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The anticoagulant effect of dabigatran is reflected in the lag time and time-to-peak, but not in the endogenous thrombin potential or peak, of thrombin generation.

Bloemen S, Zwaveling S, Douxfils J, Roest M, Kremers R, Mullier F.

Thromb Res. 2018 Nov;171:160-166. doi: 10.1016/j.thromres.2018.10.005. Epub 2018 Oct 6.


Effects of Repeated Bouts of Exercise on the Hemostatic System.

van der Vorm LN, Huskens D, Kicken CH, Remijn JA, Roest M, de Laat B, Miszta A.

Semin Thromb Hemost. 2018 Nov;44(8):710-722. doi: 10.1055/s-0038-1673619. Epub 2018 Oct 5. Review.


Trovafloxacin-induced liver injury: lack in regulation of inflammation by inhibition of nucleotide release and neutrophil movement.

Giustarini G, Vrisekoop N, Kruijssen L, Wagenaar L, van Staveren S, van Roest M, Bleumink R, Bol-Schoenmakers M, Weaver R, Koenderman L, Smit J, Pieters R.

Toxicol Sci. 2018 Sep 22. doi: 10.1093/toxsci/kfy244. [Epub ahead of print]


Glycation of the Major Milk Allergen β-Lactoglobulin Changes Its Allergenicity by Alterations in Cellular Uptake and Degradation.

Perusko M, van Roest M, Stanic-Vucinic D, Simons PJ, Pieters RHH, Cirkovic Velickovic T, Smit JJ.

Mol Nutr Food Res. 2018 Sep;62(17):e1800341. doi: 10.1002/mnfr.201800341. Epub 2018 Jul 29.


Thrombin generation and platelet activation in cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy - A prospective cohort study.

Van Poucke S, Huskens D, Van der Speeten K, Roest M, Lauwereins B, Zheng MH, Dehaene S, Penders J, Marcus A, Lancé M.

PLoS One. 2018 Jun 21;13(6):e0193657. doi: 10.1371/journal.pone.0193657. eCollection 2018.


No indications for platelet activation in acute clinical myocardial or renal ischemia/reperfusion injury.

Kortekaas KA, de Vries DK, Roest M, Reinders ME, van der Veer EP, Klautz RJ, de Groot PG, Schaapherder AF, Lindeman JH.

Am J Transl Res. 2018 Mar 15;10(3):816-826. eCollection 2018.


Platelet function is disturbed by the angiogenesis inhibitors sunitinib and sorafenib, but unaffected by bevacizumab.

Walraven M, Homs MYV, van der Veldt AAM, Dekker H, Koldenhof J, Honeywell R, Barendrecht A, Sebastian SAE, Parr N, Koekman AC, Voest EE, Roest M, Korporaal SJA, Verheul HMW.

Angiogenesis. 2018 May;21(2):325-334. doi: 10.1007/s10456-018-9598-5. Epub 2018 Mar 12.


Standardization and reference ranges for whole blood platelet function measurements using a flow cytometric platelet activation test.

Huskens D, Sang Y, Konings J, van der Vorm L, de Laat B, Kelchtermans H, Roest M.

PLoS One. 2018 Feb 1;13(2):e0192079. doi: 10.1371/journal.pone.0192079. eCollection 2018.


Tissue influx of neutrophils and monocytes is delayed during development of trovafloxacin-induced tumor necrosis factor-dependent liver injury in mice.

Giustarini G, Kruijssen L, van Roest M, Bleumink R, Weaver RJ, Bol-Schoenmakers M, Smit J, Pieters R.

J Appl Toxicol. 2018 May;38(5):753-765. doi: 10.1002/jat.3585. Epub 2018 Jan 26.


Validation of flow cytometric analysis of platelet function in patients with a suspected platelet function defect.

van Asten I, Schutgens REG, Baaij M, Zandstra J, Roest M, Pasterkamp G, Huisman A, Korporaal SJA, Urbanus RT.

J Thromb Haemost. 2018 Apr;16(4):689-698. doi: 10.1111/jth.13952. Epub 2018 Feb 1.


