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Items: 1 to 50 of 67

1.

Molecular mechanism of TRPV2 channel modulation by cannabidiol.

Pumroy RA, Samanta A, Liu Y, Hughes TE, Zhao S, Yudin Y, Rohacs T, Han S, Moiseenkova-Bell VY.

Elife. 2019 Sep 30;8. pii: e48792. doi: 10.7554/eLife.48792.

2.

G αq Sensitizes TRPM8 to Inhibition by PI(4,5)P2 Depletion upon Receptor Activation.

Liu L, Yudin Y, Nagwekar J, Kang C, Shirokova N, Rohacs T.

J Neurosci. 2019 Jul 31;39(31):6067-6080. doi: 10.1523/JNEUROSCI.2304-18.2019. Epub 2019 May 24.

PMID:
31127000
3.

The G-protein-biased agents PZM21 and TRV130 are partial agonists of μ-opioid receptor-mediated signalling to ion channels.

Yudin Y, Rohacs T.

Br J Pharmacol. 2019 Sep;176(17):3110-3125. doi: 10.1111/bph.14702. Epub 2019 Jul 9.

PMID:
31074038
4.

Tools for Understanding Nanoscale Lipid Regulation of Ion Channels.

Robinson CV, Rohacs T, Hansen SB.

Trends Biochem Sci. 2019 Sep;44(9):795-806. doi: 10.1016/j.tibs.2019.04.001. Epub 2019 May 3. Review.

PMID:
31060927
5.

A hypothetical molecular mechanism for TRPV1 activation that invokes rotation of an S6 asparagine.

Kasimova MA, Yazici AT, Yudin Y, Granata D, Klein ML, Rohacs T, Carnevale V.

J Gen Physiol. 2018 Nov 5;150(11):1554-1566. doi: 10.1085/jgp.201812124. Epub 2018 Oct 17.

6.

Structural insights on TRPV5 gating by endogenous modulators.

Hughes TET, Pumroy RA, Yazici AT, Kasimova MA, Fluck EC, Huynh KW, Samanta A, Molugu SK, Zhou ZH, Carnevale V, Rohacs T, Moiseenkova-Bell VY.

Nat Commun. 2018 Oct 10;9(1):4198. doi: 10.1038/s41467-018-06753-6.

7.

Inhibitory Gi/O-coupled receptors in somatosensory neurons: Potential therapeutic targets for novel analgesics.

Yudin Y, Rohacs T.

Mol Pain. 2018 Jan-Dec;14:1744806918763646. doi: 10.1177/1744806918763646. Review.

8.

Ion Channel Sensing: Are Fluctuations the Crux of the Matter?

Kasimova MA, Yazici A, Yudin Y, Granata D, Klein ML, Rohacs T, Carnevale V.

J Phys Chem Lett. 2018 Mar 15;9(6):1260-1264. doi: 10.1021/acs.jpclett.7b03396. Epub 2018 Feb 27.

9.

Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM.

Hughes TET, Lodowski DT, Huynh KW, Yazici A, Del Rosario J, Kapoor A, Basak S, Samanta A, Han X, Chakrapani S, Zhou ZH, Filizola M, Rohacs T, Han S, Moiseenkova-Bell VY.

Nat Struct Mol Biol. 2018 Jan;25(1):53-60. doi: 10.1038/s41594-017-0009-1. Epub 2018 Jan 1.

10.

Inhibition of Transient Receptor Potential Melastatin 3 ion channels by G-protein βγ subunits.

Badheka D, Yudin Y, Borbiro I, Hartle CM, Yazici A, Mirshahi T, Rohacs T.

Elife. 2017 Aug 15;6. pii: e26147. doi: 10.7554/eLife.26147.

11.

Regulation of Piezo Channels by Cellular Signaling Pathways.

Borbiro I, Rohacs T.

Curr Top Membr. 2017;79:245-261. doi: 10.1016/bs.ctm.2016.10.002. Epub 2016 Dec 18. Review.

12.

Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice.

Beckerman P, Bi-Karchin J, Park AS, Qiu C, Dummer PD, Soomro I, Boustany-Kari CM, Pullen SS, Miner JH, Hu CA, Rohacs T, Inoue K, Ishibe S, Saleem MA, Palmer MB, Cuervo AM, Kopp JB, Susztak K.

Nat Med. 2017 Apr;23(4):429-438. doi: 10.1038/nm.4287. Epub 2017 Feb 20.

13.

TRPV1: A Target for Rational Drug Design.

Carnevale V, Rohacs T.

Pharmaceuticals (Basel). 2016 Aug 23;9(3). pii: E52. doi: 10.3390/ph9030052. Review.

14.

A molecular determinant of phosphoinositide affinity in mammalian TRPV channels.

Velisetty P, Borbiro I, Kasimova MA, Liu L, Badheka D, Carnevale V, Rohacs T.

