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LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer's Disease.

Van Gool B, Storck SE, Reekmans SM, Lechat B, Gordts PLSM, Pradier L, Pietrzik CU, Roebroek AJM.

Mol Neurobiol. 2019 Oct;56(10):7234-7245. doi: 10.1007/s12035-019-1594-2. Epub 2019 Apr 19.


Single mild traumatic brain injury results in transiently impaired spatial long-term memory and altered search strategies.

Marschner L, Schreurs A, Lechat B, Mogensen J, Roebroek A, Ahmed T, Balschun D.

Behav Brain Res. 2019 Jun 3;365:222-230. doi: 10.1016/j.bbr.2018.02.040. Epub 2018 Feb 27.


White matter microstructural changes in adolescent anorexia nervosa including an exploratory longitudinal study.

Vogel K, Timmers I, Kumar V, Nickl-Jockschat T, Bastiani M, Roebroek A, Herpertz-Dahlmann B, Konrad K, Goebel R, Seitz J.

Neuroimage Clin. 2016 Apr 12;11:614-621. doi: 10.1016/j.nicl.2016.04.002. eCollection 2016.


The Matricellular Receptor LRP1 Forms an Interface for Signaling and Endocytosis in Modulation of the Extracellular Tumor Environment.

Van Gool B, Dedieu S, Emonard H, Roebroek AJ.

Front Pharmacol. 2015 Nov 10;6:271. doi: 10.3389/fphar.2015.00271. eCollection 2015. Review.


Hematopoietic stem/progenitor cells directly contribute to arteriosclerotic progression via integrin β2.

Wang X, Gao M, Schouteden S, Roebroek A, Eggermont K, van Veldhoven PP, Liu G, Peters T, Scharffetter-Kochanek K, Verfaillie CM, Feng Y.

Stem Cells. 2015 Apr;33(4):1230-40. doi: 10.1002/stem.1939.


Generation of an allelic series of knock-in mice using recombinase-mediated cassette exchange (RMCE).

Roebroek AJ, Van Gool B.

Methods Mol Biol. 2014;1194:63-76. doi: 10.1007/978-1-4939-1215-5_4.


LRP1 is critical for the surface distribution and internalization of the NR2B NMDA receptor subtype.

Maier W, Bednorz M, Meister S, Roebroek A, Weggen S, Schmitt U, Pietrzik CU.

Mol Neurodegener. 2013 Jul 17;8:25. doi: 10.1186/1750-1326-8-25.


Generation and characterization of an Nxf7 knockout mouse to study NXF5 deficiency in a patient with intellectual disability.

Vanmarsenille L, Verbeeck J, Belet S, Roebroek AJ, Van de Putte T, Nevelsteen J, Callaerts-Vegh Z, D'Hooge R, Marynen P, Froyen G.

PLoS One. 2013 May 13;8(5):e64144. doi: 10.1371/journal.pone.0064144. Print 2013.


The plasma concentration of HDL-associated apoM is influenced by LDL receptor-mediated clearance of apoB-containing particles.

Christoffersen C, Benn M, Christensen PM, Gordts PL, Roebroek AJ, Frikke-Schmidt R, Tybjaerg-Hansen A, Dahlbäck B, Nielsen LB.

J Lipid Res. 2012 Oct;53(10):2198-204. doi: 10.1194/jlr.P023697. Epub 2012 Jul 23.


Loss of endothelial furin leads to cardiac malformation and early postnatal death.

Kim W, Essalmani R, Szumska D, Creemers JW, Roebroek AJ, D'Orleans-Juste P, Bhattacharya S, Seidah NG, Prat A.

Mol Cell Biol. 2012 Sep;32(17):3382-91. doi: 10.1128/MCB.06331-11. Epub 2012 Jun 25.


Impaired LDL receptor-related protein 1 translocation correlates with improved dyslipidemia and atherosclerosis in apoE-deficient mice.

Gordts PL, Bartelt A, Nilsson SK, Annaert W, Christoffersen C, Nielsen LB, Heeren J, Roebroek AJ.

