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Premature Drug Release from Polyethylene Glycol (PEG)-Coated Liposomal Doxorubicin via Formation of the Membrane Attack Complex.

Chen E, Chen BM, Su YC, Chang YC, Cheng TL, Barenholz Y, Roffler SR.

ACS Nano. 2020 Mar 6. doi: 10.1021/acsnano.9b07218. [Epub ahead of print]


PEGylated Liposomal Methyl Prednisolone Succinate does not Induce Infusion Reactions in Patients: A Correlation Between in Vitro Immunological and in Vivo Clinical Studies.

Bavli Y, Chen BM, Roffler SR, Dobrovolskaia MA, Elnekave E, Ash S, Barenholz Y, Turjeman K.

Molecules. 2020 Jan 28;25(3). pii: E558. doi: 10.3390/molecules25030558.


Structural basis of polyethylene glycol recognition by antibody.

Lee CC, Su YC, Ko TP, Lin LL, Yang CY, Chang SS, Roffler SR, Wang AH.

J Biomed Sci. 2020 Jan 7;27(1):12. doi: 10.1186/s12929-019-0589-7.


Enhanced drug internalization and therapeutic efficacy of PEGylated nanoparticles by one-step formulation with anti-mPEG bispecific antibody in intrinsic drug-resistant breast cancer.

Cheng YA, Chen IJ, Su YC, Cheng KW, Lu YC, Lin WW, Hsieh YC, Kao CH, Chen FM, Roffler SR, Cheng TL.

Biomater Sci. 2019 Aug 1;7(8):3404-3417. doi: 10.1039/c9bm00323a. Epub 2019 Jun 28.


Simply Mixing Poly Protein G with Detection Antibodies Enhances the Detection Limit and Sensitivity of Immunoassays.

Chen YJ, Chen M, Cheng TL, Roffler SR, Lin SY, Hsu HL, Wang CH, Chen CY, Kao AP, Cheng JJ, Chuang KH.

Anal Chem. 2019 Jul 2;91(13):8310-8317. doi: 10.1021/acs.analchem.9b01077. Epub 2019 Jun 13.


Transient AID expression for in situ mutagenesis with improved cellular fitness.

Al-Qaisi TS, Su YC, Roffler SR.

Sci Rep. 2018 Jun 20;8(1):9413. doi: 10.1038/s41598-018-27717-2.


Pre-existing anti-polyethylene glycol antibody reduces the therapeutic efficacy and pharmacokinetics of PEGylated liposomes.

Hsieh YC, Wang HE, Lin WW, Roffler SR, Cheng TC, Su YC, Li JJ, Chen CC, Huang CH, Chen BM, Wang JY, Cheng TL, Chen FM.

Theranostics. 2018 May 9;8(11):3164-3175. doi: 10.7150/thno.22164. eCollection 2018.


Reversible glycosidic switch for secure delivery of molecular nanocargos.

Burnouf PA, Leu YL, Su YC, Wu K, Lin WC, Roffler SR.

Nat Commun. 2018 May 10;9(1):1843. doi: 10.1038/s41467-018-04225-5.


High-Affinity Ligands Can Trigger T Cell Receptor Signaling Without CD45 Segregation.

Al-Aghbar MA, Chu YS, Chen BM, Roffler SR.

Front Immunol. 2018 Apr 9;9:713. doi: 10.3389/fimmu.2018.00713. eCollection 2018.


A genome-wide association study identifies a novel susceptibility locus for the immunogenicity of polyethylene glycol.

Chang CJ, Chen CH, Chen BM, Su YC, Chen YT, Hershfield MS, Lee MM, Cheng TL, Chen YT, Roffler SR, Wu JY.

Nat Commun. 2017 Sep 12;8(1):522. doi: 10.1038/s41467-017-00622-4.


The Affinity of Elongated Membrane-Tethered Ligands Determines Potency of T Cell Receptor Triggering.

