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Differential lipid recognition by mouse versus human CD300f, inhibiting passive cutaneous anaphylaxis, depends on a single amino acid substitution in its immunoglobulin-like domain.

Izawa K, Kaitani A, Ando T, Maehara A, Nagamine M, Yamada H, Ando T, Ide T, Matsuzawa M, Okamoto Y, Yin E, Fukase S, Wang H, Kamei A, Uchida S, Keiko M, Nakano N, Uchida K, Tamura N, Ikeda K, Ebihara N, Shimizu T, Voehringer D, Roers A, Ogawa H, Okumura K, Kitaura J.

J Invest Dermatol. 2019 Aug 30. pii: S0022-202X(19)33204-X. doi: 10.1016/j.jid.2019.08.439. [Epub ahead of print] No abstract available.


Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation.

Ding X, Willenborg S, Bloch W, Wickström SA, Wagle P, Brodesser S, Roers A, Jais A, Brüning JC, Hall MN, Rüegg MA, Eming SA.

J Allergy Clin Immunol. 2019 Aug 8. pii: S0091-6749(19)31029-2. doi: 10.1016/j.jaci.2019.07.033. [Epub ahead of print]


Mast cells drive IgE-mediated disease but might be bystanders in many other inflammatory and neoplastic conditions.

Maurer M, Taube C, Schröder NWJ, Ebmeyer J, Siebenhaar F, Geldmacher A, Schubert N, Roers A.

J Allergy Clin Immunol. 2019 Oct;144(4S):S19-S30. doi: 10.1016/j.jaci.2019.07.017. Epub 2019 Jul 29.


Leukocyte-Derived Interleukin-10 Aggravates Postoperative Ileus.

Stein K, Lysson M, Schumak B, Vilz T, Specht S, Heesemann J, Roers A, Kalff JC, Wehner S.

Front Immunol. 2018 Nov 13;9:2599. doi: 10.3389/fimmu.2018.02599. eCollection 2018.


Mast Cell-Specific Expression of Human Siglec-8 in Conditional Knock-in Mice.

Wei Y, Chhiba KD, Zhang F, Ye X, Wang L, Zhang L, Robida PA, Moreno-Vinasco L, Schnaar RL, Roers A, Hartmann K, Lee CM, Demers D, Zheng T, Bochner BS, Zhu Z.

Int J Mol Sci. 2018 Dec 21;20(1). pii: E19. doi: 10.3390/ijms20010019.


IL-10 signaling in dendritic cells is required for tolerance induction in a murine model of allergic airway inflammation.

Dolch A, Kunz S, Dorn B, Alessandrini F, Müller W, Jack RS, Martin SF, Roers A, Jakob T.

Eur J Immunol. 2019 Feb;49(2):302-312. doi: 10.1002/eji.201847883. Epub 2019 Jan 3.


Mouse mast cells and mast cell proteases do not play a significant role in acute tissue injury pain induced by formalin.

Magnúsdóttir EI, Grujic M, Roers A, Hartmann K, Pejler G, Lagerström MC.

Mol Pain. 2018 Jan-Dec;14:1744806918808161. doi: 10.1177/1744806918808161. Epub 2018 Oct 3.


Unimpaired Responses to Vaccination With Protein Antigen Plus Adjuvant in Mice With Kit-Independent Mast Cell Deficiency.

Schubert N, Lisenko K, Auerbach C, Weitzmann A, Ghouse SM, Muhandes L, Haase C, Häring T, Schulze L, Voehringer D, Gunzer F, Müller W, Feyerabend TB, Rodewald HR, Dudeck A, Roers A.

Front Immunol. 2018 Aug 28;9:1870. doi: 10.3389/fimmu.2018.01870. eCollection 2018.


Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin.

Hiller B, Hoppe A, Haase C, Hiller C, Schubert N, Müller W, Reijns MAM, Jackson AP, Kunkel TA, Wenzel J, Behrendt R, Roers A.

Cancer Res. 2018 Oct 15;78(20):5917-5926. doi: 10.1158/0008-5472.CAN-18-1099. Epub 2018 Aug 28.


Deletion of Orai2 augments endogenous CRAC currents and degranulation in mast cells leading to enhanced anaphylaxis.

Tsvilovskyy V, Solís-López A, Schumacher D, Medert R, Roers A, Kriebs U, Freichel M.

