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Items: 1 to 50 of 75

1.

Paracrine mechanisms in early differentiation of human pluripotent stem cells: Insights from a mathematical model.

Gaspari E, Franke A, Robles-Diaz D, Zweigerdt R, Roeder I, Zerjatke T, Kempf H.

Stem Cell Res. 2018 Oct;32:1-7. doi: 10.1016/j.scr.2018.07.025. Epub 2018 Aug 18.

2.

Quantitative prediction of long-term molecular response in TKI-treated CML - Lessons from an imatinib versus dasatinib comparison.

Glauche I, Kuhn M, Baldow C, Schulze P, Rothe T, Liebscher H, Roy A, Wang X, Roeder I.

Sci Rep. 2018 Aug 17;8(1):12330. doi: 10.1038/s41598-018-29923-4.

3.

Reduced tyrosine kinase inhibitor dose is predicted to be as effective as standard dose in chronic myeloid leukemia: a simulation study based on phase III trial data.

Fassoni AC, Baldow C, Roeder I, Glauche I.

Haematologica. 2018 Nov;103(11):1825-1834. doi: 10.3324/haematol.2018.194522. Epub 2018 Jun 28.

4.

Metabolism is the tie: The Bertalanffy-type cancer growth model as common denominator of various modelling approaches.

Diebner HH, Zerjatke T, Griehl M, Roeder I.

Biosystems. 2018 May;167:1-23. doi: 10.1016/j.biosystems.2018.03.004. Epub 2018 Mar 29.

PMID:
29605248
5.

Whither systems medicine?

Apweiler R, Beissbarth T, Berthold MR, Blüthgen N, Burmeister Y, Dammann O, Deutsch A, Feuerhake F, Franke A, Hasenauer J, Hoffmann S, Höfer T, Jansen PL, Kaderali L, Klingmüller U, Koch I, Kohlbacher O, Kuepfer L, Lammert F, Maier D, Pfeifer N, Radde N, Rehm M, Roeder I, Saez-Rodriguez J, Sax U, Schmeck B, Schuppert A, Seilheimer B, Theis FJ, Vera J, Wolkenhauer O.

Exp Mol Med. 2018 Mar 2;50(3):e453. doi: 10.1038/emm.2017.290. Review.

6.

MAGPIE: Simplifying access and execution of computational models in the life sciences.

Baldow C, Salentin S, Schroeder M, Roeder I, Glauche I.

PLoS Comput Biol. 2017 Dec 15;13(12):e1005898. doi: 10.1371/journal.pcbi.1005898. eCollection 2017 Dec. Erratum in: PLoS Comput Biol. 2018 Mar 26;14 (3):e1006083.

7.

Rationale and design of MultiSELECt: A European Multicenter Study on the Effect of Lipoprotein(a) Elimination by lipoprotein apheresis on Cardiovascular outcomes.

Hohenstein B, Julius U, Lansberg P, Jaeger B, Mellwig KP, Weiss N, Graehlert X, Roeder I, Ramlow W.

Atheroscler Suppl. 2017 Nov;30:180-186. doi: 10.1016/j.atherosclerosissup.2017.05.009. Epub 2017 Jun 1.

PMID:
29096835
8.

Neurotrophin Receptor p75NTR Regulates Immune Function of Plasmacytoid Dendritic Cells.

Bandoła J, Richter C, Ryser M, Jamal A, Ashton MP, von Bonin M, Kuhn M, Dorschner B, Alexopoulou D, Navratiel K, Roeder I, Dahl A, Hedrich CM, Bonifacio E, Brenner S, Thieme S.

Front Immunol. 2017 Aug 17;8:981. doi: 10.3389/fimmu.2017.00981. eCollection 2017.

9.

Single Cell Phenotyping Reveals Heterogeneity Among Hematopoietic Stem Cells Following Infection.

MacLean AL, Smith MA, Liepe J, Sim A, Khorshed R, Rashidi NM, Scherf N, Krinner A, Roeder I, Lo Celso C, Stumpf MPH.

Stem Cells. 2017 Nov;35(11):2292-2304. doi: 10.1002/stem.2692. Epub 2017 Sep 24.

10.

Clonal competition in BcrAbl-driven leukemia: how transplantations can accelerate clonal conversion.

Cornils K, Thielecke L, Winkelmann D, Aranyossy T, Lesche M, Dahl A, Roeder I, Fehse B, Glauche I.

Mol Cancer. 2017 Jul 14;16(1):120. doi: 10.1186/s12943-017-0668-x.

11.

Donor cell leukemia: evidence for multiple preleukemic clones and parallel long term clonal evolution in donor and recipient.

