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CD73 on cancer-associated fibroblasts enhanced by the A2B-mediated feedforward circuit enforces an immune checkpoint.

Yu M, Guo G, Huang L, Deng L, Chang CS, Achyut BR, Canning M, Xu N, Arbab AS, Bollag RJ, Rodriguez PC, Mellor AL, Shi H, Munn DH, Cui Y.

Nat Commun. 2020 Jan 24;11(1):515. doi: 10.1038/s41467-019-14060-x.


Polyphenol-rich extract induces apoptosis with immunogenic markers in melanoma cells through the ER stress-associated kinase PERK.

Prieto K, Cao Y, Mohamed E, Trillo-Tinoco J, Sierra RA, Urueña C, Sandoval TA, Fiorentino S, Rodriguez PC, Barreto A.

Cell Death Discov. 2019 Sep 9;5:134. doi: 10.1038/s41420-019-0214-2. eCollection 2019.


Publisher Correction: ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression.

Cao Y, Trillo-Tinoco J, Sierra RA, Anadon C, Dai W, Mohamed E, Cen L, Costich TL, Magliocco A, Marchion D, Klar R, Michel S, Jaschinski F, Reich RR, Mehrotra S, Cubillos-Ruiz JR, Munn DH, Conejo-Garcia JR, Rodriguez PC.

Nat Commun. 2019 Aug 15;10(1):3680. doi: 10.1038/s41467-019-11563-5.


AMPK Alpha-1 Intrinsically Regulates the Function and Differentiation of Tumor Myeloid-Derived Suppressor Cells.

Trillo-Tinoco J, Sierra RA, Mohamed E, Cao Y, de Mingo-Pulido Á, Gilvary DL, Anadon CM, Costich TL, Wei S, Flores ER, Ruffell B, Conejo-Garcia JR, Rodriguez PC.

Cancer Res. 2019 Oct 1;79(19):5034-5047. doi: 10.1158/0008-5472.CAN-19-0880. Epub 2019 Aug 13.


Corrigendum: Adenosine A2A Receptor Stimulation Inhibits TCR-Induced Notch1 Activation in CD8+T-Cells.

Sorrentino C, Hossain F, Rodriguez PC, Sierra RA, Pannuti A, Hatfield S, Osborne BA, Minter LM, Miele L, Morello S.

Front Immunol. 2019 May 3;10:935. doi: 10.3389/fimmu.2019.00935. eCollection 2019.


ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression.

Cao Y, Trillo-Tinoco J, Sierra RA, Anadon C, Dai W, Mohamed E, Cen L, Costich TL, Magliocco A, Marchion D, Klar R, Michel S, Jaschinski F, Reich RR, Mehrotra S, Cubillos-Ruiz JR, Munn DH, Conejo-Garcia JR, Rodriguez PC.

Nat Commun. 2019 Mar 20;10(1):1280. doi: 10.1038/s41467-019-09263-1. Erratum in: Nat Commun. 2019 Aug 15;10(1):3680.


Adenosine A2A Receptor Stimulation Inhibits TCR-Induced Notch1 Activation in CD8+T-Cells.

Sorrentino C, Hossain F, Rodriguez PC, Sierra RA, Pannuti A, Osborne BA, Minter LM, Miele L, Morello S.

Front Immunol. 2019 Feb 7;10:162. doi: 10.3389/fimmu.2019.00162. eCollection 2019. Erratum in: Front Immunol. 2019 May 03;10:935.


Inhibition of Human Dendritic Cell ER Stress Response Reduces T Cell Alloreactivity Yet Spares Donor Anti-tumor Immunity.

Betts BC, Locke FL, Sagatys EM, Pidala J, Walton K, Menges M, Reff J, Saha A, Djeu JY, Kiluk JV, Lee MC, Kim J, Kang CW, Tang CH, Frieling J, Lynch CC, List A, Rodriguez PC, Blazar BR, Conejo-Garcia JR, Del Valle JR, Hu CC, Anasetti C.

Front Immunol. 2018 Dec 6;9:2887. doi: 10.3389/fimmu.2018.02887. eCollection 2018.


Congenital hyperinsulinism in two siblings with ABCC8 mutation: same genotype, different phenotypes.

Sousa-Santos F, Simões H, Castro-Feijóo L, Rodríguez PC, Fernández-Marmiesse A, Fiaño RS, Rego T, Carracedo Á, Conde JB.

