 12.


Non-coding RNAs: novel players in chromatin-regulation during viral latency.

Eilebrecht S, Schwartz C, Rohr O.

Curr Opin Virol. 2013 Aug;3(4):387-93. doi: 10.1016/j.coviro.2013.04.001. Epub 2013 May 6. Review.


[DING proteins, their biochemical and structural properties, and their ability to inhibit HIV-1 replication].

Chabriere E, Elias M, Hiblot J, Djeghader A, Schwartz C, Rohr O, Masson P.

Bull Acad Natl Med. 2012 Mar;196(3):693-703; discussion 704. French.


Histone methyltransferase inhibitors induce HIV-1 recovery in resting CD4(+) T cells from HIV-1-infected HAART-treated patients.

Bouchat S, Gatot JS, Kabeya K, Cardona C, Colin L, Herbein G, De Wit S, Clumeck N, Lambotte O, Rouzioux C, Rohr O, Van Lint C.

AIDS. 2012 Jul 31;26(12):1473-82. doi: 10.1097/QAD.0b013e32835535f5. Erratum in: AIDS. 2013 Jun 19;27(10):1683.


Inhibition of ER stress-mediated apoptosis in macrophages by nuclear-cytoplasmic relocalization of eEF1A by the HIV-1 Nef protein.

Abbas W, Khan KA, Tripathy MK, Dichamp I, Keita M, Rohr O, Herbein G.

Cell Death Dis. 2012 Apr 5;3:e292. doi: 10.1038/cddis.2012.32. Retraction in: Cell Death Dis. 2012;3:e368.


The level of DING proteins is increased in HIV-infected patients: in vitro and in vivo studies.

Djeghader A, Aragonès G, Darbinian N, Elias M, Gonzalez D, García-Heredia A, Beltrán-Debón R, Kaminski R, Gotthard G, Hiblot J, Rull A, Rohr O, Schwartz C, Alonso-Villaverde C, Joven J, Camps J, Chabriere E.

PLoS One. 2012;7(3):e33062. doi: 10.1371/journal.pone.0033062. Epub 2012 Mar 9.


Achieving a cure for HIV infection: do we have reasons to be optimistic?

Le Douce V, Janossy A, Hallay H, Ali S, Riclet R, Rohr O, Schwartz C.

J Antimicrob Chemother. 2012 May;67(5):1063-74. doi: 10.1093/jac/dkr599. Epub 2012 Feb 1. Review.


Genome-wide binding map of the HIV-1 Tat protein to the human genome.

Marban C, Su T, Ferrari R, Li B, Vatakis D, Pellegrini M, Zack JA, Rohr O, Kurdistani SK.

PLoS One. 2011;6(11):e26894. doi: 10.1371/journal.pone.0026894. Epub 2011 Nov 4.


LSD1 cooperates with CTIP2 to promote HIV-1 transcriptional silencing.

Le Douce V, Colin L, Redel L, Cherrier T, Herbein G, Aunis D, Rohr O, Van Lint C, Schwartz C.

Nucleic Acids Res. 2012 Mar;40(5):1904-15. doi: 10.1093/nar/gkr857. Epub 2011 Nov 8. Erratum in: Nucleic Acids Res. . 2014 Apr;42(6):4141.


Chromatin disruption in the promoter of bovine leukemia virus during transcriptional activation.

Colin L, Dekoninck A, Reichert M, Calao M, Merimi M, Van den Broeke A, Vierendeel V, Cleuter Y, Burny A, Rohr O, Van Lint C.

Nucleic Acids Res. 2011 Dec;39(22):9559-73. doi: 10.1093/nar/gkr671. Epub 2011 Sep 2.


Human-Phosphate-Binding-Protein inhibits HIV-1 gene transcription and replication.

Cherrier T, Elias M, Jeudy A, Gotthard G, Le Douce V, Hallay H, Masson P, Janossy A, Candolfi E, Rohr O, Chabrière E, Schwartz C.

Virol J. 2011 Jul 15;8:352. doi: 10.1186/1743-422X-8-352.


The AP-1 binding sites located in the pol gene intragenic regulatory region of HIV-1 are important for viral replication.

Colin L, Vandenhoudt N, de Walque S, Van Driessche B, Bergamaschi A, Martinelli V, Cherrier T, Vanhulle C, Guiguen A, David A, Burny A, Herbein G, Pancino G, Rohr O, Van Lint C.

PLoS One. 2011 Apr 19;6(4):e19084. doi: 10.1371/journal.pone.0019084.


DNA cytosine methylation in the bovine leukemia virus promoter is associated with latency in a lymphoma-derived B-cell line: potential involvement of direct inhibition of cAMP-responsive element (CRE)-binding protein/CRE modulator/activation transcription factor binding.

