Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 95


The Structure and the Regulation of Glycogen Phosphorylases in Brain.

Mathieu C, Dupret JM, Rodrigues-Lima F.

Adv Neurobiol. 2019;23:125-145. doi: 10.1007/978-3-030-27480-1_4.


Benzoquinone, a leukemogenic metabolite of benzene, catalytically inhibits the protein tyrosine phosphatase PTPN2 and alters STAT1 signaling.

Duval R, Bui LC, Mathieu C, Nian Q, Berthelet J, Xu X, Haddad I, Vinh J, Dupret JM, Busi F, Guidez F, Chomienne C, Rodrigues-Lima F.

J Biol Chem. 2019 Aug 16;294(33):12483-12494. doi: 10.1074/jbc.RA119.008666. Epub 2019 Jun 27.


T-Cell Protein Tyrosine Phosphatase Is Irreversibly Inhibited by Etoposide-Quinone, a Reactive Metabolite of the Chemotherapy Drug Etoposide.

Nian Q, Berthelet J, Zhang W, Bui LC, Liu R, Xu X, Duval R, Ganesan S, Leger T, Chomienne C, Busi F, Guidez F, Dupret JM, Rodrigues Lima F.

Mol Pharmacol. 2019 Aug;96(2):297-306. doi: 10.1124/mol.119.116319. Epub 2019 Jun 20.


A readout of metabolic efficiency in arylamine N-acetyltransferase-deficient mice reveals minor energy metabolism changes.

Denis RGP, Busi F, Castel J, Morel C, Zhang W, Bui LC, Sugamori KS, Prokopec SD, Boutros PC, Grant DM, Rodrigues-Lima F, Luquet S, Dupret JM.

FEBS Lett. 2019 Apr;593(8):831-841. doi: 10.1002/1873-3468.13357. Epub 2019 Mar 22.


HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis.

Sevin M, Kubovcakova L, Pernet N, Causse S, Vitte F, Villeval JL, Lacout C, Cordonnier M, Rodrigues-Lima F, Chanteloup G, Mosca M, Chrétien ML, Bastie JN, Audia S, Sagot P, Ramla S, Martin L, Gleave M, Mezger V, Skoda R, Plo I, Garrido C, Girodon F, de Thonel A.

Nat Commun. 2018 Apr 12;9(1):1431. doi: 10.1038/s41467-018-03627-9.


DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives.

Neumann F, Gourdain S, Albac C, Dekker AD, Bui LC, Dairou J, Schmitz-Afonso I, Hue N, Rodrigues-Lima F, Delabar JM, Potier MC, Le Caër JP, Touboul D, Delatour B, Cariou K, Dodd RH.

Sci Rep. 2018 Feb 12;8(1):2859. doi: 10.1038/s41598-018-20984-z.


Human Arylamine N-Acetyltransferase 1 Is Inhibited by the Dithiocarbamate Pesticide Thiram.

Xu X, Mathieu C, Berthelet J, Duval R, Bui LC, Busi F, Dupret JM, Rodrigues-Lima F.

Mol Pharmacol. 2017 Sep;92(3):358-365. doi: 10.1124/mol.117.108662. Epub 2017 Jul 3.


Crebbp loss cooperates with Bcl2 overexpression to promote lymphoma in mice.

García-Ramírez I, Tadros S, González-Herrero I, Martín-Lorenzo A, Rodríguez-Hernández G, Moore D, Ruiz-Roca L, Blanco O, Alonso-López D, Rivas JL, Hartert K, Duval R, Klinkebiel D, Bast M, Vose J, Lunning M, Fu K, Greiner T, Rodrigues-Lima F, Jiménez R, Criado FJG, Cenador MBG, Brindle P, Vicente-Dueñas C, Alizadeh A, Sánchez-García I, Green MR.

Blood. 2017 May 11;129(19):2645-2656. doi: 10.1182/blood-2016-08-733469. Epub 2017 Mar 13.


Molecular Mechanisms of Allosteric Inhibition of Brain Glycogen Phosphorylase by Neurotoxic Dithiocarbamate Chemicals.

Mathieu C, Bui LC, Petit E, Haddad I, Agbulut O, Vinh J, Dupret JM, Rodrigues-Lima F.

