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Cellular cholesterol modifies flow mediated gene expression.

Repetti RL, Meth J, Sonubi O, Flores D, Satlin LM, Rohatgi R.

Am J Physiol Renal Physiol. 2019 Jul 31. doi: 10.1152/ajprenal.00196.2019. [Epub ahead of print]


Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision.

Phua SC, Chiba S, Suzuki M, Su E, Roberson EC, Pusapati GV, Schurmans S, Setou M, Rohatgi R, Reiter JF, Ikegami K, Inoue T.

Cell. 2019 Jun 27;178(1):261. doi: 10.1016/j.cell.2019.06.015. No abstract available.


Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and Hedgehog signalling.

Kowatsch C, Woolley RE, Kinnebrew M, Rohatgi R, Siebold C.

Curr Opin Struct Biol. 2019 Aug;57:204-214. doi: 10.1016/ Epub 2019 Jun 24. Review.


Assessment and Validation of a Phenotype-Enhanced Variant Classification Framework to Promote or Demote RYR2 Missense Variants of Uncertain Significance.

Giudicessi JR, Lieve KVV, Rohatgi RK, Koca F, Tester DJ, van der Werf C, Martijn Bos J, Wilde AAM, Ackerman MJ.

Circ Genom Precis Med. 2019 May;12(5):e002510. doi: 10.1161/CIRCGEN.119.002510.


Biochemical mechanisms of vertebrate hedgehog signaling.

Kong JH, Siebold C, Rohatgi R.

Development. 2019 May 15;146(10). pii: dev166892. doi: 10.1242/dev.166892. Review.


Mexiletine Shortens the QT Interval in Patients With Potassium Channel-Mediated Type 2 Long QT Syndrome.

Bos JM, Crotti L, Rohatgi RK, Castelletti S, Dagradi F, Schwartz PJ, Ackerman MJ.

Circ Arrhythm Electrophysiol. 2019 May;12(5):e007280. doi: 10.1161/CIRCEP.118.007280.


Discovery of gene regulatory elements through a new bioinformatics analysis of haploid genetic screens.

Patel BB, Lebensohn AM, Pusapati GV, Carette JE, Salzman J, Rohatgi R.

PLoS One. 2019 Jan 29;14(1):e0198463. doi: 10.1371/journal.pone.0198463. eCollection 2019.


International Triadin Knockout Syndrome Registry.

Clemens DJ, Tester DJ, Giudicessi JR, Bos JM, Rohatgi RK, Abrams DJ, Balaji S, Crotti L, Faure J, Napolitano C, Priori SG, Probst V, Rooryck-Thambo C, Roux-Buisson N, Sacher F, Schwartz PJ, Silka MJ, Walsh MA, Ackerman MJ.

Circ Genom Precis Med. 2019 Feb;12(2):e002419. doi: 10.1161/CIRCGEN.118.002419.


Cholesterol Interaction Sites on the Transmembrane Domain of the Hedgehog Signal Transducer and Class F G Protein-Coupled Receptor Smoothened.

Hedger G, Koldsø H, Chavent M, Siebold C, Rohatgi R, Sansom MSP.

Structure. 2019 Mar 5;27(3):549-559.e2. doi: 10.1016/j.str.2018.11.003. Epub 2018 Dec 27.


Is obstructive sleep apnea the missing link between metabolic syndrome and second-generation antipsychotics: Preliminary study.

Rohatgi R, Gupta R, Ray R, Kalra V.

Indian J Psychiatry. 2018 Oct-Dec;60(4):478-484. doi: 10.4103/psychiatry.IndianJPsychiatry_105_18.


Clinical Significance of Early Repolarization in Long QT Syndrome.

Sugrue A, Rohatgi RK, Bos M, Vaidya VR, Asirvatham SJ, Noseworthy PA, Ackerman MJ.

JACC Clin Electrophysiol. 2018 Sep;4(9):1238-1244. doi: 10.1016/j.jacep.2018.06.007. Epub 2018 Aug 29.


Prevalence and clinical phenotype of concomitant long QT syndrome and arrhythmogenic bileaflet mitral valve prolapse.

Giudicessi JR, Rohatgi RK, Bos JM, Ackerman MJ.

Int J Cardiol. 2019 Jan 1;274:175-178. doi: 10.1016/j.ijcard.2018.09.046. Epub 2018 Sep 11.


Comparison of fixed versus traditional weight-based dosing of rasburicase in a pediatric population.

Savva DA, Herrera N, Rohatgi R.

Pediatr Blood Cancer. 2018 Oct;65(10):e27236. doi: 10.1002/pbc.27236. Epub 2018 Jun 15.


