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Evolutionary history of human colitis-associated colorectal cancer.

Baker AM, Cross W, Curtius K, Al Bakir I, Choi CR, Davis HL, Temko D, Biswas S, Martinez P, Williams MJ, Lindsay JO, Feakins R, Vega R, Hayes SJ, Tomlinson IPM, McDonald SAC, Moorghen M, Silver A, East JE, Wright NA, Wang LM, Rodriguez-Justo M, Jansen M, Hart AL, Leedham SJ, Graham TA.

Gut. 2018 Jul 10. pii: gutjnl-2018-316191. doi: 10.1136/gutjnl-2018-316191. [Epub ahead of print]


Diagnostic accuracy of magnetic resonance enterography and small bowel ultrasound for the extent and activity of newly diagnosed and relapsed Crohn's disease (METRIC): a multicentre trial.

Taylor SA, Mallett S, Bhatnagar G, Baldwin-Cleland R, Bloom S, Gupta A, Hamlin PJ, Hart AL, Higginson A, Jacobs I, McCartney S, Miles A, Murray CD, Plumb AA, Pollok RC, Punwani S, Quinn L, Rodriguez-Justo M, Shabir Z, Slater A, Tolan D, Travis S, Windsor A, Wylie P, Zealley I, Halligan S; METRIC study investigators.

Lancet Gastroenterol Hepatol. 2018 Jun 15. pii: S2468-1253(18)30161-4. doi: 10.1016/S2468-1253(18)30161-4. [Epub ahead of print]


Using antibody directed phototherapy to target oesophageal adenocarcinoma with heterogeneous HER2 expression.

Pye H, Butt MA, Funnell L, Reinert HW, Puccio I, Rehman Khan SU, Saouros S, Marklew JS, Stamati I, Qurashi M, Haidry R, Sehgal V, Oukrif D, Gandy M, Whitaker HC, Rodriguez-Justo M, Novelli M, Hamoudi R, Yahioglu G, Deonarain MP, Lovat LB.

Oncotarget. 2018 May 1;9(33):22945-22959. doi: 10.18632/oncotarget.25159. eCollection 2018 May 1.


A Novel Application of Indocyanine Green Immunofluorescence in Emergent Colorectal Surgery.

Keller DS, Boulton R, Rodriguez-Justo M, Cohen R, Chand M.

J Fluoresc. 2018 Mar;28(2):487-490. doi: 10.1007/s10895-018-2230-7. Epub 2018 Apr 26.


Overlap at the molecular and immunohistochemical levels between angioimmunoblastic T-cell lymphoma and a subgroup of peripheral T-cell lymphomas without specific morphological features.

Manso R, González-Rincón J, Rodríguez-Justo M, Roncador G, Gómez S, Sánchez-Beato M, Piris MA, Rodríguez-Pinilla SM.

Oncotarget. 2018 Mar 1;9(22):16124-16133. doi: 10.18632/oncotarget.24592. eCollection 2018 Mar 23.


Feasibility of fluorescence lymph node imaging in colon cancer: FLICC.

Chand M, Keller DS, Joshi HM, Devoto L, Rodriguez-Justo M, Cohen R.

Tech Coloproctol. 2018 Apr;22(4):271-277. doi: 10.1007/s10151-018-1773-6. Epub 2018 Mar 17.


MEK inhibition leads to BRCA2 downregulation and sensitization to DNA damaging agents in pancreas and ovarian cancer models.

Vena F, Jia R, Esfandiari A, Garcia-Gomez JJ, Rodriguez-Justo M, Ma J, Syed S, Crowley L, Elenbaas B, Goodstal S, Hartley JA, Hochhauser D.

Oncotarget. 2018 Jan 22;9(14):11592-11603. doi: 10.18632/oncotarget.24294. eCollection 2018 Feb 20.


Immunohistochemical assessment of Survivin and Bcl3 expression as potential biomarkers for NF-κB activation in the Barrett metaplasia-dysplasia-adenocarcinoma sequence.

Puccio I, Khan S, Butt A, Graham D, Sehgal V, Patel D, Novelli M, Lovat LB, Rodriguez-Justo M, Hamoudi RA.

