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Items: 1 to 50 of 70

1.

Reappraisal of antibodies against Saccharomyces cerevisiae (ASCA) as persistent biomarkers in quiescent Crohn's disease.

Duarte-Silva M, Afonso PC, de Souza PR, Peghini BC, Rodrigues-Júnior V, de Barros Cardoso CR.

Autoimmunity. 2019 Feb;52(1):37-47. doi: 10.1080/08916934.2019.1588889. Epub 2019 Mar 19.

PMID:
30884988
2.

Streptococcus mutans detection in saliva and colostrum samples.

Silva CBD, Mendes MM, Rodrigues BR, Pereira TL, Rodrigues DBR, Rodrigues Junior V, Ferriani VPL, Geraldo-Martins VR, Nogueira RD.

Einstein (Sao Paulo). 2019 Jan 31;17(1):eAO4515. doi: 10.31744/einstein_journal/2019AO4515. English, Portuguese.

3.

A single administration of human adipose tissue-derived mesenchymal stromal cells (MSC) induces durable and sustained long-term regulation of inflammatory response in experimental colitis.

Alves VBF, de Sousa BC, Fonseca MTC, Ogata H, Caliári-Oliveira C, Yaochite JNU, Rodrigues Júnior V, Chica JEL, da Silva JS, Malmegrim KCR, Pernomian L, Cardoso CR.

Clin Exp Immunol. 2019 May;196(2):139-154. doi: 10.1111/cei.13262. Epub 2019 Feb 17.

PMID:
30663040
4.

Design of Novel Inhibitors of Human Thymidine Phosphorylase: Synthesis, Enzyme Inhibition, in Vitro Toxicity, and Impact on Human Glioblastoma Cancer.

de Moura Sperotto ND, Deves Roth C, Rodrigues-Junior VS, Ev Neves C, Reisdorfer Paula F, da Silva Dadda A, Bergo P, Freitas de Freitas T, Souza Macchi F, Moura S, Duarte de Souza AP, Campos MM, Valim Bizarro C, Santos DS, Basso LA, Machado P.

J Med Chem. 2019 Feb 14;62(3):1231-1245. doi: 10.1021/acs.jmedchem.8b01305. Epub 2019 Jan 17.

PMID:
30615449
5.

Salivary Gland Extract of Kissing Bug, Triatoma lecticularia, Reduces the Severity of Intestinal Inflammation through the Modulation of the Local IL-6/IL-10 Axis.

Sales-Campos H, da Silva Catarino J, Roza GA, Obata Trevisan R, Menezes Silva L, Reis Machado J, da Silva MV, Andrade-Silva LE, Rodrigues-Júnior V, Freire de Oliveira CJ.

Mediators Inflamm. 2018 Jul 22;2018:1924393. doi: 10.1155/2018/1924393. eCollection 2018.

6.

Pre-clinical evaluation of quinoxaline-derived chalcones in tuberculosis.

Muradás TC, Abbadi BL, Villela AD, Macchi FS, Bergo PF, de Freitas TF, Sperotto NDM, Timmers LFSM, Norberto de Souza O, Picada JN, Fachini J, da Silva JB, de Albuquerque NCP, Habenschus MD, Carrão DB, Rocha BA, Barbosa Junior F, de Oliveira ARM, Mascarello A, Neuenfeldf P, Nunes RJ, Morbidoni HR, Campos MM, Basso LA, Rodrigues-Junior VS.

PLoS One. 2018 Aug 16;13(8):e0202568. doi: 10.1371/journal.pone.0202568. eCollection 2018.

7.

Levels of Pro and Anti-inflammatory Citokynes and C-Reactive Protein in Patients with Chronic Periodontitis Submitted to Nonsurgical Periodontal Treatment

Escobar GF, Abdalla DR, Beghini M, Gotti VB, Rodrigues Junior V, Napimoga MH, Ribeiro BM, Rodrigues DBR, Nogueira RD, Pereira SAL.

Asian Pac J Cancer Prev. 2018 Jul 27;19(7):1927-1933.

8.