High prevalence of reduced thrombin generation and/or decreased platelet response in women with unexplained heavy menstrual bleeding.

Eising HP, Roest M, de Groot PG, Huskens D, Konings J, Urbanus RT, de Laat B, Remijn JA.

Int J Lab Hematol. 2018 Jun;40(3):268-275. doi: 10.1111/ijlh.12775. Epub 2018 Jan 16.


Agonist-induced platelet reactivity correlates with bleeding in haemato-oncological patients.

Batman B, van Bladel ER, van Hamersveld M, Pasker-de Jong PCM, Korporaal SJA, Urbanus RT, Roest M, Boven LA, Fijnheer R.

Vox Sang. 2017 Nov;112(8):773-779. doi: 10.1111/vox.12557. Epub 2017 Sep 29.


Myeloperoxidase can differentiate between sepsis and non-infectious SIRS and predicts mortality in intensive care patients with SIRS.

Schrijver IT, Kemperman H, Roest M, Kesecioglu J, de Lange DW.

Intensive Care Med Exp. 2017 Sep 15;5(1):43. doi: 10.1186/s40635-017-0157-y.


The anticoagulant effect of heparin during radiofrequency ablation (RFA) in patients taking apixaban or rivaroxaban.

Brendel LC, Dobler F, Hessling G, Michel J, Braun SL, Steinsiek AL, Groha P, Eckl R, Deisenhofer I, Hyseni A, Roest M, Ott I, Steppich B.

J Interv Card Electrophysiol. 2017 Sep;49(3):237-244. doi: 10.1007/s10840-017-0274-2. Epub 2017 Jul 22.


Interdependence between osteoprotegerin and active von Willebrand factor in long-term cardiovascular mortality prediction in patients undergoing percutaneous coronary intervention.

Siller-Matula J, Lang IM, Schoergenhofer C, Roest M, Jilma B.

Thromb Haemost. 2017 Aug 30;117(9):1730-1738. doi: 10.1160/TH17-02-0087. Epub 2017 Jul 20.


Alterations in Functional Cortical Hierarchy in Hemiparkinsonian Rats.

Jávor-Duray BN, Vinck M, van der Roest M, Bezard E, Berendse HW, Boraud T, Voorn P.

J Neurosci. 2017 Aug 9;37(32):7669-7681. doi: 10.1523/JNEUROSCI.3257-16.2017. Epub 2017 Jul 7.


Soluble P-selectin as a Biomarker for Infection and Survival in Patients With a Systemic Inflammatory Response Syndrome on the Intensive Care Unit.

Schrijver IT, Kemperman H, Roest M, Kesecioglu J, de Lange DW.

Biomark Insights. 2017 Feb 7;12:1177271916684823. doi: 10.1177/1177271916684823. eCollection 2017.


Effect of the FXa inhibitors Rivaroxaban and Apixaban on platelet activation in patients with atrial fibrillation.

Steppich B, Dobler F, Brendel LC, Hessling G, Braun SL, Steinsiek AL, Deisenhofer I, Hyseni A, Roest M, Ott I.

J Thromb Thrombolysis. 2017 May;43(4):490-497. doi: 10.1007/s11239-017-1495-z.


Application of an optimized flow cytometry-based quantification of Platelet Activation (PACT): Monitoring platelet activation in platelet concentrates.

Kicken CH, Roest M, Henskens YM, de Laat B, Huskens D.

PLoS One. 2017 Feb 16;12(2):e0172265. doi: 10.1371/journal.pone.0172265. eCollection 2017.


Baseline thrombospondin-1 concentrations are not associated with mortality in septic patients: a single-center cohort study on the intensive care unit.

van der Wekken RJ, Kemperman H, Roest M, de Lange DW.

Intensive Care Med Exp. 2017 Dec;5(1):7. doi: 10.1186/s40635-017-0120-y. Epub 2017 Jan 25.


The effect of P2Y12 inhibition on platelet activation assessed with aggregation- and flow cytometry-based assays.

Leunissen TC, Wisman PP, van Holten TC, de Groot PG, Korporaal SJ, Koekman AC, Moll FL, Teraa M, Verhaar MC, de Borst GJ, Urbanus RT, Roest M.