Beyond the length and look of repolarization: Defining the non-QTc electrocardiographic profiles of patients with congenital long QT syndrome.

Lane CM, Bos JM, Rohatgi RK, Ackerman MJ.

Heart Rhythm. 2018 Sep;15(9):1413-1419. doi: 10.1016/j.hrthm.2018.04.033. Epub 2018 Apr 30.


Spatiotemporal manipulation of ciliary glutamylation reveals its roles in intraciliary trafficking and Hedgehog signaling.

Hong SR, Wang CL, Huang YS, Chang YC, Chang YC, Pusapati GV, Lin CY, Hsu N, Cheng HC, Chiang YC, Huang WE, Shaner NC, Rohatgi R, Inoue T, Lin YC.

Nat Commun. 2018 Apr 30;9(1):1732. doi: 10.1038/s41467-018-03952-z.


Long QT syndrome type 5-Lite: Defining the clinical phenotype associated with the potentially proarrhythmic p.Asp85Asn-KCNE1 common genetic variant.

Lane CM, Giudicessi JR, Ye D, Tester DJ, Rohatgi RK, Bos JM, Ackerman MJ.

Heart Rhythm. 2018 Aug;15(8):1223-1230. doi: 10.1016/j.hrthm.2018.03.038. Epub 2018 Apr 3.


Telenephrology: Providing Healthcare to Remotely Located Patients with Chronic Kidney Disease.

Tan J, Mehrotra A, Nadkarni GN, He JC, Langhoff E, Post J, Galvao-Sobrinho C, Thode HC Jr, Rohatgi R.

Am J Nephrol. 2018;47(3):200-207. doi: 10.1159/000488004. Epub 2018 Mar 20.


Nephrotoxicity: Evidence in Patients Receiving Cisplatin Therapy

Duffy EA, Fitzgerald W, Boyle K, Rohatgi R.

Clin J Oncol Nurs. 2018 Apr 1;22(2):175-183. doi: 10.1188/18.CJON.175-183. Review.


Return-to-Play for Athletes With Genetic Heart Diseases.

Turkowski KL, Bos JM, Ackerman NC, Rohatgi RK, Ackerman MJ.

Circulation. 2018 Mar 6;137(10):1086-1088. doi: 10.1161/CIRCULATIONAHA.117.031306. No abstract available.


A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing.

Wang A, Conicella AE, Schmidt HB, Martin EW, Rhoads SN, Reeb AN, Nourse A, Ramirez Montero D, Ryan VH, Rohatgi R, Shewmaker F, Naik MT, Mittag T, Ayala YM, Fawzi NL.

EMBO J. 2018 Mar 1;37(5). pii: e97452. doi: 10.15252/embj.201797452. Epub 2018 Feb 9.


G protein-coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog.

Pusapati GV, Kong JH, Patel BB, Gouti M, Sagner A, Sircar R, Luchetti G, Ingham PW, Briscoe J, Rohatgi R.

Sci Signal. 2018 Feb 6;11(516). pii: eaao5749. doi: 10.1126/scisignal.aao5749.


R-spondins can potentiate WNT signaling without LGRs.

Lebensohn AM, Rohatgi R.

Elife. 2018 Feb 6;7. pii: e33126. doi: 10.7554/eLife.33126.


CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog.

Pusapati GV, Kong JH, Patel BB, Krishnan A, Sagner A, Kinnebrew M, Briscoe J, Aravind L, Rohatgi R.

Dev Cell. 2018 Jan 22;44(2):271. doi: 10.1016/j.devcel.2018.01.002. No abstract available.


CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog.

Pusapati GV, Kong JH, Patel BB, Krishnan A, Sagner A, Kinnebrew M, Briscoe J, Aravind L, Rohatgi R.

Dev Cell. 2018 Jan 8;44(1):113-129.e8. doi: 10.1016/j.devcel.2017.12.003. Epub 2017 Dec 28. Erratum in: Dev Cell. 2018 Jan 22;44(2):271.


Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates.

Byrne EF, Luchetti G, Rohatgi R, Siebold C.

Curr Opin Cell Biol. 2018 Apr;51:81-88. doi: 10.1016/ Epub 2017 Dec 18. Review.


Architectural T-Wave Analysis and Identification of On-Therapy Breakthrough Arrhythmic Risk in Type 1 and Type 2 Long-QT Syndrome.

Sugrue A, Rohatgi RK, Noseworthy PA, Kremen V, Bos JM, Qiang B, Sapir Y, Attia ZI, Scott CG, Brady P, Asirvatham SJ, Friedman PA, Ackerman MJ.