1H-Benzo[d]imidazoles and 3,4-dihydroquinazolin-4-ones: Design, synthesis and antitubercular activity.

Macchi FS, Pissinate K, Villela AD, Abbadi BL, Rodrigues-Junior V, Nabinger DD, Altenhofen S, Sperotto N, da Silva Dadda A, Subtil FT, de Freitas TF, Erhart Rauber AP, Borsoi AF, Bonan CD, Bizarro CV, Basso LA, Santos DS, Machado P.

Eur J Med Chem. 2018 Jul 15;155:153-164. doi: 10.1016/j.ejmech.2018.06.005. Epub 2018 Jun 2.

PMID:
29885576
9.

Is IQG-607 a Potential Metallodrug or Metallopro-Drug With a Defined Molecular Target in Mycobacterium tuberculosis?

Abbadi BL, Rodrigues-Junior VDS, Dadda ADS, Pissinate K, Villela AD, Campos MM, Lopes LGF, Bizarro CV, Machado P, Sousa EHS, Basso LA.

Front Microbiol. 2018 May 1;9:880. doi: 10.3389/fmicb.2018.00880. eCollection 2018. Review.

10.

Assessing the role of deoD gene in Mycobacterium tuberculosis in vitro growth and macrophage infection.

Dalberto PF, Rodrigues-Junior V, Almeida Falcão VC, Pinto AFM, Abbadi BL, Bizarro CV, Basso LA, Villela AD, Santos DS.

Microb Pathog. 2018 Jun;119:60-64. doi: 10.1016/j.micpath.2018.03.056. Epub 2018 Mar 30.

11.

Effect of the bradykinin 1 receptor antagonist SSR240612 after oral administration in Mycobacterium tuberculosis-infected mice.

Rodrigues-Junior VS, Pail PB, Villela AD, Falcão VCA, Dadda AS, Abbadi BL, Pesquero JB, Santos DS, Basso LA, Campos MM.

Tuberculosis (Edinb). 2018 Mar;109:1-7. doi: 10.1016/j.tube.2018.01.003. Epub 2018 Feb 2.

PMID:
29559112
12.

Parasitological and immunological evaluation of cattle experimentally infected with Trypanosoma vivax.

Bassi PB, de Araújo FF, Garcia GC, Vinícius da Silva M, Oliveira CJF, Bittar ER, de Souza Gomes M, Rodrigues do Amaral L, Costa E Silva MF, Nascentes GAN, Rodrigues Junior V, Martins-Filho OA, Araújo MSS, Bittar JFF.

Exp Parasitol. 2018 Feb;185:98-106. doi: 10.1016/j.exppara.2018.01.010. Epub 2018 Jan 6.

PMID:
29309784
13.

Inhibitory activity of pentacyano(isoniazid)ferrate(II), IQG-607, against promastigotes and amastigotes forms of Leishmania braziliensis.

Amorim CF, Galina L, Carvalho NB, Sperotto NDM, Pissinate K, Machado P, Campos MM, Basso LA, Rodrigues-Junior VS, Carvalho EM, Santos DS.

PLoS One. 2017 Dec 27;12(12):e0190294. doi: 10.1371/journal.pone.0190294. eCollection 2017.

14.

Revisiting Activation of and Mechanism of Resistance to Compound IQG-607 in Mycobacterium tuberculosis.

Abbadi BL, Villela AD, Rodrigues-Junior VS, Subtil FT, Dalberto PF, Pinheiro APS, Santos DS, Machado P, Basso LA, Bizarro CV.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e02222-17. doi: 10.1128/AAC.02222-17. Print 2018 Feb.

15.

Construction of Mycobacterium tuberculosis cdd knockout and evaluation of invasion and growth in macrophages.

Villela AD, Rodrigues-Junior VS, Pinto AFM, Falcão VCA, Sánchez-Quitian ZA, Eichler P, Bizarro CV, Basso LA, Santos DS.

Mem Inst Oswaldo Cruz. 2017 Nov;112(11):785-789. doi: 10.1590/0074-02760170105.

16.

Preclinical pharmacokinetic profiling of IQG-607, a potential oral metallodrug to treat tuberculosis.