PLoS One. 2012;7(6):e38330. doi: 10.1371/journal.pone.0038330. Epub 2012 Jun 6.


A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death.

Garg AD, Krysko DV, Verfaillie T, Kaczmarek A, Ferreira GB, Marysael T, Rubio N, Firczuk M, Mathieu C, Roebroek AJ, Annaert W, Golab J, de Witte P, Vandenabeele P, Agostinis P.

EMBO J. 2012 Mar 7;31(5):1062-79. doi: 10.1038/emboj.2011.497. Epub 2012 Jan 17.


Generation of a series of knock-in alleles using RMCE in ES cells.

Roebroek AJ, Gordts PL, Reekmans S.

Methods Mol Biol. 2011;693:277-81. doi: 10.1007/978-1-60761-974-1_16.


Knock-in approaches.

Roebroek AJ, Gordts PL, Reekmans S.

Methods Mol Biol. 2011;693:257-75. doi: 10.1007/978-1-60761-974-1_15.


LRP1 mediates bidirectional transcytosis of amyloid-β across the blood-brain barrier.

Pflanzner T, Janko MC, André-Dohmen B, Reuss S, Weggen S, Roebroek AJ, Kuhlmann CR, Pietrzik CU.

Neurobiol Aging. 2011 Dec;32(12):2323.e1-11. doi: 10.1016/j.neurobiolaging.2010.05.025. Epub 2010 Jul 13.


Opposing effects of apolipoprotein m on catabolism of apolipoprotein B-containing lipoproteins and atherosclerosis.

Christoffersen C, Pedersen TX, Gordts PL, Roebroek AJ, Dahlbäck B, Nielsen LB.

Circ Res. 2010 May 28;106(10):1624-34. doi: 10.1161/CIRCRESAHA.109.211086. Epub 2010 Apr 1.


Inactivation of the proximal NPXY motif impairs early steps in LRP1 biosynthesis.

Reekmans SM, Pflanzner T, Gordts PL, Isbert S, Zimmermann P, Annaert W, Weggen S, Roebroek AJ, Pietrzik CU.

Cell Mol Life Sci. 2010 Jan;67(1):135-45. doi: 10.1007/s00018-009-0171-7. Epub 2009 Oct 25.


Inactivation of the LRP1 intracellular NPxYxxL motif in LDLR-deficient mice enhances postprandial dyslipidemia and atherosclerosis.

Gordts PL, Reekmans S, Lauwers A, Van Dongen A, Verbeek L, Roebroek AJ.

Arterioscler Thromb Vasc Biol. 2009 Sep;29(9):1258-64. doi: 10.1161/ATVBAHA.109.192211. Epub 2009 Aug 10.


Role of furin in granular acidification in the endocrine pancreas: identification of the V-ATPase subunit Ac45 as a candidate substrate.

Louagie E, Taylor NA, Flamez D, Roebroek AJ, Bright NA, Meulemans S, Quintens R, Herrera PL, Schuit F, Van de Ven WJ, Creemers JW.

Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12319-24. doi: 10.1073/pnas.0800340105. Epub 2008 Aug 19.


T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance.

Pesu M, Watford WT, Wei L, Xu L, Fuss I, Strober W, Andersson J, Shevach EM, Quezado M, Bouladoux N, Roebroek A, Belkaid Y, Creemers J, O'Shea JJ.

Nature. 2008 Sep 11;455(7210):246-50. doi: 10.1038/nature07210.


MMTV-cre-mediated fur inactivation concomitant with PLAG1 proto-oncogene activation delays salivary gland tumorigenesis in mice.

De Vos L, Declercq J, Rosas GG, Van Damme B, Roebroek A, Vermorken F, Ceuppens J, van de Ven W, Creemers J.

Int J Oncol. 2008 May;32(5):1073-83.


The functional role of the second NPXY motif of the LRP1 beta-chain in tissue-type plasminogen activator-mediated activation of N-methyl-D-aspartate receptors.

