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Aldehyde-alcohol dehydrogenase forms a high-order spirosome architecture critical for its activity.

Kim G, Azmi L, Jang S, Jung T, Hebert H, Roe AJ, Byron O, Song JJ.

Nat Commun. 2019 Oct 4;10(1):4527. doi: 10.1038/s41467-019-12427-8.


Distinct intraspecies virulence mechanisms regulated by a conserved transcription factor.

Connolly JPR, O'Boyle N, Turner NCA, Browning DF, Roe AJ.

Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19695-19704. doi: 10.1073/pnas.1903461116. Epub 2019 Sep 9.


Trichostatin A blocks aldosterone-induced Na+ transport and control of serum- and glucocorticoid-inducible kinase 1 in cortical collecting duct cells.

Mansley MK, Roe AJ, Francis SL, Gill JH, Bailey MA, Wilson SM.

Br J Pharmacol. 2019 Dec;176(24):4708-4719. doi: 10.1111/bph.14837. Epub 2019 Oct 25.


Structure and ligand binding of As-p18, an extracellular fatty acid binding protein from the eggs of a parasitic nematode.

Ibáñez-Shimabukuro M, Rey-Burusco MF, Gabrielsen M, Franchini GR, Riboldi-Tunnicliffe A, Roe AJ, Griffiths K, Cooper A, Córsico B, Kennedy MW, Smith BO.

Biosci Rep. 2019 Jul 23;39(7). pii: BSR20191292. doi: 10.1042/BSR20191292. Print 2019 Jul 31.


Genomic and transcriptomic characterization of Pseudomonas aeruginosa small colony variants derived from a chronic infection model.

Irvine S, Bunk B, Bayes HK, Spröer C, Connolly JPR, Six A, Evans TJ, Roe AJ, Overmann J, Walker D.

Microb Genom. 2019 Apr;5(4). doi: 10.1099/mgen.0.000262. Epub 2019 Mar 28.


Control freaks-signals and cues governing the regulation of virulence in attaching and effacing pathogens.

Turner NCA, Connolly JPR, Roe AJ.

Biochem Soc Trans. 2019 Feb 28;47(1):229-238. doi: 10.1042/BST20180546. Epub 2018 Dec 17. Review.


Author Correction: Host-associated niche metabolism controls enteric infection through fine-tuning the regulation of type 3 secretion.

Connolly JPR, Slater SL, O'Boyle N, Goldstone RJ, Crepin VF, Ruano-Gallego D, Herzyk P, Smith DGE, Douce GR, Frankel G, Roe AJ.

Nat Commun. 2018 Nov 29;9(1):5148. doi: 10.1038/s41467-018-07612-0.


Characterization of the Mode of Action of Aurodox, a Type III Secretion System Inhibitor from Streptomyces goldiniensis.

McHugh RE, O'Boyle N, Connolly JPR, Hoskisson PA, Roe AJ.

Infect Immun. 2019 Jan 24;87(2). pii: e00595-18. doi: 10.1128/IAI.00595-18. Print 2019 Feb.


Aberrant GSK3β nuclear localization promotes AML growth and drug resistance.

Ignatz-Hoover JJ, Wang V, Mackowski NM, Roe AJ, Ghansah IK, Ueda M, Lazarus HM, de Lima M, Paietta E, Fernandez H, Cripe L, Tallman M, Wald DN.

Blood Adv. 2018 Nov 13;2(21):2890-2903. doi: 10.1182/bloodadvances.2018016006.


Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis.

Scott NA, Andrusaite A, Andersen P, Lawson M, Alcon-Giner C, Leclaire C, Caim S, Le Gall G, Shaw T, Connolly JPR, Roe AJ, Wessel H, Bravo-Blas A, Thomson CA, Kästele V, Wang P, Peterson DA, Bancroft A, Li X, Grencis R, Mowat AM, Hall LJ, Travis MA, Milling SWF, Mann ER.

Sci Transl Med. 2018 Oct 24;10(464). pii: eaao4755. doi: 10.1126/scitranslmed.aao4755.


Host-associated niche metabolism controls enteric infection through fine-tuning the regulation of type 3 secretion.

Connolly JPR, Slater SL, O'Boyle N, Goldstone RJ, Crepin VF, Ruano-Gallego D, Herzyk P, Smith DGE, Douce GR, Frankel G, Roe AJ.

Nat Commun. 2018 Oct 10;9(1):4187. doi: 10.1038/s41467-018-06701-4. Erratum in: Nat Commun. 2018 Nov 29;9(1):5148.


Postgenomics Characterization of an Essential Genetic Determinant of Mammary Pathogenic Escherichia coli.