Dadda ADS, Rodrigues-Junior VS, Carreño F, Petersen GO, Pinto AFM, Dalberto PF, Sperotto NDM, Pissinate K, Bizarro CV, Machado P, Campos MM, Costa TD, Santos DS, Basso LA.

Eur J Pharm Sci. 2018 Jan 1;111:393-398. doi: 10.1016/j.ejps.2017.10.020. Epub 2017 Oct 14.

PMID:
29037995
17.

Cytokine and Chemokines Alterations in the Endemic Form of Pemphigus Foliaceus (Fogo Selvagem).

Timóteo RP, Silva MV, da Silva DAA, Catarino JDS, Alves FHC, Rodrigues Júnior V, Roselino AM, Sales-Campos H, Oliveira CJF.

Front Immunol. 2017 Aug 14;8:978. doi: 10.3389/fimmu.2017.00978. eCollection 2017.

18.

Activity of 2-(quinolin-4-yloxy)acetamides in Mycobacterium tuberculosis clinical isolates and identification of their molecular target by whole-genome sequencing.

Subtil FT, Villela AD, Abbadi BL, Rodrigues-Junior VS, Bizarro CV, Timmers LFSM, de Souza ON, Pissinate K, Machado P, López-Gavín A, Tudó G, González-Martín J, Basso LA, Santos DS.

Int J Antimicrob Agents. 2018 Mar;51(3):378-384. doi: 10.1016/j.ijantimicag.2017.08.023. Epub 2017 Aug 23.

19.

Toxicological profile of IQG-607 after single and repeated oral administration in minipigs: An essential step towards phase I clinical trial.

Rodrigues-Junior VS, Cintra L, Machado P, Dadda A, Basso LA, Mafra ACCN, Campos AH, Campos MM, Santos DS.

Regul Toxicol Pharmacol. 2017 Nov;90:78-86. doi: 10.1016/j.yrtph.2017.08.015. Epub 2017 Aug 23.

PMID:
28838610
20.

Evaluation of the cytotoxic response mediated by perforin and granzyme B in patients with non-Hodgkin lymphoma.

Souza BMB, De Vito FB, Calado ML, Silva MV, Oliveira LR, Rodrigues-Júnior V, Moraes-Souza H.

Leuk Lymphoma. 2018 Jan;59(1):214-220. doi: 10.1080/10428194.2017.1341978. Epub 2017 Jul 6.

PMID:
28679297
21.

Cytokine patterns in a prospective cohort of HIV-infected patients with cryptococcal meningitis following initiation of antifungal and antiretroviral therapy.

Mora DJ, Ferreira-Paim K, Andrade-Silva LE, Bragine T, Rocha IH, Ribeiro BM, Machado GH, Rodrigues Junior V, Silva-Teixeira DN, Meyer W, Silva-Vergara ML.

PLoS One. 2017 May 9;12(5):e0176304. doi: 10.1371/journal.pone.0176304. eCollection 2017.

22.

Cytotoxic outcomes of orthodontic bands with and without silver solder in different cell lineages.

Jacoby LS, Rodrigues Junior VDS, Campos MM, Macedo de Menezes L.

Am J Orthod Dentofacial Orthop. 2017 May;151(5):957-963. doi: 10.1016/j.ajodo.2016.10.030.

PMID:
28457274
23.

Functional, thermodynamics, structural and biological studies of in silico-identified inhibitors of Mycobacterium tuberculosis enoyl-ACP(CoA) reductase enzyme.

Martinelli LKB, Rotta M, Villela AD, Rodrigues-Junior VS, Abbadi BL, Trindade RV, Petersen GO, Danesi GM, Nery LR, Pauli I, Campos MM, Bonan CD, de Souza ON, Basso LA, Santos DS.

Sci Rep. 2017 Apr 24;7:46696. doi: 10.1038/srep46696.

24.

Th1/Th17-Related Cytokines and Chemokines and Their Implications in the Pathogenesis of Pemphigus Vulgaris.

Timoteo RP, da Silva MV, Miguel CB, Silva DA, Catarino JD, Rodrigues Junior V, Sales-Campos H, Freire Oliveira CJ.