Circ Arrhythm Electrophysiol. 2017 Nov;10(11). pii: e005648. doi: 10.1161/CIRCEP.117.005648.


Telenephrology: current perspectives and future directions.

Rohatgi R, Ross MJ, Majoni SW.

Kidney Int. 2017 Dec;92(6):1328-1333. doi: 10.1016/j.kint.2017.06.032. Epub 2017 Oct 12. Review.


Loss-of-Function KCNE2 Variants: True Monogenic Culprits of Long-QT Syndrome or Proarrhythmic Variants Requiring Secondary Provocation?

Roberts JD, Krahn AD, Ackerman MJ, Rohatgi RK, Moss AJ, Nazer B, Tadros R, Gerull B, Sanatani S, Wijeyeratne YD, Baruteau AE, Muir AR, Pang B, Cadrin-Tourigny J, Talajic M, Rivard L, Tester DJ, Liu T, Whitman IR, Wojciak J, Conacher S, Gula LJ, Leong-Sit P, Manlucu J, Green MS, Hamilton R, Healey JS, Lopes CM, Behr ER, Wilde AA, Gollob MH, Scheinman MM.

Circ Arrhythm Electrophysiol. 2017 Aug;10(8). pii: e005282. doi: 10.1161/CIRCEP.117.005282.


Contemporary Outcomes in Patients With Long QT Syndrome.

Rohatgi RK, Sugrue A, Bos JM, Cannon BC, Asirvatham SJ, Moir C, Owen HJ, Bos KM, Kruisselbrink T, Ackerman MJ.

J Am Coll Cardiol. 2017 Jul 25;70(4):453-462. doi: 10.1016/j.jacc.2017.05.046.


Proposing a Hybrid Model Based on Robson's Classification for Better Impact on Trends of Cesarean Deliveries.

Hans P, Rohatgi R.

J Obstet Gynaecol India. 2017 Jun;67(3):183-189. doi: 10.1007/s13224-016-0953-4. Epub 2016 Nov 21.


Automated T-wave analysis can differentiate acquired QT prolongation from congenital long QT syndrome.

Sugrue A, Noseworthy PA, Kremen V, Bos JM, Qiang B, Rohatgi RK, Sapir Y, Attia ZI, Brady P, Caraballo PJ, Asirvatham SJ, Friedman PA, Ackerman MJ.

Ann Noninvasive Electrocardiol. 2017 Nov;22(6). doi: 10.1111/anec.12455. Epub 2017 Apr 21.


Targeting Access to Kidney Care Via Telehealth: The VA Experience.

Crowley ST, Belcher J, Choudhury D, Griffin C, Pichler R, Robey B, Rohatgi R, Mielcarek B.

Adv Chronic Kidney Dis. 2017 Jan;24(1):22-30. doi: 10.1053/j.ackd.2016.11.005. Review.


Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision.

Phua SC, Chiba S, Suzuki M, Su E, Roberson EC, Pusapati GV, Setou M, Rohatgi R, Reiter JF, Ikegami K, Inoue T.

Cell. 2017 Jan 12;168(1-2):264-279.e15. doi: 10.1016/j.cell.2016.12.032. Epub 2017 Jan 12.


Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling.

Lebensohn AM, Dubey R, Neitzel LR, Tacchelly-Benites O, Yang E, Marceau CD, Davis EM, Patel BB, Bahrami-Nejad Z, Travaglini KJ, Ahmed Y, Lee E, Carette JE, Rohatgi R.

Elife. 2016 Dec 20;5. pii: e21459. doi: 10.7554/eLife.21459.


Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling.

Luchetti G, Sircar R, Kong JH, Nachtergaele S, Sagner A, Byrne EF, Covey DF, Siebold C, Rohatgi R.

Elife. 2016 Oct 5;5. pii: e20304. doi: 10.7554/eLife.20304.


Chromatin-Remodeling Complex SWI/SNF Controls Multidrug Resistance by Transcriptionally Regulating the Drug Efflux Pump ABCB1.

Dubey R, Lebensohn AM, Bahrami-Nejad Z, Marceau C, Champion M, Gevaert O, Sikic BI, Carette JE, Rohatgi R.

Cancer Res. 2016 Oct 1;76(19):5810-5821. Epub 2016 Aug 8.


In Vivo Formation of Vacuolated Multi-phase Compartments Lacking Membranes.

Schmidt HB, Rohatgi R.

Cell Rep. 2016 Aug 2;16(5):1228-1236. doi: 10.1016/j.celrep.2016.06.088. Epub 2016 Jul 21.


