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Items: 1 to 50 of 227

1.

Determination of minimal steady-state plasma level of diazepam causing seizure threshold elevation in rats.

Dhir A, Rogawski MA.

Epilepsia. 2018 May;59(5):935-944. doi: 10.1111/epi.14069. Epub 2018 Apr 6.

PMID:
29682729
2.

Intramuscular allopregnanolone and ganaxolone in a mouse model of treatment-resistant status epilepticus.

Zolkowska D, Wu CY, Rogawski MA.

Epilepsia. 2018 Feb 17. doi: 10.1111/epi.13999. [Epub ahead of print]

PMID:
29453777
3.

Commonalities in epileptogenic processes from different acute brain insults: Do they translate?

Klein P, Dingledine R, Aronica E, Bernard C, Blümcke I, Boison D, Brodie MJ, Brooks-Kayal AR, Engel J Jr, Forcelli PA, Hirsch LJ, Kaminski RM, Klitgaard H, Kobow K, Lowenstein DH, Pearl PL, Pitkänen A, Puhakka N, Rogawski MA, Schmidt D, Sillanpää M, Sloviter RS, Steinhäuser C, Vezzani A, Walker MC, Löscher W.

Epilepsia. 2018 Jan;59(1):37-66. doi: 10.1111/epi.13965. Epub 2017 Dec 15. Review.

PMID:
29247482
4.

Defective GABAergic neurotransmission in the nucleus tractus solitarius in Mecp2-null mice, a model of Rett syndrome.

Chen CY, Di Lucente J, Lin YC, Lien CC, Rogawski MA, Maezawa I, Jin LW.

Neurobiol Dis. 2018 Jan;109(Pt A):25-32. doi: 10.1016/j.nbd.2017.09.006. Epub 2017 Sep 18.

PMID:
28927958
5.

Open-Label Allopregnanolone Treatment of Men with Fragile X-Associated Tremor/Ataxia Syndrome.

Wang JY, Trivedi AM, Carrillo NR, Yang J, Schneider A, Giulivi C, Adams P, Tassone F, Kim K, Rivera SM, Lubarr N, Wu CY, Irwin RW, Brinton RD, Olichney JM, Rogawski MA, Hagerman RJ.

Neurotherapeutics. 2017 Oct;14(4):1073-1083. doi: 10.1007/s13311-017-0555-6.

PMID:
28707277
6.

First-in-man allopregnanolone use in super-refractory status epilepticus.

Vaitkevicius H, Husain AM, Rosenthal ES, Rosand J, Bobb W, Reddy K, Rogawski MA, Cole AJ.

Ann Clin Transl Neurol. 2017 Apr 26;4(6):411-414. doi: 10.1002/acn3.408. eCollection 2017 Jun.

7.

Transcriptional profile of hippocampal dentate granule cells in four rat epilepsy models.

Dingledine R, Coulter DA, Fritsch B, Gorter JA, Lelutiu N, McNamara J, Nadler JV, Pitkänen A, Rogawski MA, Skene P, Sloviter RS, Wang Y, Wadman WJ, Wasterlain C, Roopra A.

Sci Data. 2017 May 9;4:170061. doi: 10.1038/sdata.2017.61.

8.

Rapid Throughput Analysis of GABAA Receptor Subtype Modulators and Blockers Using DiSBAC1(3) Membrane Potential Red Dye.

Nik AM, Pressly B, Singh V, Antrobus S, Hulsizer S, Rogawski MA, Wulff H, Pessah IN.

Mol Pharmacol. 2017 Jul;92(1):88-99. doi: 10.1124/mol.117.108563. Epub 2017 Apr 20.

9.

Allopregnanolone decreases interictal spiking and fast ripples in an animal model of mesial temporal lobe epilepsy.

Lévesque M, Herrington R, Leclerc L, Rogawski MA, Avoli M.

Neuropharmacology. 2017 Jul 15;121:12-19. doi: 10.1016/j.neuropharm.2017.04.020. Epub 2017 Apr 15.

PMID:
28416442
10.

Effects of the synthetic neurosteroid ganaxolone on seizure activity and behavioral deficits in an Angelman syndrome mouse model.

Ciarlone SL, Wang X, Rogawski MA, Weeber EJ.

Neuropharmacology. 2017 Apr;116:142-150. doi: 10.1016/j.neuropharm.2016.12.009. Epub 2016 Dec 13.

PMID:
27986596
11.

A New SV2A Ligand for Epilepsy.