Mediators Inflamm. 2017;2017:7151285. doi: 10.1155/2017/7151285. Epub 2017 Feb 22.

25.

Validation of Mycobacterium tuberculosis dihydroneopterin aldolase as a molecular target for anti-tuberculosis drug development.

Falcão VC, Villela AD, Rodrigues-Junior VS, Pissinate K, Eichler P, Pinto AF, Basso LA, Santos DS, Bizarro CV.

Biochem Biophys Res Commun. 2017 Apr 15;485(4):814-819. doi: 10.1016/j.bbrc.2017.02.137. Epub 2017 Feb 28.

26.

Preclinical safety evaluation of IQG-607 in rats: Acute and repeated dose toxicity studies.

Rodrigues-Junior VS, Machado P, Calixto JB, Siqueira JM, Andrade EL, Bento AF, Campos MM, Basso LA, Santos DS.

Regul Toxicol Pharmacol. 2017 Jun;86:11-17. doi: 10.1016/j.yrtph.2017.02.016. Epub 2017 Feb 20.

PMID:
28232042
27.

Morinda citrifolia (Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis.

Coutinho de Sousa B, Reis Machado J, da Silva MV, da Costa TA, Lazo-Chica JE, Degasperi TD, Rodrigues Junior V, Sales-Campos H, Uber Bucek E, Freire Oliveira CJ.

Mediators Inflamm. 2017;2017:6567432. doi: 10.1155/2017/6567432. Epub 2017 Jan 17.

28.

Analysis of uracil phosphoribosyltransferase expression in Mycobacterium tuberculosis and evaluation of upp knockout strain in infected mice.

Villela AD, Pham H, Jones V, Grzegorzewicz AE, Rodrigues-Junior VD, Campos MM, Basso LA, Jackson M, Santos DS.

FEMS Microbiol Lett. 2017 Feb 1;364(4). doi: 10.1093/femsle/fnx023.

PMID:
28130366
29.

New insights into the SAR and drug combination synergy of 2-(quinolin-4-yloxy)acetamides against Mycobacterium tuberculosis.

Giacobbo BC, Pissinate K, Rodrigues-Junior V, Villela AD, Grams ES, Abbadi BL, Subtil FT, Sperotto N, Trindade RV, Back DF, Campos MM, Basso LA, Machado P, Santos DS.

Eur J Med Chem. 2017 Jan 27;126:491-501. doi: 10.1016/j.ejmech.2016.11.048. Epub 2016 Nov 23.

PMID:
27914363
30.

5-ALA-mediated photodynamic therapy reduces the parasite load in mice infected with Leishmania braziliensis.

Souza DM, Alves PM, Silva ML, Paulino TP, Coraspe HO, Mendonça MM, Ribeiro BM, da Silva MV, Rodrigues Júnior V, Rodrigues DB.

Parasite Immunol. 2017 Mar;39(3). doi: 10.1111/pim.12403.

31.

COMPARATIVE ANALYSIS OF IMMUNOLOGICAL PROFILES IN WOMEN UNDERGOING CONVENTIONAL AND SINGLE-PORT LAPAROSCOPIC CHOLECYSTECTOMY.

Borges MC, Takeuti TD, Terra GA, Ribeiro BM, Rodrigues-Júnior V, Crema E.

Arq Bras Cir Dig. 2016 Jul-Sep;29(3):164-169. doi: 10.1590/0102-6720201600030009. English, Portuguese.

32.

Mefloquine and its oxazolidine derivative compound are active against drug-resistant Mycobacterium tuberculosis strains and in a murine model of tuberculosis infection.

Rodrigues-Junior VS, Villela AD, Gonçalves RS, Abbadi BL, Trindade RV, López-Gavín A, Tudó G, González-Martín J, Basso LA, de Souza MV, Campos MM, Santos DS.

Int J Antimicrob Agents. 2016 Aug;48(2):203-7. doi: 10.1016/j.ijantimicag.2016.04.029. Epub 2016 Jun 7.

PMID:
27364701
33.

