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Items: 1 to 50 of 637

1.

Selective inhibition of HDAC3 targets synthetic vulnerabilities and activates immune surveillance in lymphoma.

Mondello P, Tadros S, Teater M, Fontan L, Chang AY, Jain N, Yang H, Singh S, Ying HY, Chu CS, Ma MCJ, Toska E, Alig S, Durant M, de Stanchina E, Ghosh S, Mottok A, Nastoupil L, Neelapu SS, Weigert O, Inghirami G, Baselga J, Younes A, Yee C, Dogan A, Scheinberg DA, Roeder RG, Melnick AM, Green MR.

Cancer Discov. 2020 Jan 8. pii: CD-19-0116. doi: 10.1158/2159-8290.CD-19-0116. [Epub ahead of print]

2.

Impaired cell fate through gain-of-function mutations in a chromatin reader.

Wan L, Chong S, Xuan F, Liang A, Cui X, Gates L, Carroll TS, Li Y, Feng L, Chen G, Wang SP, Ortiz MV, Daley SK, Wang X, Xuan H, Kentsis A, Muir TW, Roeder RG, Li H, Li W, Tjian R, Wen H, Allis CD.

Nature. 2020 Jan;577(7788):121-126. doi: 10.1038/s41586-019-1842-7. Epub 2019 Dec 18.

PMID:
31853060
3.

An OCT2 / OCA-B / MEF2B Ternary Complex Controls the Activity and Architecture of an Essential Locus Control Region for Normal and Malignant Germinal Center B-Cells.

Hellmuth JC, Chu CS, Singh R, Skrabanek LA, Doane A, Elemento O, Roeder RG, Melnick A.

Blood. 2019 Nov 13;134(Supplement_1):24. doi: 10.1182/blood-2019-130692.

PMID:
31723990
4.

Metabolic regulation of gene expression by histone lactylation.

Zhang D, Tang Z, Huang H, Zhou G, Cui C, Weng Y, Liu W, Kim S, Lee S, Perez-Neut M, Ding J, Czyz D, Hu R, Ye Z, He M, Zheng YG, Shuman HA, Dai L, Ren B, Roeder RG, Becker L, Zhao Y.

Nature. 2019 Oct;574(7779):575-580. doi: 10.1038/s41586-019-1678-1. Epub 2019 Oct 23.

PMID:
31645732
5.

Mineral deposition and vascular invasion of hydroxyapatite reinforced collagen scaffolds seeded with human adipose-derived stem cells.

Weiss-Bilka HE, Meagher MJ, Gargac JA, Niebur GL, Roeder RK, Wagner DR.

Biomater Res. 2019 Oct 17;23:15. doi: 10.1186/s40824-019-0167-9. eCollection 2019.

6.

AFF1 acetylation by p300 temporally inhibits transcription during genotoxic stress response.

Kumari N, Hassan MA, Lu X, Roeder RG, Biswas D.

Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22140-22151. doi: 10.1073/pnas.1907097116. Epub 2019 Oct 14.

7.

AID-RNA polymerase II transcription-dependent deamination of IgV DNA.

Pham P, Malik S, Mak C, Calabrese PC, Roeder RG, Goodman MF.

Nucleic Acids Res. 2019 Nov 18;47(20):10815-10829. doi: 10.1093/nar/gkz821.

8.

50+ years of eukaryotic transcription: an expanding universe of factors and mechanisms.

Roeder RG.

Nat Struct Mol Biol. 2019 Sep;26(9):783-791. doi: 10.1038/s41594-019-0287-x. Epub 2019 Aug 22. Review.

PMID:
31439941
9.

The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing.

Etchegaray JP, Zhong L, Li C, Henriques T, Ablondi E, Nakadai T, Van Rechem C, Ferrer C, Ross KN, Choi JE, Samarakkody A, Ji F, Chang A, Sadreyev RI, Ramaswamy S, Nechaev S, Whetstine JR, Roeder RG, Adelman K, Goren A, Mostoslavsky R.

Mol Cell. 2019 Aug 22;75(4):683-699.e7. doi: 10.1016/j.molcel.2019.06.034. Epub 2019 Aug 6.

PMID:
31399344
10.

MTA2/NuRD Regulates B Cell Development and Cooperates with OCA-B in Controlling the Pre-B to Immature B Cell Transition.

Lu X, Chu CS, Fang T, Rayon-Estrada V, Fang F, Patke A, Qian Y, Clarke SH, Melnick AM, Zhang Y, Papavasiliou FN, Roeder RG.

