Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 65


Bok regulates mitochondrial fusion and morphology.

Schulman JJ, Szczesniak LM, Bunker EN, Nelson HA, Roe MW, Wagner LE 2nd, Yule DI, Wojcikiewicz RJH.

Cell Death Differ. 2019 Dec;26(12):2682-2694. doi: 10.1038/s41418-019-0327-4. Epub 2019 Apr 11.


Impaired Store-Operated Calcium Entry and STIM1 Loss Lead to Reduced Insulin Secretion and Increased Endoplasmic Reticulum Stress in the Diabetic β-Cell.

Kono T, Tong X, Taleb S, Bone RN, Iida H, Lee CC, Sohn P, Gilon P, Roe MW, Evans-Molina C.

Diabetes. 2018 Nov;67(11):2293-2304. doi: 10.2337/db17-1351. Epub 2018 Aug 21.


Interplay between ER Ca2+ Binding Proteins, STIM1 and STIM2, Is Required for Store-Operated Ca2+ Entry.

Nelson HA, Leech CA, Kopp RF, Roe MW.

Int J Mol Sci. 2018 May 19;19(5). pii: E1522. doi: 10.3390/ijms19051522.


Molecular physiology and pathophysiology of stromal interaction molecules.

Nelson HA, Roe MW.

Exp Biol Med (Maywood). 2018 Mar;243(5):451-472. doi: 10.1177/1535370218754524. Epub 2018 Jan 24. Review.


Stromal Interaction Molecule 1 (STIM1) Regulates ATP-sensitive Potassium (KATP) and Store-operated Ca2+ Channels in MIN6 β-Cells.

Leech CA, Kopp RF, Nelson HA, Nandi J, Roe MW.

J Biol Chem. 2017 Feb 10;292(6):2266-2277. doi: 10.1074/jbc.M116.767681. Epub 2016 Dec 21.


Corrigendum: IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation.

Takatani T, Shirakawa J, Roe MW, Leech CA, Maier BF, Mirmira RG, Kulkarni RN.

Sci Rep. 2016 Oct 10;6:34969. doi: 10.1038/srep34969. No abstract available.


IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation.

Takatani T, Shirakawa J, Roe MW, Leech CA, Maier BF, Mirmira RG, Kulkarni RN.

Sci Rep. 2016 Jul 5;6:28177. doi: 10.1038/srep28177. Erratum in: Sci Rep. 2016 Oct 10;6:34969.


GPR119 Agonist AS1269574 Activates TRPA1 Cation Channels to Stimulate GLP-1 Secretion.

Chepurny OG, Holz GG, Roe MW, Leech CA.

Mol Endocrinol. 2016 Jun;30(6):614-29. doi: 10.1210/me.2015-1306. Epub 2016 Apr 15.


Functional role of serotonin in insulin secretion in a diet-induced insulin-resistant state.

Kim K, Oh CM, Ohara-Imaizumi M, Park S, Namkung J, Yadav VK, Tamarina NA, Roe MW, Philipson LH, Karsenty G, Nagamatsu S, German MS, Kim H.

Endocrinology. 2015 Feb;156(2):444-52. doi: 10.1210/en.2014-1687. Epub 2014 Nov 26.


Resveratrol Interferes with Fura-2 Intracellular Calcium Measurements.

Kopp RF, Leech CA, Roe MW.

J Fluoresc. 2014 Mar;24(2):279-84. doi: 10.1007/s10895-013-1312-9. Epub 2013 Oct 23.


Insulin secretion and Ca2+ dynamics in β-cells are regulated by PERK (EIF2AK3) in concert with calcineurin.

Wang R, McGrath BC, Kopp RF, Roe MW, Tang X, Chen G, Cavener DR.

J Biol Chem. 2013 Nov 22;288(47):33824-36. doi: 10.1074/jbc.M113.503664. Epub 2013 Oct 10.


Serum- and glucocorticoid-induced protein kinase 1 (SGK1) is regulated by store-operated Ca2+ entry and mediates cytoprotection against necrotic cell death.

Brickley DR, Agyeman AS, Kopp RF, Hall BA, Harbeck MC, Belova L, Volden PA, Wu W, Roe MW, Conzen SD.