J Biol Chem. 2017 Feb 3;292(5):1603-1612. doi: 10.1074/jbc.M116.766725. Epub 2016 Dec 13.


Xenobiotic-metabolizing enzymes in Bacillus anthracis: molecular and functional analysis of a truncated arylamine N-acetyltransferase isozyme.

Kubiak X, Duval R, Pluvinage B, Chaffotte AF, Dupret JM, Rodrigues-Lima F.

Br J Pharmacol. 2017 Jul;174(14):2174-2182. doi: 10.1111/bph.13647. Epub 2016 Nov 12.


The structure of brain glycogen phosphorylase-from allosteric regulation mechanisms to clinical perspectives.

Mathieu C, Dupret JM, Rodrigues Lima F.

FEBS J. 2017 Feb;284(4):546-554. doi: 10.1111/febs.13937. Epub 2016 Nov 12. Review.


An Isozyme-specific Redox Switch in Human Brain Glycogen Phosphorylase Modulates Its Allosteric Activation by AMP.

Mathieu C, Duval R, Cocaign A, Petit E, Bui LC, Haddad I, Vinh J, Etchebest C, Dupret JM, Rodrigues-Lima F.

J Biol Chem. 2016 Nov 11;291(46):23842-23853. doi: 10.1074/jbc.M116.757062. Epub 2016 Sep 22.



Mathieu C, Li de la Sierra-Gallay I, Duval R, Xu X, Cocaign A, Léger T, Woffendin G, Camadro JM, Etchebest C, Haouz A, Dupret JM, Rodrigues-Lima F.

J Biol Chem. 2016 Aug 26;291(35):18072-83. doi: 10.1074/jbc.M116.738898. Epub 2016 Jul 8.


Identification of cancer chemopreventive isothiocyanates as direct inhibitors of the arylamine N-acetyltransferase-dependent acetylation and bioactivation of aromatic amine carcinogens.

Duval R, Xu X, Bui LC, Mathieu C, Petit E, Cariou K, Dodd RH, Dupret JM, Rodrigues-Lima F.

Oncotarget. 2016 Feb 23;7(8):8688-99. doi: 10.18632/oncotarget.7086.


An acetyltransferase assay for CREB-binding protein based on reverse phase-ultra-fast liquid chromatography of fluorescent histone H3 peptides.

Duval R, Fritsch L, Bui LC, Berthelet J, Guidez F, Mathieu C, Dupret JM, Chomienne C, Ait-Si-Ali S, Rodrigues-Lima F.

Anal Biochem. 2015 Oct 1;486:35-7. doi: 10.1016/j.ab.2015.06.024. Epub 2015 Jun 20.


Screen for soil fungi highly resistant to dichloroaniline uncovers mostly Fusarium species.

Chan Ho Tong L, Dairou J, Bui LC, Bouillon J, Rodrigues-Lima F, Dupret JM, Silar P.

Fungal Genet Biol. 2015 Aug;81:82-7. doi: 10.1016/j.fgb.2015.05.011. Epub 2015 Jun 8.


A RP-UFLC Assay for Protein Tyrosine Phosphatases: Focus on Protein Tyrosine Phosphatase Non-Receptor Type 2 (PTPN2).

Duval R, Bui LC, Berthelet J, Dairou J, Mathieu C, Guidez F, Dupret JM, Cools J, Chomienne C, Rodrigues-Lima F.

Sci Rep. 2015 Jun 4;5:10750. doi: 10.1038/srep10750.


Insight into cofactor recognition in arylamine N-acetyltransferase enzymes: structure of Mesorhizobium loti arylamine N-acetyltransferase in complex with coenzyme A.

Xu X, Li de la Sierra-Gallay I, Kubiak X, Duval R, Chaffotte AF, Dupret JM, Haouz A, Rodrigues-Lima F.

Acta Crystallogr D Biol Crystallogr. 2015 Feb;71(Pt 2):266-73. doi: 10.1107/S139900471402522X. Epub 2015 Jan 23.


Effects of pesticide chemicals on the activity of metabolic enzymes: focus on thiocarbamates.

Mathieu C, Duval R, Xu X, Rodrigues-Lima F, Dupret JM.

Expert Opin Drug Metab Toxicol. 2015 Jan;11(1):81-94. doi: 10.1517/17425255.2015.975691. Epub 2014 Nov 13. Review.