Int J Exp Pathol. 2018 Feb;99(1):10-14. doi: 10.1111/iep.12260. Epub 2018 Feb 23.


An APRIL-based chimeric antigen receptor for dual targeting of BCMA and TACI in multiple myeloma.

Lee L, Draper B, Chaplin N, Philip B, Chin M, Galas-Filipowicz D, Onuoha S, Thomas S, Baldan V, Bughda R, Maciocia P, Kokalaki E, Neves MP, Patel D, Rodriguez-Justo M, Francis J, Yong K, Pule M.

Blood. 2018 Feb 15;131(7):746-758. doi: 10.1182/blood-2017-05-781351. Epub 2017 Dec 28.


Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution.

Baker AM, Huang W, Wang XM, Jansen M, Ma XJ, Kim J, Anderson CM, Wu X, Pan L, Su N, Luo Y, Domingo E, Heide T, Sottoriva A, Lewis A, Beggs AD, Wright NA, Rodriguez-Justo M, Park E, Tomlinson I, Graham TA.

Nat Commun. 2017 Dec 8;8(1):1998. doi: 10.1038/s41467-017-02295-5.


Using fluorescence lymphangiography to define the ileocolic mesentery: proof of concept for the watershed area using real-time imaging.

Keller DS, Joshi HM, Rodriguez-Justo M, Walsh D, Coffey JC, Chand M.

Tech Coloproctol. 2017 Sep;21(9):757-760. doi: 10.1007/s10151-017-1677-x. Epub 2017 Aug 29.


The histopathological classification, diagnosis and differential diagnosis of mucinous appendiceal neoplasms, appendiceal adenocarcinomas and pseudomyxoma peritonei.

Carr NJ, Bibeau F, Bradley RF, Dartigues P, Feakins RM, Geisinger KR, Gui X, Isaac S, Milione M, Misdraji J, Pai RK, Rodriguez-Justo M, Sobin LH, van Velthuysen MF, Yantiss RK.

Histopathology. 2017 Dec;71(6):847-858. doi: 10.1111/his.13324. Epub 2017 Sep 19. Review.


Visualization of Tumor-Immune Interaction - Target-Specific Imaging of S100A8/A9 Reveals Pre-Metastatic Niche Establishment.

Eisenblaetter M, Flores-Borja F, Lee JJ, Wefers C, Smith H, Hueting R, Cooper MS, Blower PJ, Patel D, Rodriguez-Justo M, Milewicz H, Vogl T, Roth J, Tutt A, Schaeffter T, Ng T.

Theranostics. 2017 Jun 15;7(9):2392-2401. doi: 10.7150/thno.17138. eCollection 2017.


Developing Raman spectroscopy as a diagnostic tool for label-free antigen detection.

Lewis AT, Gaifulina R, Guppy NJ, Isabelle M, Dorney J, Lloyd GR, Rodriguez-Justo M, Kendall C, Stone N, Thomas GM.

J Biophotonics. 2018 Feb;11(2). doi: 10.1002/jbio.201700028. Epub 2017 Aug 7.


Upregulation of mucin glycoprotein MUC1 in the progression to esophageal adenocarcinoma and therapeutic potential with a targeted photoactive antibody-drug conjugate.

Adil Butt M, Pye H, Haidry RJ, Oukrif D, Khan SU, Puccio I, Gandy M, Reinert HW, Bloom E, Rashid M, Yahioglu G, Deonarain MP, Hamoudi R, Rodriguez-Justo M, Novelli MR, Lovat LB.

Oncotarget. 2017 Apr 11;8(15):25080-25096. doi: 10.18632/oncotarget.15340.


Mirrored stainless steel substrate provides improved signal for Raman spectroscopy of tissue and cells.

Lewis AT, Gaifulina R, Isabelle M, Dorney J, Woods ML, Lloyd GR, Lau K, Rodriguez-Justo M, Kendall C, Stone N, Thomas GM.

J Raman Spectrosc. 2017 Jan;48(1):119-125. doi: 10.1002/jrs.4980. Epub 2016 Jul 29.


RORγt+ Innate Lymphoid Cells Promote Lymph Node Metastasis of Breast Cancers.