Herold S, Kuhn M, Bonin MV, Stange T, Platzbecker U, Radke J, Lange T, Sockel K, Gutsche K, Schetelig J, Röllig C, Schuster C, Roeder I, Dahl A, Mohr B, Serve H, Brandts C, Ehninger G, Bornhäuser M, Thiede C.

Leukemia. 2017 Jul;31(7):1637-1640. doi: 10.1038/leu.2017.104. Epub 2017 Mar 28. No abstract available.

PMID:
28348390
12.

Limitations and challenges of genetic barcode quantification.

Thielecke L, Aranyossy T, Dahl A, Tiwari R, Roeder I, Geiger H, Fehse B, Glauche I, Cornils K.

Sci Rep. 2017 Mar 3;7:43249. doi: 10.1038/srep43249.

13.

Response dynamics of pediatric patients with chronic myeloid leukemia on imatinib therapy.

Proschmann R, Baldow C, Rothe T, Suttorp M, Thiede C, Tauer JT, Müller MC, Hochhaus A, Roeder I, Glauche I.

Haematologica. 2017 Feb;102(2):e39-e42. doi: 10.3324/haematol.2016.154138. Epub 2016 Nov 17. No abstract available.

14.

Concepts in mature T-cell lymphomas - highlights from an international joint symposium on T-cell immunology and oncology<sup/>.

Herling M, Rengstl B, Scholtysik R, Hartmann S, Küppers R, Hansmann ML, Diebner HH, Roeder I, Abken H, Newrzela S, Kirberg J.

Leuk Lymphoma. 2017 Apr;58(4):788-796. doi: 10.1080/10428194.2016.1222381. Epub 2016 Sep 19.

PMID:
27643643
15.

The bulk of the hematopoietic stem cell population is dispensable for murine steady-state and stress hematopoiesis.

Schoedel KB, Morcos MNF, Zerjatke T, Roeder I, Grinenko T, Voehringer D, Göthert JR, Waskow C, Roers A, Gerbaulet A.

Blood. 2016 Nov 10;128(19):2285-2296. doi: 10.1182/blood-2016-03-706010. Epub 2016 Jun 29.

16.
17.

Dissecting mechanisms of mouse embryonic stem cells heterogeneity through a model-based analysis of transcription factor dynamics.

Herberg M, Glauche I, Zerjatke T, Winzi M, Buchholz F, Roeder I.

J R Soc Interface. 2016 Apr;13(117). pii: 20160167. doi: 10.1098/rsif.2016.0167.

18.

An evolutionary stability perspective on oncogenesis control in mature T-cell populations.

Diebner HH, Kirberg J, Roeder I.

J Theor Biol. 2016 Jan 21;389:88-100. doi: 10.1016/j.jtbi.2015.10.033. Epub 2015 Nov 6.

PMID:
26549469
19.

Mice in an enriched environment learn more flexibly because of adult hippocampal neurogenesis.

Garthe A, Roeder I, Kempermann G.

Hippocampus. 2016 Feb;26(2):261-71. doi: 10.1002/hipo.22520. Epub 2015 Sep 15.

20.

Computational modelling of embryonic stem-cell fate control.

Herberg M, Roeder I.

Development. 2015 Jul 1;142(13):2250-60. doi: 10.1242/dev.116343. Review.

21.

High-throughput monitoring of integration site clonality in preclinical and clinical gene therapy studies.

Giordano FA, Appelt JU, Link B, Gerdes S, Lehrer C, Scholz S, Paruzynski A, Roeder I, Wenz F, Glimm H, von Kalle C, Grez M, Schmidt M, Laufs S.

Mol Ther Methods Clin Dev. 2015 Apr 1;2:14061. doi: 10.1038/mtm.2014.61. eCollection 2015.

22.

Factor graph analysis of live cell-imaging data reveals mechanisms of cell fate decisions.

Niederberger T, Failmezger H, Uskat D, Poron D, Glauche I, Scherf N, Roeder I, Schroeder T, Tresch A.

Bioinformatics. 2015 Jun 1;31(11):1816-23. doi: 10.1093/bioinformatics/btv040. Epub 2015 Jan 31.

PMID:
25638814
23.

Distinct roles of β-cell mass and function during type 1 diabetes onset and remission.

Chmelova H, Cohrs CM, Chouinard JA, Petzold C, Kuhn M, Chen C, Roeder I, Kretschmer K, Speier S.

Diabetes. 2015 Jun;64(6):2148-60. doi: 10.2337/db14-1055. Epub 2015 Jan 20.

24.

Image-based quantification and mathematical modeling of spatial heterogeneity in ESC colonies.

Herberg M, Zerjatke T, de Back W, Glauche I, Roeder I.

Cytometry A. 2015 Jun;87(6):481-90. doi: 10.1002/cyto.a.22598. Epub 2015 Jan 20.

25.

