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Understanding basic vein physiology and venous blood pressure through simple physical assessments.

Tansey EA, Montgomery LEA, Quinn JG, Roe SM, Johnson CD.

Adv Physiol Educ. 2019 Sep 1;43(3):423-429. doi: 10.1152/advan.00182.2018.


Correction: In vitro Biological Characterization of a Novel, Synthetic Diaryl Pyrazole Resorcinol Class of Heat Shock Protein 90 Inhibitors.

Sharp SY, Boxall K, Rowlands M, Prodromou C, Roe SM, Maloney A, Powers M, Clarke PA, Box G, Sanderson S, Patterson L, Matthews TP, Cheung KJ, Ball K, Hayes A, Raynaud F, Marais R, Pearl L, Eccles S, Aherne W, McDonald E, Workman P.

Cancer Res. 2019 Jan 1;79(1):287. doi: 10.1158/0008-5472.CAN-18-3578. No abstract available.


The X-ray structure of human calbindin-D28K: an improved model.

Noble JW, Almalki R, Roe SM, Wagner A, Duman R, Atack JR.

Acta Crystallogr D Struct Biol. 2018 Oct 1;74(Pt 10):1008-1014. doi: 10.1107/S2059798318011610. Epub 2018 Oct 2.


Co-crystallization of human inositol monophosphatase with the lithium mimetic L-690,330.

Kraft L, Roe SM, Gill R, Atack JR.

Acta Crystallogr D Struct Biol. 2018 Oct 1;74(Pt 10):973-978. doi: 10.1107/S2059798318010380. Epub 2018 Oct 2.


Synthesis of novel heteroleptic delocalised cationic pyrazole gold complexes as potent HepG2 cytotoxic agents.

Afolabi F, Souissi W, Rivière G, Lemaitre C, Roe SM, Crickmore N, Viseux EME.

Dalton Trans. 2018 Nov 21;47(43):15338-15343. doi: 10.1039/c8dt02832j. Epub 2018 Oct 2.


Author Correction: RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex.

Martino F, Pal M, Muñoz-Hernández H, Rodríguez CF, Núñez-Ramírez R, Gil-Carton D, Degliesposti G, Skehel JM, Roe SM, Prodromou C, Pearl LH, Llorca O.

Nat Commun. 2018 Jul 31;9(1):3063. doi: 10.1038/s41467-018-05546-1.


Trimerisation of carbon suboxide at a di-titanium centre to form a pyrone ring system.

Tsoureas N, Green JC, Cloke FGN, Puschmann H, Roe SM, Tizzard G.

Chem Sci. 2018 May 8;9(22):5008-5014. doi: 10.1039/c8sc01127c. eCollection 2018 Jun 14.


RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex.

Martino F, Pal M, Muñoz-Hernández H, Rodríguez CF, Núñez-Ramírez R, Gil-Carton D, Degliesposti G, Skehel JM, Roe SM, Prodromou C, Pearl LH, Llorca O.

Nat Commun. 2018 Apr 16;9(1):1501. doi: 10.1038/s41467-018-03942-1. Erratum in: Nat Commun. 2018 Jul 31;9(1):3063.


The structure of FKBP38 in complex with the MEEVD tetratricopeptide binding-motif of Hsp90.

Blundell KL, Pal M, Roe SM, Pearl LH, Prodromou C.

PLoS One. 2017 Mar 9;12(3):e0173543. doi: 10.1371/journal.pone.0173543. eCollection 2017.


Elaboration of tetra-orthogonally-substituted aromatic scaffolds towards novel EGFR-kinase inhibitors.

Close AJ, Jones RN, Ocasio CA, Kemmitt P, Roe SM, Spencer J.

Org Biomol Chem. 2016 Sep 21;14(35):8246-52. doi: 10.1039/c6ob01394e. Epub 2016 Jul 25.


Ultrasound imaging in teaching cardiac physiology.

Johnson CD, Montgomery LE, Quinn JG, Roe SM, Stewart MT, Tansey EA.

Adv Physiol Educ. 2016 Sep;40(3):354-8. doi: 10.1152/advan.00011.2016.


Blood: tests used to assess the physiological and immunological properties of blood.