Cell Rep. 2019 Jul 9;28(2):472-485.e5. doi: 10.1016/j.celrep.2019.06.029.

11.

PML-RARα induces all-trans retinoic acid-dependent transcriptional activation through interaction with MED1.

Fukuoka T, Kawai A, Takahara T, Mori M, Roeder RG, Hasegawa N, Ito M.

Transcription. 2019 Jun;10(3):147-156. doi: 10.1080/21541264.2019.1624467. Epub 2019 Jun 5.

PMID:
31135261
12.

Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF.

Zhang Y, Jang Y, Lee JE, Ahn J, Xu L, Holden MR, Cornett EM, Krajewski K, Klein BJ, Wang SP, Dou Y, Roeder RG, Strahl BD, Rothbart SB, Shi X, Ge K, Kutateladze TG.

Nat Commun. 2019 May 24;10(1):2314. doi: 10.1038/s41467-019-10324-8.

13.

Gene-Specific H1 Eviction through a Transcriptional Activator→p300→NAP1→H1 Pathway.

Shimada M, Chen WY, Nakadai T, Onikubo T, Guermah M, Rhodes D, Roeder RG.

Mol Cell. 2019 Apr 18;74(2):268-283.e5. doi: 10.1016/j.molcel.2019.02.016. Epub 2019 Mar 19.

PMID:
30902546
14.

Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3.

Farrelly LA, Thompson RE, Zhao S, Lepack AE, Lyu Y, Bhanu NV, Zhang B, Loh YE, Ramakrishnan A, Vadodaria KC, Heard KJ, Erikson G, Nakadai T, Bastle RM, Lukasak BJ, Zebroski H 3rd, Alenina N, Bader M, Berton O, Roeder RG, Molina H, Gage FH, Shen L, Garcia BA, Li H, Muir TW, Maze I.

Nature. 2019 Mar;567(7749):535-539. doi: 10.1038/s41586-019-1024-7. Epub 2019 Mar 13.

15.

Quantification of multiple mixed contrast and tissue compositions using photon-counting spectral computed tomography.

Curtis TE, Roeder RK.

J Med Imaging (Bellingham). 2019 Jan;6(1):013501. doi: 10.1117/1.JMI.6.1.013501. Epub 2019 Feb 11.

PMID:
30840726
16.

Nondestructive, longitudinal measurement of collagen scaffold degradation using computed tomography and gold nanoparticles.

Finamore TA, Curtis TE, Tedesco JV, Grandfield K, Roeder RK.

Nanoscale. 2019 Mar 7;11(10):4345-4354. doi: 10.1039/c9nr00313d.

PMID:
30793721
17.

Destabilization of AETFC through C/EBPα-mediated repression of LYL1 contributes to t(8;21) leukemic cell differentiation.

Zhang MM, Liu N, Zhang YL, Rong B, Wang XL, Xu CH, Xie YY, Shen S, Zhu J, Nimer SD, Chen Z, Chen SJ, Roeder RG, Lan F, Wang L, Huang QH, Sun XJ.

Leukemia. 2019 Jul;33(7):1822-1827. doi: 10.1038/s41375-019-0398-8. Epub 2019 Feb 12. No abstract available.

PMID:
30755707
18.

Multivalent Role of Human TFIID in Recruiting Elongation Components at the Promoter-Proximal Region for Transcriptional Control.

Yadav D, Ghosh K, Basu S, Roeder RG, Biswas D.

Cell Rep. 2019 Jan 29;26(5):1303-1317.e7. doi: 10.1016/j.celrep.2019.01.012.

19.

Exfoliated Graphene Leads to Exceptional Mechanical Properties of Polymer Composite Films.

Pang Y, Yang J, Curtis TE, Luo S, Huang D, Feng Z, Morales-Ferreiro JO, Sapkota P, Lei F, Zhang J, Zhang Q, Lee E, Huang Y, Guo R, Ptasinska S, Roeder RK, Luo T.

ACS Nano. 2019 Feb 26;13(2):1097-1106. doi: 10.1021/acsnano.8b04734. Epub 2019 Jan 11.

PMID:
30633498
20.

Different roles of E proteins in t(8;21) leukemia: E2-2 compromises the function of AETFC and negatively regulates leukemogenesis.

Liu N, Song J, Xie Y, Wang XL, Rong B, Man N, Zhang MM, Zhang Q, Gao FF, Du MR, Zhang Y, Shen J, Xu CH, Hu CL, Wu JC, Liu P, Zhang YL, Xie YY, Liu P, Huang JY, Huang QH, Lan F, Shen S, Nimer SD, Chen Z, Chen SJ, Roeder RG, Wang L, Sun XJ.

Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):890-899. doi: 10.1073/pnas.1809327116. Epub 2018 Dec 28.

21.

Effects of bisphosphonate ligands and PEGylation on targeted delivery of gold nanoparticles for contrast-enhanced radiographic detection of breast microcalcifications.

Cole LE, McGinnity TL, Irimata LE, Vargo-Gogola T, Roeder RK.

Acta Biomater. 2018 Dec;82:122-132. doi: 10.1016/j.actbio.2018.10.014. Epub 2018 Oct 11.

PMID:
30316022
22.

Transcriptional elongation factor Paf1 core complex adopts a spirally wrapped solenoidal topology.

Deng P, Zhou Y, Jiang J, Li H, Tian W, Cao Y, Qin Y, Kim J, Roeder RG, Patel DJ, Wang Z.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):9998-10003. doi: 10.1073/pnas.1812256115. Epub 2018 Sep 17.

23.

Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1.

Jishage M, Yu X, Shi Y, Ganesan SJ, Chen WY, Sali A, Chait BT, Asturias FJ, Roeder RG.

Nat Struct Mol Biol. 2018 Sep;25(9):859-867. doi: 10.1038/s41594-018-0118-5. Epub 2018 Sep 6.

24.

Histone H1 acetylation at lysine 85 regulates chromatin condensation and genome stability upon DNA damage.

Li Y, Li Z, Dong L, Tang M, Zhang P, Zhang C, Cao Z, Zhu Q, Chen Y, Wang H, Wang T, Lv D, Wang L, Zhao Y, Yang Y, Wang H, Zhang H, Roeder RG, Zhu WG.

Nucleic Acids Res. 2018 Sep 6;46(15):7716-7730. doi: 10.1093/nar/gky568.

25.

Coactivator condensation at super-enhancers links phase separation and gene control.

Sabari BR, Dall'Agnese A, Boija A, Klein IA, Coffey EL, Shrinivas K, Abraham BJ, Hannett NM, Zamudio AV, Manteiga JC, Li CH, Guo YE, Day DS, Schuijers J, Vasile E, Malik S, Hnisz D, Lee TI, Cisse II, Roeder RG, Sharp PA, Chakraborty AK, Young RA.

Science. 2018 Jul 27;361(6400). pii: eaar3958. doi: 10.1126/science.aar3958. Epub 2018 Jun 21.

26.

A noncanonical PPARγ/RXRα-binding sequence regulates leptin expression in response to changes in adipose tissue mass.

Zhang Y, Dallner OS, Nakadai T, Fayzikhodjaeva G, Lu YH, Lazar MA, Roeder RG, Friedman JM.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E6039-E6047. doi: 10.1073/pnas.1806366115. Epub 2018 Jun 11.

27.

p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis.

Huang H, Tang S, Ji M, Tang Z, Shimada M, Liu X, Qi S, Locasale JW, Roeder RG, Zhao Y, Li X.

Mol Cell. 2018 Jun 7;70(5):984. doi: 10.1016/j.molcel.2018.05.035. Epub 2018 Jun 7. No abstract available.

28.

Is the SMARTLock Hybrid Maxillomandibular Fixation System Comparable to Intermaxillary Fixation Screws in Closed Reduction of Condylar Fractures?

Roeder RA, Guo L, Lim AA.

Ann Plast Surg. 2018 Dec;81(6S Suppl 1):S35-S38. doi: 10.1097/SAP.0000000000001497.

PMID:
29846213
29.

p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis.

Huang H, Tang S, Ji M, Tang Z, Shimada M, Liu X, Qi S, Locasale JW, Roeder RG, Zhao Y, Li X.

Mol Cell. 2018 May 17;70(4):663-678.e6. doi: 10.1016/j.molcel.2018.04.011. Erratum in: Mol Cell. 2018 Jun 7;70(5):984. Title and abstract corrected.

30.

Proteomic profiling identifies key coactivators utilized by mutant ERα proteins as potential new therapeutic targets.

Gates LA, Gu G, Chen Y, Rohira AD, Lei JT, Hamilton RA, Yu Y, Lonard DM, Wang J, Wang SP, Edwards DG, Lavere PF, Shao J, Yi P, Jain A, Jung SY, Malovannaya A, Li S, Shao J, Roeder RG, Ellis MJ, Qin J, Fuqua SAW, O'Malley BW, Foulds CE.