Irshad S, Flores-Borja F, Lawler K, Monypenny J, Evans R, Male V, Gordon P, Cheung A, Gazinska P, Noor F, Wong F, Grigoriadis A, Fruhwirth GO, Barber PR, Woodman N, Patel D, Rodriguez-Justo M, Owen J, Martin SG, Pinder SE, Gillett CE, Poland SP, Ameer-Beg S, McCaughan F, Carlin LM, Hasan U, Withers DR, Lane P, Vojnovic B, Quezada SA, Ellis P, Tutt AN, Ng T.

Cancer Res. 2017 Mar 1;77(5):1083-1096. doi: 10.1158/0008-5472.CAN-16-0598. Epub 2017 Jan 12.


PET/CT Imaging of Unstable Carotid Plaque with 68Ga-Labeled Somatostatin Receptor Ligand.

Wan MYS, Endozo R, Michopoulou S, Shortman R, Rodriguez-Justo M, Menezes L, Yusuf S, Richards T, Wild D, Waser B, Reubi JC, Groves A.

J Nucl Med. 2017 May;58(5):774-780. doi: 10.2967/jnumed.116.181438. Epub 2016 Dec 8.


INNOVATE: A prospective cohort study combining serum and urinary biomarkers with novel diffusion-weighted magnetic resonance imaging for the prediction and characterization of prostate cancer.

Johnston E, Pye H, Bonet-Carne E, Panagiotaki E, Patel D, Galazi M, Heavey S, Carmona L, Freeman A, Trevisan G, Allen C, Kirkham A, Burling K, Stevens N, Hawkes D, Emberton M, Moore C, Ahmed HU, Atkinson D, Rodriguez-Justo M, Ng T, Alexander D, Whitaker H, Punwani S.

BMC Cancer. 2016 Oct 21;16(1):816.


Label-free Raman spectroscopic imaging to extract morphological and chemical information from a formalin-fixed, paraffin-embedded rat colon tissue section.

Gaifulina R, Maher AT, Kendall C, Nelson J, Rodriguez-Justo M, Lau K, Thomas GM.

Int J Exp Pathol. 2016 Aug;97(4):337-350. doi: 10.1111/iep.12194. Epub 2016 Sep 1.


Diffusion-weighted imaging for evaluating inflammatory activity in Crohn's disease: comparison with histopathology, conventional MRI activity scores, and faecal calprotectin.

Pendsé DA, Makanyanga JC, Plumb AA, Bhatnagar G, Atkinson D, Rodriguez-Justo M, Halligan S, Taylor SA.

Abdom Radiol (NY). 2017 Jan;42(1):115-123. doi: 10.1007/s00261-016-0863-z.


Regulation of OGT by URI in Response to Glucose Confers c-MYC-Dependent Survival Mechanisms.

Burén S, Gomes AL, Teijeiro A, Fawal MA, Yilmaz M, Tummala KS, Perez M, Rodriguez-Justo M, Campos-Olivas R, Megías D, Djouder N.

Cancer Cell. 2016 Aug 8;30(2):290-307. doi: 10.1016/j.ccell.2016.06.023.


Patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes.

Cereda M, Gambardella G, Benedetti L, Iannelli F, Patel D, Basso G, Guerra RF, Mourikis TP, Puccio I, Sinha S, Laghi L, Spencer J, Rodriguez-Justo M, Ciccarelli FD.

Nat Commun. 2016 Jul 5;7:12072. doi: 10.1038/ncomms12072.


Evaluation of B cell maturation antigen as a target for antibody drug conjugate mediated cytotoxicity in multiple myeloma.

Lee L, Bounds D, Paterson J, Herledan G, Sully K, Seestaller-Wehr LM, Fieles WE, Tunstead J, McCahon L, Germaschewski FM, Mayes PA, Craigen JL, Rodriguez-Justo M, Yong KL.

Br J Haematol. 2016 Sep;174(6):911-22. doi: 10.1111/bjh.14145. Epub 2016 Jun 17.


Multi-centre Raman spectral mapping of oesophageal cancer tissues: a study to assess system transferability.

