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Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage: Data From the RIGHT-2 Trial.

Bath PM, Woodhouse LJ, Krishnan K, Appleton JP, Anderson CS, Berge E, Cala L, Dixon M, England TJ, Godolphin PJ, Hepburn T, Mair G, Montgomery AA, Phillips SJ, Potter J, Price CI, Randall M, Robinson TG, Roffe C, Rothwell PM, Sandset EC, Sanossian N, Saver JL, Siriwardena AN, Venables G, Wardlaw JM, Sprigg N; RIGHT-2 Investigators.

Stroke. 2019 Oct 7:STROKEAHA119026389. doi: 10.1161/STROKEAHA.119.026389. [Epub ahead of print]


Tranexamic acid to improve functional status in adults with spontaneous intracerebral haemorrhage: the TICH-2 RCT.

Sprigg N, Flaherty K, Appleton JP, Al-Shahi Salman R, Bereczki D, Beridze M, Ciccone A, Collins R, Dineen RA, Duley L, Egea-Guerrero JJ, England TJ, Karlinski M, Krishnan K, Laska AC, Law ZK, Ovesen C, Ozturk S, Pocock SJ, Roberts I, Robinson TG, Roffe C, Peters N, Scutt P, Thanabalan J, Werring D, Whynes D, Woodhouse L, Bath PM.

Health Technol Assess. 2019 Jul;23(35):1-48. doi: 10.3310/hta23350.


Association of Baseline Hyperglycemia With Outcomes of Patients With and Without Diabetes With Acute Ischemic Stroke Treated With Intravenous Thrombolysis: A Propensity Score-Matched Analysis From the SITS-ISTR Registry.

Tsivgoulis G, Katsanos AH, Mavridis D, Lambadiari V, Roffe C, Macleod MJ, Sevcik P, Cappellari M, Nevšímalová M, Toni D, Ahmed N.

Diabetes. 2019 Sep;68(9):1861-1869. doi: 10.2337/db19-0440. Epub 2019 Jun 19.


The association between early neurological deterioration and whole blood purine concentration during acute stroke.

Martin AJ, Dale N, Imray CHE, Roffe C, Smith CJ, Tian F, Price CI.

Biomark Res. 2019 Apr 3;7:7. doi: 10.1186/s40364-019-0158-y. eCollection 2019.


Point-of-care measurements reveal release of purines into venous blood of stroke patients.

Dale N, Tian F, Sagoo R, Phillips N, Imray C, Roffe C.

Purinergic Signal. 2019 Jun;15(2):237-246. doi: 10.1007/s11302-019-09647-4. Epub 2019 Mar 12.


The National Institute for Health Research Hyperacute Stroke Research Centres and the ENCHANTED trial: the impact of enhanced research infrastructure on trial metrics and patient outcomes.

Robinson TG, Wang X, Durham AC, Ford GA, Liao J, Littlewood S, Roffe C, White P, Chalmers J, Anderson CS; ENCHANTED Investigators.

Health Res Policy Syst. 2019 Feb 13;17(1):19. doi: 10.1186/s12961-019-0417-2.


Microbiological Etiologies of Pneumonia Complicating Stroke: A Systematic Review.

Kishore AK, Vail A, Jeans AR, Chamorro A, Di Napoli M, Kalra L, Langhorne P, Roffe C, Westendorp W, Nederkoorn PJ, Garau J, van de Beek D, Montaner J, Woodhead M, Meisel A, Smith CJ; Pneumonia in Stroke Consensus (PISCES) Group.

Stroke. 2018 Jul;49(7):1602-1609. doi: 10.1161/STROKEAHA.117.020250. Epub 2018 Jun 18.


Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial.

Sprigg N, Flaherty K, Appleton JP, Al-Shahi Salman R, Bereczki D, Beridze M, Christensen H, Ciccone A, Collins R, Czlonkowska A, Dineen RA, Duley L, Egea-Guerrero JJ, England TJ, Krishnan K, Laska AC, Law ZK, Ozturk S, Pocock SJ, Roberts I, Robinson TG, Roffe C, Seiffge D, Scutt P, Thanabalan J, Werring D, Whynes D, Bath PM; TICH-2 Investigators.