2-(Quinolin-4-yloxy)acetamides Are Active against Drug-Susceptible and Drug-Resistant Mycobacterium tuberculosis Strains.

Pissinate K, Villela AD, Rodrigues-Junior V, Giacobbo BC, Grams ES, Abbadi BL, Trindade RV, Roesler Nery L, Bonan CD, Back DF, Campos MM, Basso LA, Santos DS, Machado P.

ACS Med Chem Lett. 2016 Jan 11;7(3):235-9. doi: 10.1021/acsmedchemlett.5b00324. eCollection 2016 Mar 10.

34.

Effects of aspirin-triggered resolvin D1 on peripheral blood mononuclear cells from patients with Chagas' heart disease.

Ogata H, Teixeira MM, Sousa RC, Silva MV, Correia D, Rodrigues Junior V, Levy BD, Rogério Ade P.

Eur J Pharmacol. 2016 Apr 15;777:26-32. doi: 10.1016/j.ejphar.2016.02.058. Epub 2016 Feb 27.

PMID:
26927755
35.

IMMUNOLOGICAL EVALUATION OF PATIENTS WITH TYPE 2 DIABETES MELLITUS SUBMITTED TO METABOLIC SURGERY.

Borges Mde C, Terra GA, Takeuti TD, Ribeiro BM, Silva AA, Terra-Júnior JA, Rodrigues-Júnior V, Crema E.

Arq Bras Cir Dig. 2015 Nov-Dec;28(4):266-9. doi: 10.1590/S0102-6720201500040012. English, Portuguese. Erratum in: Arq Bras Cir Dig. 2017 Apr-Jun;30(2):164.

36.

Gene replacement and quantitative mass spectrometry approaches validate guanosine monophosphate synthetase as essential for Mycobacterium tuberculosis growth.

Villela AD, Eichler P, Pinto AFM, Rodrigues-Junior V, Yates Iii JR, Bizarro CV, Basso LA, Santos DS.

Biochem Biophys Rep. 2015 Oct 8;4:277-282. doi: 10.1016/j.bbrep.2015.10.005. eCollection 2015 Dec.

37.

Priming Mesenchymal Stem Cells with Endothelial Growth Medium Boosts Stem Cell Therapy for Systemic Arterial Hypertension.

de Oliveira LF, Almeida TR, Ribeiro Machado MP, Cuba MB, Alves AC, da Silva MV, Rodrigues Júnior V, Dias da Silva VJ.

Stem Cells Int. 2015;2015:685383. doi: 10.1155/2015/685383. Epub 2015 Aug 2.

38.

Assessment of angiogenesis modulators in pregnant women with pre-eclampsia: a case-control study.

Mundim GJ, Paschoini MC, Araujo Júnior E, Da Silva Costa F, Rodrigues Júnior V.

Arch Gynecol Obstet. 2016 Feb;293(2):369-75. doi: 10.1007/s00404-015-3823-x. Epub 2015 Jul 24.

PMID:
26205065
39.

Inflammation Biomarkers of Advanced Disease in Nongingival Tissues of Chronic Periodontitis Patients.

da Costa TA, Silva MJ, Alves PM, Chica JE, Barcelos EZ, Giani MA, Garlet GP, da Silva JS, Rodrigues Júnior V, Rodrigues DB, Cardoso CR.

Mediators Inflamm. 2015;2015:983782. doi: 10.1155/2015/983782. Epub 2015 May 7.

40.

Evaluation of the effectiveness of packed red blood cell irradiation by a linear accelerator.

Olivo RA, da Silva MV, Garcia FB, Soares S, Rodrigues Junior V, Moraes-Souza H.

Rev Bras Hematol Hemoter. 2015 May-Jun;37(3):153-9. doi: 10.1016/j.bjhh.2015.03.001. Epub 2015 Apr 23.

41.

Evaluation of inflammatory mediators in the deciduas of pregnant women with pre-eclampsia/eclampsia.

Peixoto AB, Araujo Júnior E, Ribeiro JU, Rodrigues DB, Castro EC, Caldas TM, Rodrigues Júnior V.

J Matern Fetal Neonatal Med. 2016;29(1):75-9. doi: 10.3109/14767058.2014.987117. Epub 2014 Dec 9.