Isabelle M, Dorney J, Lewis A, Lloyd GR, Old O, Shepherd N, Rodriguez-Justo M, Barr H, Lau K, Bell I, Ohrel S, Thomas G, Stone N, Kendall C.

Faraday Discuss. 2016 Jun 23;187:87-103. doi: 10.1039/c5fd00183h.


MRI texture analysis (MRTA) of T2-weighted images in Crohn's disease may provide information on histological and MRI disease activity in patients undergoing ileal resection.

Makanyanga J, Ganeshan B, Rodriguez-Justo M, Bhatnagar G, Groves A, Halligan S, Miles K, Taylor SA.

Eur Radiol. 2017 Feb;27(2):589-597. doi: 10.1007/s00330-016-4324-4. Epub 2016 Apr 5.


MRI texture analysis parameters of contrast-enhanced T1-weighted images of Crohn's disease differ according to the presence or absence of histological markers of hypoxia and angiogenesis.

Bhatnagar G, Makanyanga J, Ganeshan B, Groves A, Rodriguez-Justo M, Halligan S, Taylor SA.

Abdom Radiol (NY). 2016 Jul;41(7):1261-9. doi: 10.1007/s00261-016-0657-3.


Distribution of the c-MYC gene product in colorectal neoplasia.

Baker AM, Van Noorden S, Rodriguez-Justo M, Cohen P, Wright NA, Lampert IA.

Histopathology. 2016 Aug;69(2):222-9. doi: 10.1111/his.12939. Epub 2016 Mar 17.


Reply to Kristo et al.

Haidry RJ, Lipman G, Banks MR, Butt MA, Sehgal V, Graham D, Dunn JM, Gupta A, Sweis R, Miah H, Morris D, Smart HL, Bhandari P, Willert R, Fullarton G, Morris J, Di Pietro M, Gordon C, Penman I, Barr H, Patel P, Boger P, Kapoor N, Mahon B, Hoare J, Narayanasamy R, O'Toole D, Cheong E, Direkze NC, Ang Y, Veitch A, Dhar A, Nyalender D, Ragunath K, Leahy A, Fullard M, Rodriguez-Justo M, Novelli M, Lovat LB.

Endoscopy. 2016 Jan;48(1):93. doi: 10.1055/s-0035-1569618. Epub 2015 Dec 28. No abstract available.


Evolution of oesophageal adenocarcinoma from metaplastic columnar epithelium without goblet cells in Barrett's oesophagus.

Lavery DL, Martinez P, Gay LJ, Cereser B, Novelli MR, Rodriguez-Justo M, Meijer SL, Graham TA, McDonald SA, Wright NA, Jansen M.

Gut. 2016 Jun;65(6):907-13. doi: 10.1136/gutjnl-2015-310748. Epub 2015 Dec 23.


The MEK1/2 Inhibitor Pimasertib Enhances Gemcitabine Efficacy in Pancreatic Cancer Models by Altering Ribonucleotide Reductase Subunit-1 (RRM1).

Vena F, Li Causi E, Rodriguez-Justo M, Goodstal S, Hagemann T, Hartley JA, Hochhauser D.

Clin Cancer Res. 2015 Dec 15;21(24):5563-77. doi: 10.1158/1078-0432.CCR-15-0485. Epub 2015 Jul 30.


Comparing outcome of radiofrequency ablation in Barrett's with high grade dysplasia and intramucosal carcinoma: a prospective multicenter UK registry.

Haidry RJ, Lipman G, Banks MR, Butt MA, Sehgal V, Graham D, Dunn JM, Gupta A, Sweis R, Miah H, Morris D, Smart HL, Bhandari P, Willert R, Fullarton G, Morris J, Di Pietro M, Gordon C, Penman I, Barr H, Patel P, Boger P, Kapoor N, Mahon B, Hoare J, Narayanasamy R, O'Toole D, Cheong E, Direkze NC, Ang Y, Veitch A, Dhar A, Nyalender D, Ragunath K, Leahy A, Fullard M, Rodriguez-Justo M, Novelli M, Lovat LB.

Endoscopy. 2015 Nov;47(11):980-7. doi: 10.1055/s-0034-1392414. Epub 2015 Jun 30.


