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Items: 1 to 50 of 190

1.

Nicotinic acid transport into human liver involves organic anion transporter 2 (SLC22A7).

Mathialagan S, Bi YA, Costales C, Kalgutkar AS, Rodrigues AD, Varma MVS.

Biochem Pharmacol. 2020 Jan 28;174:113829. doi: 10.1016/j.bcp.2020.113829. [Epub ahead of print]

PMID:
32001236
2.

Profiling of Drug-Metabolizing Enzymes and Transporters in Human Tissue Biopsy Samples: A Review of the Literature.

Rodrigues AD, Rowland A.

J Pharmacol Exp Ther. 2020 Mar;372(3):308-319. doi: 10.1124/jpet.119.262972. Epub 2019 Dec 26.

PMID:
31879375
3.

Induction of Human Intestinal and Hepatic Organic Anion Transporting Polypeptides: Where Is the Evidence for Its Relevance in Drug-Drug Interactions?

Rodrigues AD, Lai Y, Shen H, Varma MVS, Rowland A, Oswald S.

Drug Metab Dispos. 2020 Mar;48(3):205-216. doi: 10.1124/dmd.119.089615. Epub 2019 Dec 26.

PMID:
31879282
4.

Original synthesis and spectroscopic study of thiophene triazine derivatives with enhanced luminescence properties.

Rodrigues AD, Marcotte N, Quignard F, Deabate S, Robitzer M, Lerner DA.

Spectrochim Acta A Mol Biomol Spectrosc. 2020 Feb 15;227:117708. doi: 10.1016/j.saa.2019.117708. Epub 2019 Oct 28.

PMID:
31703995
5.

Quantitative Proteomics and Mechanistic Modeling of Transporter-Mediated Disposition in Nonalcoholic Fatty Liver Disease.

Vildhede A, Kimoto E, Pelis RM, Rodrigues AD, Varma MVS.

Clin Pharmacol Ther. 2019 Oct 20. doi: 10.1002/cpt.1699. [Epub ahead of print]

PMID:
31630405
6.

Validation of a 3-h Sampling Interval to Assess Variability in Cytochrome P450 3A Phenotype and the Impact of Induction and Mechanism-Based Inhibition Using Midazolam as a Probe Substrate.

van Dyk M, Kapetas AJ, Hopkins AM, Rodrigues AD, Vourvahis M, Sorich MJ, Rowland A.

Front Pharmacol. 2019 Sep 27;10:1120. doi: 10.3389/fphar.2019.01120. eCollection 2019.

7.

Moving beyond Binary Predictions of Human Drug-Induced Liver Injury (DILI) toward Contrasting Relative Risk Potential.

Aleo MD, Shah F, Allen S, Barton HA, Costales C, Lazzaro S, Leung L, Nilson A, Obach RS, Rodrigues AD, Will Y.

Chem Res Toxicol. 2020 Jan 21;33(1):223-238. doi: 10.1021/acs.chemrestox.9b00262. Epub 2019 Oct 7.

PMID:
31532188
8.

Mobile DNA in Endocrinology: LINE-1 Retrotransposon Causing Partial Androgen Insensitivity Syndrome.

Batista RL, Yamaguchi K, Rodrigues ADS, Nishi MY, Goodier JL, Carvalho LR, Domenice S, Costa EMF, Kazazian HH, Mendonca BB.

J Clin Endocrinol Metab. 2019 Dec 1;104(12):6385-6390. doi: 10.1210/jc.2019-00144.

PMID:
31393562
9.

Renal Excretion of Dabigatran: The Potential Role of Multidrug and Toxin Extrusion (MATE) Proteins.

Shen H, Yao M, Sinz M, Marathe P, Rodrigues AD, Zhu M.

Mol Pharm. 2019 Sep 3;16(9):4065-4076. doi: 10.1021/acs.molpharmaceut.9b00472. Epub 2019 Aug 7.

PMID:
31335150
10.

Guidance for Rifampin and Midazolam Dosing Protocols To Study Intestinal and Hepatic Cytochrome P450 (CYP) 3A4 Induction and De-induction.

Kapetas AJ, Sorich MJ, Rodrigues AD, Rowland A.

AAPS J. 2019 Jun 19;21(5):78. doi: 10.1208/s12248-019-0341-y.

PMID:
31218462
11.

Quantitative Contribution of Six Major Transporters to the Hepatic Uptake of Drugs: "SLC-Phenotyping" Using Primary Human Hepatocytes.