J Biol Chem. 2013 Nov 8;288(45):32708-19. doi: 10.1074/jbc.M113.507210. Epub 2013 Sep 16.


β-Cell-specific protein kinase A activation enhances the efficiency of glucose control by increasing acute-phase insulin secretion.

Kaihara KA, Dickson LM, Jacobson DA, Tamarina N, Roe MW, Philipson LH, Wicksteed B.

Diabetes. 2013 May;62(5):1527-36. doi: 10.2337/db12-1013. Epub 2013 Jan 24.


Gating of connexin 43 gap junctions by a cytoplasmic loop calmodulin binding domain.

Xu Q, Kopp RF, Chen Y, Yang JJ, Roe MW, Veenstra RD.

Am J Physiol Cell Physiol. 2012 May 15;302(10):C1548-56. doi: 10.1152/ajpcell.00319.2011. Epub 2012 Mar 14.


Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans.

Dzhura I, Chepurny OG, Leech CA, Roe MW, Dzhura E, Xu X, Lu Y, Schwede F, Genieser HG, Smrcka AV, Holz GG.

Islets. 2011 May-Jun;3(3):121-8. Epub 2011 May 1.


Glucose-dependent potentiation of mouse islet insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM.

Kelley GG, Chepurny OG, Schwede F, Genieser HG, Leech CA, Roe MW, Li X, Dzhura I, Dzhura E, Afshari P, Holz GG.

Islets. 2009 Nov-Dec;1(3):260-5. doi: 10.4161/isl.1.3.9645.


Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice.

Dzhura I, Chepurny OG, Kelley GG, Leech CA, Roe MW, Dzhura E, Afshari P, Malik S, Rindler MJ, Xu X, Lu Y, Smrcka AV, Holz GG.

J Physiol. 2010 Dec 15;588(Pt 24):4871-89. doi: 10.1113/jphysiol.2010.198424. Epub 2010 Nov 1. Erratum in: J Physiol. 2012 Mar 15;590(Pt 6):1511.


Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain.

Wicksteed B, Brissova M, Yan W, Opland DM, Plank JL, Reinert RB, Dickson LM, Tamarina NA, Philipson LH, Shostak A, Bernal-Mizrachi E, Elghazi L, Roe MW, Labosky PA, Myers MG Jr, Gannon M, Powers AC, Dempsey PJ.

Diabetes. 2010 Dec;59(12):3090-8. doi: 10.2337/db10-0624. Epub 2010 Aug 29.


PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM in human islets of Langerhans.

Chepurny OG, Kelley GG, Dzhura I, Leech CA, Roe MW, Dzhura E, Li X, Schwede F, Genieser HG, Holz GG.

Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E622-33. doi: 10.1152/ajpendo.00630.2009. Epub 2009 Dec 15.


When BAD is good for beta cells.

Philipson LH, Roe MW.

Cell Metab. 2008 Apr;7(4):280-1. doi: 10.1016/j.cmet.2008.03.009.


Protein kinase A-mediated CREB phosphorylation is an oxidant-induced survival pathway in alveolar type II cells.

Barlow CA, Kitiphongspattana K, Siddiqui N, Roe MW, Mossman BT, Lounsbury KM.

Apoptosis. 2008 May;13(5):681-92. doi: 10.1007/s10495-008-0203-z.


Regulation of cAMP dynamics by Ca2+ and G protein-coupled receptors in the pancreatic beta-cell: a computational approach.

Fridlyand LE, Harbeck MC, Roe MW, Philipson LH.

Am J Physiol Cell Physiol. 2007 Dec;293(6):C1924-33. Epub 2007 Oct 10.


Protective role for nitric oxide during the endoplasmic reticulum stress response in pancreatic beta-cells.

Kitiphongspattana K, Khan TA, Ishii-Schrade K, Roe MW, Philipson LH, Gaskins HR.

Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1543-54. Epub 2007 Jan 30.


Ca2+-activated IK1 channels associate with lipid rafts upon cell swelling and mediate volume recovery.