Quinn JG, Tansey EA, Johnson CD, Roe SM, Montgomery LE.

Adv Physiol Educ. 2016 Jun;40(2):165-75. doi: 10.1152/advan.00079.2015.


Autonomic modification of intestinal smooth muscle contractility.

Montgomery LE, Tansey EA, Johnson CD, Roe SM, Quinn JG.

Adv Physiol Educ. 2016 Mar;40(1):104-9. doi: 10.1152/advan.00038.2015.


Tah1 helix-swap dimerization prevents mixed Hsp90 co-chaperone complexes.

Morgan RM, Pal M, Roe SM, Pearl LH, Prodromou C.

Acta Crystallogr D Biol Crystallogr. 2015 May;71(Pt 5):1197-206. doi: 10.1107/S1399004715004551. Epub 2015 Apr 25.


Investigation of physiological properties of nerves and muscles using electromyography.

Roe SM, Johnson CD, Tansey EA.

Adv Physiol Educ. 2014 Dec;38(4):348-54. doi: 10.1152/advan.00018.2014.


Mixed sandwich thorium complexes incorporating bis(tri-isopropylsilyl)cyclooctatetraenyl and pentamethylcyclopentadienyl ligands: synthesis, structure and reactivity.

Button ZE, Higgins JA, Suvova M, Cloke FG, Roe SM.

Dalton Trans. 2015 Feb 14;44(6):2588-96. doi: 10.1039/c4dt02362e.


Synthesis and electronic structure of the first cyaphide-alkynyl complexes.

Trathen N, Leech MC, Crossley IR, Greenacre VK, Roe SM.

Dalton Trans. 2014 Jun 28;43(24):9004-7. doi: 10.1039/c4dt01108b.


Structural basis for phosphorylation-dependent recruitment of Tel2 to Hsp90 by Pih1.

Pal M, Morgan M, Phelps SE, Roe SM, Parry-Morris S, Downs JA, Polier S, Pearl LH, Prodromou C.

Structure. 2014 Jun 10;22(6):805-18. doi: 10.1016/j.str.2014.04.001. Epub 2014 May 1.


Formation of cyanates in low-valent uranium chemistry: a synergistic experimental/theoretical study.

Kefalidis CE, Frey AS, Roe SM, Cloke FG, Maron L.

Dalton Trans. 2014 Aug 7;43(29):11202-8. doi: 10.1039/c4dt00618f. Epub 2014 Apr 28.


The sympathetic release test: a test used to assess thermoregulation and autonomic control of blood flow.

Tansey EA, Roe SM, Johnson CJ.

Adv Physiol Educ. 2014 Mar;38(1):87-92. doi: 10.1152/advan.00095.2013.


Synthesis of macrolactam analogues of radicicol and their binding to heat shock protein Hsp90.

Dutton BL, Kitson RR, Parry-Morris S, Roe SM, Prodromou C, Moody CJ.

Org Biomol Chem. 2014 Feb 28;12(8):1328-40. doi: 10.1039/c3ob42211a.


Investigation of the reductive cleavage of BINAP and application to the rapid synthesis of phospholes.

Gallop CW, Bobin M, Hourani P, Dwyer J, Roe SM, Viseux EM.

J Org Chem. 2013 Jul 5;78(13):6522-8. doi: 10.1021/jo4006393. Epub 2013 Jun 25.


Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90.

Kitson RR, Chang CH, Xiong R, Williams HE, Davis AL, Lewis W, Dehn DL, Siegel D, Roe SM, Prodromou C, Ross D, Moody CJ.

Nat Chem. 2013 Apr;5(4):307-14. doi: 10.1038/nchem.1596. Epub 2013 Mar 10.


Insights into the mechanism for gold catalysis: behaviour of gold(I) amide complexes in solution.

Bobin M, Day IJ, Roe SM, Viseux EM.

Dalton Trans. 2013 May 14;42(18):6592-602. doi: 10.1039/c3dt33039g. Erratum in: Dalton Trans. 2013 Nov 19;42(48):16974.


Structure of the TPR domain of AIP: lack of client protein interaction with the C-terminal α-7 helix of the TPR domain of AIP is sufficient for pituitary adenoma predisposition.