PMID:
25388357
42.

Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation.

Nicoletti NF, Rodrigues-Junior V, Santos AA Jr, Leite CE, Dias AC, Batista EL Jr, Basso LA, Campos MM, Santos DS, Souto AA.

J Nat Prod. 2014 Oct 24;77(10):2190-5. doi: 10.1021/np5003143. Epub 2014 Oct 10.

PMID:
25302422
43.

IL-17-expressing CD4⁺ and CD8⁺ T lymphocytes in human toxoplasmosis.

Silva JL, Rezende-Oliveira K, da Silva MV, Gómez-Hernández C, Peghini BC, Silva NM, Mineo JR, Rodrigues Júnior V.

Mediators Inflamm. 2014;2014:573825. doi: 10.1155/2014/573825. Epub 2014 Aug 17.

44.

Real time PCR quantification of viable Mycobacterium tuberculosis from sputum samples treated with propidium monoazide.

de Assunção TM, Batista EL Jr, Deves C, Villela AD, Pagnussatti VE, de Oliveira Dias AC, Kritski A, Rodrigues-Junior V, Basso LA, Santos DS.

Tuberculosis (Edinb). 2014 Jul;94(4):421-7. doi: 10.1016/j.tube.2014.04.008. Epub 2014 May 9.

PMID:
24863654
45.

Polymorphic sites at the immunoregulatory CTLA-4 gene are associated with chronic chagas disease and its clinical manifestations.

Dias FC, Medina Tda S, Mendes-Junior CT, Dantas RO, Pissetti CW, Rodrigues Junior V, Dellalibera-Joviliano R, Marin-Neto JA, Gutierrez FR, Moreau P, Silva JS, Donadi EA.

PLoS One. 2013 Oct 24;8(10):e78367. doi: 10.1371/journal.pone.0078367. eCollection 2013.

46.

IQG-607 abrogates the synthesis of mycolic acids and displays intracellular activity against Mycobacterium tuberculosis in infected macrophages.

Rodrigues-Junior VS, dos Santos Junior AA, Villela AD, Belardinelli JM, Morbidoni HR, Basso LA, Campos MM, Santos DS.

Int J Antimicrob Agents. 2014 Jan;43(1):82-5. doi: 10.1016/j.ijantimicag.2013.08.021. Epub 2013 Oct 1.

PMID:
24139881
47.

Anti-leishmania infantum IgG antibody avidity in visceral leishmaniasis.

Tiburcio MG, Anversa L, Kanunfre KA, Ferreira AW, Rodrigues Júnior V, Silva Lde A.

Clin Vaccine Immunol. 2013 Nov;20(11):1697-702. doi: 10.1128/CVI.00367-13. Epub 2013 Sep 4.

48.

Evaluation of breathing exercise in hormonal and immunological responses in patients undergoing abdominal surgery.

Carneiro EM, Ramos Mde C, Terra GA, Rodrigues Júnior V, Matos D, Crema E.

Acta Cir Bras. 2013 May;28(5):385-90.

49.

Implication of purinergic P2X7 receptor in M. tuberculosis infection and host interaction mechanisms: a mouse model study.

Santos AA Jr, Rodrigues-Junior V, Zanin RF, Borges TJ, Bonorino C, Coutinho-Silva R, Takyia CM, Santos DS, Campos MM, Morrone FB.

Immunobiology. 2013 Aug;218(8):1104-12. doi: 10.1016/j.imbio.2013.03.003. Epub 2013 Mar 16.

PMID:
23583008
50.

Activity of IQG-607, a new orally active compound, in a murine model of Mycobacterium tuberculosis infection.

Rodrigues-Junior VS, Dos Santos Junior A, Dos Santos AJ, Schneider CZ, Calixto JB, Sousa EH, de França Lopes LG, Souto AA, Basso LA, Santos DS, Campos MM.

Int J Antimicrob Agents. 2012 Aug;40(2):182-5. doi: 10.1016/j.ijantimicag.2012.04.019. Epub 2012 Jun 27.

PMID:
22748570

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