Cell Calcium. 2018 May;71:24-33. doi: 10.1016/j.ceca.2017.11.004. Epub 2017 Nov 27.


Loss of epigenetic regulator TET2 and oncogenic KIT regulate myeloid cell transformation via PI3K pathway.

Palam LR, Mali RS, Ramdas B, Srivatsan SN, Visconte V, Tiu RV, Vanhaesebroeck B, Roers A, Gerbaulet A, Xu M, Janga SC, Takemoto CM, Paczesny S, Kapur R.

JCI Insight. 2018 Feb 22;3(4). pii: 94679. doi: 10.1172/jci.insight.94679. eCollection 2018 Feb 22.


Although Abundant in Tumor Tissue, Mast Cells Have No Effect on Immunological Micro-milieu or Growth of HPV-Induced or Transplanted Tumors.

Ghouse SM, Polikarpova A, Muhandes L, Dudeck J, Tantcheva-Poór I, Hartmann K, Lesche M, Dahl A, Eming S, Müller W, Behrendt R, Roers A.

Cell Rep. 2018 Jan 2;22(1):27-35. doi: 10.1016/j.celrep.2017.12.010.


The transcription factors GATA2 and microphthalmia-associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE/mast cell-mediated anaphylaxis.

Li Y, Liu B, Harmacek L, Long Z, Liang J, Lukin K, Leach SM, O'Connor B, Gerber AN, Hagman J, Roers A, Finkelman FD, Huang H.

J Allergy Clin Immunol. 2018 Oct;142(4):1173-1184. doi: 10.1016/j.jaci.2017.10.043. Epub 2017 Dec 24.


Mast cells increase adult neural precursor proliferation and differentiation but this potential is not realized in vivo under physiological conditions.

Wasielewska JM, Grönnert L, Rund N, Donix L, Rust R, Sykes AM, Hoppe A, Roers A, Kempermann G, Walker TL.

Sci Rep. 2017 Dec 19;7(1):17859. doi: 10.1038/s41598-017-18184-2.


Role of the Ceramide-CD300f Interaction in Gram-Negative Bacterial Skin Infections.

Maehara A, Kaitani A, Izawa K, Shiba E, Nagamine M, Takamori A, Isobe M, Uchida S, Uchida K, Ando T, Maeda K, Nakano N, Voehringer D, Roers A, Shimizu T, Ogawa H, Okumura K, Kitamura T, Kitaura J.

J Invest Dermatol. 2018 May;138(5):1221-1224. doi: 10.1016/j.jid.2017.11.025. Epub 2017 Dec 5. No abstract available.


Lack of Trex1 Causes Systemic Autoimmunity despite the Presence of Antiretroviral Drugs.

Achleitner M, Kleefisch M, Hennig A, Peschke K, Polikarpova A, Oertel R, Gabriel B, Schulze L, Lindeman D, Gerbaulet A, Fiebig U, Lee-Kirsch MA, Roers A, Behrendt R.

J Immunol. 2017 Oct 1;199(7):2261-2269. doi: 10.4049/jimmunol.1700714. Epub 2017 Aug 23.


Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment.

Izawa K, Maehara A, Isobe M, Yasuda Y, Urai M, Hoshino Y, Ueno K, Matsukawa T, Takahashi M, Kaitani A, Shiba E, Takamori A, Uchida S, Uchida K, Maeda K, Nakano N, Yamanishi Y, Oki T, Voehringer D, Roers A, Nakae S, Ishikawa J, Kinjo Y, Shimizu T, Ogawa H, Okumura K, Kitamura T, Kitaura J.

Sci Rep. 2017 Jun 27;7(1):4298. doi: 10.1038/s41598-017-04647-z.


SCA-1 Expression Level Identifies Quiescent Hematopoietic Stem and Progenitor Cells.

Morcos MNF, Schoedel KB, Hoppe A, Behrendt R, Basak O, Clevers HC, Roers A, Gerbaulet A.

Stem Cell Reports. 2017 Jun 6;8(6):1472-1478. doi: 10.1016/j.stemcr.2017.04.012. Epub 2017 May 11.


Imaging protective mast cells in living mice during severe contact hypersensitivity.

Reber LL, Sibilano R, Starkl P, Roers A, Grimbaldeston MA, Tsai M, Gaudenzio N, Galli SJ.

JCI Insight. 2017 May 4;2(9). pii: 92900. doi: 10.1172/jci.insight.92900. eCollection 2017 May 4.