Structural and functional characterization of an arylamine N-acetyltransferase from the pathogen Mycobacterium abscessus: differences from other mycobacterial isoforms and implications for selective inhibition.

Cocaign A, Kubiak X, Xu X, Garnier G, Li de la Sierra-Gallay I, Chi-Bui L, Dairou J, Busi F, Abuhammad A, Haouz A, Dupret JM, Herrmann JL, Rodrigues-Lima F.

Acta Crystallogr D Biol Crystallogr. 2014 Nov;70(Pt 11):3066-79. doi: 10.1107/S1399004714021282. Epub 2014 Oct 29.


Activation of the aryl hydrocarbon receptor by carcinogenic aromatic amines and modulatory effects of their N-acetylated metabolites.

Juricek L, Bui LC, Busi F, Pierre S, Guyot E, Lamouri A, Dupret JM, Barouki R, Coumoul X, Rodrigues-Lima F.

Arch Toxicol. 2015 Dec;89(12):2403-12. doi: 10.1007/s00204-014-1367-7. Epub 2014 Sep 17.


From arylamine N-acetyltransferase to folate-dependent acetyl CoA hydrolase: impact of folic acid on the activity of (HUMAN)NAT1 and its homologue (MOUSE)NAT2.

Laurieri N, Dairou J, Egleton JE, Stanley LA, Russell AJ, Dupret JM, Sim E, Rodrigues-Lima F.

PLoS One. 2014 May 13;9(5):e96370. doi: 10.1371/journal.pone.0096370. eCollection 2014.


Intracellular signal modulation by nanomaterials.

Hussain S, Garantziotis S, Rodrigues-Lima F, Dupret JM, Baeza-Squiban A, Boland S.

Adv Exp Med Biol. 2014;811:111-34. doi: 10.1007/978-94-017-8739-0_7. Review.


A high-performance liquid chromatography assay for Dyrk1a, a Down syndrome-associated kinase.

Bui LC, Tabouy L, Busi F, Dupret JM, Janel N, Planque C, Delabar JM, Rodrigues-Lima F, Dairou J.

Anal Biochem. 2014 Mar 15;449:172-8. doi: 10.1016/j.ab.2013.12.024. Epub 2013 Dec 25.


Arylamine N-acetyltransferases: a structural perspective. Comments regarding the BJP paper by Zhou et al., 2013.

Xu X, Kubiak X, Dupret JM, Rodrigues-Lima F.

Br J Pharmacol. 2014 Jan;171(1):279-80. doi: 10.1111/bph.12273. No abstract available.


Skeletal muscle glycogen phosphorylase is irreversibly inhibited by mercury: molecular, cellular and kinetic aspects.

Xu X, Mathieu C, Boitard SE, Dairou J, Dupret JM, Agbulut O, Rodrigues-Lima F.

FEBS Lett. 2014 Jan 3;588(1):138-42. doi: 10.1016/j.febslet.2013.11.021. Epub 2013 Nov 21.


Development of DANDYs, new 3,5-diaryl-7-azaindoles demonstrating potent DYRK1A kinase inhibitory activity.

Gourdain S, Dairou J, Denhez C, Bui LC, Rodrigues-Lima F, Janel N, Delabar JM, Cariou K, Dodd RH.

J Med Chem. 2013 Dec 12;56(23):9569-85. doi: 10.1021/jm401049v. Epub 2013 Nov 19.


A novel color change mechanism for breast cancer biomarker detection: naphthoquinones as specific ligands of human arylamine N-acetyltransferase 1.

Laurieri N, Egleton JE, Varney A, Thinnes CC, Quevedo CE, Seden PT, Thompson S, Rodrigues-Lima F, Dairou J, Dupret JM, Russell AJ, Sim E.

PLoS One. 2013 Aug 5;8(8):e70600. doi: 10.1371/journal.pone.0070600. Print 2013.


Structural and biochemical characterization of an active arylamine N-acetyltransferase possessing a non-canonical Cys-His-Glu catalytic triad.

Kubiak X, Li de la Sierra-Gallay I, Chaffotte AF, Pluvinage B, Weber P, Haouz A, Dupret JM, Rodrigues-Lima F.