Rogawski MA.

Cell. 2016 Oct 20;167(3):587. doi: 10.1016/j.cell.2016.09.057.

12.

Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents.

Pessah IN, Rogawski MA, Tancredi DJ, Wulff H, Zolkowska D, Bruun DA, Hammock BD, Lein PJ.

Ann N Y Acad Sci. 2016 Aug;1378(1):124-136. doi: 10.1111/nyas.13137. Epub 2016 Jul 28. Review.

13.

A fatty acid in the MCT ketogenic diet for epilepsy treatment blocks AMPA receptors.

Rogawski MA.

Brain. 2016 Feb;139(Pt 2):306-9. doi: 10.1093/brain/awv369. No abstract available.

PMID:
26912516
14.

Mechanisms of Action of Antiseizure Drugs and the Ketogenic Diet.

Rogawski MA, Löscher W, Rho JM.

Cold Spring Harb Perspect Med. 2016 May 2;6(5). pii: a022780. doi: 10.1101/cshperspect.a022780. Review.

15.

Is a separate monotherapy indication warranted for antiepileptic drugs?

Mintzer S, French JA, Perucca E, Cramer JA, Messenheimer JA, Blum DE, Rogawski MA, Baulac M.

Lancet Neurol. 2015 Dec;14(12):1229-40. doi: 10.1016/S1474-4422(15)00229-X. Review.

PMID:
26581972
16.

Evaluation of the neuroactive steroid ganaxolone on social and repetitive behaviors in the BTBR mouse model of autism.

Kazdoba TM, Hagerman RJ, Zolkowska D, Rogawski MA, Crawley JN.

Psychopharmacology (Berl). 2016 Jan;233(2):309-23. doi: 10.1007/s00213-015-4115-7. Epub 2015 Nov 3.

17.

Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the α1 β3 γ2L GABAA receptor account for their in vivo effects.

Desai R, Savechenkov PY, Zolkowska D, Ge RL, Rogawski MA, Bruzik KS, Forman SA, Raines DE, Miller KW.

J Physiol. 2015 Nov 15;593(22):4943-61. doi: 10.1113/JP270971.

18.

Allopregnanolone preclinical acute pharmacokinetic and pharmacodynamic studies to predict tolerability and efficacy for Alzheimer's disease.

Irwin RW, Solinsky CM, Loya CM, Salituro FG, Rodgers KE, Bauer G, Rogawski MA, Brinton RD.

PLoS One. 2015 Jun 3;10(6):e0128313. doi: 10.1371/journal.pone.0128313. eCollection 2015. Erratum in: PLoS One. 2015;10(6):e0132210.

19.

Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures.

Bruun DA, Cao Z, Inceoglu B, Vito ST, Austin AT, Hulsizer S, Hammock BD, Tancredi DJ, Rogawski MA, Pessah IN, Lein PJ.

Neuropharmacology. 2015 Aug;95:332-42. doi: 10.1016/j.neuropharm.2015.03.035. Epub 2015 Apr 14.

20.

Current understanding of the mechanism of action of the antiepileptic drug lacosamide.

Rogawski MA, Tofighy A, White HS, Matagne A, Wolff C.

Epilepsy Res. 2015 Feb;110:189-205. doi: 10.1016/j.eplepsyres.2014.11.021. Epub 2014 Dec 3. Review.

PMID:
25616473
21.

Post-exposure administration of diazepam combined with soluble epoxide hydrolase inhibition stops seizures and modulates neuroinflammation in a murine model of acute TETS intoxication.

Vito ST, Austin AT, Banks CN, Inceoglu B, Bruun DA, Zolkowska D, Tancredi DJ, Rogawski MA, Hammock BD, Lein PJ.

Toxicol Appl Pharmacol. 2014 Dec 1;281(2):185-94. doi: 10.1016/j.taap.2014.10.001. Epub 2014 Oct 14.

22.

Pediatric super-refractory status epilepticus treated with allopregnanolone.

Broomall E, Natale JE, Grimason M, Goldstein J, Smith CM, Chang C, Kanes S, Rogawski MA, Wainwright MS.

Ann Neurol. 2014 Dec;76(6):911-5. doi: 10.1002/ana.24295. Epub 2014 Nov 11.

23.

The riluzole derivative 2-amino-6-trifluoromethylthio-benzothiazole (SKA-19), a mixed KCa2 activator and NaV blocker, is a potent novel anticonvulsant.