Blum SE, Goldstone RJ, Connolly JPR, Répérant-Ferter M, Germon P, Inglis NF, Krifucks O, Mathur S, Manson E, Mclean K, Rainard P, Roe AJ, Leitner G, Smith DGE.

mBio. 2018 Apr 3;9(2). pii: e00423-18. doi: 10.1128/mBio.00423-18.


Drp1 phosphorylation by MAPK1 causes mitochondrial dysfunction in cell culture model of Huntington's disease.

Roe AJ, Qi X.

Biochem Biophys Res Commun. 2018 Feb 5;496(2):706-711. doi: 10.1016/j.bbrc.2018.01.114. Epub 2018 Jan 31.


Tracking elusive cargo: Illuminating spatio-temporal Type 3 effector protein dynamics using reporters.

O'Boyle N, Connolly JPR, Roe AJ.

Cell Microbiol. 2018 Jan;20(1). doi: 10.1111/cmi.12797. Epub 2017 Nov 23. Review.


Novel compounds targeting the enterohemorrhagic Escherichia coli type three secretion system reveal insights into mechanisms of secretion inhibition.

Zambelloni R, Connolly JPR, Huerta Uribe A, Burgess K, Marquez R, Roe AJ.

Mol Microbiol. 2017 Aug;105(4):606-619. doi: 10.1111/mmi.13719. Epub 2017 Jun 14.


Choline and its metabolites are differently associated with cardiometabolic risk factors, history of cardiovascular disease, and MRI-documented cerebrovascular disease in older adults.

Roe AJ, Zhang S, Bhadelia RA, Johnson EJ, Lichtenstein AH, Rogers GT, Rosenberg IH, Smith CE, Zeisel SH, Scott TM.

Am J Clin Nutr. 2017 Jun;105(6):1283-1290. doi: 10.3945/ajcn.116.137158. Epub 2017 Mar 29.


Identification and Characterization of Novel Compounds Blocking Shiga Toxin Expression in Escherichia coli O157:H7.

Huerta-Uribe A, Marjenberg ZR, Yamaguchi N, Fitzgerald S, Connolly JP, Carpena N, Uvell H, Douce G, Elofsson M, Byron O, Marquez R, Gally DL, Roe AJ.

Front Microbiol. 2016 Nov 30;7:1930. eCollection 2016.


Lighting Up Clostridium Difficile: Reporting Gene Expression Using Fluorescent Lov Domains.

Buckley AM, Jukes C, Candlish D, Irvine JJ, Spencer J, Fagan RP, Roe AJ, Christie JM, Fairweather NF, Douce GR.

Sci Rep. 2016 Mar 21;6:23463. doi: 10.1038/srep23463.


Visualizing the Translocation and Localization of Bacterial Type III Effector Proteins by Using a Genetically Encoded Reporter System.

Gawthorne JA, Audry L, McQuitty C, Dean P, Christie JM, Enninga J, Roe AJ.

Appl Environ Microbiol. 2016 Apr 18;82(9):2700-2708. doi: 10.1128/AEM.03418-15. Print 2016 May.


A Highly Conserved Bacterial D-Serine Uptake System Links Host Metabolism and Virulence.

Connolly JP, Gabrielsen M, Goldstone RJ, Grinter R, Wang D, Cogdell RJ, Walker D, Smith DG, Roe AJ.

PLoS Pathog. 2016 Jan 4;12(1):e1005359. doi: 10.1371/journal.ppat.1005359. eCollection 2016 Jan.


Cultured enterocytes internalise bacteria across their basolateral surface for, pathogen-inhibitable, trafficking to the apical compartment.

Dean P, Quitard S, Bulmer DM, Roe AJ, Kenny B.

Sci Rep. 2015 Nov 27;5:17359. doi: 10.1038/srep17359.


Diversity in the structures and ligand-binding sites of nematode fatty acid and retinol-binding proteins revealed by Na-FAR-1 from Necator americanus.

Rey-Burusco MF, Ibáñez-Shimabukuro M, Gabrielsen M, Franchini GR, Roe AJ, Griffiths K, Zhan B, Cooper A, Kennedy MW, Córsico B, Smith BO.

Biochem J. 2015 Nov 1;471(3):403-14. doi: 10.1042/BJ20150068. Epub 2015 Aug 28.


From ingestion to colonization: the influence of the host environment on regulation of the LEE encoded type III secretion system in enterohaemorrhagic Escherichia coli.

Connolly JP, Finlay BB, Roe AJ.

Front Microbiol. 2015 Jun 5;6:568. doi: 10.3389/fmicb.2015.00568. eCollection 2015. Review.


LOV-based reporters for fluorescence imaging.

Buckley AM, Petersen J, Roe AJ, Douce GR, Christie JM.