J Biol Chem. 2013 Aug 2;288(31):22493-505. doi: 10.1074/jbc.M113.468595. Epub 2013 Jun 16.


Biotransformation of Trichoderma spp. and their tolerance to aromatic amines, a major class of pollutants.

Cocaign A, Bui LC, Silar P, Chan Ho Tong L, Busi F, Lamouri A, Mougin C, Rodrigues-Lima F, Dupret JM, Dairou J.

Appl Environ Microbiol. 2013 Aug;79(15):4719-26. doi: 10.1128/AEM.00989-13. Epub 2013 May 31.


Acrolein, an α,β-unsaturated aldehyde, irreversibly inhibits the acetylation of aromatic amine xenobiotics by human arylamine N-acetyltransferase 1.

Bui LC, Manaa A, Xu X, Duval R, Busi F, Dupret JM, Rodrigues-Lima F, Dairou J.

Drug Metab Dispos. 2013 Jul;41(7):1300-5. doi: 10.1124/dmd.113.052258. Epub 2013 Apr 30.


Comparative analysis of interactions of RASSF1-10.

Chan JJ, Flatters D, Rodrigues-Lima F, Yan J, Thalassinos K, Katan M.

Adv Biol Regul. 2013 May;53(2):190-201. doi: 10.1016/j.jbior.2012.12.001. Epub 2013 Jan 11.


Crystal structure of arylamine N-acetyltransferases: insights into the mechanisms of action and substrate selectivity.

Kubiak X, Dairou J, Dupret JM, Rodrigues-Lima F.

Expert Opin Drug Metab Toxicol. 2013 Mar;9(3):349-62. doi: 10.1517/17425255.2013.742505. Epub 2013 Jan 7. Review.


Characterization of an acetyltransferase that detoxifies aromatic chemicals in Legionella pneumophila.

Kubiak X, Dervins-Ravault D, Pluvinage B, Chaffotte AF, Gomez-Valero L, Dairou J, Busi F, Dupret JM, Buchrieser C, Rodrigues-Lima F.

Biochem J. 2012 Jul 15;445(2):219-28. doi: 10.1042/BJ20120528.


Purification, crystallization and preliminary X-ray characterization of Bacillus cereus arylamine N-acetyltransferase 3 [(BACCR)NAT3].

Kubiak X, Pluvinage B, Li de la Sierra-Gallay I, Weber P, Haouz A, Dupret JM, Rodrigues-Lima F.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Feb 1;68(Pt 2):196-8. doi: 10.1107/S1744309111053942. Epub 2012 Jan 26.


The Bacillus anthracis arylamine N-acetyltransferase ((BACAN)NAT1) that inactivates sulfamethoxazole, reveals unusual structural features compared with the other NAT isoenzymes.

Pluvinage B, Li de la Sierra-Gallay I, Kubiak X, Xu X, Dairou J, Dupret JM, Rodrigues-Lima F.

FEBS Lett. 2011 Dec 15;585(24):3947-52. doi: 10.1016/j.febslet.2011.10.041. Epub 2011 Nov 2.


Pharmacogenomics, biochemistry, toxicology, microbiology and cancer research in one go.

Rodrigues-Lima F, Dairou J, Laurieri N, Busi F, Dupret JM.

Pharmacogenomics. 2011 Aug;12(8):1091-3. doi: 10.2217/pgs.11.59.


Rearfoot alignment and medial longitudinal arch configurations of runners with symptoms and histories of plantar fasciitis.

Ribeiro AP, Trombini-Souza F, Tessutti V, Rodrigues Lima F, Sacco Ide C, João SM.

Clinics (Sao Paulo). 2011;66(6):1027-33.


Effect of red wine polyphenol dietary supplementation on two phase II enzymes in liver of hyperhomocysteinemic mice.

Noll C, Dairou J, Ripoll C, Paul JL, Dupret JM, Delabar JM, Rodrigues-Lima F, Janel N.

Food Chem Toxicol. 2011 Aug;49(8):1764-9. doi: 10.1016/j.fct.2011.04.024. Epub 2011 Apr 28.


Carbon black nanoparticles impair acetylation of aromatic amine carcinogens through inactivation of arylamine N-acetyltransferase enzymes.

Sanfins E, Dairou J, Hussain S, Busi F, Chaffotte AF, Rodrigues-Lima F, Dupret JM.