Photoacoustic imaging of human lymph nodes with endogenous lipid and hemoglobin contrast.

Guggenheim JA, Allen TJ, Plumb A, Zhang EZ, Rodriguez-Justo M, Punwani S, Beard PC.

J Biomed Opt. 2015 May;20(5):50504. doi: 10.1117/1.JBO.20.5.050504.


Esophageal neoplasia arising from subsquamous buried glands after an apparently successful photodynamic therapy or radiofrequency ablation for Barrett's associated neoplasia.

Kohoutova D, Haidry R, Banks M, Bown S, Sehgal V, Butt MA, Graham D, Thorpe S, Novelli M, Rodriguez-Justo M, Lovat L.

Scand J Gastroenterol. 2015;50(11):1315-21. doi: 10.3109/00365521.2015.1043578. Epub 2015 May 8.


Characterization of LGR5 stem cells in colorectal adenomas and carcinomas.

Baker AM, Graham TA, Elia G, Wright NA, Rodriguez-Justo M.

Sci Rep. 2015 Mar 2;5:8654. doi: 10.1038/srep08654.


Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage.

Tummala KS, Gomes AL, Yilmaz M, Graña O, Bakiri L, Ruppen I, Ximénez-Embún P, Sheshappanavar V, Rodriguez-Justo M, Pisano DG, Wagner EF, Djouder N.

Cancer Cell. 2014 Dec 8;26(6):826-839. doi: 10.1016/j.ccell.2014.10.002. Epub 2014 Nov 20.


Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche.

Davis H, Irshad S, Bansal M, Rafferty H, Boitsova T, Bardella C, Jaeger E, Lewis A, Freeman-Mills L, Giner FC, Rodenas-Cuadrado P, Mallappa S, Clark S, Thomas H, Jeffery R, Poulsom R, Rodriguez-Justo M, Novelli M, Chetty R, Silver A, Sansom OJ, Greten FR, Wang LM, East JE, Tomlinson I, Leedham SJ.

Nat Med. 2015 Jan;21(1):62-70. doi: 10.1038/nm.3750. Epub 2014 Dec 1.


Mucosal transcriptomics implicates under expression of BRINP3 in the pathogenesis of ulcerative colitis.

Smith PJ, Levine AP, Dunne J, Guilhamon P, Turmaine M, Sewell GW, OʼShea NR, Vega R, Paterson JC, Oukrif D, Beck S, Bloom SL, Novelli M, Rodriguez-Justo M, Smith AM, Segal AW.

Inflamm Bowel Dis. 2014 Oct;20(10):1802-12. doi: 10.1097/MIB.0000000000000169. Erratum in: Inflamm Bowel Dis. 2015 Apr;21(4):911. Inflamm Bowel Dis. 2016 Feb;22(2):E10.


Type 1 autoimmune pancreatitis and IgG4-related sclerosing cholangitis is associated with extrapancreatic organ failure, malignancy, and mortality in a prospective UK cohort.

Huggett MT, Culver EL, Kumar M, Hurst JM, Rodriguez-Justo M, Chapman MH, Johnson GJ, Pereira SP, Chapman RW, Webster GJM, Barnes E.

Am J Gastroenterol. 2014 Oct;109(10):1675-1683. doi: 10.1038/ajg.2014.223. Epub 2014 Aug 26.


Quantification of crypt and stem cell evolution in the normal and neoplastic human colon.

Baker AM, Cereser B, Melton S, Fletcher AG, Rodriguez-Justo M, Tadrous PJ, Humphries A, Elia G, McDonald SA, Wright NA, Simons BD, Jansen M, Graham TA.

Cell Rep. 2014 Aug 21;8(4):940-7. doi: 10.1016/j.celrep.2014.07.019. Epub 2014 Aug 7.


METRIC (MREnterography or ulTRasound in Crohn's disease): a study protocol for a multicentre, non-randomised, single-arm, prospective comparison study of magnetic resonance enterography and small bowel ultrasound compared to a reference standard in those aged 16 and over.