Pierard V, Guiguen A, Colin L, Wijmeersch G, Vanhulle C, Van Driessche B, Dekoninck A, Blazkova J, Cardona C, Merimi M, Vierendeel V, Calomme C, Nguyên TL, Nuttinck M, Twizere JC, Kettmann R, Portetelle D, Burny A, Hirsch I, Rohr O, Van Lint C.

J Biol Chem. 2010 Jun 18;285(25):19434-49. doi: 10.1074/jbc.M110.107607. Epub 2010 Apr 22.


Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage.

Le Douce V, Herbein G, Rohr O, Schwartz C.

Retrovirology. 2010 Apr 9;7:32. doi: 10.1186/1742-4690-7-32. Review.


[Molecular basis of HIV-1 latency - Part II: HIV-1 reactivation and therapeutic implications].

Cherrier T, Le Douce V, Redel L, Marban C, Aunis D, Rohr O, Schwartz C.

Med Sci (Paris). 2010 Mar;26(3):291-5. doi: 10.1051/medsci/2010263291. Review. French.


[Molecular basis of HIV-1 latency - part I: physiology of HIV-1 latency].

Schwartz C, Le Douce V, Cherrier T, Redel L, Marban C, Aunis D, Rohr O.

Med Sci (Paris). 2010 Feb;26(2):159-63. doi: 10.1051/medsci/2010262159. Review. French.


HIV-1 regulation of latency in the monocyte-macrophage lineage and in CD4+ T lymphocytes.

Redel L, Le Douce V, Cherrier T, Marban C, Janossy A, Aunis D, Van Lint C, Rohr O, Schwartz C.

J Leukoc Biol. 2010 Apr;87(4):575-88. doi: 10.1189/jlb.0409264. Epub 2009 Oct 2. Review.


p21(WAF1) gene promoter is epigenetically silenced by CTIP2 and SUV39H1.

Cherrier T, Suzanne S, Redel L, Calao M, Marban C, Samah B, Mukerjee R, Schwartz C, Gras G, Sawaya BE, Zeichner SL, Aunis D, Van Lint C, Rohr O.

Oncogene. 2009 Sep 24;28(38):3380-9. doi: 10.1038/onc.2009.193. Epub 2009 Jul 6.


Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infection.

Reuse S, Calao M, Kabeya K, Guiguen A, Gatot JS, Quivy V, Vanhulle C, Lamine A, Vaira D, Demonte D, Martinelli V, Veithen E, Cherrier T, Avettand V, Poutrel S, Piette J, de Launoit Y, Moutschen M, Burny A, Rouzioux C, De Wit S, Herbein G, Rohr O, Collette Y, Lambotte O, Clumeck N, Van Lint C.

PLoS One. 2009 Jun 30;4(6):e6093. doi: 10.1371/journal.pone.0006093.


Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing.

Marban C, Suzanne S, Dequiedt F, de Walque S, Redel L, Van Lint C, Aunis D, Rohr O.

EMBO J. 2007 Jan 24;26(2):412-23.


Identification of morphine-6-glucuronide in chromaffin cell secretory granules.

Goumon Y, Muller A, Glattard E, Marban C, Gasnier C, Strub JM, Chasserot-Golaz S, Rohr O, Stefano GB, Welters ID, Van Dorsselaer A, Schoentgen F, Aunis D, Metz-Boutigue MH.

J Biol Chem. 2006 Mar 24;281(12):8082-9. Epub 2006 Jan 24.


COUP-TF interacting protein 2 represses the initial phase of HIV-1 gene transcription in human microglial cells.

Marban C, Redel L, Suzanne S, Van Lint C, Lecestre D, Chasserot-Golaz S, Leid M, Aunis D, Schaeffer E, Rohr O.

Nucleic Acids Res. 2005 Apr 22;33(7):2318-31. Print 2005.


Regulation of HIV-1 gene transcription: from lymphocytes to microglial cells.

Rohr O, Marban C, Aunis D, Schaeffer E.

J Leukoc Biol. 2003 Nov;74(5):736-49. Epub 2003 Aug 11. Review.


Recruitment of Tat to heterochromatin protein HP1 via interaction with CTIP2 inhibits human immunodeficiency virus type 1 replication in microglial cells.

Rohr O, Lecestre D, Chasserot-Golaz S, Marban C, Avram D, Aunis D, Leid M, Schaeffer E.

J Virol. 2003 May;77(9):5415-27.


Dopamine stimulates expression of the human immunodeficiency virus type 1 via NF-kappaB in cells of the immune system.

Rohr O, Sawaya BE, Lecestre D, Aunis D, Schaeffer E.

Nucleic Acids Res. 1999 Aug 15;27(16):3291-9.

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