Barfod ET, Moore AL, Roe MW, Lidofsky SD.

J Biol Chem. 2007 Mar 23;282(12):8984-93. Epub 2007 Jan 30.


Increases in mitochondrial reactive oxygen species trigger hypoxia-induced calcium responses in pulmonary artery smooth muscle cells.

Waypa GB, Guzy R, Mungai PT, Mack MM, Marks JD, Roe MW, Schumacker PT.

Circ Res. 2006 Oct 27;99(9):970-8. Epub 2006 Sep 28.


Simultaneous optical measurements of cytosolic Ca2+ and cAMP in single cells.

Harbeck MC, Chepurny O, Nikolaev VO, Lohse MJ, Holz GG, Roe MW.

Sci STKE. 2006 Sep 19;2006(353):pl6.


Cell physiology of cAMP sensor Epac.

Holz GG, Kang G, Harbeck M, Roe MW, Chepurny OG.

J Physiol. 2006 Nov 15;577(Pt 1):5-15. Epub 2006 Sep 14. Review.


Visualizing calcium signaling in cells by digitized wide-field and confocal fluorescent microscopy.

Roe MW, Fiekers JF, Philipson LH, Bindokas VP.

Methods Mol Biol. 2006;319:37-66.


Downstream regulatory element antagonistic modulator regulates islet prodynorphin expression.

Jacobson DA, Cho J, Landa LR Jr, Tamarina NA, Roe MW, Buxbaum JD, Philipson LH.

Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E587-95. Epub 2006 Apr 18.


Interplay of Ca2+ and cAMP signaling in the insulin-secreting MIN6 beta-cell line.

Landa LR Jr, Harbeck M, Kaihara K, Chepurny O, Kitiphongspattana K, Graf O, Nikolaev VO, Lohse MJ, Holz GG, Roe MW.

J Biol Chem. 2005 Sep 2;280(35):31294-302. Epub 2005 Jun 29.


A cAMP and Ca2+ coincidence detector in support of Ca2+-induced Ca2+ release in mouse pancreatic beta cells.

Kang G, Chepurny OG, Rindler MJ, Collis L, Chepurny Z, Li WH, Harbeck M, Roe MW, Holz GG.

J Physiol. 2005 Jul 1;566(Pt 1):173-88. Epub 2005 Apr 28.


5-amino-imidazole carboxamide riboside acutely potentiates glucose-stimulated insulin secretion from mouse pancreatic islets by KATP channel-dependent and -independent pathways.

Wang CZ, Wang Y, Di A, Magnuson MA, Ye H, Roe MW, Nelson DJ, Bell GI, Philipson LH.

Biochem Biophys Res Commun. 2005 May 20;330(4):1073-9.


Imaging endoplasmic reticulum calcium with a fluorescent biosensor in transgenic mice.

Hara M, Bindokas V, Lopez JP, Kaihara K, Landa LR Jr, Harbeck M, Roe MW.

Am J Physiol Cell Physiol. 2004 Oct;287(4):C932-8. Epub 2004 May 26.


Insulin regulation of hepatic gluconeogenesis through phosphorylation of CREB-binding protein.

Zhou XY, Shibusawa N, Naik K, Porras D, Temple K, Ou H, Kaihara K, Roe MW, Brady MJ, Wondisford FE.

Nat Med. 2004 Jun;10(6):633-7. Epub 2004 May 16.


Store-operated Ca2+ entry activates the CREB transcription factor in vascular smooth muscle.

Pulver RA, Rose-Curtis P, Roe MW, Wellman GC, Lounsbury KM.

Circ Res. 2004 May 28;94(10):1351-8. Epub 2004 Apr 8.


Visualizing superoxide production in normal and diabetic rat islets of Langerhans.

Bindokas VP, Kuznetsov A, Sreenan S, Polonsky KS, Roe MW, Philipson LH.

J Biol Chem. 2003 Mar 14;278(11):9796-801. Epub 2003 Jan 4.


Calcium mobilization evoked by hepatocellular swelling is linked to activation of phospholipase Cgamma.

Moore AL, Roe MW, Melnick RF, Lidofsky SD.