Coleman N, Nguyen HM, Cao Z, Brown BM, Jenkins DP, Zolkowska D, Chen YJ, Tanaka BS, Goldin AL, Rogawski MA, Pessah IN, Wulff H.

Neurotherapeutics. 2015 Jan;12(1):234-49. doi: 10.1007/s13311-014-0305-y.

24.

Perampanel inhibition of AMPA receptor currents in cultured hippocampal neurons.

Chen CY, Matt L, Hell JW, Rogawski MA.

PLoS One. 2014 Sep 17;9(9):e108021. doi: 10.1371/journal.pone.0108021. eCollection 2014.

25.

Role of GluK1 kainate receptors in seizures, epileptic discharges, and epileptogenesis.

Fritsch B, Reis J, Gasior M, Kaminski RM, Rogawski MA.

J Neurosci. 2014 Apr 23;34(17):5765-75. doi: 10.1523/JNEUROSCI.5307-13.2014.

26.

Anticonvulsant potencies of the enantiomers of the neurosteroids androsterone and etiocholanolone exceed those of the natural forms.

Zolkowska D, Dhir A, Krishnan K, Covey DF, Rogawski MA.

Psychopharmacology (Berl). 2014 Sep;231(17):3325-32. doi: 10.1007/s00213-014-3546-x. Epub 2014 Apr 5.

27.

The potential of antiseizure drugs and agents that act on novel molecular targets as antiepileptogenic treatments.

Kaminski RM, Rogawski MA, Klitgaard H.

Neurotherapeutics. 2014 Apr;11(2):385-400. doi: 10.1007/s13311-014-0266-1. Review.

28.

Epoxy fatty acids and inhibition of the soluble epoxide hydrolase selectively modulate GABA mediated neurotransmission to delay onset of seizures.

Inceoglu B, Zolkowska D, Yoo HJ, Wagner KM, Yang J, Hackett E, Hwang SH, Lee KS, Rogawski MA, Morisseau C, Hammock BD.

PLoS One. 2013 Dec 11;8(12):e80922. doi: 10.1371/journal.pone.0080922. eCollection 2013.

29.

Neuroactive steroids for the treatment of status epilepticus.

Rogawski MA, Loya CM, Reddy K, Zolkowska D, Lossin C.

Epilepsia. 2013 Sep;54 Suppl 6:93-8. doi: 10.1111/epi.12289. Review.

30.

Issues related to development of new antiseizure treatments.

Wilcox KS, Dixon-Salazar T, Sills GJ, Ben-Menachem E, White HS, Porter RJ, Dichter MA, Moshé SL, Noebels JL, Privitera MD, Rogawski MA.

Epilepsia. 2013 Aug;54 Suppl 4:24-34. doi: 10.1111/epi.12296. Review.

31.

Epilepsy therapy development: technical and methodologic issues in studies with animal models.

Galanopoulou AS, Kokaia M, Loeb JA, Nehlig A, Pitkänen A, Rogawski MA, Staley KJ, Whittemore VH, Dudek FE.

Epilepsia. 2013 Aug;54 Suppl 4:13-23. doi: 10.1111/epi.12295. Review.

32.

Proconvulsant actions of intrahippocampal botulinum neurotoxin B in the rat.

Bröer S, Zolkowska D, Gernert M, Rogawski MA.

Neuroscience. 2013 Nov 12;252:253-61. doi: 10.1016/j.neuroscience.2013.07.050. Epub 2013 Jul 29.

33.

Seizure protection by intrapulmonary delivery of midazolam in mice.

Dhir A, Zolkowska D, Rogawski MA.

Neuropharmacology. 2013 Oct;73:425-31. doi: 10.1016/j.neuropharm.2013.06.002. Epub 2013 Jun 15.

PMID:
23774136
34.

Long-lasting attenuation of amygdala-kindled seizures after convection-enhanced delivery of botulinum neurotoxins a and B into the amygdala in rats.

Gasior M, Tang R, Rogawski MA.

J Pharmacol Exp Ther. 2013 Sep;346(3):528-34. doi: 10.1124/jpet.113.205070. Epub 2013 Jun 14.

35.

The intrinsic severity hypothesis of pharmacoresistance to antiepileptic drugs.

Rogawski MA.

Epilepsia. 2013 May;54 Suppl 2:33-40. doi: 10.1111/epi.12182. Review.

36.

Preclinical pharmacology of perampanel, a selective non-competitive AMPA receptor antagonist.