Martin AM, Kuhlmann C, Trossbach S, Jaeger S, Waldron E, Roebroek A, Luhmann HJ, Laatsch A, Weggen S, Lessmann V, Pietrzik CU.

J Biol Chem. 2008 May 2;283(18):12004-13. doi: 10.1074/jbc.M707607200. Epub 2008 Mar 5.


Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons.

Van Dyck F, Braem CV, Chen Z, Declercq J, Deckers R, Kim BM, Ito S, Wu MK, Cohen DE, Dewerchin M, Derua R, Waelkens E, Fiette L, Roebroek A, Schuit F, Van de Ven WJ, Shivdasani RA.

Cell Metab. 2007 Nov;6(5):406-13.


Cellular uptake of mammalian heparanase precursor involves low density lipoprotein receptor-related proteins, mannose 6-phosphate receptors, and heparan sulfate proteoglycans.

Vreys V, Delande N, Zhang Z, Coomans C, Roebroek A, Dürr J, David G.

J Biol Chem. 2005 Sep 30;280(39):33141-8. Epub 2005 Jul 26.


Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice.

Dominguez D, Tournoy J, Hartmann D, Huth T, Cryns K, Deforce S, Serneels L, Camacho IE, Marjaux E, Craessaerts K, Roebroek AJ, Schwake M, D'Hooge R, Bach P, Kalinke U, Moechars D, Alzheimer C, Reiss K, Saftig P, De Strooper B.

J Biol Chem. 2005 Sep 2;280(35):30797-806. Epub 2005 Jun 29.


Limited redundancy of the proprotein convertase furin in mouse liver.

Roebroek AJ, Taylor NA, Louagie E, Pauli I, Smeijers L, Snellinx A, Lauwers A, Van de Ven WJ, Hartmann D, Creemers JW.

J Biol Chem. 2004 Dec 17;279(51):53442-50. Epub 2004 Oct 7.


Low-density lipoprotein receptor-related protein interacts with MafB, a regulator of hindbrain development.

Petersen HH, Hilpert J, Jacobsen C, Lauwers A, Roebroek AJ, Willnow TE.

FEBS Lett. 2004 May 7;565(1-3):23-7.


Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule.

Petersen HH, Hilpert J, Militz D, Zandler V, Jacobsen C, Roebroek AJ, Willnow TE.

J Cell Sci. 2003 Feb 1;116(Pt 3):453-61.


Knockin approaches.

Roebroek AJ, Wu X, Bram RJ.

Methods Mol Biol. 2003;209:187-200. No abstract available.


Functional expression of murine LRP1 requires correction of Lrp1 cDNA sequences.

Smeijers L, Willems S, Lauwers A, Thiry E, van Leuven F, Roebroek AJ.

Biochim Biophys Acta. 2002 Aug 19;1577(1):155-8.


Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin.

Roebroek AJ, Umans L, Pauli IG, Robertson EJ, van Leuven F, Van de Ven WJ, Constam DB.

Development. 1998 Dec;125(24):4863-76.


cDNA cloning, genomic organization, and expression of the human RTN2 gene, a member of a gene family encoding reticulons.

Roebroek AJ, Contreras B, Pauli IG, Van de Ven WJ.

Genomics. 1998 Jul 1;51(1):98-106.


Neuronal differentiation is accompanied by NSP-C expression.

Hens J, Nuydens R, Geerts H, Senden NH, Van de Ven WJ, Roebroek AJ, van de Velde HJ, Ramaekers FC, Broers JL.

Cell Tissue Res. 1998 May;292(2):229-37.


Biosynthesis, distinct post-translational modifications, and functional characterization of lymphoma proprotein convertase.

van de Loo JW, Creemers JW, Bright NA, Young BD, Roebroek AJ, Van de Ven WJ.

J Biol Chem. 1997 Oct 24;272(43):27116-23.


Neuroendocrine-specific protein (NSP)-reticulons as independent markers for non-small cell lung cancer with neuroendocrine differentiation. An in vitro histochemical study.