Taylor S, Mallett S, Bhatnagar G, Bloom S, Gupta A, Halligan S, Hamlin J, Hart A, Higginson A, Jacobs I, McCartney S, Morris S, Muirhead N, Murray C, Punwani S, Rodriguez-Justo M, Slater A, Travis S, Tolan D, Windsor A, Wylie P, Zealley I.

BMC Gastroenterol. 2014 Aug 11;14:142. doi: 10.1186/1471-230X-14-142.


The bone marrow stromal compartment in multiple myeloma patients retains capability for osteogenic differentiation in vitro: defining the stromal defect in myeloma.

Kassen D, Moore S, Percy L, Herledan G, Bounds D, Rodriguez-Justo M, Croucher P, Yong K.

Br J Haematol. 2014 Oct;167(2):194-206. doi: 10.1111/bjh.13020. Epub 2014 Jul 31.


Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia.

Piazzolla D, Palla AR, Pantoja C, Cañamero M, de Castro IP, Ortega S, Gómez-López G, Dominguez O, Megías D, Roncador G, Luque-Garcia JL, Fernandez-Tresguerres B, Fernandez AF, Fraga MF, Rodriguez-Justo M, Manzanares M, Sánchez-Carbayo M, García-Pedrero JM, Rodrigo JP, Malumbres M, Serrano M.

Nat Commun. 2014 Jun 30;5:4226. doi: 10.1038/ncomms5226.


The use of molecular imaging combined with genomic techniques to understand the heterogeneity in cancer metastasis.

Chowdhury R, Ganeshan B, Irshad S, Lawler K, Eisenblätter M, Milewicz H, Rodriguez-Justo M, Miles K, Ellis P, Groves A, Punwani S, Ng T.

Br J Radiol. 2014 Jun;87(1038):20140065. doi: 10.1259/bjr.20140065. Epub 2014 Mar 6. Review.


The stem cell organisation, and the proliferative and gene expression profile of Barrett's epithelium, replicates pyloric-type gastric glands.

Lavery DL, Nicholson AM, Poulsom R, Jeffery R, Hussain A, Gay LJ, Jankowski JA, Zeki SS, Barr H, Harrison R, Going J, Kadirkamanathan S, Davis P, Underwood T, Novelli MR, Rodriguez-Justo M, Shepherd N, Jansen M, Wright NA, McDonald SA.

Gut. 2014 Dec;63(12):1854-63. doi: 10.1136/gutjnl-2013-306508. Epub 2014 Feb 18.


Multifunctional imaging signature for V-KI-RAS2 Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations in colorectal cancer.

Miles KA, Ganeshan B, Rodriguez-Justo M, Goh VJ, Ziauddin Z, Engledow A, Meagher M, Endozo R, Taylor SA, Halligan S, Ell PJ, Groves AM.

J Nucl Med. 2014 Mar;55(3):386-91. doi: 10.2967/jnumed.113.120485. Epub 2014 Feb 10.


Evaluation of follicular T-helper cells in primary cutaneous CD4+ small/medium pleomorphic T-cell lymphoma and dermatitis.

Ally MS, Prasad Hunasehally RY, Rodriguez-Justo M, Martin B, Verdolini R, Attard N, Child F, Attygalle A, Whittaker S, Morris S, Robson A.

J Cutan Pathol. 2013 Dec;40(12):1006-13. doi: 10.1111/cup.12234. Epub 2013 Oct 12.


Clonal selection and persistence in dysplastic Barrett's esophagus and intramucosal cancers after failed radiofrequency ablation.

Zeki SS, Haidry R, Graham TA, Rodriguez-Justo M, Novelli M, Hoare J, Dunn J, Wright NA, Lovat LB, McDonald SA.

Am J Gastroenterol. 2013 Oct;108(10):1584-92. doi: 10.1038/ajg.2013.238. Epub 2013 Aug 13.


Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution.

Humphries A, Cereser B, Gay LJ, Miller DS, Das B, Gutteridge A, Elia G, Nye E, Jeffery R, Poulsom R, Novelli MR, Rodriguez-Justo M, McDonald SA, Wright NA, Graham TA.

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2490-9. doi: 10.1073/pnas.1220353110. Epub 2013 Jun 13.

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