Lancet. 2018 May 26;391(10135):2107-2115. doi: 10.1016/S0140-6736(18)31033-X. Epub 2018 May 16.


Routine low-dose continuous or nocturnal oxygen for people with acute stroke: three-arm Stroke Oxygen Supplementation RCT.

Roffe C, Nevatte T, Bishop J, Sim J, Penaloza C, Jowett S, Ives N, Gray R, Ferdinand P, Muddegowda G.

Health Technol Assess. 2018 Mar;22(14):1-88. doi: 10.3310/hta22140.


Prophylactic Low-Dose Oxygen for Patients With Acute Stroke-Reply.

Roffe C, Sim J, Gray R.

JAMA. 2018 Feb 6;319(5):502. doi: 10.1001/jama.2017.20349. No abstract available.


Effect of Routine Low-Dose Oxygen Supplementation on Death and Disability in Adults With Acute Stroke: The Stroke Oxygen Study Randomized Clinical Trial.

Roffe C, Nevatte T, Sim J, Bishop J, Ives N, Ferdinand P, Gray R; Stroke Oxygen Study Investigators and the Stroke OxygenStudy Collaborative Group.

JAMA. 2017 Sep 26;318(12):1125-1135. doi: 10.1001/jama.2017.11463. Erratum in: JAMA. 2017 Nov 14;318(18):1831-1832.


Outcomes of Nonagenarians with Acute Ischemic Stroke Treated with Intravenous Thrombolytics.

Behrouz R, Masjuán-Vallejo J, Vera R, Willey JZ, Zedet M, Moulin S, Cordonnier C, Klijn CJM, Kanselaar K, Dirks M, Silver B, Khan M, Azarpazhooh MR, Godoy DA, Roffe C, Paley L, Bray BD, Smith CJ, Di Napoli M; ITAS-90+ Collaborative.

J Stroke Cerebrovasc Dis. 2018 Jan;27(1):246-256. doi: 10.1016/j.jstrokecerebrovasdis.2017.08.031. Epub 2017 Sep 19.


Management of Acute Stroke in the Older Person.

Parr E, Ferdinand P, Roffe C.

Geriatrics (Basel). 2017 Aug 15;2(3). pii: E27. doi: 10.3390/geriatrics2030027.


Route of Feeding as a Proxy for Dysphagia After Stroke and the Effect of Transdermal Glyceryl Trinitrate: Data from the Efficacy of Nitric Oxide in Stroke Randomised Controlled Trial.

Woodhouse LJ, Scutt P, Hamdy S, Smithard DG, Cohen DL, Roffe C, Bereczki D, Berge E, Bladin CF, Caso V, Christensen HK, Collins R, Czlonkowska A, de Silva A, Etribi A, Laska AC, Ntaios G, Ozturk S, Phillips SJ, Prasad K, Szatmari S, Sprigg N, Bath PM.

Transl Stroke Res. 2018 Apr;9(2):120-129. doi: 10.1007/s12975-017-0548-0. Epub 2017 Aug 2.


Hypoxia after stroke: a review of experimental and clinical evidence.

Ferdinand P, Roffe C.

Exp Transl Stroke Med. 2016 Dec 7;8:9. eCollection 2016. Review.


Standards for providing safe acute ischaemic stroke thrombectomy services (September 2015).

White PM, Bhalla A, Dinsmore J, James M, McConachie N, Roffe C, Young G.

Clin Radiol. 2017 Feb;72(2):175.e1-175.e9. doi: 10.1016/j.crad.2016.11.008. Epub 2016 Dec 11. No abstract available.


e-ASPECTS software is non-inferior to neuroradiologists in applying the ASPECT score to computed tomography scans of acute ischemic stroke patients.

Nagel S, Sinha D, Day D, Reith W, Chapot R, Papanagiotou P, Warburton EA, Guyler P, Tysoe S, Fassbender K, Walter S, Essig M, Heidenrich J, Konstas AA, Harrison M, Papadakis M, Greveson E, Joly O, Gerry S, Maguire H, Roffe C, Hampton-Till J, Buchan AM, Grunwald IQ.