Bi YA, Costales C, Mathialagan S, West M, Eatemadpour S, Lazzaro S, Tylaska L, Scialis R, Zhang H, Umland J, Kimoto E, Tess DA, Feng B, Tremaine LM, Varma MVS, Rodrigues AD.

J Pharmacol Exp Ther. 2019 Jul;370(1):72-83. doi: 10.1124/jpet.119.257600. Epub 2019 Apr 11. Erratum in: J Pharmacol Exp Ther. 2020 Mar;372(3):354.

PMID:
30975793
12.

Mechanistic Evaluation of the Complex Drug-Drug Interactions of Maraviroc: Contribution of Cytochrome P450 3A, P-Glycoprotein and Organic Anion Transporting Polypeptide 1B1.

Kimoto E, Vourvahis M, Scialis RJ, Eng H, Rodrigues AD, Varma MVS.

Drug Metab Dispos. 2019 May;47(5):493-503. doi: 10.1124/dmd.118.085241. Epub 2019 Mar 12.

PMID:
30862625
13.

Use of Physiologically Based Pharmacokinetic Modeling to Identify Physiological and Molecular Characteristics Driving Variability in Axitinib Exposure: A Fresh Approach to Precision Dosing in Oncology.

Sorich MJ, Mutlib F, van Dyk M, Hopkins AM, Polasek TM, Marshall JC, Rodrigues AD, Rowland A.

J Clin Pharmacol. 2019 Jun;59(6):872-879. doi: 10.1002/jcph.1377. Epub 2019 Jan 11.

PMID:
30633368
14.

First-principles calculations and Raman scattering evidence for local symmetry lowering in rhombohedral ilmenite: temperature- and pressure-dependent studies.

Rodrigues JE, Ferrer MM, Cunha TR, Costa RC, Sambrano JR, Rodrigues AD, Pizani PS.

J Phys Condens Matter. 2018 Dec 5;30(48):485401. doi: 10.1088/1361-648X/aae803. Epub 2018 Nov 7.

PMID:
30403190
15.

Plasma extracellular nanovesicle (exosome)-derived biomarkers for drug metabolism pathways: a novel approach to characterize variability in drug exposure.

Rowland A, Ruanglertboon W, van Dyk M, Wijayakumara D, Wood LS, Meech R, Mackenzie PI, Rodrigues AD, Marshall JC, Sorich MJ.

Br J Clin Pharmacol. 2019 Jan;85(1):216-226. doi: 10.1111/bcp.13793. Epub 2018 Nov 16.

16.

PBPK Modeling of Coproporphyrin I as an Endogenous Biomarker for Drug Interactions Involving Inhibition of Hepatic OATP1B1 and OATP1B3.

Yoshikado T, Toshimoto K, Maeda K, Kusuhara H, Kimoto E, Rodrigues AD, Chiba K, Sugiyama Y.

CPT Pharmacometrics Syst Pharmacol. 2018 Nov;7(11):739-747. doi: 10.1002/psp4.12348. Epub 2018 Sep 30.

17.

Human Pluripotent Stem Cell-Derived Kidney Model for Nephrotoxicity Studies.

Bajaj P, Rodrigues AD, Steppan CM, Engle SJ, Mathialagan S, Schroeter T.

Drug Metab Dispos. 2018 Nov;46(11):1703-1711. doi: 10.1124/dmd.118.082727. Epub 2018 Aug 31.

PMID:
30171163
18.

Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective.

Kenna JG, Taskar KS, Battista C, Bourdet DL, Brouwer KLR, Brouwer KR, Dai D, Funk C, Hafey MJ, Lai Y, Maher J, Pak YA, Pedersen JM, Polli JW, Rodrigues AD, Watkins PB, Yang K, Yucha RW; International Transporter Consortium.

Clin Pharmacol Ther. 2018 Nov;104(5):916-932. doi: 10.1002/cpt.1222. Review.

19.

Physiologically Relevant, Humanized Intestinal Systems to Study Metabolism and Transport of Small Molecule Therapeutics.

Sawant-Basak A, Rodrigues AD, Lech M, Doyonnas R, Kasaian M, Prasad B, Tsamandouras N.

Drug Metab Dispos. 2018 Nov;46(11):1581-1587. doi: 10.1124/dmd.118.082784. Epub 2018 Aug 20. Review.

PMID:
30126862
20.

Quantification of Hepatic Organic Anion Transport Proteins OAT2 and OAT7 in Human Liver Tissue and Primary Hepatocytes.

Vildhede A, Kimoto E, Rodrigues AD, Varma MVS.