J Biol Chem. 2002 Sep 13;277(37):34030-5. Epub 2002 Jul 11.


Purinergic-independent calcium signaling mediates recovery from hepatocellular swelling: implications for volume regulation.

Roe MW, Moore AL, Lidofsky SD.

J Biol Chem. 2001 Aug 17;276(33):30871-7. Epub 2001 Jun 18.


Glucagon-like peptide-1 stimulates insulin secretion by a Ca2+-independent mechanism in Zucker diabetic fatty rat islets of Langerhans.

Sreenan SK, Mittal AA, Dralyuk F, Pugh WL, Polonsky KS, Roe MW.

Metabolism. 2000 Dec;49(12):1579-87.


Activation of potassium and chloride channels by tumor necrosis factor alpha. Role in liver cell death.

Nietsch HH, Roe MW, Fiekers JF, Moore AL, Lidofsky SD.

J Biol Chem. 2000 Jul 7;275(27):20556-61.


Overexpression of Bcl-x(L) in beta-cells prevents cell death but impairs mitochondrial signal for insulin secretion.

Zhou YP, Pena JC, Roe MW, Mittal A, Levisetti M, Baldwin AC, Pugh W, Ostrega D, Ahmed N, Bindokas VP, Philipson LH, Hanahan D, Thompson CB, Polonsky KS.

Am J Physiol Endocrinol Metab. 2000 Feb;278(2):E340-51.


Adaptation to hyperglycemia enhances insulin secretion in glucokinase mutant mice.

Sreenan SK, Cockburn BN, Baldwin AC, Ostrega DM, Levisetti M, Grupe A, Bell GI, Stewart TA, Roe MW, Polonsky KS.

Diabetes. 1998 Dec;47(12):1881-8.


Defective pancreatic beta-cell glycolytic signaling in hepatocyte nuclear factor-1alpha-deficient mice.

Dukes ID, Sreenan S, Roe MW, Levisetti M, Zhou YP, Ostrega D, Bell GI, Pontoglio M, Yaniv M, Philipson L, Polonsky KS.

J Biol Chem. 1998 Sep 18;273(38):24457-64.


Characterization of a Ca2+ release-activated nonselective cation current regulating membrane potential and [Ca2+]i oscillations in transgenically derived beta-cells.

Roe MW, Worley JF 3rd, Qian F, Tamarina N, Mittal AA, Dralyuk F, Blair NT, Mertz RJ, Philipson LH, Dukes ID.

J Biol Chem. 1998 Apr 24;273(17):10402-10.


Apoptosis in insulin-secreting cells. Evidence for the role of intracellular Ca2+ stores and arachidonic acid metabolism.

Zhou YP, Teng D, Dralyuk F, Ostrega D, Roe MW, Philipson L, Polonsky KS.

J Clin Invest. 1998 Apr 15;101(8):1623-32.


Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3.

Bonini JA, Martin SK, Dralyuk F, Roe MW, Philipson LH, Steiner DF.

DNA Cell Biol. 1997 Oct;16(10):1249-56.


Expression and function of pancreatic beta-cell delayed rectifier K+ channels. Role in stimulus-secretion coupling.

Roe MW, Worley JF 3rd, Mittal AA, Kuznetsov A, DasGupta S, Mertz RJ, Witherspoon SM 3rd, Blair N, Lancaster ME, McIntyre MS, Shehee WR, Dukes ID, Philipson LH.

J Biol Chem. 1996 Dec 13;271(50):32241-6.


NIDDM is associated with loss of pancreatic beta-cell L-type Ca2+ channel activity.

Roe MW, Worley JF 3rd, Tokuyama Y, Philipson LH, Sturis J, Tang J, Dukes ID, Bell GI, Polonsky KS.

Am J Physiol. 1996 Jan;270(1 Pt 1):E133-40.


Absence of effect of culture duration on glucose-activated alterations in intracellular calcium concentration in mouse pancreatic islets.

Roe MW, Spencer B, Lancaster ME, Mertz RJ, Worley JF 3rd, Dukes ID.

Diabetologia. 1995 Jul;38(7):876-9. No abstract available.


Supplemental Content

Support Center