ACS Nano. 2011 Jun 28;5(6):4504-11. doi: 10.1021/nn103534d. Epub 2011 May 3.


Fungi as a promising tool for bioremediation of soils contaminated with aromatic amines, a major class of pollutants.

Silar P, Dairou J, Cocaign A, Busi F, Rodrigues-Lima F, Dupret JM.

Nat Rev Microbiol. 2011 Jun;9(6):477. doi: 10.1038/nrmicro2519-c1. Epub 2011 Apr 18. No abstract available.


Protection and reversal of hepatic fibrosis by red wine polyphenols in hyperhomocysteinemic mice.

Noll C, Raaf L, Planque C, Benard L, Secardin L, Petit E, Dairou J, Paul JL, Samuel JL, Delcayre C, Rodrigues-Lima F, Janel N.

J Nutr Biochem. 2011 Sep;22(9):856-64. doi: 10.1016/j.jnutbio.2010.07.010. Epub 2010 Dec 24.


Cadmium alters the biotransformation of carcinogenic aromatic amines by arylamine N-acetyltransferase xenobiotic-metabolizing enzymes: molecular, cellular, and in vivo studies.

Ragunathan N, Dairou J, Sanfins E, Busi F, Noll C, Janel N, Dupret JM, Rodrigues-Lima F.

Environ Health Perspect. 2010 Dec;118(12):1685-91. doi: 10.1289/ehp.1002334. Epub 2010 Sep 1.


Insights into the phylogeny or arylamine N-acetyltransferases in fungi.

Martins M, Dairou J, Rodrigues-Lima F, Dupret JM, Silar P.

J Mol Evol. 2010 Aug;71(2):141-52. doi: 10.1007/s00239-010-9371-x. Epub 2010 Jul 31.


The human xenobiotic-metabolizing enzyme arylamine N-acetyltransferase 1 (NAT1) is irreversibly inhibited by inorganic (Hg2+) and organic mercury (CH3Hg+): mechanism and kinetics.

Ragunathan N, Busi F, Pluvinage B, Sanfins E, Dupret JM, Rodrigues-Lima F, Dairou J.

FEBS Lett. 2010 Aug 4;584(15):3366-9. doi: 10.1016/j.febslet.2010.06.022. Epub 2010 Jun 18.


Nanoparticles: molecular targets and cell signalling.

Marano F, Hussain S, Rodrigues-Lima F, Baeza-Squiban A, Boland S.

Arch Toxicol. 2011 Jul;85(7):733-41. doi: 10.1007/s00204-010-0546-4. Epub 2010 May 26. Review.


Desmin myopathy with severe cardiomyopathy in a Uruguayan family due to a codon deletion in a new location within the desmin 1A rod domain.

Vernengo L, Chourbagi O, Panuncio A, Lilienbaum A, Batonnet-Pichon S, Bruston F, Rodrigues-Lima F, Mesa R, Pizzarossa C, Demay L, Richard P, Vicart P, Rodriguez MM.

Neuromuscul Disord. 2010 Mar;20(3):178-87. doi: 10.1016/j.nmd.2010.01.001. Epub 2010 Feb 4.


Human arylamine N-acetyltransferase 1: a drug-metabolizing enzyme and a drug target?

Rodrigues-Lima F, Dairou J, Busi F, Dupret JM.

Curr Drug Targets. 2010 Jun;11(6):759-66. Review.


Mechanisms and kinetics of human arylamine N-acetyltransferase 1 inhibition by disulfiram.

Malka F, Dairou J, Ragunathan N, Dupret JM, Rodrigues-Lima F.

FEBS J. 2009 Sep;276(17):4900-8. doi: 10.1111/j.1742-4658.2009.07189.x. Epub 2009 Jul 31.


Characterization of phospholipase C gamma enzymes with gain-of-function mutations.

Everett KL, Bunney TD, Yoon Y, Rodrigues-Lima F, Harris R, Driscoll PC, Abe K, Fuchs H, de Angelis MH, Yu P, Cho W, Katan M.

J Biol Chem. 2009 Aug 21;284(34):23083-93. doi: 10.1074/jbc.M109.019265. Epub 2009 Jun 16.

Supplemental Content

Loading ...
Support Center