Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 525

1.

50+ years of eukaryotic transcription: an expanding universe of factors and mechanisms.

Roeder RG.

Nat Struct Mol Biol. 2019 Aug 22. doi: 10.1038/s41594-019-0287-x. [Epub ahead of print] Review.

PMID:
31439941
2.

The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing.

Etchegaray JP, Zhong L, Li C, Henriques T, Ablondi E, Nakadai T, Van Rechem C, Ferrer C, Ross KN, Choi JE, Samarakkody A, Ji F, Chang A, Sadreyev RI, Ramaswamy S, Nechaev S, Whetstine JR, Roeder RG, Adelman K, Goren A, Mostoslavsky R.

Mol Cell. 2019 Aug 22;75(4):683-699.e7. doi: 10.1016/j.molcel.2019.06.034. Epub 2019 Aug 6.

PMID:
31399344
3.

MTA2/NuRD Regulates B Cell Development and Cooperates with OCA-B in Controlling the Pre-B to Immature B Cell Transition.

Lu X, Chu CS, Fang T, Rayon-Estrada V, Fang F, Patke A, Qian Y, Clarke SH, Melnick AM, Zhang Y, Papavasiliou FN, Roeder RG.

Cell Rep. 2019 Jul 9;28(2):472-485.e5. doi: 10.1016/j.celrep.2019.06.029.

4.

PML-RARα induces all-trans retinoic acid-dependent transcriptional activation through interaction with MED1.

Fukuoka T, Kawai A, Takahara T, Mori M, Roeder RG, Hasegawa N, Ito M.

Transcription. 2019 Jun;10(3):147-156. doi: 10.1080/21541264.2019.1624467. Epub 2019 Jun 5.

PMID:
31135261
5.

Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF.

Zhang Y, Jang Y, Lee JE, Ahn J, Xu L, Holden MR, Cornett EM, Krajewski K, Klein BJ, Wang SP, Dou Y, Roeder RG, Strahl BD, Rothbart SB, Shi X, Ge K, Kutateladze TG.

Nat Commun. 2019 May 24;10(1):2314. doi: 10.1038/s41467-019-10324-8.

6.

Gene-Specific H1 Eviction through a Transcriptional Activator→p300→NAP1→H1 Pathway.

Shimada M, Chen WY, Nakadai T, Onikubo T, Guermah M, Rhodes D, Roeder RG.

Mol Cell. 2019 Apr 18;74(2):268-283.e5. doi: 10.1016/j.molcel.2019.02.016. Epub 2019 Mar 19.

PMID:
30902546
7.

Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3.

Farrelly LA, Thompson RE, Zhao S, Lepack AE, Lyu Y, Bhanu NV, Zhang B, Loh YE, Ramakrishnan A, Vadodaria KC, Heard KJ, Erikson G, Nakadai T, Bastle RM, Lukasak BJ, Zebroski H 3rd, Alenina N, Bader M, Berton O, Roeder RG, Molina H, Gage FH, Shen L, Garcia BA, Li H, Muir TW, Maze I.

Nature. 2019 Mar;567(7749):535-539. doi: 10.1038/s41586-019-1024-7. Epub 2019 Mar 13.

PMID:
30867594
8.

Destabilization of AETFC through C/EBPα-mediated repression of LYL1 contributes to t(8;21) leukemic cell differentiation.

Zhang MM, Liu N, Zhang YL, Rong B, Wang XL, Xu CH, Xie YY, Shen S, Zhu J, Nimer SD, Chen Z, Chen SJ, Roeder RG, Lan F, Wang L, Huang QH, Sun XJ.

Leukemia. 2019 Jul;33(7):1822-1827. doi: 10.1038/s41375-019-0398-8. Epub 2019 Feb 12. No abstract available.

PMID:
30755707
9.

Multivalent Role of Human TFIID in Recruiting Elongation Components at the Promoter-Proximal Region for Transcriptional Control.

Yadav D, Ghosh K, Basu S, Roeder RG, Biswas D.

Cell Rep. 2019 Jan 29;26(5):1303-1317.e7. doi: 10.1016/j.celrep.2019.01.012.

10.

Different roles of E proteins in t(8;21) leukemia: E2-2 compromises the function of AETFC and negatively regulates leukemogenesis.

Liu N, Song J, Xie Y, Wang XL, Rong B, Man N, Zhang MM, Zhang Q, Gao FF, Du MR, Zhang Y, Shen J, Xu CH, Hu CL, Wu JC, Liu P, Zhang YL, Xie YY, Liu P, Huang JY, Huang QH, Lan F, Shen S, Nimer SD, Chen Z, Chen SJ, Roeder RG, Wang L, Sun XJ.

Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):890-899. doi: 10.1073/pnas.1809327116. Epub 2018 Dec 28.

11.

Transcriptional elongation factor Paf1 core complex adopts a spirally wrapped solenoidal topology.

Deng P, Zhou Y, Jiang J, Li H, Tian W, Cao Y, Qin Y, Kim J, Roeder RG, Patel DJ, Wang Z.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):9998-10003. doi: 10.1073/pnas.1812256115. Epub 2018 Sep 17.

12.

Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1.

Jishage M, Yu X, Shi Y, Ganesan SJ, Chen WY, Sali A, Chait BT, Asturias FJ, Roeder RG.

Nat Struct Mol Biol. 2018 Sep;25(9):859-867. doi: 10.1038/s41594-018-0118-5. Epub 2018 Sep 6.

13.

Histone H1 acetylation at lysine 85 regulates chromatin condensation and genome stability upon DNA damage.

Li Y, Li Z, Dong L, Tang M, Zhang P, Zhang C, Cao Z, Zhu Q, Chen Y, Wang H, Wang T, Lv D, Wang L, Zhao Y, Yang Y, Wang H, Zhang H, Roeder RG, Zhu WG.

Nucleic Acids Res. 2018 Sep 6;46(15):7716-7730. doi: 10.1093/nar/gky568.

14.

Coactivator condensation at super-enhancers links phase separation and gene control.

Sabari BR, Dall'Agnese A, Boija A, Klein IA, Coffey EL, Shrinivas K, Abraham BJ, Hannett NM, Zamudio AV, Manteiga JC, Li CH, Guo YE, Day DS, Schuijers J, Vasile E, Malik S, Hnisz D, Lee TI, Cisse II, Roeder RG, Sharp PA, Chakraborty AK, Young RA.

Science. 2018 Jul 27;361(6400). pii: eaar3958. doi: 10.1126/science.aar3958. Epub 2018 Jun 21.

15.

A noncanonical PPARγ/RXRα-binding sequence regulates leptin expression in response to changes in adipose tissue mass.

Zhang Y, Dallner OS, Nakadai T, Fayzikhodjaeva G, Lu YH, Lazar MA, Roeder RG, Friedman JM.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E6039-E6047. doi: 10.1073/pnas.1806366115. Epub 2018 Jun 11.

16.

p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis.

Huang H, Tang S, Ji M, Tang Z, Shimada M, Liu X, Qi S, Locasale JW, Roeder RG, Zhao Y, Li X.

Mol Cell. 2018 Jun 7;70(5):984. doi: 10.1016/j.molcel.2018.05.035. Epub 2018 Jun 7. No abstract available.

17.

p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis.

Huang H, Tang S, Ji M, Tang Z, Shimada M, Liu X, Qi S, Locasale JW, Roeder RG, Zhao Y, Li X.

Mol Cell. 2018 May 17;70(4):663-678.e6. doi: 10.1016/j.molcel.2018.04.011. Erratum in: Mol Cell. 2018 Jun 7;70(5):984. Title and abstract corrected.

18.

Proteomic profiling identifies key coactivators utilized by mutant ERα proteins as potential new therapeutic targets.

Gates LA, Gu G, Chen Y, Rohira AD, Lei JT, Hamilton RA, Yu Y, Lonard DM, Wang J, Wang SP, Edwards DG, Lavere PF, Shao J, Yi P, Jain A, Jung SY, Malovannaya A, Li S, Shao J, Roeder RG, Ellis MJ, Qin J, Fuqua SAW, O'Malley BW, Foulds CE.

Oncogene. 2018 Aug;37(33):4581-4598. doi: 10.1038/s41388-018-0284-2. Epub 2018 May 11.

19.

Germline Lysine-Specific Demethylase 1 (LSD1/KDM1A) Mutations Confer Susceptibility to Multiple Myeloma.

Wei X, Calvo-Vidal MN, Chen S, Wu G, Revuelta MV, Sun J, Zhang J, Walsh MF, Nichols KE, Joseph V, Snyder C, Vachon CM, McKay JD, Wang SP, Jayabalan DS, Jacobs LM, Becirovic D, Waller RG, Artomov M, Viale A, Patel J, Phillip J, Chen-Kiang S, Curtin K, Salama M, Atanackovic D, Niesvizky R, Landgren O, Slager SL, Godley LA, Churpek J, Garber JE, Anderson KC, Daly MJ, Roeder RG, Dumontet C, Lynch HT, Mullighan CG, Camp NJ, Offit K, Klein RJ, Yu H, Cerchietti L, Lipkin SM.

