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Comment on "A National Cancer Database Analysis of Microsatellite Instability and Pathologic Complete Response in Locally Advanced Rectal Cancer".

You YN, Rodriguez-Bigas MA, Das P, Healy M, Chiang YJ, George T, Vilar E.

Ann Surg. 2020 Jan 14. doi: 10.1097/SLA.0000000000003785. [Epub ahead of print] No abstract available.


Who Should Get Lateral Pelvic Lymph Node Dissection After Neoadjuvant Chemoradiation?

Malakorn S, Yang Y, Bednarski BK, Kaur H, You YN, Holliday EB, Dasari A, Skibber JM, Rodriguez-Bigas MA, Chang GJ.

Dis Colon Rectum. 2019 Oct;62(10):1158-1166. doi: 10.1097/DCR.0000000000001465.


A Phase II Study of Capecitabine/Oxaliplatin With Concurrent Radiotherapy in Locally Advanced Squamous Cell Carcinoma of the Anal Canal.

Eng C, Jácome AA, Das P, Chang GJ, Rodriguez-Bigas M, Skibber JM, Wolff RA, Qiao W, Xing Y, Sethi S, Ohinata A, Crane CH.

Clin Colorectal Cancer. 2019 Dec;18(4):301-306. doi: 10.1016/j.clcc.2019.06.003. Epub 2019 Jul 2.


Energy balance related lifestyle factors and risk of endometrial and colorectal cancer among individuals with lynch syndrome: a systematic review.

Coletta AM, Peterson SK, Gatus LA, Krause KJ, Schembre SM, Gilchrist SC, Pande M, Vilar E, You YN, Rodriguez-Bigas MA, Strong LL, Lynch PM, Lu KH, Basen-Engquist K.

Fam Cancer. 2019 Oct;18(4):399-420. doi: 10.1007/s10689-019-00135-7. Epub 2019 Jun 24.


Outcomes of disease-specific next-generation sequencing gene panel testing in adolescents and young adults with colorectal cancer.

Mork ME, Rodriguez A, Bannon SA, Lynch PM, Rodriguez-Bigas MA, Thirumurthi S, You YN, Vilar E.

Cancer Genet. 2019 Jun;235-236:77-83. doi: 10.1016/j.cancergen.2019.04.064. Epub 2019 Apr 26.


Health and lifestyle behaviors in colorectal cancer survivors with and without Lynch syndrome.

Donato KM, Moore K, Parker WM, Peterson SK, Gritz ER, Amos CI, Lu KH, Lynch PM, Rodriguez-Bigas MA, You YN, Burton-Chase AM.

J Community Genet. 2020 Jan;11(1):59-63. doi: 10.1007/s12687-019-00421-y. Epub 2019 Apr 23.


Detection of Pathogenic Germline Variants Among Patients With Advanced Colorectal Cancer Undergoing Tumor Genomic Profiling for Precision Medicine.

You YN, Borras E, Chang K, Price BA, Mork M, Chang GJ, Rodriguez-Bigas MA, Bednarski BK, Meric-Bernstam F, Vilar E.

Dis Colon Rectum. 2019 Apr;62(4):429-437. doi: 10.1097/DCR.0000000000001322.


Universal screening for Lynch syndrome in a large consecutive cohort of Chinese colorectal cancer patients: High prevalence and unique molecular features.

Jiang W, Cai MY, Li SY, Bei JX, Wang F, Hampel H, Ling YH, Frayling IM, Sinicrope FA, Rodriguez-Bigas MA, Dignam JJ, Kerr DJ, Rosell R, Mao M, Li JB, Guo YM, Wu XY, Kong LH, Tang JH, Wu XD, Li CF, Chen JR, Ou QJ, Ye MZ, Guo FM, Han P, Wang QW, Wan DS, Li L, Xu RH, Pan ZZ, Ding PR; Written on behalf of AME Colorectal Cancer Cooperative Group.

Int J Cancer. 2019 May 1;144(9):2161-2168. doi: 10.1002/ijc.32044. Epub 2019 Jan 9.


Treatment of primary rectal adenocarcinoma after prior pelvic radiation: The role of hyperfractionated accelerated reirradiation.

Jensen G, Tao R, Eng C, Skibber JM, Rodriguez-Bigas M, Chang GJ, You YN, Bednarski BK, Minsky BD, Koay E, Taniguchi C, Krishnan S, Das P.

Adv Radiat Oncol. 2018 Jul 17;3(4):595-600. doi: 10.1016/j.adro.2018.07.003. eCollection 2018 Oct-Dec.


