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Items: 1 to 50 of 89

1.

Commentary: Thyrotropin Stimulates Differentiation Not Proliferation of Normal Human Thyrocytes in Culture.

Kyrilli A, Paternot S, Miot F, Corvilain B, Vassart G, Roger PP, Dumont JE.

Front Endocrinol (Lausanne). 2017 Aug 25;8:214. doi: 10.3389/fendo.2017.00214. eCollection 2017. No abstract available.

2.

CDK4 phosphorylation status and a linked gene expression profile predict sensitivity to palbociclib.

Raspé E, Coulonval K, Pita JM, Paternot S, Rothé F, Twyffels L, Brohée S, Craciun L, Larsimont D, Kruys V, Sandras F, Salmon I, Van Laere S, Piccart M, Ignatiadis M, Sotiriou C, Roger PP.

EMBO Mol Med. 2017 Aug;9(8):1052-1066. doi: 10.15252/emmm.201607084.

3.

JNKs function as CDK4-activating kinases by phosphorylating CDK4 and p21.

Colleoni B, Paternot S, Pita JM, Bisteau X, Coulonval K, Davis RJ, Raspé E, Roger PP.

Oncogene. 2017 Jul 27;36(30):4349-4361. doi: 10.1038/onc.2017.7. Epub 2017 Apr 3.

4.

Ontogeny, Anatomy, Metabolism and Physiology of the Thyroid.

Maenhaut C, Christophe D, Vassart G, Dumont J, Roger PP, Opitz R.

In: Feingold KR, Anawalt B, Boyce A, Chrousos G, Dungan K, Grossman A, Hershman JM, Kaltsas G, Koch C, Kopp P, Korbonits M, McLachlan R, Morley JE, New M, Perreault L, Purnell J, Rebar R, Singer F, Trence DL, Vinik A, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-.
2015 Jul 15.

5.

Inhibitory effects of 2-iodohexadecanal on FRTL-5 thyroid cells proliferation.

Thomasz L, Coulonval K, Salvarredi L, Oglio R, Fusco A, Rossich L, Pisarev MA, Roger PP, Juvenal GJ.

Mol Cell Endocrinol. 2015 Mar 15;404:123-31. doi: 10.1016/j.mce.2015.01.038. Epub 2015 Feb 2.

PMID:
25657048
6.

The CDK4/CDK6 inhibitor PD0332991 paradoxically stabilizes activated cyclin D3-CDK4/6 complexes.

Paternot S, Colleoni B, Bisteau X, Roger PP.

Cell Cycle. 2014;13(18):2879-88. doi: 10.4161/15384101.2014.946841.

7.

Catecholamine-induced lipolysis causes mTOR complex dissociation and inhibits glucose uptake in adipocytes.

Mullins GR, Wang L, Raje V, Sherwood SG, Grande RC, Boroda S, Eaton JM, Blancquaert S, Roger PP, Leitinger N, Harris TE.

Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17450-5. doi: 10.1073/pnas.1410530111. Epub 2014 Nov 24.

8.

SHIP2 signaling in normal and pathological situations: Its impact on cell proliferation.

Elong Edimo W, Schurmans S, Roger PP, Erneux C.

Adv Biol Regul. 2014 Jan;54:142-51. doi: 10.1016/j.jbior.2013.09.002. Epub 2013 Sep 15. Review.

PMID:
24091101
9.

Acetylation at lysine 346 controls the transforming activity of the HTLV-1 Tax oncoprotein in the Rat-1 fibroblast model.

Lodewick J, Sampaio C, Boxus M, Rinaldi AS, Coulonval K, Willems L, Roger PP, Bex F.

Retrovirology. 2013 Jul 23;10:75. doi: 10.1186/1742-4690-10-75.

10.

CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point.

Bisteau X, Paternot S, Colleoni B, Ecker K, Coulonval K, De Groote P, Declercq W, Hengst L, Roger PP.

PLoS Genet. 2013 May;9(5):e1003546. doi: 10.1371/journal.pgen.1003546. Epub 2013 May 30.

11.

p53 promotes VEGF expression and angiogenesis in the absence of an intact p21-Rb pathway.

Farhang Ghahremani M, Goossens S, Nittner D, Bisteau X, Bartunkova S, Zwolinska A, Hulpiau P, Haigh K, Haenebalcke L, Drogat B, Jochemsen A, Roger PP, Marine JC, Haigh JJ.

Cell Death Differ. 2013 Jul;20(7):888-97. doi: 10.1038/cdd.2013.12. Epub 2013 Mar 1.

12.

Coupling of T161 and T14 phosphorylations protects cyclin B-CDK1 from premature activation.