Sci Rep. 2016 Jun 13;6:27652. doi: 10.1038/srep27652.

15.

Phospholipase C δ4 regulates cold sensitivity in mice.

Yudin Y, Lutz B, Tao YX, Rohacs T.

J Physiol. 2016 Jul 1;594(13):3609-28. doi: 10.1113/JP272321. Epub 2016 May 29.

16.

Phosphoinositide signaling in somatosensory neurons.

Rohacs T.

Adv Biol Regul. 2016 May;61:2-16. doi: 10.1016/j.jbior.2015.11.012. Epub 2015 Dec 19. Review.

17.

Understanding TRPV1 activation by ligands: Insights from the binding modes of capsaicin and resiniferatoxin.

Elokely K, Velisetty P, Delemotte L, Palovcak E, Klein ML, Rohacs T, Carnevale V.

Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):E137-45. doi: 10.1073/pnas.1517288113. Epub 2015 Dec 30.

18.

TRPM3 joins the ranks of PI(4,5)P2 sensitive ion channels.

Badheka D, Rohacs T.

Channels (Austin). 2015;9(5):233-4. doi: 10.1080/19336950.2015.1089072. No abstract available.

19.

Transient receptor potential melastatin 3 is a phosphoinositide-dependent ion channel.

Badheka D, Borbiro I, Rohacs T.

J Gen Physiol. 2015 Jul;146(1):65-77. doi: 10.1085/jgp.201411336.

20.

Phosphoinositide regulation of TRPV1 revisited.

Rohacs T.

Pflugers Arch. 2015 Sep;467(9):1851-69. doi: 10.1007/s00424-015-1695-3. Epub 2015 Mar 11. Review.

21.

Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides.

Borbiro I, Badheka D, Rohacs T.

Sci Signal. 2015 Feb 10;8(363):ra15. doi: 10.1126/scisignal.2005667.

22.

Phosphoinositide regulation of TRP channels.

Rohacs T.

Handb Exp Pharmacol. 2014;223:1143-76. doi: 10.1007/978-3-319-05161-1_18. Review.

23.
24.

Regulation of transient receptor potential channels by the phospholipase C pathway.

Rohacs T.

Adv Biol Regul. 2013 Sep;53(3):341-55. doi: 10.1016/j.jbior.2013.07.004. Epub 2013 Jul 17. Review.

25.

Polyester modification of the mammalian TRPM8 channel protein: implications for structure and function.

Cao C, Yudin Y, Bikard Y, Chen W, Liu T, Li H, Jendrossek D, Cohen A, Pavlov E, Rohacs T, Zakharian E.

Cell Rep. 2013 Jul 25;4(2):302-315. doi: 10.1016/j.celrep.2013.06.022. Epub 2013 Jul 11.

26.

Distinctive changes in plasma membrane phosphoinositides underlie differential regulation of TRPV1 in nociceptive neurons.

Lukacs V, Yudin Y, Hammond GR, Sharma E, Fukami K, Rohacs T.

J Neurosci. 2013 Jul 10;33(28):11451-63. doi: 10.1523/JNEUROSCI.5637-12.2013.

27.

Recording macroscopic currents in large patches from Xenopus oocytes.

Rohacs T.

Methods Mol Biol. 2013;998:119-31. doi: 10.1007/978-1-62703-351-0_9.

PMID:
23529425
28.

Interplay between calmodulin and phosphatidylinositol 4,5-bisphosphate in Ca2+-induced inactivation of transient receptor potential vanilloid 6 channels.

Cao C, Zakharian E, Borbiro I, Rohacs T.

J Biol Chem. 2013 Feb 22;288(8):5278-90. doi: 10.1074/jbc.M112.409482. Epub 2013 Jan 8.

29.

Sphingosine and the transient receptor potential channel kinase(s).

Rohacs T.

Br J Pharmacol. 2013 Mar;168(6):1291-3. doi: 10.1111/bph.12070.

30.

Phosphoinositide sensitivity of ion channels, a functional perspective.

Gamper N, Rohacs T.

Subcell Biochem. 2012;59:289-333. doi: 10.1007/978-94-007-3015-1_10. Review.

PMID:
22374095
31.

Signal termination: how many different ways can you hit the brakes in biological systems?

Rohacs T.

Acta Physiol (Oxf). 2012 Apr;204(4):465. doi: 10.1111/j.1748-1716.2012.02415.x. No abstract available.

PMID:
22364640
32.

Regulation of TRPM8 channel activity.

Yudin Y, Rohacs T.

Mol Cell Endocrinol. 2012 Apr 28;353(1-2):68-74. doi: 10.1016/j.mce.2011.10.023. Epub 2011 Oct 28. Review.

33.