Structural basis of Smoothened regulation by its extracellular domains.

Byrne EFX, Sircar R, Miller PS, Hedger G, Luchetti G, Nachtergaele S, Tully MD, Mydock-McGrane L, Covey DF, Rambo RP, Sansom MSP, Newstead S, Rohatgi R, Siebold C.

Nature. 2016 Jul 28;535(7613):517-522. doi: 10.1038/nature18934. Epub 2016 Jul 20.


Identification of Concealed and Manifest Long QT Syndrome Using a Novel T Wave Analysis Program.

Sugrue A, Noseworthy PA, Kremen V, Bos JM, Qiang B, Rohatgi RK, Sapir Y, Attia ZI, Brady P, Asirvatham SJ, Friedman PA, Ackerman MJ.

Circ Arrhythm Electrophysiol. 2016 Jul;9(7). pii: e003830. doi: 10.1161/CIRCEP.115.003830.


Albuminuria confers renal resistance to loop diuretics via the stimulation of NLRP3 inflammasome/prostaglandin signaling in thick ascending limb.

Zhuang Y, Jia Z, Hu C, Ding G, Zhang X, Zhang Y, Yang G, Rohatgi R, Huang S, He JC, Zhang A.

Oncotarget. 2016 Jun 23;8(44):75808-75821. doi: 10.18632/oncotarget.10257. eCollection 2017 Sep 29.


Albuminuria enhances NHE3 and NCC via stimulation of mitochondrial oxidative stress/angiotensin II axis.

Jia Z, Zhuang Y, Hu C, Zhang X, Ding G, Zhang Y, Rohatgi R, Hua H, Huang S, He JC, Zhang A.

Oncotarget. 2016 Jul 26;7(30):47134-47144. doi: 10.18632/oncotarget.9972.


Selective Serotonin Re-uptake Inhibitors (SSRIs) Induced Weight Changes: A Dose and Duration Dependent Study on Albino Rats.

Aggarwal A, Jethani SL, Rohatgi RK, Kalra J.

J Clin Diagn Res. 2016 Mar;10(3):AF01-3. doi: 10.7860/JCDR/2016/16482.7376. Epub 2016 Mar 1.


An essential role for Grk2 in Hedgehog signalling downstream of Smoothened.

Zhao Z, Lee RT, Pusapati GV, Iyu A, Rohatgi R, Ingham PW.

EMBO Rep. 2016 May;17(5):739-52. doi: 10.15252/embr.201541532. Epub 2016 Apr 4.


An autophagy-independent function for Beclin 1 in cancer.

Rohatgi RA, Shaw LM.

Mol Cell Oncol. 2016 Jan 2;3(1). pii: e1030539. Epub 2015 Apr 14.


Left ventricular outflow track obstruction and mitral valve regurgitation in a patient with takotsubo cardiomyopathy.

Wu Y, Fan W, Chachula L, Costacurta G, Rohatgi R, Elmi F.

J Community Hosp Intern Med Perspect. 2015 Dec 11;5(6):29419. doi: 10.3402/jchimp.v5.29419. eCollection 2015.


Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling.

Marada S, Navarro G, Truong A, Stewart DP, Arensdorf AM, Nachtergaele S, Angelats E, Opferman JT, Rohatgi R, McCormick PJ, Ogden SK.

PLoS Genet. 2015 Aug 20;11(8):e1005473. doi: 10.1371/journal.pgen.1005473. eCollection 2015 Aug.


Rapid Screening of Gli2/3 Mutants Using the Flp-In System.

Niewiadomski P, Rohatgi R.

Methods Mol Biol. 2015;1322:125-30. doi: 10.1007/978-1-4939-2772-2_11.


Measuring Gli2 Phosphorylation by Selected Reaction Monitoring Mass Spectrometry.

Ahrends R, Niewiadomski P, Teruel MN, Rohatgi R.

Methods Mol Biol. 2015;1322:105-23. doi: 10.1007/978-1-4939-2772-2_10.


Measuring Expression Levels of Endogenous Gli Genes by Immunoblotting and Real-Time PCR.

Niewiadomski P, Rohatgi R.

Methods Mol Biol. 2015;1322:81-92. doi: 10.1007/978-1-4939-2772-2_8.


Stimulant therapy in children with attention-deficit/hyperactivity disorder and concomitant long QT syndrome: A safe combination?

Rohatgi RK, Bos JM, Ackerman MJ.

Heart Rhythm. 2015 Aug;12(8):1807-12. doi: 10.1016/j.hrthm.2015.04.043. Epub 2015 May 5.

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