Oncogene. 2018 Aug;37(33):4581-4598. doi: 10.1038/s41388-018-0284-2. Epub 2018 May 11.

31.

Super-resolution fluorescence microscopy by stepwise optical saturation.

Zhang Y, Nallathamby PD, Vigil GD, Khan AA, Mason DE, Boerckel JD, Roeder RK, Howard SS.

Biomed Opt Express. 2018 Mar 12;9(4):1613-1629. doi: 10.1364/BOE.9.001613. eCollection 2018 Apr 1.

32.

Germline Lysine-Specific Demethylase 1 (LSD1/KDM1A) Mutations Confer Susceptibility to Multiple Myeloma.

Wei X, Calvo-Vidal MN, Chen S, Wu G, Revuelta MV, Sun J, Zhang J, Walsh MF, Nichols KE, Joseph V, Snyder C, Vachon CM, McKay JD, Wang SP, Jayabalan DS, Jacobs LM, Becirovic D, Waller RG, Artomov M, Viale A, Patel J, Phillip J, Chen-Kiang S, Curtin K, Salama M, Atanackovic D, Niesvizky R, Landgren O, Slager SL, Godley LA, Churpek J, Garber JE, Anderson KC, Daly MJ, Roeder RG, Dumontet C, Lynch HT, Mullighan CG, Camp NJ, Offit K, Klein RJ, Yu H, Cerchietti L, Lipkin SM.

Cancer Res. 2018 May 15;78(10):2747-2759. doi: 10.1158/0008-5472.CAN-17-1900. Epub 2018 Mar 20.

33.

Intracellular Crotonyl-CoA Stimulates Transcription through p300-Catalyzed Histone Crotonylation.

Sabari BR, Tang Z, Huang H, Yong-Gonzalez V, Molina H, Kong HE, Dai L, Shimada M, Cross JR, Zhao Y, Roeder RG, Allis CD.

Mol Cell. 2018 Feb 1;69(3):533. doi: 10.1016/j.molcel.2018.01.013. No abstract available.

34.

Regulation of RNA polymerase III transcription during transformation of human IMR90 fibroblasts with defined genetic elements.

Durrieu-Gaillard S, Dumay-Odelot H, Boldina G, Tourasse NJ, Allard D, André F, Macari F, Choquet A, Lagarde P, Drutel G, Leste-Lasserre T, Petitet M, Lesluyes T, Lartigue-Faustin L, Dupuy JW, Chibon F, Roeder RG, Joubert D, Vagner S, Teichmann M.

Cell Cycle. 2018;17(5):605-615. doi: 10.1080/15384101.2017.1405881. Epub 2018 Jan 22.

35.

The fracture toughness of small animal cortical bone measured using arc-shaped tension specimens: Effects of bisphosphonate and deproteinization treatments.

Hunckler MD, Chu ED, Baumann AP, Curtis TE, Ravosa MJ, Allen MR, Roeder RK.

Bone. 2017 Dec;105:67-74. doi: 10.1016/j.bone.2017.08.015. Epub 2017 Aug 18.

PMID:
28826844
36.

A UTX-MLL4-p300 Transcriptional Regulatory Network Coordinately Shapes Active Enhancer Landscapes for Eliciting Transcription.

Wang SP, Tang Z, Chen CW, Shimada M, Koche RP, Wang LH, Nakadai T, Chramiec A, Krivtsov AV, Armstrong SA, Roeder RG.

Mol Cell. 2017 Jul 20;67(2):308-321.e6. doi: 10.1016/j.molcel.2017.06.028.

37.
38.

DND1 maintains germline stem cells via recruitment of the CCR4-NOT complex to target mRNAs.

Yamaji M, Jishage M, Meyer C, Suryawanshi H, Der E, Yamaji M, Garzia A, Morozov P, Manickavel S, McFarland HL, Roeder RG, Hafner M, Tuschl T.

Nature. 2017 Mar 23;543(7646):568-572. doi: 10.1038/nature21690. Epub 2017 Mar 15.

39.

Inhibition of Adhesion Molecule Gene Expression and Cell Adhesion by the Metabolic Regulator PGC-1α.

Minsky N, Roeder RG.

PLoS One. 2016 Dec 16;11(12):e0165598. doi: 10.1371/journal.pone.0165598. eCollection 2016.

40.

Control of Secreted Protein Gene Expression and the Mammalian Secretome by the Metabolic Regulator PGC-1α.

Minsky N, Roeder RG.