Chen BM, Al-Aghbar MA, Lee CH, Chang TC, Su YC, Li YC, Chang SE, Chen CC, Chung TH, Liao YC, Lee CH, Roffler SR.

Front Immunol. 2017 Jul 10;8:793. doi: 10.3389/fimmu.2017.00793. eCollection 2017.


Conditional internalization of PEGylated nanomedicines by PEG engagers for triple negative breast cancer therapy.

Su YC, Burnouf PA, Chuang KH, Chen BM, Cheng TL, Roffler SR.

Nat Commun. 2017 Jun 8;8:15507. doi: 10.1038/ncomms15507.


Enhancement Effect of a Variable Topology of a Membrane-Tethered Anti-Poly(ethylene glycol) Antibody on the Sensitivity for Quantifying PEG and PEGylated Molecules.

Lin WW, Cheng YA, Kao CH, Roffler SR, Lee YC, Chen BM, Hsieh YC, Chen IJ, Huang BC, Wang YT, Tung YC, Huang MY, Chen FM, Cheng TL.

Anal Chem. 2017 Jun 6;89(11):6082-6090. doi: 10.1021/acs.analchem.7b00730. Epub 2017 May 23.


Optimization of an Anti-poly(ethylene glycol) (anti-PEG) Cell-Based Capture System To Quantify PEG and PEGylated Molecules.

Lin WW, Hsieh YC, Cheng YA, Chuang KH, Huang CC, Chuang CH, Chen IJ, Cheng KW, Lu YC, Cheng TC, Wang YT, Roffler SR, Cheng TL.

Anal Chem. 2016 Dec 20;88(24):12371-12379. doi: 10.1021/acs.analchem.6b03614. Epub 2016 Nov 30.


Using anti-poly(ethylene glycol) bioparticles for the quantitation of PEGylated nanoparticles.

Hsieh YC, Cheng TC, Wang HE, Li JJ, Lin WW, Huang CC, Chuang CH, Wang YT, Wang JY, Roffler SR, Chuang KH, Cheng TL.

Sci Rep. 2016 Dec 19;6:39119. doi: 10.1038/srep39119.


Reloadable multidrug capturing delivery system for targeted ischemic disease treatment.

Wu JP, Cheng B, Roffler SR, Lundy DJ, Yen CY, Chen P, Lai JJ, Pun SH, Stayton PS, Hsieh PC.

Sci Transl Med. 2016 Nov 16;8(365):365ra160.


Endothelial SCUBE2 Interacts With VEGFR2 and Regulates VEGF-Induced Angiogenesis.

Lin YC, Chao TY, Yeh CT, Roffler SR, Kannagi R, Yang RB.

Arterioscler Thromb Vasc Biol. 2017 Jan;37(1):144-155. doi: 10.1161/ATVBAHA.116.308546. Epub 2016 Nov 10.


Measurement of Pre-Existing IgG and IgM Antibodies against Polyethylene Glycol in Healthy Individuals.

Chen BM, Su YC, Chang CJ, Burnouf PA, Chuang KH, Chen CH, Cheng TL, Chen YT, Wu JY, Roffler SR.

Anal Chem. 2016 Nov 1;88(21):10661-10666. Epub 2016 Oct 21.


A Secondary Antibody-Detecting Molecular Weight Marker with Mouse and Rabbit IgG Fc Linear Epitopes for Western Blot Analysis.

Lin WW, Chen IJ, Cheng TC, Tung YC, Chu PY, Chuang CH, Hsieh YC, Huang CC, Wang YT, Kao CH, Roffler SR, Cheng TL.

PLoS One. 2016 Aug 5;11(8):e0160418. doi: 10.1371/journal.pone.0160418. eCollection 2016.


Anti-PEG antibodies alter the mobility and biodistribution of densely PEGylated nanoparticles in mucus.

Henry CE, Wang YY, Yang Q, Hoang T, Chattopadhyay S, Hoen T, Ensign LM, Nunn KL, Schroeder H, McCallen J, Moench T, Cone R, Roffler SR, Lai SK.