Senden N, Linnoila I, Timmer E, van de Velde H, Roebroek A, Van de Ven W, Broers J, Ramaekers F.

Histochem Cell Biol. 1997 Aug;108(2):155-65.


A comparison of NSP-reticulons with conventional neuroendocrine markers in immunophenotyping of lung cancers.

Senden NH, Timmer ED, de Bruïne A, Wagenaar SS, Van de Velde HJ, Roebroek AJ, Van de Ven WJ, Broers JL, Ramaekers FC.

J Pathol. 1997 May;182(1):13-21.


Neuroendocrine-specific protein C (NSP-C): subcellular localization and differential expression in relation to NSP-A.

Senden NH, Timmer ED, Boers JE, van de Velde HJ, Roebroek AJ, Van de Ven WJ, Broers JL, Ramaekers FC.

Eur J Cell Biol. 1996 Mar;69(3):197-213.


Genomic organization of the human NSP gene, prototype of a novel gene family encoding reticulons.

Roebroek AJ, Ayoubi TA, Van de Velde HJ, Schoenmakers EF, Pauli IG, Van de Ven WJ.

Genomics. 1996 Mar 1;32(2):191-9.


A new member of the proprotein convertase gene family (LPC) is located at a chromosome translocation breakpoint in lymphomas.

Meerabux J, Yaspo ML, Roebroek AJ, Van de Ven WJ, Lister TA, Young BD.

Cancer Res. 1996 Feb 1;56(3):448-51.


Assignment of the human proprotein convertase gene PCSK5 to chromosome 9q21.3.

van de Loo JW, Creemers JW, Kas K, Roebroek AJ, Van de Ven WJ.

Cytogenet Cell Genet. 1996;75(4):227-9.


Endoproteolytic cleavage of its propeptide is a prerequisite for efficient transport of furin out of the endoplasmic reticulum.

Creemers JW, Vey M, Schäfer W, Ayoubi TA, Roebroek AJ, Klenk HD, Garten W, Van de Ven WJ.

J Biol Chem. 1995 Feb 10;270(6):2695-702.


Processing specificity and biosynthesis of the Drosophila melanogaster convertases dfurin1, dfurin1-CRR, dfurin1-X, and dfurin2.

De Bie I, Savaria D, Roebroek AJ, Day R, Lazure C, Van de Ven WJ, Seidah NG.

J Biol Chem. 1995 Jan 20;270(3):1020-8.


Subcellular localization and supramolecular organization of neuroendocrine-specific protein B (NSP-B) in small cell lung cancer.

Senden NH, van de Velde HJ, Broers JL, Timmer ED, Kuijpers HJ, Roebroek AJ, Van de Ven WJ, Ramaekers FC.

Eur J Cell Biol. 1994 Dec;65(2):341-53.


NSP-encoded reticulons are neuroendocrine markers of a novel category in human lung cancer diagnosis.

van de Velde HJ, Senden NH, Roskams TA, Broers JL, Ramaekers FC, Roebroek AJ, Van de Ven WJ.

Cancer Res. 1994 Sep 1;54(17):4769-76.


NSP-encoded reticulons, neuroendocrine proteins of a novel gene family associated with membranes of the endoplasmic reticulum.

van de Velde HJ, Roebroek AJ, Senden NH, Ramaekers FC, Van de Ven WJ.

J Cell Sci. 1994 Sep;107 ( Pt 9):2403-16.


Molecular analysis of expression in rat brain of NSP-A, a novel neuroendocrine-specific protein of the endoplasmic reticulum.

van de Velde HJ, Roebroek AJ, van Leeuwen FW, Van de Ven WJ.

Brain Res Mol Brain Res. 1994 Apr;23(1-2):81-92.


Expression of the dibasic proprotein processing enzyme furin is directed by multiple promoters.

Ayoubi TA, Creemers JW, Roebroek AJ, Van de Ven WJ.

J Biol Chem. 1994 Mar 25;269(12):9298-303.

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