Int J Stroke. 2017 Aug;12(6):615-622. doi: 10.1177/1747493016681020. Epub 2016 Dec 1.


Principles of practice parameters for the treatment of sleep disordered breathing in the elderly and frail elderly: the consensus of the International Geriatric Sleep Medicine Task Force.

Netzer NC Chair, Ancoli-Israel S Co-Chair, Bliwise DL, Fulda S, Roffe C, Almeida F, Onen H, Onen F, Raschke F, Martinez Garcia MA, Frohnhofen H.

Eur Respir J. 2016 Oct;48(4):992-1018. doi: 10.1183/13993003.01975-2015. Epub 2016 Jul 28.


Clinical risk scores for predicting stroke-associated pneumonia: A systematic review.

Kishore AK, Vail A, Bray BD, Chamorro A, Napoli MD, Kalra L, Langhorne P, Montaner J, Roffe C, Rudd AG, Tyrrell PJ, van de Beek D, Woodhead M, Meisel A, Smith CJ.

Eur Stroke J. 2016 Jun;1(2):76-84. doi: 10.1177/2396987316651759. Epub 2016 Jun 1. Review.


Validation and Recalibration of Two Multivariable Prognostic Models for Survival and Independence in Acute Stroke.

Sim J, Teece L, Dennis MS, Roffe C; SOࠢS Study Team.

PLoS One. 2016 May 26;11(5):e0153527. doi: 10.1371/journal.pone.0153527. eCollection 2016.


Determinants and Outcomes of Stroke Following Percutaneous Coronary Intervention by Indication.

Myint PK, Kwok CS, Roffe C, Kontopantelis E, Zaman A, Berry C, Ludman PF, de Belder MA, Mamas MA; British Cardiovascular Intervention Society and the National Institute for Cardiovascular Outcomes Research.

Stroke. 2016 Jun;47(6):1500-7. doi: 10.1161/STROKEAHA.116.012700. Epub 2016 May 10.


Low-Dose versus Standard-Dose Intravenous Alteplase in Acute Ischemic Stroke.

Anderson CS, Robinson T, Lindley RI, Arima H, Lavados PM, Lee TH, Broderick JP, Chen X, Chen G, Sharma VK, Kim JS, Thang NH, Cao Y, Parsons MW, Levi C, Huang Y, Olavarría VV, Demchuk AM, Bath PM, Donnan GA, Martins S, Pontes-Neto OM, Silva F, Ricci S, Roffe C, Pandian J, Billot L, Woodward M, Li Q, Wang X, Wang J, Chalmers J; ENCHANTED Investigators and Coordinators.

N Engl J Med. 2016 Jun 16;374(24):2313-23. doi: 10.1056/NEJMoa1515510. Epub 2016 May 10. Erratum in: N Engl J Med. 2018 Apr 12;378(15):1465-1466.


Intravenous tranexamic acid for hyperacute primary intracerebral hemorrhage: Protocol for a randomized, placebo-controlled trial.

Sprigg N, Robson K, Bath P, Dineen R, Roberts I, Robinson T, Roffe C, Werring D, Al-Shahi Salman R, Pocock S, Duley L, England T, Whynes D, Ciccone A, Laska AC, Christensen H, Ozturk S, Collins R, Bereczki D, Egea-Guerrero JJ, Law ZK, Czlonkowska A, Seiffge D, Beredzie M; TICH-2 Investigators.

Int J Stroke. 2016 Aug;11(6):683-94. doi: 10.1177/1747493016641960. Epub 2016 Apr 5.


Post-stroke dysphagia: A review and design considerations for future trials.

Cohen DL, Roffe C, Beavan J, Blackett B, Fairfield CA, Hamdy S, Havard D, McFarlane M, McLauglin C, Randall M, Robson K, Scutt P, Smith C, Smithard D, Sprigg N, Warusevitane A, Watkins C, Woodhouse L, Bath PM.

Int J Stroke. 2016 Jun;11(4):399-411. doi: 10.1177/1747493016639057. Epub 2016 Mar 22. Review.


