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Items: 17


An uncommon cause of lower leg pain.

Rohena CD, Brown TC.

JAAPA. 2019 Mar;32(3):36-37. doi: 10.1097/01.JAA.0000553382.37142.76.


Single-Cell Imaging of Metastatic Potential of Cancer Cells.

Midde K, Sun N, Rohena C, Joosen L, Dhillon H, Ghosh P.

iScience. 2018 Dec 21;10:53-65. doi: 10.1016/j.isci.2018.11.022. Epub 2018 Nov 15.


Ortho group activation of a bromopyrrole ester in Suzuki-Miyaura cross-coupling reactions: Application to the synthesis of new microtubule depolymerizing agents with potent cytotoxic activities.

Gupton JT, Yeudall S, Telang N, Hoerrner M, Huff E, Crawford E, Lounsbury K, Kimmel M, Curry W, Harrison A, Juekun W, Shimozono A, Ortolani J, Lescalleet K, Patteson J, Moore-Stoll V, Rohena CC, Mooberry SL, Obaidullah AJ, Kellogg GE, Sikorski JA.

Bioorg Med Chem. 2017 Jun 15;25(12):3206-3214. doi: 10.1016/j.bmc.2017.04.012. Epub 2017 Apr 11.


Erythrocyte sialoglycoproteins engage Siglec-9 on neutrophils to suppress activation.

Lizcano A, Secundino I, Döhrmann S, Corriden R, Rohena C, Diaz S, Ghosh P, Deng L, Nizet V, Varki A.

Blood. 2017 Jun 8;129(23):3100-3110. doi: 10.1182/blood-2016-11-751636. Epub 2017 Apr 17.


Biochemical, Biophysical and Cellular Techniques to Study the Guanine Nucleotide Exchange Factor, GIV/Girdin.

Ghosh P, Aznar N, Swanson L, Lo IC, Lopez-Sanchez I, Ear J, Rohena C, Kalogriopoulos N, Joosen L, Dunkel Y, Sun N, Nguyen P, Bhandari D.

Curr Protoc Chem Biol. 2016 Dec 7;8(4):265-298. doi: 10.1002/cpch.13.


Janus Compounds, 5-Chloro-N⁴-methyl-N⁴-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause Both Microtubule Depolymerizing and Stabilizing Effects.

Rohena CC, Risinger AL, Devambatla RK, Dybdal-Hargreaves NF, Kaul R, Choudhary S, Gangjee A, Mooberry SL.

Molecules. 2016 Dec 2;21(12). pii: E1661.


AMP-activated protein kinase fortifies epithelial tight junctions during energetic stress via its effector GIV/Girdin.

Aznar N, Patel A, Rohena CC, Dunkel Y, Joosen LP, Taupin V, Kufareva I, Farquhar MG, Ghosh P.

Elife. 2016 Nov 4;5. pii: e20795. doi: 10.7554/eLife.20795.


Drosophila Ringmaker regulates microtubule stabilization and axonal extension during embryonic development.

Mino RE, Rogers SL, Risinger AL, Rohena C, Banerjee S, Bhat MA.

J Cell Sci. 2016 Sep 1;129(17):3282-94. doi: 10.1242/jcs.187294. Epub 2016 Jul 15.


Design, Synthesis, and Preclinical Evaluation of 4-Substituted-5-methyl-furo[2,3-d]pyrimidines as Microtubule Targeting Agents That Are Effective against Multidrug Resistant Cancer Cells.

Devambatla RK, Namjoshi OA, Choudhary S, Hamel E, Shaffer CV, Rohena CC, Mooberry SL, Gangjee A.

J Med Chem. 2016 Jun 23;59(12):5752-65. doi: 10.1021/acs.jmedchem.6b00237. Epub 2016 Jun 7.


Biological Characterization of an Improved Pyrrole-Based Colchicine Site Agent Identified through Structure-Based Design.

Rohena CC, Telang NS, Da C, Risinger AL, Sikorski JA, Kellogg GE, Gupton JT, Mooberry SL.

Mol Pharmacol. 2016 Feb;89(2):287-96. doi: 10.1124/mol.115.101592. Epub 2015 Dec 11. Erratum in: Mol Pharmacol. 2016 Sep;90(3):411-2.


The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents.

Zhang X, Raghavan S, Ihnat M, Thorpe JE, Disch BC, Bastian A, Bailey-Downs LC, Dybdal-Hargreaves NF, Rohena CC, Hamel E, Mooberry SL, Gangjee A.

Bioorg Med Chem. 2014 Jul 15;22(14):3753-72. doi: 10.1016/j.bmc.2014.04.049. Epub 2014 May 14.


Antiproliferative effects of 12-oxoheteronemin vs heteronemin.

Kittiwisut S, Rohena CC, Yuenyongsawad S, Mooberry SL, Plubrukarn A.

Nat Prod Commun. 2014 Mar;9(3):359-60.


Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities.

Rohena CC, Mooberry SL.

Nat Prod Rep. 2014 Mar;31(3):335-55. doi: 10.1039/c3np70092e. Review.


The bat flower: a source of microtubule-destabilizing and -stabilizing compounds with synergistic antiproliferative actions.

Risinger AL, Peng J, Rohena CC, Aguilar HR, Frantz DE, Mooberry SL.

J Nat Prod. 2013 Oct 25;76(10):1923-9. doi: 10.1021/np4005079. Epub 2013 Oct 2.


Taccalonolide binding to tubulin imparts microtubule stability and potent in vivo activity.

Risinger AL, Li J, Bennett MJ, Rohena CC, Peng J, Schriemer DC, Mooberry SL.

Cancer Res. 2013 Nov 15;73(22):6780-92. doi: 10.1158/0008-5472.CAN-13-1346. Epub 2013 Sep 18.


Chemically diverse microtubule stabilizing agents initiate distinct mitotic defects and dysregulated expression of key mitotic kinases.

Rohena CC, Peng J, Johnson TA, Crews P, Mooberry SL.

Biochem Pharmacol. 2013 Apr 15;85(8):1104-14. doi: 10.1016/j.bcp.2013.01.030. Epub 2013 Feb 8.

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