Arch Endocrinol Metab. 2018 Oct;62(5):560-565. doi: 10.20945/2359-3997000000077.


Differential effects of two therapeutic cancer vaccines on short- and long-term survival populations among patients with advanced lung cancer.

Sanchez L, Muchene L, Lorenzo-Luaces P, Viada C, Rodriguez PC, Alfonso S, Crombet T, Neninger E, Shkedy Z, Lage A.

Semin Oncol. 2018 Jan;45(1-2):52-57. doi: 10.1053/j.seminoncol.2018.04.005. Epub 2018 May 1.


IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity.

Song M, Sandoval TA, Chae CS, Chopra S, Tan C, Rutkowski MR, Raundhal M, Chaurio RA, Payne KK, Konrad C, Bettigole SE, Shin HR, Crowley MJP, Cerliani JP, Kossenkov AV, Motorykin I, Zhang S, Manfredi G, Zamarin D, Holcomb K, Rodriguez PC, Rabinovich GA, Conejo-Garcia JR, Glimcher LH, Cubillos-Ruiz JR.

Nature. 2018 Oct;562(7727):423-428. doi: 10.1038/s41586-018-0597-x. Epub 2018 Oct 10.


Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses.

Fouda AY, Xu Z, Shosha E, Lemtalsi T, Chen J, Toque HA, Tritz R, Cui X, Stansfield BK, Huo Y, Rodriguez PC, Smith SB, Caldwell RW, Narayanan SP, Caldwell RB.

Cell Death Dis. 2018 Sep 25;9(10):1001. doi: 10.1038/s41419-018-1051-6.


Notch Signaling in Myeloid Cells as a Regulator of Tumor Immune Responses.

Hossain F, Majumder S, Ucar DA, Rodriguez PC, Golde TE, Minter LM, Osborne BA, Miele L.

Front Immunol. 2018 Jun 4;9:1288. doi: 10.3389/fimmu.2018.01288. eCollection 2018. Review.


The cellular metabolic landscape in the tumor milieu regulates the activity of myeloid infiltrates.

Mohamed E, Al-Khami AA, Rodriguez PC.

Cell Mol Immunol. 2018 May;15(5):421-427. doi: 10.1038/s41423-018-0001-7. Epub 2018 Mar 22. Review.


Arginase: A Multifaceted Enzyme Important in Health and Disease.

Caldwell RW, Rodriguez PC, Toque HA, Narayanan SP, Caldwell RB.

Physiol Rev. 2018 Apr 1;98(2):641-665. doi: 10.1152/physrev.00037.2016. Review.


Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c+CD103+ Monocytic Antigen-Presenting Cells in Tumors.

Sharma MD, Rodriguez PC, Koehn BH, Baban B, Cui Y, Guo G, Shimoda M, Pacholczyk R, Shi H, Lee EJ, Xu H, Johnson TS, He Y, Mergoub T, Venable C, Bronte V, Wolchok JD, Blazar BR, Munn DH.

Immunity. 2018 Jan 16;48(1):91-106.e6. doi: 10.1016/j.immuni.2017.12.014.


Exogenous lipid uptake induces metabolic and functional reprogramming of tumor-associated myeloid-derived suppressor cells.

Al-Khami AA, Zheng L, Del Valle L, Hossain F, Wyczechowska D, Zabaleta J, Sanchez MD, Dean MJ, Rodriguez PC, Ochoa AC.

Oncoimmunology. 2017 Jun 30;6(10):e1344804. doi: 10.1080/2162402X.2017.1344804. eCollection 2017.


Canonical NFκB signaling in myeloid cells is required for the glioblastoma growth.

Achyut BR, Angara K, Jain M, Borin TF, Rashid MH, Iskander ASM, Ara R, Kolhe R, Howard S, Venugopal N, Rodriguez PC, Bradford JW, Arbab AS.

Sci Rep. 2017 Oct 23;7(1):13754. doi: 10.1038/s41598-017-14079-4.


The anti-CD6 antibody itolizumab provides clinical benefit without lymphopenia in rheumatoid arthritis patients: results from a 6-month, open-label Phase I clinical trial.

Rodríguez PC, Prada DM, Moreno E, Aira LE, Molinero C, López AM, Gómez JA, Hernández IM, Martínez JP, Reyes Y, Milera JM, Hernández MV, Torres R, Avila Y, Barrese Y, Viada C, Montero E, Hernández P.

Clin Exp Immunol. 2018 Feb;191(2):229-239. doi: 10.1111/cei.13061. Epub 2017 Nov 16.