Mast cell-derived prostaglandin D2 attenuates anaphylactic reactions in mice.

Nakamura T, Fujiwara Y, Yamada R, Fujii W, Hamabata T, Lee MY, Maeda S, Aritake K, Roers A, Sessa WC, Nakamura M, Urade Y, Murata T.

J Allergy Clin Immunol. 2017 Aug;140(2):630-632.e9. doi: 10.1016/j.jaci.2017.02.030. Epub 2017 Apr 27. No abstract available.


A TNFRSF14-FcɛRI-mast cell pathway contributes to development of multiple features of asthma pathology in mice.

Sibilano R, Gaudenzio N, DeGorter MK, Reber LL, Hernandez JD, Starkl PM, Zurek OW, Tsai M, Zahner S, Montgomery SB, Roers A, Kronenberg M, Yu M, Galli SJ.

Nat Commun. 2016 Dec 16;7:13696. doi: 10.1038/ncomms13696.


No Role for Mast Cells in Obesity-Related Metabolic Dysregulation.

Chmelař J, Chatzigeorgiou A, Chung KJ, Prucnal M, Voehringer D, Roers A, Chavakis T.

Front Immunol. 2016 Nov 24;7:524. eCollection 2016.


Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis.

Marichal T, Gaudenzio N, El Abbas S, Sibilano R, Zurek O, Starkl P, Reber LL, Pirottin D, Kim J, Chambon P, Roers A, Antoine N, Kawakami Y, Kawakami T, Bureau F, Tam SY, Tsai M, Galli SJ.

J Clin Invest. 2016 Dec 1;126(12):4497-4515. doi: 10.1172/JCI86359. Epub 2016 Nov 7.


Constitutive Kit activity triggers B-cell acute lymphoblastic leukemia-like disease in mice.

Weidemann RR, Behrendt R, Schoedel KB, Müller W, Roers A, Gerbaulet A.

Exp Hematol. 2017 Jan;45:45-55.e6. doi: 10.1016/j.exphem.2016.09.005. Epub 2016 Sep 21.


Contact allergens induce CD8+ T cell-derived interleukin 10 that appears dispensable for regulation of contact hypersensitivity.

Dolch A, Kunz S, Dorn B, Roers A, Martin SF, Jakob T.

Exp Dermatol. 2017 May;26(5):449-451. doi: 10.1111/exd.13237. Epub 2017 Mar 2.


Different activation signals induce distinct mast cell degranulation strategies.

Gaudenzio N, Sibilano R, Marichal T, Starkl P, Reber LL, Cenac N, McNeil BD, Dong X, Hernandez JD, Sagi-Eisenberg R, Hammel I, Roers A, Valitutti S, Tsai M, Espinosa E, Galli SJ.

J Clin Invest. 2016 Oct 3;126(10):3981-3998. doi: 10.1172/JCI85538. Epub 2016 Sep 19.


Nucleic acid-mediated autoinflammation and autoimmunity-type I interferonopathies.

Lee-Kirsch MA, Günther C, Roers A.

J Mol Med (Berl). 2016 Oct;94(10):1081-1084. No abstract available.


Mast cells promote melanoma colonization of lungs.

Öhrvik H, Grujic M, Waern I, Gustafson AM, Ernst N, Roers A, Hartmann K, Pejler G.

Oncotarget. 2016 Oct 18;7(42):68990-69001. doi: 10.18632/oncotarget.11837.


Loss of Trex1 in Dendritic Cells Is Sufficient To Trigger Systemic Autoimmunity.

Peschke K, Achleitner M, Frenzel K, Gerbaulet A, Ada SR, Zeller N, Lienenklaus S, Lesche M, Poulet C, Naumann R, Dahl A, Ravens U, Günther C, Müller W, Knobeloch KP, Prinz M, Roers A, Behrendt R.

J Immunol. 2016 Sep 15;197(6):2157-66. doi: 10.4049/jimmunol.1600722. Epub 2016 Aug 10.


Mucosal mast cells are indispensable for the timely termination of Strongyloides ratti infection.

Reitz M, Brunn ML, Rodewald HR, Feyerabend TB, Roers A, Dudeck A, Voehringer D, Jönsson F, Kühl AA, Breloer M.

Mucosal Immunol. 2017 Mar;10(2):481-492. doi: 10.1038/mi.2016.56. Epub 2016 Jul 6.