Session 4: Shaping radiotherapy for rectal cancer: should this be personalized?

Dattani M, Marijnen C, Moran B, Tait D, Cunningham C, Rodriguez-Bigas M, Brown G.

Colorectal Dis. 2018 May;20 Suppl 1:92-96. doi: 10.1111/codi.14087. Review.


Short course radiation as a component of definitive multidisciplinary treatment for select patients with metastatic rectal adenocarcinoma.

Holliday EB, Hunt A, You YN, Chang GJ, Skibber JM, Rodriguez-Bigas MA, Bednarski BK, Eng C, Koay EJ, Minsky BD, Taniguchi C, Krishnan S, Herman JM, Das P.

J Gastrointest Oncol. 2017 Dec;8(6):990-997. doi: 10.21037/jgo.2017.09.02.


Clinical and Genetic Implications of DNA Mismatch Repair Deficiency in Biliary Tract Cancers Associated with Lynch Syndrome.

Cloyd JM, Chun YS, Ikoma N, Vauthey JN, Aloia TA, Cuddy A, Rodriguez-Bigas MA, Nancy You Y.

J Gastrointest Cancer. 2018 Mar;49(1):93-96. doi: 10.1007/s12029-017-0040-9.


Clinical features and survival of gastric cancer patients with DNA mismatch repair deficiency.

Ikoma N, Cloyd J, Badgwell BD, Agnes A, Rodriguez-Bigas M, Ajani JA, You YN.

J Surg Oncol. 2018 Mar;117(4):707-709. doi: 10.1002/jso.24926. Epub 2017 Dec 11.


Assessment of Ileostomy Output Using Telemedicine: A Feasibility Trial.

Bednarski BK, Slack RS, Katz M, You YN, Papadopolous J, Rodriguez-Bigas MA, Skibber JM, Matin SF, Chang GJ.

Dis Colon Rectum. 2018 Jan;61(1):77-83. doi: 10.1097/DCR.0000000000000945.


Preoperative radiation dose escalation for rectal cancer using a concomitant boost strategy improves tumor downstaging without increasing toxicity: A matched-pair analysis.

Gunther JR, Chadha AS, Shin US, Park IJ, Kattepogu KV, Grant JD, Weksberg DC, Eng C, Kopetz SE, Das P, Delclos ME, Kaur H, Maru DM, Skibber JM, Rodriguez-Bigas MA, You YN, Krishnan S, Chang GJ.

Adv Radiat Oncol. 2017 Apr 12;2(3):455-464. doi: 10.1016/j.adro.2017.04.001. eCollection 2017 Jul-Sep.


Comparison of Internet and Telephone Interventions for Weight Loss Among Cancer Survivors: Randomized Controlled Trial and Feasibility Study.

Cox M, Basen-Engquist K, Carmack CL, Blalock J, Li Y, Murray J, Pisters L, Rodriguez-Bigas M, Song J, Cox-Martin E, Demark-Wahnefried W.

JMIR Cancer. 2017 Sep 27;3(2):e16. doi: 10.2196/cancer.7166.


In Silico Systems Biology Analysis of Variants of Uncertain Significance in Lynch Syndrome Supports the Prioritization of Functional Molecular Validation.

Borras E, Chang K, Pande M, Cuddy A, Bosch JL, Bannon SA, Mork ME, Rodriguez-Bigas MA, Taggart MW, Lynch PM, You YN, Vilar E.

Cancer Prev Res (Phila). 2017 Oct;10(10):580-587. doi: 10.1158/1940-6207.CAPR-17-0058. Epub 2017 Aug 1.


Impact of Recurrence and Salvage Surgery on Survival After Multidisciplinary Treatment of Rectal Cancer.

Ikoma N, You YN, Bednarski BK, Rodriguez-Bigas MA, Eng C, Das P, Kopetz S, Messick C, Skibber JM, Chang GJ.

J Clin Oncol. 2017 Aug 10;35(23):2631-2638. doi: 10.1200/JCO.2016.72.1464. Epub 2017 Jun 28.


Can Microsatellite Status of Colorectal Cancer Be Reliably Assessed after Neoadjuvant Therapy?

Goldstein JB, Wu W, Borras E, Masand G, Cuddy A, Mork ME, Bannon SA, Lynch PM, Rodriguez-Bigas M, Taggart MW, Wu J, Scheet P, Kopetz S, You YN, Vilar E.

Clin Cancer Res. 2017 Sep 1;23(17):5246-5254. doi: 10.1158/1078-0432.CCR-16-2994. Epub 2017 May 18.


