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Items: 1 to 50 of 112

1.

A novel role for coenzyme A during hydride transfer in 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

Steussy CN, Critchelow CJ, Schmidt T, Min JK, Wrensford LV, Burgner JW 2nd, Rodwell VW, Stauffacher CV.

Biochemistry. 2013 Aug 6;52(31):5195-205. doi: 10.1021/bi400335g. Epub 2013 Jul 24.

2.

A structural limitation on enzyme activity: the case of HMG-CoA synthase.

Steussy CN, Robison AD, Tetrick AM, Knight JT, Rodwell VW, Stauffacher CV, Sutherlin AL.

Biochemistry. 2006 Dec 5;45(48):14407-14.

PMID:
17128980
3.

X-ray crystal structures of HMG-CoA synthase from Enterococcus faecalis and a complex with its second substrate/inhibitor acetoacetyl-CoA.

Steussy CN, Vartia AA, Burgner JW 2nd, Sutherlin A, Rodwell VW, Stauffacher CV.

Biochemistry. 2005 Nov 1;44(43):14256-67.

PMID:
16245942
4.

Enterococcus faecalis phosphomevalonate kinase.

Doun SS, Burgner JW 2nd, Briggs SD, Rodwell VW.

Protein Sci. 2005 May;14(5):1134-9. Epub 2005 Mar 31.

5.

The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases.

Friesen JA, Rodwell VW.

Genome Biol. 2004;5(11):248. Epub 2004 Nov 1. Review.

6.

Multienzyme mevalonate pathway bioreactor.

Sutherlin A, Rodwell VW.

Biotechnol Bioeng. 2004 Aug 20;87(4):546-51.

PMID:
15286992
7.

Inhibition of the class II HMG-CoA reductase of Pseudomonas mevalonii.

Hedl M, Rodwell VW.

Protein Sci. 2004 Jun;13(6):1693-7.

8.

Class II 3-hydroxy-3-methylglutaryl coenzyme A reductases.

Hedl M, Tabernero L, Stauffacher CV, Rodwell VW.

J Bacteriol. 2004 Apr;186(7):1927-32. Review. No abstract available.

9.

Enterococcus faecalis mevalonate kinase.

Hedl M, Rodwell VW.

Protein Sci. 2004 Mar;13(3):687-93. Epub 2004 Feb 6.

10.

Crystal structure of a statin bound to a class II hydroxymethylglutaryl-CoA reductase.

Tabernero L, Rodwell VW, Stauffacher CV.

J Biol Chem. 2003 May 30;278(22):19933-8. Epub 2003 Mar 5.

11.

Enterococcus faecalis 3-hydroxy-3-methylglutaryl coenzyme A synthase, an enzyme of isopentenyl diphosphate biosynthesis.

Sutherlin A, Hedl M, Sanchez-Neri B, Burgner JW 2nd, Stauffacher CV, Rodwell VW.

J Bacteriol. 2002 Aug;184(15):4065-70.

12.

Enterococcus faecalis acetoacetyl-coenzyme A thiolase/3-hydroxy-3-methylglutaryl-coenzyme A reductase, a dual-function protein of isopentenyl diphosphate biosynthesis.

Hedl M, Sutherlin A, Wilding EI, Mazzulla M, McDevitt D, Lane P, Burgner JW 2nd, Lehnbeuter KR, Stauffacher CV, Gwynn MN, Rodwell VW.

J Bacteriol. 2002 Apr;184(8):2116-22.

13.

3-Hydroxy-3-methylglutaryl-CoA reductase.

Rodwell VW, Beach MJ, Bischoff KM, Bochar DA, Darnay BG, Friesen JA, Gill JF, Hedl M, Jordan-Starck T, Kennelly PJ, Kim DY, Wang Y.

Methods Enzymol. 2000;324:259-80. No abstract available.

PMID:
10989436
14.

Essentiality, expression, and characterization of the class II 3-hydroxy-3-methylglutaryl coenzyme A reductase of Staphylococcus aureus.

Wilding EI, Kim DY, Bryant AP, Gwynn MN, Lunsford RD, McDevitt D, Myers JE Jr, Rosenberg M, Sylvester D, Stauffacher CV, Rodwell VW.

J Bacteriol. 2000 Sep;182(18):5147-52.

15.

Dual coenzyme specificity of Archaeoglobus fulgidus HMG-CoA reductase.

Kim DY, Stauffacher CV, Rodwell VW.

Protein Sci. 2000 Jun;9(6):1226-34.

16.
17.

Investigation of the conserved lysines of Syrian hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase.

Bochar DA, Stauffacher CV, Rodwell VW.

Biochemistry. 1999 Nov 30;38(48):15848-52.

PMID:
10625449
18.

Expression and characterization of the HMG-CoA reductase of the thermophilic archaeon Sulfolobus solfataricus.

Kim DY, Bochar DA, Stauffacher CV, Rodwell VW.

Protein Expr Purif. 1999 Dec;17(3):435-42.

PMID:
10600463
19.
20.
21.

Sequence comparisons reveal two classes of 3-hydroxy-3-methylglutaryl coenzyme A reductase.

Bochar DA, Stauffacher CV, Rodwell VW.

Mol Genet Metab. 1999 Feb;66(2):122-7.

PMID:
10068515
23.

Active form of Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl coenzyme A reductase.

Rogers KS, Rodwell VW, Geiger P.

Biochem Mol Med. 1997 Jun;61(1):114-20.

PMID:
9232206
28.
30.

Crystal structure of Pseudomonas mevalonii HMG-CoA reductase at 3.0 angstrom resolution.

Lawrence CM, Rodwell VW, Stauffacher CV.

Science. 1995 Jun 23;268(5218):1758-62.

PMID:
7792601
31.

Crystallization of HMG-CoA reductase from Pseudomonas mevalonii.

Lawrence CM, Chi YI, Rodwell VW, Stauffacher CV.

Acta Crystallogr D Biol Crystallogr. 1995 May 1;51(Pt 3):386-9.

PMID:
15299306
32.
34.

Modulation of Syrian hamster 3-hydroxy-3-methylglutaryl-CoA reductase activity by phosphorylation. Role of serine 871.

Omkumar RV, Darnay BG, Rodwell VW.

J Biol Chem. 1994 Mar 4;269(9):6810-4. Erratum in: J Biol Chem 1994 Jun 10;269(23):16518.

36.
37.
38.

Biosynthesis and characterization of (S)-and (R)-3-hydroxy-3-methylglutaryl coenzyme A.

Bischoff KM, Rodwell VW.

Biochem Med Metab Biol. 1992 Oct;48(2):149-58.

PMID:
1419147
39.
40.
41.

3-Hydroxy-3-methylglutaryldithio-coenzyme A: a potent inhibitor of Pseudomonas mevalonii HMG-CoA reductase.

Wrensford LV, Rodwell VW, Anderson VE.

Biochem Med Metab Biol. 1991 Apr;45(2):204-8.

PMID:
1679340
42.
45.
47.

3-Hydroxy-3-methylglutaryl coenzyme A lyase from Pseudomonas mevalonii.

Scher DS, Rodwell VW.

Biochim Biophys Acta. 1989 Jun 28;1003(3):321-6.

PMID:
2742863
50.

Rat liver 3-hydroxy-3-methylglutaryl-CoA reductase. Catalysis of the reverse reaction and two half-reactions.

Sherban DG, Kennelly PJ, Brandt KG, Rodwell VW.

J Biol Chem. 1985 Oct 15;260(23):12579-85.

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