Coulonval K, Kooken H, Roger PP.

Mol Biol Cell. 2011 Nov;22(21):3971-85. doi: 10.1091/mbc.E11-02-0136. Epub 2011 Sep 7.

13.

cAMP-dependent activation of mammalian target of rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4.

Blancquaert S, Wang L, Paternot S, Coulonval K, Dumont JE, Harris TE, Roger PP.

Mol Endocrinol. 2010 Jul;24(7):1453-68. doi: 10.1210/me.2010-0087. Epub 2010 May 19.

14.

Rb inactivation in cell cycle and cancer: the puzzle of highly regulated activating phosphorylation of CDK4 versus constitutively active CDK-activating kinase.

Paternot S, Bockstaele L, Bisteau X, Kooken H, Coulonval K, Roger PP.

Cell Cycle. 2010 Feb 15;9(4):689-99. Epub 2010 Feb 12. Review.

PMID:
20107323
15.

Signal transduction in the human thyrocyte and its perversion in thyroid tumors.

Roger PP, van Staveren WC, Coulonval K, Dumont JE, Maenhaut C.

Mol Cell Endocrinol. 2010 May 28;321(1):3-19. doi: 10.1016/j.mce.2009.11.015. Epub 2009 Dec 3. Review.

PMID:
19962425
16.

Cancer stem cells: a reality, a myth, a fuzzy concept or a misnomer? An analysis.

Maenhaut C, Dumont JE, Roger PP, van Staveren WC.

Carcinogenesis. 2010 Feb;31(2):149-58. doi: 10.1093/carcin/bgp259. Epub 2009 Oct 25. Review.

PMID:
19858069
17.

Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation.

Bockstaele L, Bisteau X, Paternot S, Roger PP.

Mol Cell Biol. 2009 Aug;29(15):4188-200. doi: 10.1128/MCB.01823-08. Epub 2009 Jun 1.

18.
19.

Thyroid gene expression in familial nonautoimmune hyperthyroidism shows common characteristics with hyperfunctioning autonomous adenomas.

Hébrant A, Van Sande J, Roger PP, Patey M, Klein M, Bournaud C, Savagner F, Leclère J, Dumont JE, van Staveren WC, Maenhaut C.

J Clin Endocrinol Metab. 2009 Jul;94(7):2602-9. doi: 10.1210/jc.2008-2191. Epub 2009 Apr 21.

PMID:
19383781
20.

Cyclic AMP inhibits the proliferation of thyroid carcinoma cell lines through regulation of CDK4 phosphorylation.

Rocha AS, Paternot S, Coulonval K, Dumont JE, Soares P, Roger PP.

Mol Biol Cell. 2008 Nov;19(11):4814-25. doi: 10.1091/mbc.E08-06-0617. Epub 2008 Sep 17.

21.

Cyclic adenosine 3',5'-monophosphate (cAMP)-dependent protein kinases, but not exchange proteins directly activated by cAMP (Epac), mediate thyrotropin/cAMP-dependent regulation of thyroid cells.

Dremier S, Milenkovic M, Blancquaert S, Dumont JE, Døskeland SO, Maenhaut C, Roger PP.

Endocrinology. 2007 Oct;148(10):4612-22. Epub 2007 Jun 21.

PMID:
17584967
22.

Regulation of CDK4.

Bockstaele L, Coulonval K, Kooken H, Paternot S, Roger PP.

Cell Div. 2006 Nov 8;1:25.

23.
24.

Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors".

Bockstaele L, Kooken H, Libert F, Paternot S, Dumont JE, de Launoit Y, Roger PP, Coulonval K.

Mol Cell Biol. 2006 Jul;26(13):5070-85.

25.

G1/S Cyclins interact with regulatory subunit of PKA via A-kinase anchoring protein, AKAP95.

Arsenijevic T, Degraef C, Dumont JE, Roger PP, Pirson I.

Cell Cycle. 2006 Jun;5(11):1217-22. Epub 2006 Jun 1.

PMID:
16721056
26.

Distinct specificities of pRb phosphorylation by CDK4 activated by cyclin D1 or cyclin D3: differential involvement in the distinct mitogenic modes of thyroid epithelial cells.

Paternot S, Arsenijevic T, Coulonval K, Bockstaele L, Dumont JE, Roger PP.

Cell Cycle. 2006 Jan;5(1):61-70. Epub 2006 Jan 18.

PMID:
16294008
27.
28.

A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95.

Arsenijevic T, Degraef C, Dumont JE, Roger PP, Pirson I.

Biochem J. 2004 Mar 1;378(Pt 2):673-9.

30.