Decrease in phosphatidylinositol 4,5-bisphosphate levels mediates desensitization of the cold sensor TRPM8 channels.

Yudin Y, Lukacs V, Cao C, Rohacs T.

J Physiol. 2011 Dec 15;589(Pt 24):6007-27. doi: 10.1113/jphysiol.2011.220228. Epub 2011 Oct 17.

34.

Cool channel subunits reveal their independent interactions with menthol.

Rohacs T.

J Physiol. 2011 Oct 15;589(Pt 20):4809. doi: 10.1113/jphysiol.2011.219543. No abstract available.

35.

Intracellular ATP supports TRPV6 activity via lipid kinases and the generation of PtdIns(4,5) P₂.

Zakharian E, Cao C, Rohacs T.

FASEB J. 2011 Nov;25(11):3915-28. doi: 10.1096/fj.11-184630. Epub 2011 Aug 2.

36.

Gating of transient receptor potential melastatin 8 (TRPM8) channels activated by cold and chemical agonists in planar lipid bilayers.

Zakharian E, Cao C, Rohacs T.

J Neurosci. 2010 Sep 15;30(37):12526-34. doi: 10.1523/JNEUROSCI.3189-10.2010.

37.

Inorganic polyphosphate modulates TRPM8 channels.

Zakharian E, Thyagarajan B, French RJ, Pavlov E, Rohacs T.

PLoS One. 2009;4(4):e5404. doi: 10.1371/journal.pone.0005404. Epub 2009 Apr 30.

38.

Phosphoinositide regulation of non-canonical transient receptor potential channels.

Rohacs T.

Cell Calcium. 2009 Jun;45(6):554-65. doi: 10.1016/j.ceca.2009.03.011. Epub 2009 Apr 18. Review.

39.

Phospholipase C-mediated regulation of transient receptor potential vanilloid 6 channels: implications in active intestinal Ca2+ transport.

Thyagarajan B, Benn BS, Christakos S, Rohacs T.

Mol Pharmacol. 2009 Mar;75(3):608-16. doi: 10.1124/mol.108.052449. Epub 2008 Dec 10.

40.

Protein kinase A modulates PLC-dependent regulation and PIP2-sensitivity of K+ channels.

Lopes CM, Remon JI, Matavel A, Sui JL, Keselman I, Medei E, Shen Y, Rosenhouse-Dantsker A, Rohacs T, Logothetis DE.

Channels (Austin). 2007 Mar-Apr;1(2):124-34. Epub 2007 Apr 23.

PMID:
18690021
41.

Phospholipase C mediated modulation of TRPV1 channels.

Rohacs T, Thyagarajan B, Lukacs V.

Mol Neurobiol. 2008 Apr-Jun;37(2-3):153-63. doi: 10.1007/s12035-008-8027-y. Epub 2008 Jun 5. Review.

42.

Hydrolysis of phosphatidylinositol 4,5-bisphosphate mediates calcium-induced inactivation of TRPV6 channels.

Thyagarajan B, Lukacs V, Rohacs T.

J Biol Chem. 2008 May 30;283(22):14980-7. doi: 10.1074/jbc.M704224200. Epub 2008 Apr 7.

43.

Dual regulation of TRPV1 by phosphoinositides.

Lukacs V, Thyagarajan B, Varnai P, Balla A, Balla T, Rohacs T.

J Neurosci. 2007 Jun 27;27(26):7070-80.

44.

Regulation of transient receptor potential (TRP) channels by phosphoinositides.

Rohacs T, Nilius B.

Pflugers Arch. 2007 Oct;455(1):157-68. Epub 2007 May 4. Review.

PMID:
17479281
46.

Regulation of TRP channels by PIP(2).

Rohacs T.

Pflugers Arch. 2007 Mar;453(6):753-62. Epub 2006 Oct 10. Review.

PMID:
17031667
47.

Teaching resources. TRP channels.

Rohacs T.

Sci STKE. 2005 May 3;2005(282):tr14.

48.

PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain.

Rohács T, Lopes CM, Michailidis I, Logothetis DE.

Nat Neurosci. 2005 May;8(5):626-34. Epub 2005 Apr 24.

PMID:
15852009
49.

PIP2 hydrolysis underlies agonist-induced inhibition and regulates voltage gating of two-pore domain K+ channels.

Lopes CM, Rohács T, Czirják G, Balla T, Enyedi P, Logothetis DE.

J Physiol. 2005 Apr 1;564(Pt 1):117-29. Epub 2005 Jan 27.

50.

Characteristic interactions with phosphatidylinositol 4,5-bisphosphate determine regulation of kir channels by diverse modulators.

Du X, Zhang H, Lopes C, Mirshahi T, Rohacs T, Logothetis DE.

J Biol Chem. 2004 Sep 3;279(36):37271-81. Epub 2004 May 20.

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