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Items: 30


The KCNE2 potassium channel β subunit is required for normal lung function and resilience to ischemia and reperfusion injury.

Zhou L, Köhncke C, Hu Z, Roepke TK, Abbott GW.

FASEB J. 2019 Sep;33(9):9762-9774. doi: 10.1096/fj.201802519R. Epub 2019 Jun 4.


Deletion in mice of X-linked, Brugada syndrome- and atrial fibrillation-associated Kcne5 augments ventricular KV currents and predisposes to ventricular arrhythmia.

David JP, Lisewski U, Crump SM, Jepps TA, Bocksteins E, Wilck N, Lossie J, Roepke TK, Schmitt N, Abbott GW.

FASEB J. 2019 Feb;33(2):2537-2552. doi: 10.1096/fj.201800502R. Epub 2018 Oct 5.


Pericardial Tamponade in an Adult Suffering from Acute Mumps Infection.

Kahlfuss S, Flieger RR, Mankertz A, Yilmaz K, Roepke TK.

Case Rep Med. 2016;2016:7980936. Epub 2016 Oct 12.


Diagnosis and treatment of cardiac echinococcosis.

Kahlfuß S, Flieger RR, Roepke TK, Yilmaz K.

Heart. 2016 Sep 1;102(17):1348-53. doi: 10.1136/heartjnl-2016-309350. Epub 2016 May 19. Review.


Increased aldosterone-dependent Kv1.5 recycling predisposes to pacing-induced atrial fibrillation in Kcne3-/- mice.

Lisewski U, Koehncke C, Wilck N, Buschmeyer B, Pieske B, Roepke TK.

FASEB J. 2016 Jul;30(7):2476-89. doi: 10.1096/fj.201600317R. Epub 2016 Mar 16.


Kcne2 deletion causes early-onset nonalcoholic fatty liver disease via iron deficiency anemia.

Lee SM, Nguyen D, Anand M, Kant R, Köhncke C, Lisewski U, Roepke TK, Hu Z, Abbott GW.

Sci Rep. 2016 Mar 17;6:23118. doi: 10.1038/srep23118.


KCNE2 and gastric cancer: bench to bedside.

Abbott GW, Roepke TK.

Oncotarget. 2016 Apr 5;7(14):17286-7. doi: 10.18632/oncotarget.7921. No abstract available.


Evidence for MOR on cell membrane, sarcoplasmatic reticulum and mitochondria in left ventricular myocardium in rats.

Treskatsch S, Shaqura M, Dehe L, Roepke TK, Shakibaei M, Schäfer M, Mousa SA.

Heart Vessels. 2016 Aug;31(8):1380-8. doi: 10.1007/s00380-015-0784-8. Epub 2015 Dec 19.


Upregulation of the kappa opioidergic system in left ventricular rat myocardium in response to volume overload: Adaptive changes of the cardiac kappa opioid system in heart failure.

Treskatsch S, Shaqura M, Dehe L, Feldheiser A, Roepke TK, Shakibaei M, Spies CD, Schäfer M, Mousa SA.

Pharmacol Res. 2015 Dec;102:33-41. doi: 10.1016/j.phrs.2015.09.005. Epub 2015 Sep 10.


Ultrastructural changes associated with myocardial apoptosis, in failing rat hearts induced by volume overload.

Treskatsch S, Shakibaei M, Feldheiser A, Shaqura M, Dehe L, Roepke TK, Spies C, Schäfer M, Mousa SA.

Int J Cardiol. 2015 Oct 15;197:327-32. doi: 10.1016/j.ijcard.2015.06.067. Epub 2015 Jun 28.


Glucagonoma-induced acute heart failure.

Zhang K, Lehner LJ, Praeger D, Baumann G, Knebel F, Quinkler M, Roepke TK.

Endocrinol Diabetes Metab Case Rep. 2014;2014:140061. doi: 10.1530/EDM-14-0061. Epub 2014 Nov 1.


KCNQ1, KCNE2, and Na+-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitability.

Abbott GW, Tai KK, Neverisky DL, Hansler A, Hu Z, Roepke TK, Lerner DJ, Chen Q, Liu L, Zupan B, Toth M, Haynes R, Huang X, Demirbas D, Buccafusca R, Gross SS, Kanda VA, Berry GT.

Sci Signal. 2014 Mar 4;7(315):ra22. doi: 10.1126/scisignal.2005025.


Isolation and Kv channel recordings in murine atrial and ventricular cardiomyocytes.

Köhncke C, Lisewski U, Schleußner L, Gaertner C, Reichert S, Roepke TK.

J Vis Exp. 2013 Mar 12;(73):e50145. doi: 10.3791/50145.


KCNE2 forms potassium channels with KCNA3 and KCNQ1 in the choroid plexus epithelium.

Roepke TK, Kanda VA, Purtell K, King EC, Lerner DJ, Abbott GW.

FASEB J. 2011 Dec;25(12):4264-73. doi: 10.1096/fj.11-187609. Epub 2011 Aug 22.