ABC294640, A Novel Sphingosine Kinase 2 Inhibitor, Induces Oncogenic Virus-Infected Cell Autophagic Death and Represses Tumor Growth.

Dai L, Bai A, Smith CD, Rodriguez PC, Yu F, Qin Z.

Mol Cancer Ther. 2017 Dec;16(12):2724-2734. doi: 10.1158/1535-7163.MCT-17-0485. Epub 2017 Sep 22.


Anti-Jagged Immunotherapy Inhibits MDSCs and Overcomes Tumor-Induced Tolerance.

Sierra RA, Trillo-Tinoco J, Mohamed E, Yu L, Achyut BR, Arbab A, Bradford JW, Osborne BA, Miele L, Rodriguez PC.

Cancer Res. 2017 Oct 15;77(20):5628-5638. doi: 10.1158/0008-5472.CAN-17-0357. Epub 2017 Sep 13.


Severe neurological abnormalities in a young boy with impaired thyroid hormone sensitivity due to a novel mutation in the MCT8 gene.

Rego T, Lado CG, Rodríguez PC, Santos FS, Angueira FB, Castro-Feijóo L, Conde JB, Castro-Gago M.

Hormones (Athens). 2017 Apr;16(2):194-199. doi: 10.14310/horm.2002.1733.


Enhanced Therapeutic Efficacy and Memory of Tumor-Specific CD8 T Cells by Ex Vivo PI3K-δ Inhibition.

Abu Eid R, Ahmad S, Lin Y, Webb M, Berrong Z, Shrimali R, Kumai T, Ananth S, Rodriguez PC, Celis E, Janik J, Mkrtichyan M, Khleif SN.

Cancer Res. 2017 Aug 1;77(15):4135-4145. doi: 10.1158/0008-5472.CAN-16-1925. Epub 2017 Jun 14.


Endoplasmic reticulum stress regulates tumor growth and anti-tumor immunity: a promising opportunity for cancer immunotherapy.

Mohamed E, Cao Y, Rodriguez PC.

Cancer Immunol Immunother. 2017 Aug;66(8):1069-1078. doi: 10.1007/s00262-017-2019-6. Epub 2017 Jun 2. Review.


Energy metabolic pathways control the fate and function of myeloid immune cells.

Al-Khami AA, Rodriguez PC, Ochoa AC.

J Leukoc Biol. 2017 Aug;102(2):369-380. doi: 10.1189/jlb.1VMR1216-535R. Epub 2017 May 17. Review.


Sildenafil Suppresses Inflammation-Driven Colorectal Cancer in Mice.

Islam BN, Sharman SK, Hou Y, Bridges AE, Singh N, Kim S, Kolhe R, Trillo-Tinoco J, Rodriguez PC, Berger FG, Sridhar S, Browning DD.

Cancer Prev Res (Phila). 2017 Jul;10(7):377-388. doi: 10.1158/1940-6207.CAPR-17-0015. Epub 2017 May 3.


Fuelling the mechanisms of asthma: Increased fatty acid oxidation in inflammatory immune cells may represent a novel therapeutic target.

Al-Khami AA, Ghonim MA, Del Valle L, Ibba SV, Zheng L, Pyakurel K, Okpechi SC, Garay J, Wyczechowska D, Sanchez-Pino MD, Rodriguez PC, Boulares AH, Ochoa AC.

Clin Exp Allergy. 2017 Sep;47(9):1170-1184. doi: 10.1111/cea.12947. Epub 2017 Jul 5.


An aggregation-removal model for the formation and size determination of post-synaptic scaffold domains.

Ranft J, Almeida LG, Rodriguez PC, Triller A, Hakim V.

PLoS Comput Biol. 2017 Apr 24;13(4):e1005516. doi: 10.1371/journal.pcbi.1005516. eCollection 2017 Apr.


Participation of phosphofructokinase, malate dehydrogenase and isocitrate dehydrogenase in capacitation and acrosome reaction of boar spermatozoa.

Breininger E, Dubois D, Pereyra VE, Rodriguez PC, Satorre MM, Cetica PD.

Reprod Domest Anim. 2017 Oct;52(5):731-740. doi: 10.1111/rda.12973. Epub 2017 Apr 10.


Arginine Metabolism in Myeloid Cells Shapes Innate and Adaptive Immunity.

Rodriguez PC, Ochoa AC, Al-Khami AA.