Timing of Surgical Resection for Curative Colorectal Cancer with Liver Metastasis.

Ali SM, Pawlik TM, Rodriguez-Bigas MA, Monson JRT, Chang GJ, Larson DW.

Ann Surg Oncol. 2018 Jan;25(1):32-37. doi: 10.1245/s10434-016-5745-7. Epub 2017 Feb 21. Review.


A comparison between Lynch syndrome and sporadic colorectal cancer survivors' satisfaction with their healthcare providers.

Burton-Chase AM, Parker WM, Polivka KM, Gritz ER, Amos CI, Lu KH, Lynch PM, Rodriguez-Bigas MA, Nancy You Y, Peterson SK.

Cancer Med. 2017 Mar;6(3):698-707. doi: 10.1002/cam4.1033. Epub 2017 Feb 17.


Hyperfractionated accelerated reirradiation for rectal cancer: An analysis of outcomes and toxicity.

Tao R, Tsai CJ, Jensen G, Eng C, Kopetz S, Overman MJ, Skibber JM, Rodriguez-Bigas M, Chang GJ, You YN, Bednarski BK, Minsky BD, Delclos ME, Koay E, Krishnan S, Crane CH, Das P.

Radiother Oncol. 2017 Jan;122(1):146-151. doi: 10.1016/j.radonc.2016.12.015. Epub 2017 Jan 3.


Health-related quality of life in colorectal cancer survivors: are there differences between sporadic and hereditary patients?

Burton-Chase AM, Parker WM, Donato KM, McCormick S, Gritz ER, Amos CI, Lu KH, Lynch PM, Rodriguez-Bigas MA, Nancy You Y, Peterson SK.

J Patient Rep Outcomes. 2017;2(1):21. doi: 10.1186/s41687-018-0047-4. Epub 2018 May 1.


Identification of MSH2 inversion of exons 1-7 in clinical evaluation of families with suspected Lynch syndrome.

Mork ME, Rodriguez A, Taggart MW, Rodriguez-Bigas MA, Lynch PM, Bannon SA, You YN, Vilar E.

Fam Cancer. 2017 Jul;16(3):357-361. doi: 10.1007/s10689-016-9960-y.


Anal Dysplasia.

Messick CA, Rodriguez-Bigas MA.

Surg Oncol Clin N Am. 2017 Jan;26(1):33-43. doi: 10.1016/j.soc.2016.07.005. Review.


Locally Recurrent Disease Related to Anal Canal Cancers.

Sammour T, Rodriguez-Bigas MA, Skibber JM.

Surg Oncol Clin N Am. 2017 Jan;26(1):115-125. doi: 10.1016/j.soc.2016.07.006. Review.


Serum exosomal miR-4772-3p is a predictor of tumor recurrence in stage II and III colon cancer.

Liu C, Eng C, Shen J, Lu Y, Takata Y, Mehdizadeh A, Chang GJ, Rodriguez-Bigas MA, Li Y, Chang P, Mao Y, Hassan MM, Wang F, Li D.

Oncotarget. 2016 Nov 15;7(46):76250-76260. doi: 10.18632/oncotarget.12841.


Hyperfractionated Accelerated Reirradiation for Patients With Recurrent Anal Cancer Previously Treated With Definitive Chemoradiation.

Osborne EM, Eng C, Skibber JM, Rodriguez-Bigas MA, Chang GJ, Nancy You YQ, Bednarski BK, Minsky BD, Delclos ME, Koay E, Krishnan S, Crane CH, Das P.

Am J Clin Oncol. 2018 Jul;41(7):632-637. doi: 10.1097/COC.0000000000000338.


Comparative effectiveness of primary tumor resection in patients with stage IV colon cancer.

Alawadi Z, Phatak UR, Hu CY, Bailey CE, You YN, Kao LS, Massarweh NN, Feig BW, Rodriguez-Bigas MA, Skibber JM, Chang GJ.

Cancer. 2017 Apr 1;123(7):1124-1133. doi: 10.1002/cncr.30230. Epub 2016 Aug 1.


DNA Mismatch Repair Deficiency in Rectal Cancer: Benchmarking Its Impact on Prognosis, Neoadjuvant Response Prediction, and Clinical Cancer Genetics.

de Rosa N, Rodriguez-Bigas MA, Chang GJ, Veerapong J, Borras E, Krishnan S, Bednarski B, Messick CA, Skibber JM, Feig BW, Lynch PM, Vilar E, You YN.

J Clin Oncol. 2016 Sep 1;34(25):3039-46. doi: 10.1200/JCO.2016.66.6826. Epub 2016 Jul 18.