J Biol Chem. 2017 Jan 6;292(1):43-50. doi: 10.1074/jbc.C116.761049. Epub 2016 Dec 1.

41.

Mediator: A Drawbridge across the Enhancer-Promoter Divide.

Malik S, Roeder RG.

Mol Cell. 2016 Nov 3;64(3):433-434. doi: 10.1016/j.molcel.2016.10.024.

42.

Chromatin Kinases Act on Transcription Factors and Histone Tails in Regulation of Inducible Transcription.

Josefowicz SZ, Shimada M, Armache A, Li CH, Miller RM, Lin S, Yang A, Dill BD, Molina H, Park HS, Garcia BA, Taunton J, Roeder RG, Allis CD.

Mol Cell. 2016 Oct 20;64(2):347-361. doi: 10.1016/j.molcel.2016.09.026.

43.

CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas.

Jiang Y, Ortega-Molina A, Geng H, Ying HY, Hatzi K, Parsa S, McNally D, Wang L, Doane AS, Agirre X, Teater M, Meydan C, Li Z, Poloway D, Wang S, Ennishi D, Scott DW, Stengel KR, Kranz JE, Holson E, Sharma S, Young JW, Chu CS, Roeder RG, Shaknovich R, Hiebert SW, Gascoyne RD, Tam W, Elemento O, Wendel HG, Melnick AM.

Cancer Discov. 2017 Jan;7(1):38-53. doi: 10.1158/2159-8290.CD-16-0975. Epub 2016 Oct 12.

44.

Ectopic models for endochondral ossification: comparing pellet and alginate bead culture methods.

Weiss-Bilka HE, McGann ME, Meagher MJ, Roeder RK, Wagner DR.

J Tissue Eng Regen Med. 2018 Jan;12(1):e541-e549. doi: 10.1002/term.2324. Epub 2017 Apr 9.

45.

Periostin supports hematopoietic progenitor cells and niche-dependent myeloblastoma cells in vitro.

Tanaka S, Maekawa A, Matsubara L, Imanishi A, Yano M, Roeder RG, Hasegawa N, Asano S, Ito M.

Biochem Biophys Res Commun. 2016 Sep 30;478(4):1706-12. doi: 10.1016/j.bbrc.2016.09.008. Epub 2016 Sep 3.

46.

Hafnia (HfO2) nanoparticles as an X-ray contrast agent and mid-infrared biosensor.

McGinnity TL, Dominguez O, Curtis TE, Nallathamby PD, Hoffman AJ, Roeder RK.

Nanoscale. 2016 Jul 14;8(28):13627-37. doi: 10.1039/c6nr03217f.

PMID:
27364973
47.

Acellular hydroxyapatite-collagen scaffolds support angiogenesis and osteogenic gene expression in an ectopic murine model: Effects of hydroxyapatite volume fraction.

Meagher MJ, Weiss-Bilka HE, Best ME, Boerckel JD, Wagner DR, Roeder RK.

J Biomed Mater Res A. 2016 Sep;104(9):2178-88. doi: 10.1002/jbm.a.35760. Epub 2016 May 3.

PMID:
27112109
48.

Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation.

Xie Z, Zhang D, Chung D, Tang Z, Huang H, Dai L, Qi S, Li J, Colak G, Chen Y, Xia C, Peng C, Ruan H, Kirkey M, Wang D, Jensen LM, Kwon OK, Lee S, Pletcher SD, Tan M, Lombard DB, White KP, Zhao H, Li J, Roeder RG, Yang X, Zhao Y.

Mol Cell. 2016 Apr 21;62(2):194-206. doi: 10.1016/j.molcel.2016.03.036.

49.

Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain.

Li Y, Sabari BR, Panchenko T, Wen H, Zhao D, Guan H, Wan L, Huang H, Tang Z, Zhao Y, Roeder RG, Shi X, Allis CD, Li H.

Mol Cell. 2016 Apr 21;62(2):181-193. doi: 10.1016/j.molcel.2016.03.028.

50.

Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters.

Goudarzi A, Zhang D, Huang H, Barral S, Kwon OK, Qi S, Tang Z, Buchou T, Vitte AL, He T, Cheng Z, Montellier E, Gaucher J, Curtet S, Debernardi A, Charbonnier G, Puthier D, Petosa C, Panne D, Rousseaux S, Roeder RG, Zhao Y, Khochbin S.

Mol Cell. 2016 Apr 21;62(2):169-180. doi: 10.1016/j.molcel.2016.03.014.

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