Acta Biomater. 2016 Oct 1;43:61-70. doi: 10.1016/j.actbio.2016.07.019. Epub 2016 Jul 14.


Display of GPI-anchored anti-EGFR nanobodies on extracellular vesicles promotes tumour cell targeting.

Kooijmans SA, Aleza CG, Roffler SR, van Solinge WW, Vader P, Schiffelers RM.

J Extracell Vesicles. 2016 Mar 14;5:31053. doi: 10.3402/jev.v5.31053. eCollection 2016.


Synthesis and Antitumor Properties of BQC-Glucuronide, a Camptothecin Prodrug for Selective Tumor Activation.

Prijovich ZM, Burnouf PA, Chou HC, Huang PT, Chen KC, Cheng TL, Leu YL, Roffler SR.

Mol Pharm. 2016 Apr 4;13(4):1242-50. doi: 10.1021/acs.molpharmaceut.5b00771. Epub 2016 Mar 8.


Engineering Chimeric Receptors To Investigate the Size- and Rigidity-Dependent Interaction of PEGylated Nanoparticles with Cells.

Huang WC, Burnouf PA, Su YC, Chen BM, Chuang KH, Lee CW, Wei PK, Cheng TL, Roffler SR.

ACS Nano. 2016 Jan 26;10(1):648-62. doi: 10.1021/acsnano.5b05661. Epub 2016 Jan 13.


Effect of Cellular Location of Human Carboxylesterase 2 on CPT-11 Hydrolysis and Anticancer Activity.

Hsieh YT, Lin HP, Chen BM, Huang PT, Roffler SR.

PLoS One. 2015 Oct 28;10(10):e0141088. doi: 10.1371/journal.pone.0141088. eCollection 2015.


Toward reducing immunogenicity of enzyme replacement therapy: altering the specificity of human β-glucuronidase to compensate for α-iduronidase deficiency.

Chuang HY, Suen CS, Hwang MJ, Roffler SR.

Protein Eng Des Sel. 2015 Nov;28(11):519-29. doi: 10.1093/protein/gzv041. Epub 2015 Aug 28.


Selective Delivery of PEGylated Compounds to Tumor Cells by Anti-PEG Hybrid Antibodies.

Tung HY, Su YC, Chen BM, Burnouf PA, Huang WC, Chuang KH, Yan YT, Cheng TL, Roffler SR.

Mol Cancer Ther. 2015 Jun;14(6):1317-26. doi: 10.1158/1535-7163.MCT-15-0151. Epub 2015 Apr 7.


Discovery of specific inhibitors for intestinal E. coli  β-glucuronidase through in silico virtual screening.

Cheng TC, Chuang KH, Roffler SR, Cheng KW, Leu YL, Chuang CH, Huang CC, Kao CH, Hsieh YC, Chang LS, Cheng TL, Chen CS.

ScientificWorldJournal. 2015;2015:740815. doi: 10.1155/2015/740815. Epub 2015 Mar 9.


Impediments to enhancement of CPT-11 anticancer activity by E. coli directed beta-glucuronidase therapy.

Hsieh YT, Chen KC, Cheng CM, Cheng TL, Tao MH, Roffler SR.

PLoS One. 2015 Feb 17;10(2):e0118028. doi: 10.1371/journal.pone.0118028. eCollection 2015.


Disruption of Scube2 Impairs Endochondral Bone Formation.

Lin YC, Roffler SR, Yan YT, Yang RB.

J Bone Miner Res. 2015 Jul;30(7):1255-67. doi: 10.1002/jbmr.2451.


PET imaging of β-glucuronidase activity by an activity-based 124I-trapping probe for the personalized glucuronide prodrug targeted therapy.

Su YC, Cheng TC, Leu YL, Roffler SR, Wang JY, Chuang CH, Kao CH, Chen KC, Wang HE, Cheng TL.