Front Immunol. 2017 Feb 7;8:93. doi: 10.3389/fimmu.2017.00093. eCollection 2017. Review.


Differential PI3Kδ Signaling in CD4+ T-cell Subsets Enables Selective Targeting of T Regulatory Cells to Enhance Cancer Immunotherapy.

Ahmad S, Abu-Eid R, Shrimali R, Webb M, Verma V, Doroodchi A, Berrong Z, Samara R, Rodriguez PC, Mkrtichyan M, Khleif SN.

Cancer Res. 2017 Apr 15;77(8):1892-1904. doi: 10.1158/0008-5472.CAN-16-1839. Epub 2017 Jan 20.


Unfolding anti-tumor immunity: ER stress responses sculpt tolerogenic myeloid cells in cancer.

Cubillos-Ruiz JR, Mohamed E, Rodriguez PC.

J Immunother Cancer. 2017 Jan 17;5:5. doi: 10.1186/s40425-016-0203-4. eCollection 2017. Review.


Metabolic reprogramming of myeloid-derived suppressor cells (MDSC) in cancer.

Al-Khami AA, Rodriguez PC, Ochoa AC.

Oncoimmunology. 2016 Jun 27;5(8):e1200771. doi: 10.1080/2162402X.2016.1200771. eCollection 2016 Aug.


Editorial: A matter of survival: HMGB1 regulates autophagy in tumor MDSC.

Kumai T, Celis E, Rodriguez PC.

J Leukoc Biol. 2016 Sep;100(3):447-9. doi: 10.1189/jlb.3CE0216-091R. No abstract available.


Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards.

Bronte V, Brandau S, Chen SH, Colombo MP, Frey AB, Greten TF, Mandruzzato S, Murray PJ, Ochoa A, Ostrand-Rosenberg S, Rodriguez PC, Sica A, Umansky V, Vonderheide RH, Gabrilovich DI.

Nat Commun. 2016 Jul 6;7:12150. doi: 10.1038/ncomms12150. Review.


T cells conditioned with MDSC show an increased anti-tumor activity after adoptive T cell based immunotherapy.

Raber PL, Sierra RA, Thevenot PT, Shuzhong Z, Wyczechowska DD, Kumai T, Celis E, Rodriguez PC.

Oncotarget. 2016 Apr 5;7(14):17565-78. doi: 10.18632/oncotarget.8197.


A Phase III Clinical Trial of the Epidermal Growth Factor Vaccine CIMAvax-EGF as Switch Maintenance Therapy in Advanced Non-Small Cell Lung Cancer Patients.

Rodriguez PC, Popa X, Martínez O, Mendoza S, Santiesteban E, Crespo T, Amador RM, Fleytas R, Acosta SC, Otero Y, Romero GN, de la Torre A, Cala M, Arzuaga L, Vello L, Reyes D, Futiel N, Sabates T, Catala M, Flores YI, Garcia B, Viada C, Lorenzo-Luaces P, Marrero MA, Alonso L, Parra J, Aguilera N, Pomares Y, Sierra P, Rodríguez G, Mazorra Z, Lage A, Crombet T, Neninger E.

Clin Cancer Res. 2016 Aug 1;22(15):3782-90. doi: 10.1158/1078-0432.CCR-15-0855. Epub 2016 Feb 29.


Fluorescent false neurotransmitter reveals functionally silent dopamine vesicle clusters in the striatum.

Pereira DB, Schmitz Y, Mészáros J, Merchant P, Hu G, Li S, Henke A, Lizardi-Ortiz JE, Karpowicz RJ Jr, Morgenstern TJ, Sonders MS, Kanter E, Rodriguez PC, Mosharov EV, Sames D, Sulzer D.

Nat Neurosci. 2016 Apr;19(4):578-86. doi: 10.1038/nn.4252. Epub 2016 Feb 22.


Therapeutic Targeting of CD6 in Autoimmune Diseases: A Review of Cuban Clinical Studies with the Antibodies IOR-T1 and Itolizumab.

Hernández P, Moreno E, Aira LE, Rodríguez PC.

Curr Drug Targets. 2016;17(6):666-77. Review.


CIMAvax EGF (EGF-P64K) vaccine for the treatment of non-small-cell lung cancer.

Crombet Ramos T, Rodríguez PC, Neninger Vinageras E, Garcia Verdecia B, Lage Davila A.