The bulk of the hematopoietic stem cell population is dispensable for murine steady-state and stress hematopoiesis.

Schoedel KB, Morcos MNF, Zerjatke T, Roeder I, Grinenko T, Voehringer D, Göthert JR, Waskow C, Roers A, Gerbaulet A.

Blood. 2016 Nov 10;128(19):2285-2296. doi: 10.1182/blood-2016-03-706010. Epub 2016 Jun 29.


T cell derived IL-10 is dispensable for tolerance induction in a murine model of allergic airway inflammation.

Kunz S, Dolch A, Surianarayanan S, Dorn B, Bewersdorff M, Alessandrini F, Behrendt R, Karp CL, Muller W, Martin SF, Roers A, Jakob T.

Eur J Immunol. 2016 Aug;46(8):2018-27. doi: 10.1002/eji.201646319. Epub 2016 Jul 11.


Recognition of Endogenous Nucleic Acids by the Innate Immune System.

Roers A, Hiller B, Hornung V.

Immunity. 2016 Apr 19;44(4):739-54. doi: 10.1016/j.immuni.2016.04.002. Review.


Type I interferonopathies--an expanding disease spectrum of immunodysregulation.

Lee-Kirsch MA, Wolf C, Kretschmer S, Roers A.

Semin Immunopathol. 2015 Jul;37(4):349-57. doi: 10.1007/s00281-015-0500-x. Epub 2015 May 22. Review.


T-cell Expression of IL10 Is Essential for Tumor Immune Surveillance in the Small Intestine.

Dennis KL, Saadalla A, Blatner NR, Wang S, Venkateswaran V, Gounari F, Cheroutre H, Weaver CT, Roers A, Egilmez NK, Khazaie K.

Cancer Immunol Res. 2015 Jul;3(7):806-14. doi: 10.1158/2326-6066.CIR-14-0169. Epub 2015 Apr 8.


Activation of KIT modulates the function of tumor necrosis factor-related apoptosis-inducing ligand receptor (TRAIL-R) in mast cells.

Förster A, Grotha SP, Seeger JM, Rabenhorst A, Gehring M, Raap U, Létard S, Dubreuil P, Kashkar H, Walczak H, Roers A, Hartmann K.

Allergy. 2015 Jul;70(7):764-74. doi: 10.1111/all.12612. Epub 2015 Apr 16.


A novel Cre recombinase reporter mouse strain facilitates selective and efficient infection of primary immune cells with adenoviral vectors.

Heger K, Kober M, Rieß D, Drees C, de Vries I, Bertossi A, Roers A, Sixt M, Schmidt-Supprian M.

Eur J Immunol. 2015 Jun;45(6):1614-20. doi: 10.1002/eji.201545457. Epub 2015 Apr 17.


Neutrophils are required for both the sensitization and elicitation phase of contact hypersensitivity.

Weber FC, Németh T, Csepregi JZ, Dudeck A, Roers A, Ozsvári B, Oswald E, Puskás LG, Jakob T, Mócsai A, Martin SF.

J Exp Med. 2015 Jan 12;212(1):15-22. doi: 10.1084/jem.20130062. Epub 2014 Dec 15.


Defective removal of ribonucleotides from DNA promotes systemic autoimmunity.

Günther C, Kind B, Reijns MA, Berndt N, Martinez-Bueno M, Wolf C, Tüngler V, Chara O, Lee YA, Hübner N, Bicknell L, Blum S, Krug C, Schmidt F, Kretschmer S, Koss S, Astell KR, Ramantani G, Bauerfeind A, Morris DL, Cunninghame Graham DS, Bubeck D, Leitch A, Ralston SH, Blackburn EA, Gahr M, Witte T, Vyse TJ, Melchers I, Mangold E, Nöthen MM, Aringer M, Kuhn A, Lüthke K, Unger L, Bley A, Lorenzi A, Isaacs JD, Alexopoulou D, Conrad K, Dahl A, Roers A, Alarcon-Riquelme ME, Jackson AP, Lee-Kirsch MA.

J Clin Invest. 2015 Jan;125(1):413-24. doi: 10.1172/JCI78001. Epub 2014 Dec 15.


Dicer is indispensable for the development of murine mast cells.

Förster A, Blissenbach B, Machova A, Leja S, Rabenhorst A, Wilmschen S, Heger K, Schmidt-Supprian M, Roers A, Hartmann K, Papadopoulou N.