Cancer Res. 2018 May 15;78(10):2747-2759. doi: 10.1158/0008-5472.CAN-17-1900. Epub 2018 Mar 20.

20.

Intracellular Crotonyl-CoA Stimulates Transcription through p300-Catalyzed Histone Crotonylation.

Sabari BR, Tang Z, Huang H, Yong-Gonzalez V, Molina H, Kong HE, Dai L, Shimada M, Cross JR, Zhao Y, Roeder RG, Allis CD.

Mol Cell. 2018 Feb 1;69(3):533. doi: 10.1016/j.molcel.2018.01.013. No abstract available.

21.

Regulation of RNA polymerase III transcription during transformation of human IMR90 fibroblasts with defined genetic elements.

Durrieu-Gaillard S, Dumay-Odelot H, Boldina G, Tourasse NJ, Allard D, André F, Macari F, Choquet A, Lagarde P, Drutel G, Leste-Lasserre T, Petitet M, Lesluyes T, Lartigue-Faustin L, Dupuy JW, Chibon F, Roeder RG, Joubert D, Vagner S, Teichmann M.

Cell Cycle. 2018;17(5):605-615. doi: 10.1080/15384101.2017.1405881. Epub 2018 Jan 22.

22.

A UTX-MLL4-p300 Transcriptional Regulatory Network Coordinately Shapes Active Enhancer Landscapes for Eliciting Transcription.

Wang SP, Tang Z, Chen CW, Shimada M, Koche RP, Wang LH, Nakadai T, Chramiec A, Krivtsov AV, Armstrong SA, Roeder RG.

Mol Cell. 2017 Jul 20;67(2):308-321.e6. doi: 10.1016/j.molcel.2017.06.028.

23.

DND1 maintains germline stem cells via recruitment of the CCR4-NOT complex to target mRNAs.

Yamaji M, Jishage M, Meyer C, Suryawanshi H, Der E, Yamaji M, Garzia A, Morozov P, Manickavel S, McFarland HL, Roeder RG, Hafner M, Tuschl T.

Nature. 2017 Mar 23;543(7646):568-572. doi: 10.1038/nature21690. Epub 2017 Mar 15.

24.

Inhibition of Adhesion Molecule Gene Expression and Cell Adhesion by the Metabolic Regulator PGC-1α.

Minsky N, Roeder RG.

PLoS One. 2016 Dec 16;11(12):e0165598. doi: 10.1371/journal.pone.0165598. eCollection 2016.

25.

Control of Secreted Protein Gene Expression and the Mammalian Secretome by the Metabolic Regulator PGC-1α.

Minsky N, Roeder RG.

J Biol Chem. 2017 Jan 6;292(1):43-50. doi: 10.1074/jbc.C116.761049. Epub 2016 Dec 1.

26.

Mediator: A Drawbridge across the Enhancer-Promoter Divide.

Malik S, Roeder RG.

Mol Cell. 2016 Nov 3;64(3):433-434. doi: 10.1016/j.molcel.2016.10.024.

27.

Chromatin Kinases Act on Transcription Factors and Histone Tails in Regulation of Inducible Transcription.

Josefowicz SZ, Shimada M, Armache A, Li CH, Miller RM, Lin S, Yang A, Dill BD, Molina H, Park HS, Garcia BA, Taunton J, Roeder RG, Allis CD.

Mol Cell. 2016 Oct 20;64(2):347-361. doi: 10.1016/j.molcel.2016.09.026.

28.

CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas.

Jiang Y, Ortega-Molina A, Geng H, Ying HY, Hatzi K, Parsa S, McNally D, Wang L, Doane AS, Agirre X, Teater M, Meydan C, Li Z, Poloway D, Wang S, Ennishi D, Scott DW, Stengel KR, Kranz JE, Holson E, Sharma S, Young JW, Chu CS, Roeder RG, Shaknovich R, Hiebert SW, Gascoyne RD, Tam W, Elemento O, Wendel HG, Melnick AM.

Cancer Discov. 2017 Jan;7(1):38-53. doi: 10.1158/2159-8290.CD-16-0975. Epub 2016 Oct 12.

29.

Periostin supports hematopoietic progenitor cells and niche-dependent myeloblastoma cells in vitro.