Expert Rev Vaccines. 2015;14(10):1303-11. doi: 10.1586/14760584.2015.1079488. Epub 2015 Aug 20. Review.


Inhibition of Fatty Acid Oxidation Modulates Immunosuppressive Functions of Myeloid-Derived Suppressor Cells and Enhances Cancer Therapies.

Hossain F, Al-Khami AA, Wyczechowska D, Hernandez C, Zheng L, Reiss K, Valle LD, Trillo-Tinoco J, Maj T, Zou W, Rodriguez PC, Ochoa AC.

Cancer Immunol Res. 2015 Nov;3(11):1236-47. doi: 10.1158/2326-6066.CIR-15-0036. Epub 2015 May 29.


DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4⁺ T-cell function without causing severe combined immunodeficiency.

Ghonim MA, Pyakurel K, Ju J, Rodriguez PC, Lammi MR, Davis C, Abughazleh MQ, Mansy MS, Naura AS, Boulares AH.

J Allergy Clin Immunol. 2015 Feb;135(2):425-40. doi: 10.1016/j.jaci.2014.09.005. Epub 2014 Oct 19.


l-Arginine depletion blunts antitumor T-cell responses by inducing myeloid-derived suppressor cells.

Fletcher M, Ramirez ME, Sierra RA, Raber P, Thevenot P, Al-Khami AA, Sanchez-Pino D, Hernandez C, Wyczechowska DD, Ochoa AC, Rodriguez PC.

Cancer Res. 2015 Jan 15;75(2):275-83. doi: 10.1158/0008-5472.CAN-14-1491. Epub 2014 Nov 18.


Evaluating The Effect Of Immunotherapy In Advanced Non-Small- Cell Lung Cancer Patients Using Two Components Mixture Model.

Sánchez L, Muchene L, Luaces P, Viada C, Rodríguez PC, Frias A, Shkedy Z, Lage A.

Value Health. 2014 Nov;17(7):A566. doi: 10.1016/j.jval.2014.08.1884. Epub 2014 Oct 26. No abstract available.


The statistical analysis of delayed effects in survival outcomes for immunotherapies. Estimation of time-delay and application of weighted log rank.

Luaces P, Sánchez L, Viada C, Frias A, Alvarez M, Rodríguez PC.

Value Health. 2014 Nov;17(7):A547. doi: 10.1016/j.jval.2014.08.1774. Epub 2014 Oct 26. No abstract available.


The stress-response sensor chop regulates the function and accumulation of myeloid-derived suppressor cells in tumors.

Thevenot PT, Sierra RA, Raber PL, Al-Khami AA, Trillo-Tinoco J, Zarreii P, Ochoa AC, Cui Y, Del Valle L, Rodriguez PC.

Immunity. 2014 Sep 18;41(3):389-401. doi: 10.1016/j.immuni.2014.08.015.


Macrophage arginase-1 controls bacterial growth and pathology in hypoxic tuberculosis granulomas.

Duque-Correa MA, Kühl AA, Rodriguez PC, Zedler U, Schommer-Leitner S, Rao M, Weiner J 3rd, Hurwitz R, Qualls JE, Kosmiadi GA, Murray PJ, Kaufmann SH, Reece ST.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):E4024-32. doi: 10.1073/pnas.1408839111. Epub 2014 Sep 8.


Arginase I levels are decreased in the plasma of pediatric patients with atopic dermatitis.

Dimitriades V, Rodriguez PC, Zabaleta J, Ochoa AC.

Ann Allergy Asthma Immunol. 2014 Sep;113(3):271-5. doi: 10.1016/j.anai.2014.06.010. Epub 2014 Jul 11.


Expression of arginase I in myeloid cells limits control of residual disease after radiation therapy of tumors in mice.

Crittenden MR, Savage T, Cottam B, Baird J, Rodriguez PC, Newell P, Young K, Jackson AM, Gough MJ.

Radiat Res. 2014 Aug;182(2):182-90. doi: 10.1667/RR13493.1. Epub 2014 Jul 3.


Rescue of notch-1 signaling in antigen-specific CD8+ T cells overcomes tumor-induced T-cell suppression and enhances immunotherapy in cancer.

Sierra RA, Thevenot P, Raber PL, Cui Y, Parsons C, Ochoa AC, Trillo-Tinoco J, Del Valle L, Rodriguez PC.

Cancer Immunol Res. 2014 Aug;2(8):800-11. doi: 10.1158/2326-6066.CIR-14-0021. Epub 2014 May 15.

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