Platelets. 2017 Sep;28(6):567-575. doi: 10.1080/09537104.2016.1246713. Epub 2016 Nov 25.


Lower Platelet Reactivity Is Associated with Presentation of Unstable Coronary Artery Disease.

Leunissen TC, Gijsberts CM, Wisman PP, Huisman A, Berg MT, Asselbergs FW, Hoefer IE, Pasterkamp G, Moll FL, de Borst GJ, Roest M.

Int J Angiol. 2016 Dec;25(4):210-218. Epub 2016 Oct 24.


The Impact of Socioeconomic Status, Surgical Resection and Type of Hospital on Survival in Patients with Pancreatic Cancer. A Population-Based Study in The Netherlands.

van Roest MH, van der Aa MA, van der Geest LG, de Jong KP.

PLoS One. 2016 Nov 10;11(11):e0166449. doi: 10.1371/journal.pone.0166449. eCollection 2016.


Evaluation of the sensitizing potential of food proteins using two mouse models.

Smit J, Zeeuw-Brouwer ML, van Roest M, de Jong G, van Bilsen J.

Toxicol Lett. 2016 Nov 16;262:62-69. doi: 10.1016/j.toxlet.2016.09.005. Epub 2016 Sep 20.


Normalization methods in time series of platelet function assays: A SQUIRE compliant study.

Van Poucke S, Zhang Z, Roest M, Vukicevic M, Beran M, Lauwereins B, Zheng MH, Henskens Y, Lancé M, Marcus A.

Medicine (Baltimore). 2016 Jul;95(28):e4188. doi: 10.1097/MD.0000000000004188.


Platelet reactivity in patients with venous thrombosis who use rosuvastatin: a randomized controlled clinical trial.

Biedermann JS, Cannegieter SC, Roest M, van der Meer FJ, Reitsma PH, Kruip MJ, Lijfering WM.

J Thromb Haemost. 2016 Jul;14(7):1404-9. doi: 10.1111/jth.13343. Epub 2016 Jun 10.


Functional recovery of stored platelets after transfusion.

Bikker A, Bouman E, Sebastian S, Korporaal SJ, Urbanus RT, Fijnheer R, Boven LA, Roest M.

Transfusion. 2016 May;56(5):1030-7. doi: 10.1111/trf.13544. Epub 2016 Mar 2.


Intra- and inter-laboratory validation of an innovative huFcεRIα-RBL-2H3 degranulation assay for in vitro allergenicity assessment of whey hydrolysates.

Knipping K, van Roest M, Kruijssen L, Smits M, Teunis M, Cox L, de Jong N, Simons PJ, Boon L, Teshima R, Gros M, Kegler D, Garssen J, Knippels LM, Pieters R.

Toxicol In Vitro. 2016 Jun;33:29-34. doi: 10.1016/j.tiv.2016.02.018. Epub 2016 Feb 24.


The mycotoxin deoxynivalenol facilitates allergic sensitization to whey in mice.

Bol-Schoenmakers M, Braber S, Akbari P, de Graaff P, van Roest M, Kruijssen L, Smit JJ, van Esch BC, Jeurink PV, Garssen J, Fink-Gremmels J, Pieters RH.

Mucosal Immunol. 2016 Nov;9(6):1477-1486. doi: 10.1038/mi.2016.13. Epub 2016 Feb 17.


Strenuous exercise induces a hyperreactive rebalanced haemostatic state that is more pronounced in men.

Huskens D, Roest M, Remijn JA, Konings J, Kremers RM, Bloemen S, Schurgers E, Selmeczi A, Kelchtermans H, van Meel R, Meex SJ, Kleinegris MC, de Groot PG, Urbanus RT, Ninivaggi M, de Laat B.

Thromb Haemost. 2016 Jun 2;115(6):1109-19. doi: 10.1160/TH15-10-0821. Epub 2016 Feb 11.


The ethnicity-specific association of biomarkers with the angiographic severity of coronary artery disease.

Gijsberts CM, Seneviratna A, Bank IE, den Ruijter HM, Asselbergs FW, Agostoni P, Remijn JA, Pasterkamp G, Kiat HC, Roest M, Richards AM, Chan MY, de Kleijn DP, Hoefer IE.