Tanaka S, Maekawa A, Matsubara L, Imanishi A, Yano M, Roeder RG, Hasegawa N, Asano S, Ito M.

Biochem Biophys Res Commun. 2016 Sep 30;478(4):1706-12. doi: 10.1016/j.bbrc.2016.09.008. Epub 2016 Sep 3.

30.

Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation.

Xie Z, Zhang D, Chung D, Tang Z, Huang H, Dai L, Qi S, Li J, Colak G, Chen Y, Xia C, Peng C, Ruan H, Kirkey M, Wang D, Jensen LM, Kwon OK, Lee S, Pletcher SD, Tan M, Lombard DB, White KP, Zhao H, Li J, Roeder RG, Yang X, Zhao Y.

Mol Cell. 2016 Apr 21;62(2):194-206. doi: 10.1016/j.molcel.2016.03.036.

31.

Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain.

Li Y, Sabari BR, Panchenko T, Wen H, Zhao D, Guan H, Wan L, Huang H, Tang Z, Zhao Y, Roeder RG, Shi X, Allis CD, Li H.

Mol Cell. 2016 Apr 21;62(2):181-193. doi: 10.1016/j.molcel.2016.03.028.

32.

Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters.

Goudarzi A, Zhang D, Huang H, Barral S, Kwon OK, Qi S, Tang Z, Buchou T, Vitte AL, He T, Cheng Z, Montellier E, Gaucher J, Curtet S, Debernardi A, Charbonnier G, Puthier D, Petosa C, Panne D, Rousseaux S, Roeder RG, Zhao Y, Khochbin S.

Mol Cell. 2016 Apr 21;62(2):169-180. doi: 10.1016/j.molcel.2016.03.014.

33.

MLL-AF9- and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C.

Zhu N, Chen M, Eng R, DeJong J, Sinha AU, Rahnamay NF, Koche R, Al-Shahrour F, Minehart JC, Chen CW, Deshpande AJ, Xu H, Chu SH, Ebert BL, Roeder RG, Armstrong SA.

J Clin Invest. 2016 Mar 1;126(3):997-1011. doi: 10.1172/JCI82978. Epub 2016 Feb 15.

34.

RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II.

Yu M, Yang W, Ni T, Tang Z, Nakadai T, Zhu J, Roeder RG.

Science. 2015 Dec 11;350(6266):1383-6. doi: 10.1126/science.aad2338.

35.

JMJD1C is required for the survival of acute myeloid leukemia by functioning as a coactivator for key transcription factors.

Chen M, Zhu N, Liu X, Laurent B, Tang Z, Eng R, Shi Y, Armstrong SA, Roeder RG.

Genes Dev. 2015 Oct 15;29(20):2123-39. doi: 10.1101/gad.267278.115.

36.

Direct link between metabolic regulation and the heat-shock response through the transcriptional regulator PGC-1α.

Minsky N, Roeder RG.

Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):E5669-78. doi: 10.1073/pnas.1516219112. Epub 2015 Oct 5.

37.

The Mediator subunit MED23 couples H2B mono-ubiquitination to transcriptional control and cell fate determination.

Yao X, Tang Z, Fu X, Yin J, Liang Y, Li C, Li H, Tian Q, Roeder RG, Wang G.

EMBO J. 2015 Dec 2;34(23):2885-902. doi: 10.15252/embj.201591279. Epub 2015 Sep 1.

38.

Identification of a functional hotspot on ubiquitin required for stimulation of methyltransferase activity on chromatin.

Holt MT, David Y, Pollock S, Tang Z, Jeon J, Kim J, Roeder RG, Muir TW.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10365-70. doi: 10.1073/pnas.1504483112. Epub 2015 Aug 3.

39.

Intracellular crotonyl-CoA stimulates transcription through p300-catalyzed histone crotonylation.

Sabari BR, Tang Z, Huang H, Yong-Gonzalez V, Molina H, Kong HE, Dai L, Shimada M, Cross JR, Zhao Y, Roeder RG, Allis CD.

Mol Cell. 2015 Apr 16;58(2):203-15. doi: 10.1016/j.molcel.2015.02.029. Epub 2015 Mar 26. Erratum in: Mol Cell. 2018 Feb 1;69(3):533.

40.

Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia.