Early Diagnosis of Pneumonia in Severe Stroke: Clinical Features and the Diagnostic Role of C-Reactive Protein.

Warusevitane A, Karunatilake D, Sim J, Smith C, Roffe C.

PLoS One. 2016 Mar 3;11(3):e0150269. doi: 10.1371/journal.pone.0150269. eCollection 2016.


In vitro experiments of cerebral blood flow during aspiration thrombectomy: potential effects on cerebral perfusion pressure and collateral flow.

Lally F, Soorani M, Woo T, Nayak S, Jadun C, Yang Y, McCrudden J, Naire S, Grunwald I, Roffe C.

J Neurointerv Surg. 2016 Sep;8(9):969-72. doi: 10.1136/neurintsurg-2015-011909. Epub 2015 Aug 28.


Diagnosis of Stroke-Associated Pneumonia: Recommendations From the Pneumonia in Stroke Consensus Group.

Smith CJ, Kishore AK, Vail A, Chamorro A, Garau J, Hopkins SJ, Di Napoli M, Kalra L, Langhorne P, Montaner J, Roffe C, Rudd AG, Tyrrell PJ, van de Beek D, Woodhead M, Meisel A.

Stroke. 2015 Aug;46(8):2335-40. doi: 10.1161/STROKEAHA.115.009617. Epub 2015 Jun 25. Review.


How is pneumonia diagnosed in clinical stroke research? A systematic review and meta-analysis.

Kishore AK, Vail A, Chamorro A, Garau J, Hopkins SJ, Di Napoli M, Kalra L, Langhorne P, Montaner J, Roffe C, Rudd AG, Tyrrell PJ, van de Beek D, Woodhead M, Meisel A, Smith CJ.

Stroke. 2015 May;46(5):1202-9. doi: 10.1161/STROKEAHA.114.007843. Epub 2015 Apr 9. Review.


Trends in Door-to-Thrombolysis Time in the Safe Implementation of Stroke Thrombolysis Registry: Effect of Center Volume and Duration of Registry Membership.

Strbian D, Ahmed N, Wahlgren N, Lees KR, Toni D, Roffe C, Surakka IL, Tatlisumak T; SITS Investigators.

Stroke. 2015 May;46(5):1275-80. doi: 10.1161/STROKEAHA.114.007170. Epub 2015 Mar 31.


Safety and effect of metoclopramide to prevent pneumonia in patients with stroke fed via nasogastric tubes trial.

Warusevitane A, Karunatilake D, Sim J, Lally F, Roffe C.

Stroke. 2015 Feb;46(2):454-60. doi: 10.1161/STROKEAHA.114.006639. Epub 2014 Dec 16.


Extending the role of peritoneal dialysis: can we win hearts and minds?

Davies S, Lally F, Satchithananda D, Kadam U, Roffe C.

Nephrol Dial Transplant. 2014 Sep;29(9):1648-54. doi: 10.1093/ndt/gfu001. Epub 2014 Feb 10. Review.


Mechanical thrombectomy for ischaemic stroke: the first UK case series.

Ahmad N, Nayak S, Jadun C, Natarajan I, Jain P, Roffe C.

PLoS One. 2013 Dec 26;8(12):e82218. doi: 10.1371/journal.pone.0082218. eCollection 2013.


Does sex influence the response to intravenous thrombolysis in ischemic stroke?: answers from safe implementation of treatments in Stroke-International Stroke Thrombolysis Register.

Lorenzano S, Ahmed N, Falcou A, Mikulik R, Tatlisumak T, Roffe C, Wahlgren N, Toni D; SITS Investigators.

Stroke. 2013 Dec;44(12):3401-6. doi: 10.1161/STROKEAHA.113.002908. Epub 2013 Oct 30.


Incidence of venous thromboembolism in the wake of the Clots in Legs Or sTockings after Stroke (CLOTS) study.

Jain P, Ward E, Nevatte T, Roffe C.

Stroke. 2013 Oct;44(10):2910-2. doi: 10.1161/STROKEAHA.113.001458. Epub 2013 Aug 8.


Coiling occlusion of the vertebral artery for a patient with recurrent posterior circulation TIAs.