Rogawski MA, Hanada T.

Acta Neurol Scand Suppl. 2013;(197):19-24. doi: 10.1111/ane.12100. Review.

37.

AMPA receptors as a molecular target in epilepsy therapy.

Rogawski MA.

Acta Neurol Scand Suppl. 2013;(197):9-18. doi: 10.1111/ane.12099. Review.

38.

Glia and epilepsy: excitability and inflammation.

Devinsky O, Vezzani A, Najjar S, De Lanerolle NC, Rogawski MA.

Trends Neurosci. 2013 Mar;36(3):174-84. doi: 10.1016/j.tins.2012.11.008. Epub 2013 Jan 5. Review.

PMID:
23298414
39.

How theories evolved concerning the mechanism of action of barbiturates.

Löscher W, Rogawski MA.

Epilepsia. 2012 Dec;53 Suppl 8:12-25. doi: 10.1111/epi.12025.

40.

Mechanisms of action of antiseizure drugs.

Porter RJ, Dhir A, Macdonald RL, Rogawski MA.

Handb Clin Neurol. 2012;108:663-81. doi: 10.1016/B978-0-444-52899-5.00021-6. Review. No abstract available.

PMID:
22939059
41.

Altered fast and slow inactivation of the N440K Nav1.4 mutant in a periodic paralysis syndrome.

Lossin C, Nam TS, Shahangian S, Rogawski MA, Choi SY, Kim MK, Sunwoo IN.

Neurology. 2012 Sep 4;79(10):1033-40. doi: 10.1212/WNL.0b013e3182684683. Epub 2012 Aug 22.

PMID:
22914841
42.

Tetramethylenedisulfotetramine alters Ca²⁺ dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation.

Cao Z, Hammock BD, McCoy M, Rogawski MA, Lein PJ, Pessah IN.

Toxicol Sci. 2012 Dec;130(2):362-72. doi: 10.1093/toxsci/kfs244. Epub 2012 Aug 13.

43.

Adjunctive perampanel for refractory partial-onset seizures: randomized phase III study 304.

French JA, Krauss GL, Biton V, Squillacote D, Yang H, Laurenza A, Kumar D, Rogawski MA.

Neurology. 2012 Aug 7;79(6):589-96. doi: 10.1212/WNL.0b013e3182635735. Epub 2012 Jul 25.

44.

Migraine and Epilepsy—Shared Mechanisms within the Family of Episodic Disorders.

Rogawski MA.

In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, editors. Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition. Bethesda (MD): National Center for Biotechnology Information (US); 2012.

45.

Neurosteroids — Endogenous Regulators of Seizure Susceptibility and Role in the Treatment of Epilepsy.

Reddy DS, Rogawski MA.

In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, editors. Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition. Bethesda (MD): National Center for Biotechnology Information (US); 2012.

46.

Compromised function in the Na(v)1.2 Dravet syndrome mutation R1312T.

Lossin C, Shi X, Rogawski MA, Hirose S.

Neurobiol Dis. 2012 Sep;47(3):378-84. doi: 10.1016/j.nbd.2012.05.017. Epub 2012 Jun 4.

PMID:
22677033
47.

Clustered burst firing in FMR1 premutation hippocampal neurons: amelioration with allopregnanolone.

Cao Z, Hulsizer S, Tassone F, Tang HT, Hagerman RJ, Rogawski MA, Hagerman PJ, Pessah IN.

Hum Mol Genet. 2012 Jul 1;21(13):2923-35. doi: 10.1093/hmg/dds118. Epub 2012 Mar 30.

48.

Propofol hemisuccinate suppresses cortical spreading depression.

Dhir A, Lossin C, Rogawski MA.

Neurosci Lett. 2012 Apr 11;514(1):67-70. doi: 10.1016/j.neulet.2012.02.058. Epub 2012 Feb 25.

PMID:
22390898
49.

Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine.

Zolkowska D, Banks CN, Dhir A, Inceoglu B, Sanborn JR, McCoy MR, Bruun DA, Hammock BD, Lein PJ, Rogawski MA.

J Pharmacol Exp Ther. 2012 May;341(2):435-46. doi: 10.1124/jpet.111.190579. Epub 2012 Feb 10.

50.

Role of neurosteroids in the anticonvulsant activity of midazolam.

Dhir A, Rogawski MA.

Br J Pharmacol. 2012 Apr;165(8):2684-91. doi: 10.1111/j.1476-5381.2011.01733.x.

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