Geng H, Hurtz C, Lenz KB, Chen Z, Baumjohann D, Thompson S, Goloviznina NA, Chen WY, Huan J, LaTocha D, Ballabio E, Xiao G, Lee JW, Deucher A, Qi Z, Park E, Huang C, Nahar R, Kweon SM, Shojaee S, Chan LN, Yu J, Kornblau SM, Bijl JJ, Ye BH, Ansel KM, Paietta E, Melnick A, Hunger SP, Kurre P, Tyner JW, Loh ML, Roeder RG, Druker BJ, Burger JA, Milne TA, Chang BH, Müschen M.

Cancer Cell. 2015 Mar 9;27(3):409-25. doi: 10.1016/j.ccell.2015.02.003.

41.

PRDM16 enhances nuclear receptor-dependent transcription of the brown fat-specific Ucp1 gene through interactions with Mediator subunit MED1.

Iida S, Chen W, Nakadai T, Ohkuma Y, Roeder RG.

Genes Dev. 2015 Feb 1;29(3):308-21. doi: 10.1101/gad.252809.114.

42.

Chromatin and transcriptional tango on the immune dance floor.

Roy AL, Roeder RG.

Front Immunol. 2014 Dec 15;5:631. doi: 10.3389/fimmu.2014.00631. eCollection 2014. No abstract available.

43.

AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes.

Deshpande AJ, Deshpande A, Sinha AU, Chen L, Chang J, Cihan A, Fazio M, Chen CW, Zhu N, Koche R, Dzhekieva L, Ibáñez G, Dias S, Banka D, Krivtsov A, Luo M, Roeder RG, Bradner JE, Bernt KM, Armstrong SA.

Cancer Cell. 2014 Dec 8;26(6):896-908. doi: 10.1016/j.ccell.2014.10.009. Epub 2014 Nov 20.

44.

Reconstitution of active human core Mediator complex reveals a critical role of the MED14 subunit.

Cevher MA, Shi Y, Li D, Chait BT, Malik S, Roeder RG.

Nat Struct Mol Biol. 2014 Dec;21(12):1028-34. doi: 10.1038/nsmb.2914. Epub 2014 Nov 10.

45.

Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion.

Zhang P, Tu B, Wang H, Cao Z, Tang M, Zhang C, Gu B, Li Z, Wang L, Yang Y, Zhao Y, Wang H, Luo J, Deng CX, Gao B, Roeder RG, Zhu WG.

Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10684-9. doi: 10.1073/pnas.1411026111. Epub 2014 Jul 9.

46.

Linker Histone H1.2 cooperates with Cul4A and PAF1 to drive H4K31 ubiquitylation-mediated transactivation.

Kim K, Lee B, Kim J, Choi J, Kim JM, Xiong Y, Roeder RG, An W.

Cell Rep. 2013 Dec 26;5(6):1690-703. doi: 10.1016/j.celrep.2013.11.038. Epub 2013 Dec 19.

47.

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation.

Shi J, Whyte WA, Zepeda-Mendoza CJ, Milazzo JP, Shen C, Roe JS, Minder JL, Mercan F, Wang E, Eckersley-Maslin MA, Campbell AE, Kawaoka S, Shareef S, Zhu Z, Kendall J, Muhar M, Haslinger C, Yu M, Roeder RG, Wigler MH, Blobel GA, Zuber J, Spector DL, Young RA, Vakoc CR.

Genes Dev. 2013 Dec 15;27(24):2648-62. doi: 10.1101/gad.232710.113. Epub 2013 Nov 27.

48.

CCAR1/CoCoA pair-mediated recruitment of the Mediator defines a novel pathway for GATA1 function.

Mizuta S, Minami T, Fujita H, Kaminaga C, Matsui K, Ishino R, Fujita A, Oda K, Kawai A, Hasegawa N, Urahama N, Roeder RG, Ito M.

Genes Cells. 2014 Jan;19(1):28-51. doi: 10.1111/gtc.12104. Epub 2013 Nov 19.

49.

Biochemistry. Have your PIC!

Malik S, Roeder RG.

Science. 2013 Nov 8;342(6159):706-7. doi: 10.1126/science.1246170. No abstract available.

PMID:
24202169
50.

Histone H3K27 trimethylation inhibits H3 binding and function of SET1-like H3K4 methyltransferase complexes.

Kim DH, Tang Z, Shimada M, Fierz B, Houck-Loomis B, Bar-Dagen M, Lee S, Lee SK, Muir TW, Roeder RG, Lee JW.

Mol Cell Biol. 2013 Dec;33(24):4936-46. doi: 10.1128/MCB.00601-13. Epub 2013 Oct 14.

Supplemental Content

Loading ...
Support Center