Mol Pharm. 2018 Aug 6;15(8):3227-3235. doi: 10.1021/acs.molpharmaceut.8b00320. Epub 2018 Jun 25.

PMID:
29906129
21.

Simultaneous Assessment of Transporter-Mediated Drug-Drug Interactions Using a Probe Drug Cocktail in Cynomolgus Monkey.

Kosa RE, Lazzaro S, Bi YA, Tierney B, Gates D, Modi S, Costales C, Rodrigues AD, Tremaine LM, Varma MV.

Drug Metab Dispos. 2018 Aug;46(8):1179-1189. doi: 10.1124/dmd.118.081794. Epub 2018 Jun 7.

PMID:
29880631
22.

Species differences in bile acids II. Bile acid metabolism.

Thakare R, Alamoudi JA, Gautam N, Rodrigues AD, Alnouti Y.

J Appl Toxicol. 2018 Oct;38(10):1336-1352. doi: 10.1002/jat.3645. Epub 2018 May 29.

PMID:
29845631
23.

Species differences in bile acids I. Plasma and urine bile acid composition.

Thakare R, Alamoudi JA, Gautam N, Rodrigues AD, Alnouti Y.

J Appl Toxicol. 2018 Oct;38(10):1323-1335. doi: 10.1002/jat.3644. Epub 2018 May 21.

PMID:
29785833
24.

Endogenous probes for human liver organic anion-transporting polypeptides: the intersection of bioanalytical and ADME science.

Rodrigues AD.

Bioanalysis. 2018 May 1;10(9):615-618. doi: 10.4155/bio-2017-0201. Epub 2018 May 16. No abstract available.

PMID:
29768033
25.

LC-MS/MS assay for N1-methylnicotinamide in humans, an endogenous probe for renal transporters.

Luo L, Kay J, Zhang J, Holliman CL, Rodrigues AD, Dowty M, Banfield C, Ramanathan R.

Bioanalysis. 2018 May 1;10(9):673-689. doi: 10.4155/bio-2017-0272. Epub 2018 May 11.

PMID:
29749253
26.

A multiplex HRMS assay for quantifying selected human plasma bile acids as candidate OATP biomarkers.

Rago B, Tierney B, Rodrigues AD, L Holliman C, Ramanathan R.

Bioanalysis. 2018 May 1;10(9):645-657. doi: 10.4155/bio-2017-0274. Epub 2018 May 11.

PMID:
29749252
27.

A fully automated and validated human plasma LC-MS/MS assay for endogenous OATP biomarkers coproporphyrin-I and coproporphyrin-III.

King-Ahmad A, Clemens S, Ramanathan R, Zhang Y, Raha N, Zhang Y, Holliman C, Rodrigues AD, Li F.

Bioanalysis. 2018 May 1;10(9):691-701. doi: 10.4155/bio-2017-0270. Epub 2018 May 11.

PMID:
29747517
28.

Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro-In Vivo Scaling of Hepatic Uptake Clearance.

De Bruyn T, Ufuk A, Cantrill C, Kosa RE, Bi YA, Niosi M, Modi S, Rodrigues AD, Tremaine LM, Varma MVS, Galetin A, Houston JB.

Drug Metab Dispos. 2018 Jul;46(7):989-1000. doi: 10.1124/dmd.118.081315. Epub 2018 May 2.

PMID:
29720472
29.

Mus musculus bone fluoride concentration as a useful biomarker for risk assessment of skeletal fluorosis in volcanic areas.

Linhares D, Camarinho R, Garcia PV, Rodrigues ADS.

Chemosphere. 2018 Aug;205:540-544. doi: 10.1016/j.chemosphere.2018.04.144. Epub 2018 Apr 23.

PMID:
29709804
30.

In Vitro-In Vivo Extrapolation of OATP1B-Mediated Drug-Drug Interactions in Cynomolgus Monkey.

Ufuk A, Kosa RE, Gao H, Bi YA, Modi S, Gates D, Rodrigues AD, Tremaine LM, Varma MVS, Houston JB, Galetin A.

J Pharmacol Exp Ther. 2018 Jun;365(3):688-699. doi: 10.1124/jpet.118.247767. Epub 2018 Apr 11.

PMID:
29643253
31.

Comparison of Proteomic Quantification Approaches for Hepatic Drug Transporters: Multiplexed Global Quantitation Correlates with Targeted Proteomic Quantitation.

Vildhede A, Nguyen C, Erickson BK, Kunz RC, Jones R, Kimoto E, Bourbonais F, Rodrigues AD, Varma MVS.