Curr Opin Chem Biol. 2015 Aug;27:39-45. doi: 10.1016/j.cbpa.2015.05.011. Epub 2015 Jun 15. Review.


The host metabolite D-serine contributes to bacterial niche specificity through gene selection.

Connolly JP, Goldstone RJ, Burgess K, Cogdell RJ, Beatson SA, Vollmer W, Smith DG, Roe AJ.

ISME J. 2015 Mar 17;9(4):1052. doi: 10.1038/ismej.2015.17. No abstract available.


The host metabolite D-serine contributes to bacterial niche specificity through gene selection.

Connolly JP, Goldstone RJ, Burgess K, Cogdell RJ, Beatson SA, Vollmer W, Smith DG, Roe AJ.

ISME J. 2015 Mar 17;9(4):1039-51. doi: 10.1038/ismej.2014.242. Erratum in: ISME J. 2015 Apr;9(4):1052.


Development of antivirulence compounds: a biochemical review.

Zambelloni R, Marquez R, Roe AJ.

Chem Biol Drug Des. 2015 Jan;85(1):43-55. doi: 10.1111/cbdd.12430. Review.


From screen to target: insights and approaches for the development of anti-virulence compounds.

Beckham KS, Roe AJ.

Front Cell Infect Microbiol. 2014 Sep 30;4:139. doi: 10.3389/fcimb.2014.00139. eCollection 2014. Review.


The metabolic enzyme AdhE controls the virulence of Escherichia coli O157:H7.

Beckham KS, Connolly JP, Ritchie JM, Wang D, Gawthorne JA, Tahoun A, Gally DL, Burgess K, Burchmore RJ, Smith BO, Beatson SA, Byron O, Wolfe AJ, Douce GR, Roe AJ.

Mol Microbiol. 2014 Jul;93(1):199-211. doi: 10.1111/mmi.12651. Epub 2014 Jun 9.


Use of a dual reporter plasmid to demonstrate Bactofection with an attenuated AroA(-) derivative of Pasteurella multocida B:2.

Othman S, Roe AJ, Parton R, Coote JG.

PLoS One. 2013 Aug 12;8(8):e71524. doi: 10.1371/journal.pone.0071524. eCollection 2013.


Increased S-nitrosylation and proteasomal degradation of caspase-3 during infection contribute to the persistence of adherent invasive Escherichia coli (AIEC) in immune cells.

Dunne KA, Allam A, McIntosh A, Houston SA, Cerovic V, Goodyear CS, Roe AJ, Beatson SA, Milling SW, Walker D, Wall DM.

PLoS One. 2013 Jul 4;8(7):e68386. doi: 10.1371/journal.pone.0068386. Print 2013.


High-throughput methods for the detection of protein overexpression using fluorescence markers.

Gabrielsen M, Roe AJ, McLuskey K.

Methods Cell Biol. 2013;113:189-208. doi: 10.1016/B978-0-12-407239-8.00010-0.


Express your LOV: an engineered flavoprotein as a reporter for protein expression and purification.

Gawthorne JA, Reddick LE, Akpunarlieva SN, Beckham KS, Christie JM, Alto NM, Gabrielsen M, Roe AJ.

PLoS One. 2012;7(12):e52962. doi: 10.1371/journal.pone.0052962. Epub 2012 Dec 27.


Salmonella transforms follicle-associated epithelial cells into M cells to promote intestinal invasion.

Tahoun A, Mahajan S, Paxton E, Malterer G, Donaldson DS, Wang D, Tan A, Gillespie TL, O'Shea M, Roe AJ, Shaw DJ, Gally DL, Lengeling A, Mabbott NA, Haas J, Mahajan A.

Cell Host Microbe. 2012 Nov 15;12(5):645-56. doi: 10.1016/j.chom.2012.10.009.


Useable diffraction data from a multiple microdomain-containing crystal of Ascaris suum As-p18 fatty-acid-binding protein using a microfocus beamline.

Gabrielsen M, Riboldi-Tunnicliffe A, Ibáñez-Shimabukuro M, Griffiths K, Roe AJ, Cooper A, Smith BO, Córsico B, Kennedy MW.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Aug 1;68(Pt 8):939-41. doi: 10.1107/S1744309112026553. Epub 2012 Jul 31.


Two crystal forms of a helix-rich fatty acid- and retinol-binding protein, Na-FAR-1, from the parasitic nematode Necator americanus.

Gabrielsen M, Rey-Burusco MF, Griffiths K, Roe AJ, Cooper A, Smith BO, Kennedy MW, Corsico B.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jul 1;68(Pt 7):835-8. doi: 10.1107/S1744309112023597. Epub 2012 Jun 28.