Phosphorylations of cyclin-dependent kinase 2 revisited using two-dimensional gel electrophoresis.

Coulonval K, Bockstaele L, Paternot S, Roger PP.

J Biol Chem. 2003 Dec 26;278(52):52052-60. Epub 2003 Oct 9.

31.

Cyclic AMP-dependent phosphorylation of cyclin D3-bound CDK4 determines the passage through the cell cycle restriction point in thyroid epithelial cells.

Paternot S, Coulonval K, Dumont JE, Roger PP.

J Biol Chem. 2003 Jul 18;278(29):26533-40. Epub 2003 Apr 30.

32.

Growth and proliferation of the thyroid cell in normal physiology and in disease.

Dumont JE, Maenhaut C, Lamy F, Pirson I, Clement S, Roger PP.

Ann Endocrinol (Paris). 2003 Feb;64(1):10-1. Review. No abstract available.

PMID:
12707625
33.

The role of cyclic AMP and its effect on protein kinase A in the mitogenic action of thyrotropin on the thyroid cell.

Dremier S, Coulonval K, Perpete S, Vandeput F, Fortemaison N, Van Keymeulen A, Deleu S, Ledent C, Clément S, Schurmans S, Dumont JE, Lamy F, Roger PP, Maenhaut C.

Ann N Y Acad Sci. 2002 Jun;968:106-21. Review.

PMID:
12119271
34.

Regulation of thyroid cell proliferation by TSH and other factors: a critical evaluation of in vitro models.

Kimura T, Van Keymeulen A, Golstein J, Fusco A, Dumont JE, Roger PP.

Endocr Rev. 2001 Oct;22(5):631-56. Review.

PMID:
11588145
35.

Respective roles of carbamylcholine and cyclic adenosine monophosphate in their synergistic regulation of cell cycle in thyroid primary cultures.

Van Keymeulen A, Deleu S, Bartek J, Dumont JE, Roger PP.

Endocrinology. 2001 Mar;142(3):1251-9.

PMID:
11181542
36.

TSH induces insulin receptors that mediate insulin costimulation of growth in normal human thyroid cells.

Van Keymeulen A, Dumont JE, Roger PP.

Biochem Biophys Res Commun. 2000 Dec 9;279(1):202-7.

PMID:
11112439
37.

TSH and cAMP do not signal mitogenesis through Ras activation.

Van Keymeulen A, Roger PP, Dumont JE, Dremier S.

Biochem Biophys Res Commun. 2000 Jun 24;273(1):154-8.

PMID:
10873578
39.
40.
41.

Critical residues of the homeodomain involved in contacting DNA bases also specify the nuclear accumulation of thyroid transcription factor-1.

Christophe-Hobertus C, Duquesne V, Pichon B, Roger PP, Christophe D.

Eur J Biochem. 1999 Oct 1;265(1):491-7.

42.

IGF-1 or insulin, and the TSH cyclic AMP cascade separately control dog and human thyroid cell growth and DNA synthesis, and complement each other in inducing mitogenesis.

Deleu S, Pirson I, Coulonval K, Drouin A, Taton M, Clermont F, Roger PP, Nakamura T, Dumont JE, Maenhaut C.

Mol Cell Endocrinol. 1999 Mar 25;149(1-2):41-51.

PMID:
10375016
43.

A requirement for cyclin D3-cyclin-dependent kinase (cdk)-4 assembly in the cyclic adenosine monophosphate-dependent proliferation of thyrocytes.

Depoortere F, Van Keymeulen A, Lukas J, Costagliola S, Bartkova J, Dumont JE, Bartek J, Roger PP, Dremier S.

J Cell Biol. 1998 Mar 23;140(6):1427-39.

44.

The dog thyroid primary culture system: a model of the regulation of function, growth and differentiation expression by cAMP and other well-defined signaling cascades.

Roger PP, Christophe D, Dumont JE, Pirson I.

Eur J Endocrinol. 1997 Dec;137(6):579-98. Review. No abstract available.

PMID:
9437219
45.

Activation of cyclic AMP-dependent kinase is required but may not be sufficient to mimic cyclic AMP-dependent DNA synthesis and thyroglobulin expression in dog thyroid cells.

Dremier S, Pohl V, Poteet-Smith C, Roger PP, Corbin J, Doskeland SO, Dumont JE, Maenhaut C.

Mol Cell Biol. 1997 Nov;17(11):6717-26.

48.

Thyrotropin-dependent transforming growth factor beta expression in thyroid gland.

Roger PP.

Eur J Endocrinol. 1996 Mar;134(3):269-71. Review. No abstract available.

PMID:
8616522

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