Morgan RM, Hernández-Ramírez LC, Trivellin G, Zhou L, Roe SM, Korbonits M, Prodromou C.

PLoS One. 2012;7(12):e53339. doi: 10.1371/journal.pone.0053339. Epub 2012 Dec 31.


Co-crystalization and in vitro biological characterization of 5-aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors.

Sharp SY, Roe SM, Kazlauskas E, Cikotienė I, Workman P, Matulis D, Prodromou C.

PLoS One. 2012;7(9):e44642. doi: 10.1371/journal.pone.0044642. Epub 2012 Sep 11.


Facile self-assembly of the first diphosphametacyclophane.

Saunders AJ, Crossley IR, Coles MP, Roe SM.

Chem Commun (Camb). 2012 Jun 11;48(46):5766-8. doi: 10.1039/c2cc32247a. Epub 2012 May 2.


Targeting the Hsp90 molecular chaperone with novel macrolactams. Synthesis, structural, binding, and cellular studies.

Day JE, Sharp SY, Rowlands MG, Aherne W, Hayes A, Raynaud FI, Lewis W, Roe SM, Prodromou C, Pearl LH, Workman P, Moody CJ.

ACS Chem Biol. 2011 Dec 16;6(12):1339-47. doi: 10.1021/cb200196e. Epub 2011 Oct 4.


Features of the Streptomyces hygroscopicus HtpG reveal how partial geldanamycin resistance can arise with mutation to the ATP binding pocket of a eukaryotic Hsp90.

Millson SH, Chua CS, Roe SM, Polier S, Solovieva S, Pearl LH, Sim TS, Prodromou C, Piper PW.

FASEB J. 2011 Nov;25(11):3828-37. doi: 10.1096/fj.11-188821. Epub 2011 Jul 21.


The crystal structure of yeast CCT reveals intrinsic asymmetry of eukaryotic cytosolic chaperonins.

Dekker C, Roe SM, McCormack EA, Beuron F, Pearl LH, Willison KR.

EMBO J. 2011 Jun 24;30(15):3078-90. doi: 10.1038/emboj.2011.208.


Inhibition of Hsp90 with resorcylic acid macrolactones: synthesis and binding studies.

Day JE, Sharp SY, Rowlands MG, Aherne W, Lewis W, Roe SM, Prodromou C, Pearl LH, Workman P, Moody CJ.

Chemistry. 2010 Sep 10;16(34):10366-72. doi: 10.1002/chem.201001119.


Molecular structure of the N-terminal domain of the APC/C subunit Cdc27 reveals a homo-dimeric tetratricopeptide repeat architecture.

Zhang Z, Roe SM, Diogon M, Kong E, El Alaoui H, Barford D.

J Mol Biol. 2010 Apr 16;397(5):1316-28. doi: 10.1016/j.jmb.2010.02.045. Epub 2010 Mar 3.


A pocket on the surface of the N-terminal BRCT domain of Mcph1 is required to prevent abnormal chromosome condensation.

Richards MW, Leung JW, Roe SM, Li K, Chen J, Bayliss R.

J Mol Biol. 2010 Feb 5;395(5):908-15. doi: 10.1016/j.jmb.2009.11.029. Epub 2009 Nov 17.


Tutorials for large classes of Common Foundation Program biomedical science students: successes and challenges.

al-Modhefer AK, Roe SM.

Nurse Educ Today. 2010 May;30(4):365-9. doi: 10.1016/j.nedt.2009.09.009.


Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor.

Yang J, Zhang Z, Roe SM, Marshall CJ, Barford D.

Science. 2009 Sep 11;325(5946):1398-402. doi: 10.1126/science.1174468.


Structural insights into formation of an active signaling complex between Rac and phospholipase C gamma 2.

Bunney TD, Opaleye O, Roe SM, Vatter P, Baxendale RW, Walliser C, Everett KL, Josephs MB, Christow C, Rodrigues-Lima F, Gierschik P, Pearl LH, Katan M.

Mol Cell. 2009 Apr 24;34(2):223-33. doi: 10.1016/j.molcel.2009.02.023.


The characteristics and experiences of mature nursing students.

Montgomery LE, Tansey EA, Roe SM.

Nurs Stand. 2009 Jan 21-27;23(20):35-40.