Neth Heart J. 2016 Mar;24(3):188-98. doi: 10.1007/s12471-015-0798-y.


Postpartum Circulating Markers of Inflammation and the Systemic Acute-Phase Response After Early-Onset Preeclampsia.

van Rijn BB, Bruinse HW, Veerbeek JH, Post Uiterweer ED, Koenen SV, van der Bom JG, Rijkers GT, Roest M, Franx A.

Hypertension. 2016 Feb;67(2):404-14. doi: 10.1161/HYPERTENSIONAHA.115.06455. Epub 2015 Dec 28.


Risk factor analysis of cerebral white matter hyperintensities in children with sickle cell disease.

van der Land V, Mutsaerts HJ, Engelen M, Heijboer H, Roest M, Hollestelle MJ, Kuijpers TW, Nederkoorn PJ, Cnossen MH, Majoie CB, Nederveen AJ, Fijnvandraat K.

Br J Haematol. 2016 Jan;172(2):274-84. doi: 10.1111/bjh.13819. Epub 2015 Oct 22.


Platelet density per monocyte predicts adverse events in patients after percutaneous coronary intervention.

Rutten B, Roest M, McClellan EA, Sels JW, Stubbs A, Jukema JW, Doevendans PA, Waltenberger J, van Zonneveld AJ, Pasterkamp G, De Groot PG, Hoefer IE.

Thromb Haemost. 2016 Jan;115(2):353-60. doi: 10.1160/TH15-03-0227. Epub 2015 Oct 1. Erratum in: Thromb Haemost. 2017 Feb 28;117(3):641.


In Vitro Hemocompatibility Testing of Dyneema Purity Fibers in Blood Contact.

Basir A, de Groot P, Gründeman PF, Tersteeg C, Maas C, Barendrecht A, van Herwaarden J, Kluin J, Moll F, Pasterkamp G, Roest M.

Innovations (Phila). 2015 May-Jun;10(3):195-201. doi: 10.1097/IMI.0000000000000163.


Baseline Platelet Activation and Reactivity in Patients with Critical Limb Ischemia.

Wisman PP, Teraa M, de Borst GJ, Verhaar MC, Roest M, Moll FL.

PLoS One. 2015 Jul 6;10(7):e0131356. doi: 10.1371/journal.pone.0131356. eCollection 2015.


Decreased plasma levels of activated factor VII in patients with deep vein thrombosis.

Schut AM, Meijers JC, Lisman-van Leeuwen Y, van Montfoort ML, Roest M, de Groot PG, Urbanus RT, Coppens M, Lisman T.

J Thromb Haemost. 2015 Jul;13(7):1320-4. doi: 10.1111/jth.12980. Epub 2015 May 22.


Heterogeneous responses and cross reactivity between the major peanut allergens Ara h 1, 2,3 and 6 in a mouse model for peanut allergy.

Smit JJ, Pennings MT, Willemsen K, van Roest M, van Hoffen E, Pieters RH.

Clin Transl Allergy. 2015 Mar 23;5:13. doi: 10.1186/s13601-015-0056-9. eCollection 2015.


Early recognition of cardiac tamponade using cerebral oximetry during ventricular tachycardia ablation.

van Roest MH, Vercauteren M, Vrints C, Sarkozy A.

Eur J Anaesthesiol. 2015 Aug;32(8):581-2. doi: 10.1097/EJA.0000000000000216. No abstract available.


Normal platelet activation profile in patients with peripheral arterial disease on aspirin.

van Geffen JP, Kleinegris MC, Verdoold R, Baaten CC, Cosemans JM, Clemetson KJ, Ten Cate H, Roest M, de Laat B, Heemskerk JW.

Thromb Res. 2015 Mar;135(3):513-20. doi: 10.1016/j.thromres.2014.12.029. Epub 2015 Jan 6.


Response to letter regarding article, "plasmin cleavage of von willebrand factor as an emergency bypass for ADAMTS13 deficiency in thrombotic microangiopathy".