J Allergy Clin Immunol. 2015 Apr;135(4):1077-80.e4. doi: 10.1016/j.jaci.2014.10.005. Epub 2014 Oct 30. No abstract available.


Cre/loxP-based mouse models of mast cell deficiency and mast cell-specific gene inactivation.

Peschke K, Dudeck A, Rabenhorst A, Hartmann K, Roers A.

Methods Mol Biol. 2015;1220:403-21. doi: 10.1007/978-1-4939-1568-2_25.


IκB kinase 2 is essential for IgE-induced mast cell de novo cytokine production but not for degranulation.

Peschke K, Weitzmann A, Heger K, Behrendt R, Schubert N, Scholten J, Voehringer D, Hartmann K, Dudeck A, Schmidt-Supprian M, Roers A.

Cell Rep. 2014 Sep 11;8(5):1300-7. doi: 10.1016/j.celrep.2014.07.046. Epub 2014 Aug 28.


Regulatory T cells and T-cell-derived IL-10 interfere with effective anti-cytomegalovirus immune response.

Jost NH, Abel S, Hutzler M, Sparwasser T, Zimmermann A, Roers A, Müller W, Klopfleisch R, Hengel H, Westendorf AM, Buer J, Hansen W.

Immunol Cell Biol. 2014 Nov;92(10):860-71. doi: 10.1038/icb.2014.62. Epub 2014 Jul 29.


Immunoglobulin E signal inhibition during allergen ingestion leads to reversal of established food allergy and induction of regulatory T cells.

Burton OT, Noval Rivas M, Zhou JS, Logsdon SL, Darling AR, Koleoglou KJ, Roers A, Houshyar H, Crackower MA, Chatila TA, Oettgen HC.

Immunity. 2014 Jul 17;41(1):141-51. doi: 10.1016/j.immuni.2014.05.017. Epub 2014 Jul 10.


Transient ablation of regulatory T cells improves antitumor immunity in colitis-associated colon cancer.

Pastille E, Bardini K, Fleissner D, Adamczyk A, Frede A, Wadwa M, von Smolinski D, Kasper S, Sparwasser T, Gruber AD, Schuler M, Sakaguchi S, Roers A, Müller W, Hansen W, Buer J, Westendorf AM.

Cancer Res. 2014 Aug 15;74(16):4258-69. doi: 10.1158/0008-5472.CAN-13-3065. Epub 2014 Jun 6.


TREX1 deficiency triggers cell-autonomous immunity in a cGAS-dependent manner.

Ablasser A, Hemmerling I, Schmid-Burgk JL, Behrendt R, Roers A, Hornung V.

J Immunol. 2014 Jun 15;192(12):5993-7. doi: 10.4049/jimmunol.1400737. Epub 2014 May 9.


Loss of function of TET2 cooperates with constitutively active KIT in murine and human models of mastocytosis.

De Vita S, Schneider RK, Garcia M, Wood J, Gavillet M, Ebert BL, Gerbaulet A, Roers A, Levine RL, Mullally A, Williams DA.

PLoS One. 2014 May 2;9(5):e96209. doi: 10.1371/journal.pone.0096209. eCollection 2014.


Mast cells are activated by Staphylococcus aureus in vitro but do not influence the outcome of intraperitoneal S. aureus infection in vivo.

Rönnberg E, Johnzon CF, Calounova G, Garcia Faroldi G, Grujic M, Hartmann K, Roers A, Guss B, Lundequist A, Pejler G.

Immunology. 2014 Oct;143(2):155-63. doi: 10.1111/imm.12297.


Donor and host B cell-derived IL-10 contributes to suppression of graft-versus-host disease.

Weber M, Stein P, Prüfer S, Rudolph B, Kreft A, Schmitt E, Bopp T, Roers A, Schild H, Fillatreau S, Radsak MP.

Eur J Immunol. 2014 Jun;44(6):1857-65. doi: 10.1002/eji.201344081. Epub 2014 Mar 25.


In vivo visualization of uterine mast cells by two-photon microscopy.

Schmerse F, Woidacki K, Riek-Burchardt M, Reichardt P, Roers A, Tadokoro C, Zenclussen AC.

Reproduction. 2014 Jun;147(6):781-8. doi: 10.1530/REP-13-0570. Epub 2014 Feb 17.


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