Chembala J, Jadun C, Natarajan I, Roffe C.

Neuroradiol J. 2013 Feb;26(1):80-3. Epub 2013 Mar 8.


The stroke oxygen pilot study: a randomized controlled trial of the effects of routine oxygen supplementation early after acute stroke--effect on key outcomes at six months.

Ali K, Warusevitane A, Lally F, Sim J, Sills S, Pountain S, Nevatte T, Allen M, Roffe C.

PLoS One. 2013 Jun 3;8(6):e59274. doi: 10.1371/journal.pone.0059274. Print 2014.


[Does routine oxygen administration in acute stroke patients improve treatment outcome].

Pountain SJ, Roffe C.

Praxis (Bern 1994). 2013 Apr 10;102(8):481-5. doi: 10.1024/1661-8157/a001265. Review. German. No abstract available.


Developing an education framework for stroke.

Leathley MJ, Fitzgerald J, Fletcher M, Golton I, Jenkinson D, Price C, Quinn T, Roffe C, Williams J, Watkins C.

Nurs Times. 2012 Nov 20-26;108(47):20-1.


Mechanical thrombectomy in acute ischaemic stroke: a review of the literature, clinical effectiveness and future use.

Lally F, Grunwald IQ, Sanyal R, Natarajan I, Roffe C.

CNS Neurol Disord Drug Targets. 2013 Mar;12(2):170-90. Review.


The 2010 British Association of Stroke Physicians Survey of interventional treatments for stroke in the United Kingdom.

Sanyal R, Barrick J, Bhalla A, Cassidy T, Collas D, Cloud G, Fearon P, Gompertz P, Keir S, Khanna P, Power M, White P, Roffe C.

Int J Stroke. 2013 Oct;8 Suppl A100:62-8. doi: 10.1111/j.1747-4949.2012.00931.x. Epub 2013 Jan 7.


Does routine oxygen supplementation in patients with acute stroke improve outcome?

Pountain SJ, Roffe C.

BMJ. 2012 Nov 30;345:e6976. doi: 10.1136/bmj.e6976. Review. No abstract available.


Safety and efficacy of the Aperio thrombectomy device when compared to the Solitaire AB/FR and the Revive devices in a pulsatile flow system.

Saleh M, Spence JN, Nayak S, Pearce G, Tennuci C, Roffe C.

Am J Cardiovasc Dis. 2012;2(4):301-8. Epub 2012 Oct 25.


A randomized controlled trial of surface neuromuscular electrical stimulation applied early after acute stroke: effects on wrist pain, spasticity and contractures.

Malhotra S, Rosewilliam S, Hermens H, Roffe C, Jones P, Pandyan AD.

Clin Rehabil. 2013 Jul;27(7):579-90. doi: 10.1177/0269215512464502. Epub 2012 Nov 5.


Intermittent nocturnal hypoxemia in individuals with dementia: prevalence and relationship with functional status.

Frohnhofen H, Roffe C.

J Am Geriatr Soc. 2012 Oct;60(10):1997-9. doi: 10.1111/j.1532-5415.2012.04183.x. No abstract available.


Thrombolysis in a stroke patient with Marfan syndrome.

Chembala J, Natarajan I, Roffe C.

JRSM Short Rep. 2012 Apr;3(4):22. doi: 10.1258/shorts.2012.012001. Epub 2012 Apr 10. No abstract available.


Can surface neuromuscular electrical stimulation of the wrist and hand combined with routine therapy facilitate recovery of arm function in patients with stroke?

Rosewilliam S, Malhotra S, Roffe C, Jones P, Pandyan AD.

Arch Phys Med Rehabil. 2012 Oct;93(10):1715-21.e1. doi: 10.1016/j.apmr.2012.05.017. Epub 2012 Jun 4.


The SOS pilot study: a RCT of routine oxygen supplementation early after acute stroke--effect on recovery of neurological function at one week.

Roffe C, Ali K, Warusevitane A, Sills S, Pountain S, Allen M, Hodsoll J, Lally F, Jones P, Crome P.

PLoS One. 2011;6(5):e19113. doi: 10.1371/journal.pone.0019113. Epub 2011 May 19.

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