Tersteeg C, de Maat S, De Meyer SF, Smeets MW, Barendrecht AD, Roest M, Pasterkamp G, Fijnheer R, Vanhoorelbeke K, de Groot PG, Maas C.

Circulation. 2015 Jan 13;131(2):e19-20. doi: 10.1161/CIRCULATIONAHA.114.012802. No abstract available.


Coagulation activation during air travel is not initiated via the extrinsic pathway.

Schut AM, Venemans-Jellema A, Meijers JC, Middeldorp S, de Groot PG, Rosendaal FR, Roest M, Lisman T, Cannegieter SC.

Br J Haematol. 2015 Jun;169(6):903-5. doi: 10.1111/bjh.13257. Epub 2014 Dec 17. No abstract available.


Early-onset cortico-cortical synchronization in the hemiparkinsonian rat model.

Jávor-Duray BN, Vinck M, van der Roest M, Mulder AB, Stam CJ, Berendse HW, Voorn P.

J Neurophysiol. 2015 Feb 1;113(3):925-36. doi: 10.1152/jn.00690.2014. Epub 2014 Nov 12.


Reduced platelet hyperreactivity and platelet-monocyte aggregation in HIV-infected individuals receiving a raltegravir-based regimen.

Tunjungputri RN, Van Der Ven AJ, Schonsberg A, Mathan TS, Koopmans P, Roest M, Fijnheer R, Groot PG, de Mast Q.

AIDS. 2014 Sep 10;28(14):2091-6. doi: 10.1097/QAD.0000000000000415.


Endocannabinoids control platelet activation and limit aggregate formation under flow.

De Angelis V, Koekman AC, Weeterings C, Roest M, de Groot PG, Herczenik E, Maas C.

PLoS One. 2014 Sep 29;9(9):e108282. doi: 10.1371/journal.pone.0108282. eCollection 2014.


The influence of Erythropoietin on platelet activation, thrombin generation and FVII/active FVII in patients with AMI.

Demetz G, Laux M, Scherhag A, Hoekstra T, Suttorp MM, Dekker F, Roest M, Marcus-Kalish M, Mittelman M, Ott I.

Thromb J. 2014 Aug 28;12:18. doi: 10.1186/1477-9560-12-18. eCollection 2014.


Cirrhosis patients have a coagulopathy that is associated with decreased clot formation capacity.

Kleinegris MC, Bos MH, Roest M, Henskens Y, Ten Cate-Hoek A, Van Deursen C, Spronk HM, Reitsma PH, De Groot PG, Ten Cate H, Koek G.

J Thromb Haemost. 2014 Oct;12(10):1647-57. doi: 10.1111/jth.12706. Epub 2014 Sep 30.


Increased platelet reactivity is associated with circulating platelet-monocyte complexes and macrophages in human atherosclerotic plaques.

Rutten B, Tersteeg C, Vrijenhoek JE, van Holten TC, Elsenberg EH, Mak-Nienhuis EM, de Borst GJ, Jukema JW, Pijls NH, Waltenberger J, van Zonneveld AJ, Moll FL, McClellan E, Stubbs A, Pasterkamp G, Hoefer I, de Groot PG, Roest M.

PLoS One. 2014 Aug 14;9(8):e105019. doi: 10.1371/journal.pone.0105019. eCollection 2014.


Hemocompatibility assessment of two siRNA nanocarrier formulations.

Yousefi A, Lauwers M, Nemes R, van Holten T, Babae N, Roest M, Storm G, Schiffelers R, Mastrobattista E.

Pharm Res. 2014 Nov;31(11):3127-35. doi: 10.1007/s11095-014-1405-4. Epub 2014 May 20.


Plasma levels of active Von Willebrand factor are increased in patients with first ST-segment elevation myocardial infarction: a multicenter and multiethnic study.

Rutten B, Maseri A, Cianflone D, Laricchia A, Cristell NA, Durante A, Spartera M, Ancona F, Limite L, Hu D, Li H, Uren NG, de Groot PG, Mannucci PM, Roest M.

Eur Heart J Acute Cardiovasc Care. 2015 Feb;4(1):64-74. doi: 10.1177/2048872614534388. Epub 2014 May 15.


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