The structure of an orthorhombic crystal form of a 'forced reduced' thiol peroxidase reveals lattice formation aided by the presence of the affinity tag.

Beckham KS, Byron O, Roe AJ, Gabrielsen M.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 May 1;68(Pt 5):522-6. doi: 10.1107/S1744309112011487. Epub 2012 Apr 20.


Lysogeny with Shiga toxin 2-encoding bacteriophages represses type III secretion in enterohemorrhagic Escherichia coli.

Xu X, McAteer SP, Tree JJ, Shaw DJ, Wolfson EB, Beatson SA, Roe AJ, Allison LJ, Chase-Topping ME, Mahajan A, Tozzoli R, Woolhouse ME, Morabito S, Gally DL.

PLoS Pathog. 2012;8(5):e1002672. doi: 10.1371/journal.ppat.1002672. Epub 2012 May 17.


FolX from Pseudomonas aeruginosa is octameric in both crystal and solution.

Gabrielsen M, Beckham KS, Cogdell RJ, Byron O, Roe AJ.

FEBS Lett. 2012 Apr 24;586(8):1160-5. doi: 10.1016/j.febslet.2012.03.031. Epub 2012 Mar 24.


LOV to BLUF: flavoprotein contributions to the optogenetic toolkit.

Christie JM, Gawthorne J, Young G, Fraser NJ, Roe AJ.

Mol Plant. 2012 May;5(3):533-44. doi: 10.1093/mp/sss020. Epub 2012 Mar 19. Review.


Expression and regulation of the Escherichia coli O157:H7 effector proteins NleH1 and NleH2.

Holmes A, Lindestam Arlehamn CS, Wang D, Mitchell TJ, Evans TJ, Roe AJ.

PLoS One. 2012;7(3):e33408. doi: 10.1371/journal.pone.0033408. Epub 2012 Mar 12.


Structural characterisation of Tpx from Yersinia pseudotuberculosis reveals insights into the binding of salicylidene acylhydrazide compounds.

Gabrielsen M, Beckham KS, Feher VA, Zetterström CE, Wang D, Müller S, Elofsson M, Amaro RE, Byron O, Roe AJ.

PLoS One. 2012;7(2):e32217. doi: 10.1371/journal.pone.0032217. Epub 2012 Feb 27.


High-throughput identification of purification conditions leads to preliminary crystallization conditions for three inner membrane proteins.

Gabrielsen M, Kroner F, Black I, Isaacs NW, Roe AJ, McLuskey K.

Mol Membr Biol. 2011 Oct-Nov;28(7-8):445-53. doi: 10.3109/09687688.2011.628954.


Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence-blocking compounds.

Wang D, Zetterström CE, Gabrielsen M, Beckham KS, Tree JJ, Macdonald SE, Byron O, Mitchell TJ, Gally DL, Herzyk P, Mahajan A, Uvell H, Burchmore R, Smith BO, Elofsson M, Roe AJ.

J Biol Chem. 2011 Aug 26;286(34):29922-31. doi: 10.1074/jbc.M111.233858. Epub 2011 Jul 1.


Transcriptional regulators of the GAD acid stress island are carried by effector protein-encoding prophages and indirectly control type III secretion in enterohemorrhagic Escherichia coli O157:H7.

Tree JJ, Roe AJ, Flockhart A, McAteer SP, Xu X, Shaw D, Mahajan A, Beatson SA, Best A, Lotz S, Woodward MJ, La Ragione R, Murphy KC, Leong JM, Gally DL.

Mol Microbiol. 2011 Jun;80(5):1349-65. doi: 10.1111/j.1365-2958.2011.07650.x. Epub 2011 Apr 15.


Expression, purification, crystallization and initial X-ray diffraction analysis of thiol peroxidase from Yersinia pseudotuberculosis.

Gabrielsen M, Zetterström CE, Wang D, Beckham KS, Elofsson M, Isaacs NW, Roe AJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Dec 1;66(Pt 12):1606-9. doi: 10.1107/S1744309110039679. Epub 2010 Nov 25.


The EspF effector, a bacterial pathogen's Swiss army knife.

Holmes A, Mühlen S, Roe AJ, Dean P.

Infect Immun. 2010 Nov;78(11):4445-53. doi: 10.1128/IAI.00635-10. Epub 2010 Aug 2.


Controlling injection: regulation of type III secretion in enterohaemorrhagic Escherichia coli.

Tree JJ, Wolfson EB, Wang D, Roe AJ, Gally DL.

Trends Microbiol. 2009 Aug;17(8):361-70. doi: 10.1016/j.tim.2009.06.001. Epub 2009 Aug 5. Review.


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