Structural basis of the radicicol resistance displayed by a fungal hsp90.

Prodromou C, Nuttall JM, Millson SH, Roe SM, Sim TS, Tan D, Workman P, Pearl LH, Piper PW.

ACS Chem Biol. 2009 Apr 17;4(4):289-97. doi: 10.1021/cb9000316.


Enhancement of the seed-target recognition step in RNA silencing by a PIWI/MID domain protein.

Parker JS, Parizotto EA, Wang M, Roe SM, Barford D.

Mol Cell. 2009 Jan 30;33(2):204-14. doi: 10.1016/j.molcel.2008.12.012.


Structural basis for the requirement of additional factors for MLL1 SET domain activity and recognition of epigenetic marks.

Southall SM, Wong PS, Odho Z, Roe SM, Wilson JR.

Mol Cell. 2009 Jan 30;33(2):181-91. doi: 10.1016/j.molcel.2008.12.029.


Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors.

Zhang MQ, Gaisser S, Nur-E-Alam M, Sheehan LS, Vousden WA, Gaitatzis N, Peck G, Coates NJ, Moss SJ, Radzom M, Foster TA, Sheridan RM, Gregory MA, Roe SM, Prodromou C, Pearl L, Boyd SM, Wilkinson B, Martin CJ.

J Med Chem. 2008 Sep 25;51(18):5494-7. doi: 10.1021/jm8006068.


Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair.

Kilkenny ML, Doré AS, Roe SM, Nestoras K, Ho JC, Watts FZ, Pearl LH.

Genes Dev. 2008 Aug 1;22(15):2034-47. doi: 10.1101/gad.472808.


Molecular characterization of macbecin as an Hsp90 inhibitor.

Martin CJ, Gaisser S, Challis IR, Carletti I, Wilkinson B, Gregory M, Prodromou C, Roe SM, Pearl LH, Boyd SM, Zhang MQ.

J Med Chem. 2008 May 8;51(9):2853-7. doi: 10.1021/jm701558c. Epub 2008 Mar 22.


Insights into histone code syntax from structural and biochemical studies of CARM1 methyltransferase.

Yue WW, Hassler M, Roe SM, Thompson-Vale V, Pearl LH.

EMBO J. 2007 Oct 17;26(20):4402-12. Epub 2007 Sep 20.


The structure of Tap42/alpha4 reveals a tetratricopeptide repeat-like fold and provides insights into PP2A regulation.

Yang J, Roe SM, Prickett TD, Brautigan DL, Barford D.

Biochemistry. 2007 Jul 31;46(30):8807-15. Epub 2007 Jul 6.


Experience with vacuum-pack temporary abdominal wound closure in 258 trauma and general and vascular surgical patients.

Barker DE, Green JM, Maxwell RA, Smith PW, Mejia VA, Dart BW, Cofer JB, Roe SM, Burns RP.

J Am Coll Surg. 2007 May;204(5):784-92; discussion 792-3. Epub 2007 Mar 26.


Molecular mechanism of target RNA transcript recognition by Argonaute-guide complexes.

Parker JS, Roe SM, Barford D.

Cold Spring Harb Symp Quant Biol. 2006;71:45-50. Review.


In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors.

Sharp SY, Boxall K, Rowlands M, Prodromou C, Roe SM, Maloney A, Powers M, Clarke PA, Box G, Sanderson S, Patterson L, Matthews TP, Cheung KM, Ball K, Hayes A, Raynaud F, Marais R, Pearl L, Eccles S, Aherne W, McDonald E, Workman P.

Cancer Res. 2007 Mar 1;67(5):2206-16. Erratum in: Cancer Res. 2019 Jan 1;79(1):287.


Reversible oxidation of the membrane distal domain of receptor PTPalpha is mediated by a cyclic sulfenamide.

Yang J, Groen A, Lemeer S, Jans A, Slijper M, Roe SM, den Hertog J, Barford D.

Biochemistry. 2007 Jan 23;46(3):709-19.


Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol.

Proisy N, Sharp SY, Boxall K, Connelly S, Roe SM, Prodromou C, Slawin AM, Pearl LH, Workman P, Moody CJ.

Chem Biol. 2006 Nov;13(11):1203-15.

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