Quantification and modeling of stem cell-niche interaction.

Krinner A, Roeder I.

Adv Exp Med Biol. 2014;844:11-36. doi: 10.1007/978-1-4939-2095-2_2. Review.

PMID:
25480635
26.

Elucidating functional heterogeneity in hematopoietic progenitor cells: a combined experimental and modeling approach.

Bach E, Zerjatke T, Herklotz M, Scherf N, Niederwieser D, Roeder I, Pompe T, Cross M, Glauche I.

Exp Hematol. 2014 Sep;42(9):826-37.e1-17. doi: 10.1016/j.exphem.2014.05.011. Epub 2014 May 28.

PMID:
24878352
27.

In vivo time-lapse imaging shows diverse niche engagement by quiescent and naturally activated hematopoietic stem cells.

Rashidi NM, Scott MK, Scherf N, Krinner A, Kalchschmidt JS, Gounaris K, Selkirk ME, Roeder I, Lo Celso C.

Blood. 2014 Jul 3;124(1):79-83. doi: 10.1182/blood-2013-10-534859. Epub 2014 May 21.

28.

A model-based analysis of culture-dependent phenotypes of mESCs.

Herberg M, Kalkan T, Glauche I, Smith A, Roeder I.

PLoS One. 2014 Mar 18;9(3):e92496. doi: 10.1371/journal.pone.0092496. eCollection 2014.

29.

Placement makes a difference: accuracy of an accelerometer in measuring step number and stair climbing.

Lützner C, Voigt H, Roeder I, Kirschner S, Lützner J.

Gait Posture. 2014 Apr;39(4):1126-32. doi: 10.1016/j.gaitpost.2014.01.022. Epub 2014 Feb 18.

PMID:
24629310
30.

Multiplexing clonality: combining RGB marking and genetic barcoding.

Cornils K, Thielecke L, Hüser S, Forgber M, Thomaschewski M, Kleist N, Hussein K, Riecken K, Volz T, Gerdes S, Glauche I, Dahl A, Dandri M, Roeder I, Fehse B.

Nucleic Acids Res. 2014 Apr;42(7):e56. doi: 10.1093/nar/gku081. Epub 2014 Jan 29.

31.

Mathematical modeling of oncogenesis control in mature T-cell populations.

Gerdes S, Newrzela S, Glauche I, von Laer D, Hansmann ML, Roeder I.

Front Immunol. 2013 Nov 21;4:380. doi: 10.3389/fimmu.2013.00380. eCollection 2013.

32.

Merging concepts - coupling an agent-based model of hematopoietic stem cells with an ODE model of granulopoiesis.

Krinner A, Roeder I, Loeffler M, Scholz M.

BMC Syst Biol. 2013 Nov 1;7:117. doi: 10.1186/1752-0509-7-117.

33.

Heparin modification of a biomimetic bone matrix for controlled release of VEGF.

Knaack S, Lode A, Hoyer B, Rösen-Wolff A, Gabrielyan A, Roeder I, Gelinsky M.

J Biomed Mater Res A. 2014 Oct;102(10):3500-11. doi: 10.1002/jbm.a.35020. Epub 2013 Nov 15.

PMID:
24178515
34.

High-speed panoramic light-sheet microscopy reveals global endodermal cell dynamics.

Schmid B, Shah G, Scherf N, Weber M, Thierbach K, Campos CP, Roeder I, Aanstad P, Huisken J.

Nat Commun. 2013;4:2207. doi: 10.1038/ncomms3207.

35.

Stem cell clonality -- theoretical concepts, experimental techniques, and clinical challenges.

Glauche I, Bystrykh L, Eaves C, Roeder I; other participants.

Blood Cells Mol Dis. 2013 Apr;50(4):232-40. doi: 10.1016/j.bcmd.2013.01.007. Epub 2013 Feb 19. Review.

PMID:
23433531
36.

Activation of Evi1 inhibits cell cycle progression and differentiation of hematopoietic progenitor cells.

Kustikova OS, Schwarzer A, Stahlhut M, Brugman MH, Neumann T, Yang M, Li Z, Schambach A, Heinz N, Gerdes S, Roeder I, Ha TC, Steinemann D, Schlegelberger B, Baum C.

Leukemia. 2013 Apr;27(5):1127-38. doi: 10.1038/leu.2012.355. Epub 2012 Dec 5.

PMID:
23212151
37.

Model-based decision rules reduce the risk of molecular relapse after cessation of tyrosine kinase inhibitor therapy in chronic myeloid leukemia.

Horn M, Glauche I, Müller MC, Hehlmann R, Hochhaus A, Loeffler M, Roeder I.

Blood. 2013 Jan 10;121(2):378-84. doi: 10.1182/blood-2012-07-441956. Epub 2012 Nov 21.