Oncologic and Functional Hazards of Obesity Among Patients With Locally Advanced Rectal Cancer Following Neoadjuvant Chemoradiation Therapy.

Park IJ, You YN, Skibber JM, Rodriguez-Bigas MA, Das P, Eng C, Kopetz S, Wolff RA, Crane CH, Krishnan S, Minsky B, Hu CY, Nguyen S, Chang GJ.

Am J Clin Oncol. 2017 Jun;40(3):277-282. doi: 10.1097/COC.0000000000000150.


Identification of a novel PMS2 alteration c.505C>G (R169G) in trans with a PMS2 pathogenic mutation in a patient with constitutional mismatch repair deficiency.

Mork ME, Borras E, Taggart MW, Cuddy A, Bannon SA, You YN, Lynch PM, Ramirez PT, Rodriguez-Bigas MA, Vilar E.

Fam Cancer. 2016 Oct;15(4):587-91. doi: 10.1007/s10689-016-9902-8.


Impact of multimodal therapy in locally recurrent rectal cancer.

You YN, Skibber JM, Hu CY, Crane CH, Das P, Kopetz ES, Eng C, Feig BW, Rodriguez-Bigas MA, Chang GJ.

Br J Surg. 2016 May;103(6):753-762. doi: 10.1002/bjs.10079. Epub 2016 Mar 2.


A proposed staging system and stage-specific interventions for familial adenomatous polyposis.

Lynch PM, Morris JS, Wen S, Advani SM, Ross W, Chang GJ, Rodriguez-Bigas M, Raju GS, Ricciardiello L, Iwama T, Rossi BM, Pellise M, Stoffel E, Wise PE, Bertario L, Saunders B, Burt R, Belluzzi A, Ahnen D, Matsubara N, Bülow S, Jespersen N, Clark SK, Erdman SH, Markowitz AJ, Bernstein I, De Haas N, Syngal S, Moeslein G.

Gastrointest Endosc. 2016 Jul;84(1):115-125.e4. doi: 10.1016/j.gie.2015.12.029. Epub 2016 Jan 6.


Clinicopathologic Features Associated With Human Papillomavirus/p16 in Patients With Metastatic Squamous Cell Carcinoma of the Anal Canal.

Morris VK, Rashid A, Rodriguez-Bigas M, Das P, Chang G, Ohinata A, Rogers J, Crane C, Wolff RA, Eng C.

Oncologist. 2015 Nov;20(11):1247-52. doi: 10.1634/theoncologist.2015-0091. Epub 2015 Sep 17.


ACR Appropriateness Criteria® Local Excision in Early Stage Rectal Cancer.

Russo S, Blackstock AW, Herman JM, Abdel-Wahab M, Azad N, Das P, Goodman KA, Hong TS, Jabbour SK, Jones WE 3rd, Konski AA, Koong AC, Kumar R, Rodriguez-Bigas M, Small W Jr, Thomas CR Jr, Suh WW.

Am J Clin Oncol. 2015 Oct;38(5):520-5. doi: 10.1097/COC.0000000000000197. Review.


High Prevalence of Hereditary Cancer Syndromes in Adolescents and Young Adults With Colorectal Cancer.

Mork ME, You YN, Ying J, Bannon SA, Lynch PM, Rodriguez-Bigas MA, Vilar E.

J Clin Oncol. 2015 Nov 1;33(31):3544-9. doi: 10.1200/JCO.2015.61.4503. Epub 2015 Jul 20.


A Prospective Six Sigma Quality Improvement Trial to Optimize Universal Screening for Genetic Syndrome Among Patients With Young-Onset Colorectal Cancer.

Dineen S, Lynch PM, Rodriguez-Bigas MA, Bannon S, Taggart M, Reeves C, Modaro C, Overman M, Chang GJ, Skibber JM, You YN.

J Natl Compr Canc Netw. 2015 Jul;13(7):865-72.


Overtreatment of young adults with colon cancer: more intense treatments with unmatched survival gains.

Kneuertz PJ, Chang GJ, Hu CY, Rodriguez-Bigas MA, Eng C, Vilar E, Skibber JM, Feig BW, Cormier JN, You YN.

JAMA Surg. 2015 May;150(5):402-9. doi: 10.1001/jamasurg.2014.3572.


Reply to N.H. Turner et al and Ł. Dziki et al.

Massarweh NN, Hu CY, Rodriguez-Bigas MA, Chang GJ.

J Clin Oncol. 2015 Apr 20;33(12):1412-3. doi: 10.1200/JCO.2014.59.9399. Epub 2015 Mar 23. No abstract available.