Genetic dissection reveals unexpected influence of beta subunits on KCNQ1 K+ channel polarized trafficking in vivo.

Roepke TK, King EC, Purtell K, Kanda VA, Lerner DJ, Abbott GW.

FASEB J. 2011 Feb;25(2):727-36. doi: 10.1096/fj.10-173682. Epub 2010 Nov 17.


Cardiac arrhythmia and thyroid dysfunction: a novel genetic link.

Purtell K, Roepke TK, Abbott GW.

Int J Biochem Cell Biol. 2010 Nov;42(11):1767-70. doi: 10.1016/j.biocel.2010.07.013. Epub 2010 Aug 3. Review.


Targeted deletion of Kcne2 causes gastritis cystica profunda and gastric neoplasia.

Roepke TK, Purtell K, King EC, La Perle KM, Lerner DJ, Abbott GW.

PLoS One. 2010 Jul 6;5(7):e11451. doi: 10.1371/journal.pone.0011451.


Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis.

Roepke TK, King EC, Reyna-Neyra A, Paroder M, Purtell K, Koba W, Fine E, Lerner DJ, Carrasco N, Abbott GW.

Nat Med. 2009 Oct;15(10):1186-94. doi: 10.1038/nm.2029. Epub 2009 Sep 20.


HERG biosynthesis: the positive influence of negative charge.

Abbott GW, Roepke TK.

Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1211-2. doi: 10.1152/ajpheart.00218.2009. Epub 2009 Mar 13. No abstract available.


Regulation of the Kv2.1 potassium channel by MinK and MiRP1.

McCrossan ZA, Roepke TK, Lewis A, Panaghie G, Abbott GW.

J Membr Biol. 2009 Mar;228(1):1-14. doi: 10.1007/s00232-009-9154-8. Epub 2009 Feb 14.


MinK-dependent internalization of the IKs potassium channel.

Xu X, Kanda VA, Choi E, Panaghie G, Roepke TK, Gaeta SA, Christini DJ, Lerner DJ, Abbott GW.

Cardiovasc Res. 2009 Jun 1;82(3):430-8. doi: 10.1093/cvr/cvp047. Epub 2009 Feb 7.


Targeted deletion of kcne2 impairs ventricular repolarization via disruption of I(K,slow1) and I(to,f).

Roepke TK, Kontogeorgis A, Ovanez C, Xu X, Young JB, Purtell K, Goldstein PA, Christini DJ, Peters NS, Akar FG, Gutstein DE, Lerner DJ, Abbott GW.

FASEB J. 2008 Oct;22(10):3648-60. doi: 10.1096/fj.08-110171. Epub 2008 Jul 4.


Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population.

Yang L, Soonpaa MH, Adler ED, Roepke TK, Kattman SJ, Kennedy M, Henckaerts E, Bonham K, Abbott GW, Linden RM, Field LJ, Keller GM.

Nature. 2008 May 22;453(7194):524-8. doi: 10.1038/nature06894. Epub 2008 Apr 23.


Pharmacogenetics of drug-induced arrhythmias.

Abbott GW, Roepke TK.

Expert Rev Clin Pharmacol. 2008 Jan;1(1):93-104. doi: 10.1586/17512433.1.1.93.


A KCNE2 mutation in a patient with cardiac arrhythmia induced by auditory stimuli and serum electrolyte imbalance.

Gordon E, Panaghie G, Deng L, Bee KJ, Roepke TK, Krogh-Madsen T, Christini DJ, Ostrer H, Basson CT, Chung W, Abbott GW.

Cardiovasc Res. 2008 Jan;77(1):98-106. Epub 2007 Oct 4.


Impact of ancillary subunits on ventricular repolarization.

Abbott GW, Xu X, Roepke TK.

J Electrocardiol. 2007 Nov-Dec;40(6 Suppl):S42-6. Review.


Calcium-sensing receptor abrogates secretagogue- induced increases in intestinal net fluid secretion by enhancing cyclic nucleotide destruction.

Geibel J, Sritharan K, Geibel R, Geibel P, Persing JS, Seeger A, Roepke TK, Deichstetter M, Prinz C, Cheng SX, Martin D, Hebert SC.

Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9390-7. Epub 2006 Jun 7.


The KCNE2 potassium channel ancillary subunit is essential for gastric acid secretion.

Roepke TK, Anantharam A, Kirchhoff P, Busque SM, Young JB, Geibel JP, Lerner DJ, Abbott GW.

J Biol Chem. 2006 Aug 18;281(33):23740-7. Epub 2006 Jun 5.


Pharmacogenetics and cardiac ion channels.

Roepke TK, Abbott GW.

Vascul Pharmacol. 2006 Feb;44(2):90-106. Epub 2005 Dec 15. Review.


Endogenous KCNE subunits govern Kv2.1 K+ channel activation kinetics in Xenopus oocyte studies.

Gordon E, Roepke TK, Abbott GW.

Biophys J. 2006 Feb 15;90(4):1223-31. Epub 2005 Dec 2.

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