38.

Comparative clonal analysis of reconstitution kinetics after transplantation of hematopoietic stem cells gene marked with a lentiviral SIN or a γ-retroviral LTR vector.

Cornils K, Bartholomae CC, Thielecke L, Lange C, Arens A, Glauche I, Mock U, Riecken K, Gerdes S, von Kalle C, Schmidt M, Roeder I, Fehse B.

Exp Hematol. 2013 Jan;41(1):28-38.e3. doi: 10.1016/j.exphem.2012.09.003. Epub 2012 Sep 16.

PMID:
22989760
39.

Imaging, quantification and visualization of spatio-temporal patterning in mESC colonies under different culture conditions.

Scherf N, Herberg M, Thierbach K, Zerjatke T, Kalkan T, Humphreys P, Smith A, Glauche I, Roeder I.

Bioinformatics. 2012 Sep 15;28(18):i556-i561. doi: 10.1093/bioinformatics/bts404.

40.

T-cell receptor diversity prevents T-cell lymphoma development.

Newrzela S, Al-Ghaili N, Heinrich T, Petkova M, Hartmann S, Rengstl B, Kumar A, Jäck HM, Gerdes S, Roeder I, Hansmann ML, von Laer D.

Leukemia. 2012 Dec;26(12):2499-507. doi: 10.1038/leu.2012.142. Epub 2012 May 30.

PMID:
22643706
41.

Therapy of chronic myeloid leukaemia can benefit from the activation of stem cells: simulation studies of different treatment combinations.

Glauche I, Horn K, Horn M, Thielecke L, Essers MA, Trumpp A, Roeder I.

Br J Cancer. 2012 May 22;106(11):1742-52. doi: 10.1038/bjc.2012.142. Epub 2012 Apr 26.

42.

On the symmetry of siblings: automated single-cell tracking to quantify the behavior of hematopoietic stem cells in a biomimetic setup.

Scherf N, Franke K, Glauche I, Kurth I, Bornhäuser M, Werner C, Pompe T, Roeder I.

Exp Hematol. 2012 Feb;40(2):119-30.e9. doi: 10.1016/j.exphem.2011.10.009. Epub 2011 Nov 13.

PMID:
22085452
43.

Epigenetic Nanog regulation and the role of functional heterogeneity.

Herberg M, Roeder I.

Cell Cycle. 2011 Jul 15;10(14):2252-3. Epub 2011 Jul 15. No abstract available.

PMID:
21670592
44.

Towards a quantitative understanding of stem cell-niche interaction: experiments, models, and technologies.

Roeder I, Loeffler M, Glauche I; other participants.

Blood Cells Mol Dis. 2011 Apr 15;46(4):308-17. doi: 10.1016/j.bcmd.2011.03.001. Epub 2011 Mar 29.

PMID:
21450497
45.

Cellular aging leads to functional heterogeneity of hematopoietic stem cells: a modeling perspective.

Glauche I, Thielecke L, Roeder I.

Aging Cell. 2011 Jun;10(3):457-65. doi: 10.1111/j.1474-9726.2011.00692.x. Epub 2011 Apr 5.

46.

Clonal inventory screens uncover monoclonality following serial transplantation of MGMT P140K-transduced stem cells and dose-intense chemotherapy.

Giordano FA, Sorg UR, Appelt JU, Lachmann N, Bleier S, Roeder I, Kleff V, Flasshove M, Zeller WJ, Allgayer H, von Kalle C, Fruehauf S, Moritz T, Laufs S.

Hum Gene Ther. 2011 Jun;22(6):697-710. doi: 10.1089/hum.2010.088. Epub 2011 Apr 11.

PMID:
21319998
47.

Nanog variability and pluripotency regulation of embryonic stem cells--insights from a mathematical model analysis.

Glauche I, Herberg M, Roeder I.

PLoS One. 2010 Jun 21;5(6):e11238. doi: 10.1371/journal.pone.0011238.

48.

Stem cell biology meets systems biology.

Roeder I, Radtke F.

Development. 2009 Nov;136(21):3525-30. doi: 10.1242/dev.040758.

49.

Stem cell proliferation and quiescence--two sides of the same coin.

Glauche I, Moore K, Thielecke L, Horn K, Loeffler M, Roeder I.

PLoS Comput Biol. 2009 Jul;5(7):e1000447. doi: 10.1371/journal.pcbi.1000447. Epub 2009 Jul 24.

50.

New experimental and theoretical investigations of hematopoietic stem cells and chronic myeloid leukemia.

Roeder I, d'Inverno M; other participants.

Blood Cells Mol Dis. 2009 Jul-Aug;43(1):88-97. doi: 10.1016/j.bcmd.2009.03.003. Epub 2009 May 2.

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