An international randomised trial of celecoxib versus celecoxib plus difluoromethylornithine in patients with familial adenomatous polyposis.

Lynch PM, Burke CA, Phillips R, Morris JS, Slack R, Wang X, Liu J, Patterson S, Sinicrope FA, Rodriguez-Bigas MA, Half E, Bulow S, Latchford A, Clark S, Ross WA, Malone B, Hasson H, Richmond E, Hawk E.

Gut. 2016 Feb;65(2):286-95. doi: 10.1136/gutjnl-2014-307235. Epub 2015 Mar 19.


Time trend analysis of primary tumor resection for stage IV colorectal cancer: less surgery, improved survival.

Hu CY, Bailey CE, You YN, Skibber JM, Rodriguez-Bigas MA, Feig BW, Chang GJ.

JAMA Surg. 2015 Mar 1;150(3):245-51. doi: 10.1001/jamasurg.2014.2253.


Role of microsatellite instability-low as a diagnostic biomarker of Lynch syndrome in colorectal cancer.

Vilar E, Mork ME, Cuddy A, Borras E, Bannon SA, Taggart MW, Ying J, Broaddus RR, Luthra R, Rodriguez-Bigas MA, Lynch PM, You YQ.

Cancer Genet. 2014 Oct-Dec;207(10-12):495-502. doi: 10.1016/j.cancergen.2014.10.002. Epub 2014 Oct 13.


The role of systemic chemotherapy and multidisciplinary management in improving the overall survival of patients with metastatic squamous cell carcinoma of the anal canal.

Eng C, Chang GJ, You YN, Das P, Rodriguez-Bigas M, Xing Y, Vauthey JN, Rogers JE, Ohinata A, Pathak P, Sethi S, Phillips JK, Crane CH, Wolff RA.

Oncotarget. 2014 Nov 30;5(22):11133-42.


Increasing disparities in the age-related incidences of colon and rectal cancers in the United States, 1975-2010.

Bailey CE, Hu CY, You YN, Bednarski BK, Rodriguez-Bigas MA, Skibber JM, Cantor SB, Chang GJ.

JAMA Surg. 2015 Jan;150(1):17-22. doi: 10.1001/jamasurg.2014.1756. Erratum in: JAMA Surg. 2015 Mar 1;150(3):277.


ACR Appropriateness Criteria® rectal cancer: metastatic disease at presentation.

Goodman KA, Milgrom SA, Herman JM, Abdel-Wahab M, Azad N, Blackstock AW, Das P, Hong TS, Jabbour SK, Jones WE 3rd, Konski AA, Koong AC, Kumar R, Rodriguez-Bigas M, Small W Jr, Thomas CR Jr, Suh WW; American College of Radiology (ACR).

Oncology (Williston Park). 2014 Oct;28(10):867-71, 876, 878. Review.


Definitive Chemoradiation for Squamous Cell Carcinoma of the Rectum.

Sturgeon JD, Crane CH, Krishnan S, Minsky BD, Skibber JM, Rodriguez-Bigas MA, Chang GJ, You YN, Eng C, Das P.

Am J Clin Oncol. 2017 Apr;40(2):163-166. doi: 10.1097/COC.0000000000000126.


Functional deficits and symptoms of long-term survivors of colorectal cancer treated by multimodality therapy differ by age at diagnosis.

Bailey CE, Tran Cao HS, Hu CY, Chang GJ, Feig BW, Rodriguez-Bigas MA, Nguyen ST, Skibber JM, You YN.

J Gastrointest Surg. 2015 Jan;19(1):180-8; discussio 188. doi: 10.1007/s11605-014-2645-7. Epub 2014 Sep 12.


Risk-adjusted pathologic margin positivity rate as a quality indicator in rectal cancer surgery.

Massarweh NN, Hu CY, You YN, Bednarski BK, Rodriguez-Bigas MA, Skibber JM, Cantor SB, Cormier JN, Feig BW, Chang GJ.

J Clin Oncol. 2014 Sep 20;32(27):2967-74.


ACR Appropriateness Criteria®-Anal Cancer.

Expert Panel on Radiation Oncology–Rectal/Anal Cancer, Hong TS, Pretz JL, Herman JM, Abdel-Wahab M, Azad N, Blackstock AW, Das P, Goodman KA, Jabbour SK, Jones WE 3rd, Konski AA, Koong AC, Rodriguez-Bigas M, Small W Jr, Thomas CR Jr, Zook J, Suh WW.

Gastrointest Cancer Res. 2014 Jan;7(1):4-14.

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