Mol Cancer Ther. 2014 Dec;13(12):2852-63. doi: 10.1158/1535-7163.MCT-14-0212. Epub 2014 Oct 2.


One-step mixing with humanized anti-mPEG bispecific antibody enhances tumor accumulation and therapeutic efficacy of mPEGylated nanoparticles.

Kao CH, Wang JY, Chuang KH, Chuang CH, Cheng TC, Hsieh YC, Tseng YL, Chen BM, Roffler SR, Cheng TL.

Biomaterials. 2014 Dec;35(37):9930-9940. doi: 10.1016/j.biomaterials.2014.08.032. Epub 2014 Sep 8.


High-throughput sorting of the highest producing cell via a transiently protein-anchored system.

Chuang KH, Hsieh YC, Chiang IS, Chuang CH, Kao CH, Cheng TC, Wang YT, Lin WW, Chen BM, Roffler SR, Huang MY, Cheng TL.

PLoS One. 2014 Jul 18;9(7):e102569. doi: 10.1371/journal.pone.0102569. eCollection 2014.


Mimicking the germinal center reaction in hybridoma cells to isolate temperature-selective anti-PEG antibodies.

Su YC, Al-Qaisi TS, Tung HY, Cheng TL, Chuang KH, Chen BM, Roffler SR.

MAbs. 2014 Jul-Aug;6(4):1069-83. doi: 10.4161/mabs.29124. Epub 2014 May 14.


Inhibition of the plasma SCUBE1, a novel platelet adhesive protein, protects mice against thrombosis.

Wu MY, Lin YC, Liao WJ, Tu CF, Chen MH, Roffler SR, Yang RB.

Arterioscler Thromb Vasc Biol. 2014 Jul;34(7):1390-8. doi: 10.1161/ATVBAHA.114.303779. Epub 2014 May 15.


Clearance kinetics of biomaterials affects stem cell retention and therapeutic efficacy.

Lai CY, Wu PJ, Roffler SR, Lee ST, Hwang SM, Wang SS, Wang K, Hsieh PC.

Biomacromolecules. 2014 Feb 10;15(2):564-73. doi: 10.1021/bm401583b. Epub 2014 Jan 6.


Versatile online SPE-HPLC method for the analysis of Irinotecan and its clinically relevant metabolites in biomaterials.

Prijovich ZM, Burnouf PA, Roffler SR.

J Sep Sci. 2014 Feb;37(4):360-7. doi: 10.1002/jssc.201301191. Epub 2014 Jan 10.


The B7-1 cytoplasmic tail enhances intracellular transport and mammalian cell surface display of chimeric proteins in the absence of a linear ER export motif.

Lin YC, Chen BM, Lu WC, Su CI, Prijovich ZM, Chung WC, Wu PY, Chen KC, Lee IC, Juan TY, Roffler SR.

PLoS One. 2013 Sep 20;8(9):e75084. doi: 10.1371/journal.pone.0075084. eCollection 2013.


Sensitivity of PEGylated interferon detection by anti-polyethylene glycol (PEG) antibodies depends on PEG length.

Cheng TC, Chuang KH, Chen M, Wang HE, Tzou SC, Su YC, Chuang CH, Kao CH, Chen BM, Chang LS, Roffler SR, Cheng TL.

Bioconjug Chem. 2013 Aug 21;24(8):1408-13.


A recombinant scFv-FasLext as a targeting cytotoxic agent against human Jurkat-Ras cancer.

Chan DV, Sharma R, Ju CY, Roffler SR, Ju ST.

J Biomed Sci. 2013 Mar 5;20:16. doi: 10.1186/1423-0127-20-16.


Selective cancer therapy by extracellular activation of a highly potent glycosidic duocarmycin analogue.

Chen KC, Schmuck K, Tietze LF, Roffler SR.

Mol Pharm. 2013 May 6;10(5):1773-82. doi: 10.1021/mp300581u. Epub 2013 Mar 26.


A regularly spaced and self-revealing protein ladder for anti-tag Western blot analysis.

Kao CH, Cheng CM, Chuang KH, Chuang CH, Tzou SC, Cheng TC, Hsieh YC, Liao KW, Wang YM, Chang LS, Roffler SR, Chen FM, Cheng TL.

Anal Biochem. 2012 Dec 1;431(1):1-3. doi: 10.1016/j.ab.2012.08.001. Epub 2012 Aug 9.


ECSTASY, an adjustable membrane-tethered/soluble protein expression system for the directed evolution of mammalian proteins.

Chen CP, Hsieh YT, Prijovich ZM, Chuang HY, Chen KC, Lu WC, Tseng Q, Leu YL, Cheng TL, Roffler SR.

Protein Eng Des Sel. 2012 Jul;25(7):367-75. doi: 10.1093/protein/gzs033. Epub 2012 Jun 12.


Cancer immunotherapy using a membrane-bound interleukin-12 with B7-1 transmembrane and cytoplasmic domains.

Pan WY, Lo CH, Chen CC, Wu PY, Roffler SR, Shyue SK, Tao MH.

Mol Ther. 2012 May;20(5):927-37. doi: 10.1038/mt.2012.10. Epub 2012 Feb 14.


Analytical measurement of PEGylated molecules.

Cheng TL, Chuang KH, Chen BM, Roffler SR.

Bioconjug Chem. 2012 May 16;23(5):881-99. doi: 10.1021/bc200478w. Epub 2012 Feb 2. Review.


An activity-based near-infrared glucuronide trapping probe for imaging β-glucuronidase expression in deep tissues.

Cheng TC, Roffler SR, Tzou SC, Chuang KH, Su YC, Chuang CH, Kao CH, Chen CS, Harn IH, Liu KY, Cheng TL, Leu YL.

J Am Chem Soc. 2012 Feb 15;134(6):3103-10. doi: 10.1021/ja209335z. Epub 2012 Feb 1.


In vivo positron emission tomography imaging of protease activity by generation of a hydrophobic product from a noninhibitory protease substrate.

Chuang CH, Chuang KH, Wang HE, Roffler SR, Shiea JT, Tzou SC, Cheng TC, Kao CH, Wu SY, Tseng WL, Cheng CM, Hou MF, Wang JM, Cheng TL.

Clin Cancer Res. 2012 Jan 1;18(1):238-47. doi: 10.1158/1078-0432.CCR-11-0608. Epub 2011 Oct 21.


A humanized immunoenzyme with enhanced activity for glucuronide prodrug activation in the tumor microenvironment.

Chen KC, Wu SY, Leu YL, Prijovich ZM, Chen BM, Wang HE, Cheng TL, Roffler SR.

Bioconjug Chem. 2011 May 18;22(5):938-48. doi: 10.1021/bc1005784. Epub 2011 Apr 12.


Enhancement of CPT-11 antitumor activity by adenovirus-mediated expression of β-glucuronidase in tumors.

Huang PT, Chen KC, Prijovich ZM, Cheng TL, Leu YL, Roffler SR.

Cancer Gene Ther. 2011 Jun;18(6):381-9. doi: 10.1038/cgt.2011.3. Epub 2011 Feb 25.


Sensitive quantification of PEGylated compounds by second-generation anti-poly(ethylene glycol) monoclonal antibodies.

Su YC, Chen BM, Chuang KH, Cheng TL, Roffler SR.

Bioconjug Chem. 2010 Jul 21;21(7):1264-70. doi: 10.1021/bc100067t.


Endocytosis of PEGylated agents enhances cancer imaging and anticancer efficacy.

Chuang KH, Wang HE, Chen FM, Tzou SC, Cheng CM, Chang YC, Tseng WL, Shiea J, Lin SR, Wang JY, Chen BM, Roffler SR, Cheng TL.

Mol Cancer Ther. 2010 Jun;9(6):1903-12. doi: 10.1158/1535-7163.MCT-09-0899. Epub 2010 May 25.

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