Drug Metab Dispos. 2018 May;46(5):692-696. doi: 10.1124/dmd.117.079285. Epub 2018 Feb 8.

PMID:
29439128
32.

Role of Hepatic Organic Anion Transporter 2 in the Pharmacokinetics of R- and S-Warfarin: In Vitro Studies and Mechanistic Evaluation.

Bi YA, Lin J, Mathialagan S, Tylaska L, Callegari E, Rodrigues AD, Varma MVS.

Mol Pharm. 2018 Mar 5;15(3):1284-1295. doi: 10.1021/acs.molpharmaceut.7b01108. Epub 2018 Feb 20.

PMID:
29433307
33.

Impacts of estrus expression and intensity during a timed-AI protocol on variables associated with fertility and pregnancy success in Bos indicus-influenced beef cows.

Rodrigues AD, Cooke RF, Cipriano RS, Silva LGT, Cerri RLA, Cruppe LH, Meneghetti M, Pohler KG, Vasconcelos JLM.

J Anim Sci. 2018 Feb 15;96(1):236-249. doi: 10.1093/jas/skx043.

34.

Organic Anion Transporter 2 Mediates Hepatic Uptake of Tolbutamide, a CYP2C9 Probe Drug.

Bi YA, Mathialagan S, Tylaska L, Fu M, Keefer J, Vildhede A, Costales C, Rodrigues AD, Varma MVS.

J Pharmacol Exp Ther. 2018 Mar;364(3):390-398. doi: 10.1124/jpet.117.245951. Epub 2018 Jan 11.

PMID:
29326367
35.

A highly selective and sensitive LC-MS/HRMS assay for quantifying coproporphyrins as organic anion-transporting peptide biomarkers.

Ramanathan R, King-Ahmad AJ, Holliman CL, Rodrigues AD.

Bioanalysis. 2017 Nov;9(22):1787-1806. doi: 10.4155/bio-2017-0181. Epub 2017 Oct 5.

PMID:
28978230
36.

Impact of a timed-release FSH treatment from 2 to 6 months of age in bulls I: Endocrine and testicular development of beef bulls.

Harstine BR, Cruppe LH, Abreu FM, Rodrigues AD, Premanandan C, DeJarnette JM, Day ML.

Theriogenology. 2018 Jan 1;105:142-149. doi: 10.1016/j.theriogenology.2017.09.018. Epub 2017 Sep 21.

PMID:
28965026
37.

Impact of a timed-release FSH treatment from 2 to 6 months of age in bulls II: Endocrinology, puberty attainment, and mature sperm production in Holstein bulls.

Harstine BR, Cruppe LH, Abreu FM, Rodrigues AD, DeJarnette JM, Day ML.

Theriogenology. 2018 Jan 1;105:135-141. doi: 10.1016/j.theriogenology.2017.09.019. Epub 2017 Sep 21.

PMID:
28965025
38.

In vitro studies with two human organic anion transporters: OAT2 and OAT7.

Mathialagan S, Costales C, Tylaska L, Kimoto E, Vildhede A, Johnson J, Johnson N, Sarashina T, Hashizume K, Isringhausen CD, Vermeer LMM, Wolff AR, Rodrigues AD.

Xenobiotica. 2018 Oct;48(10):1037-1049. doi: 10.1080/00498254.2017.1384595. Epub 2017 Oct 13.

PMID:
28945155
39.

Horticulture in Portugal 1850-1900: The role of science and public utility in shaping knowledge.

Rodrigues AD, Simões A.

Ann Sci. 2017 Jul;74(3):192-213. doi: 10.1080/00033790.2017.1357083. Epub 2017 Aug 7.

PMID:
28782460
40.

A recurrent synonymous mutation in the human androgen receptor gene causing complete androgen insensitivity syndrome.

Batista RL, Rodrigues ADS, Nishi MY, Gomes NL, Faria JAD Junior, Moraes DR, Carvalho LR, Costa EMF, Domenice S, Mendonca BB.

J Steroid Biochem Mol Biol. 2017 Nov;174:14-16. doi: 10.1016/j.jsbmb.2017.07.020. Epub 2017 Jul 22.

PMID:
28743543
41.

Endogenous Probes for Drug Transporters: Balancing Vision With Reality.

Rodrigues AD, Taskar KS, Kusuhara H, Sugiyama Y.

Clin Pharmacol Ther. 2018 Mar;103(3):434-448. doi: 10.1002/cpt.749. Epub 2017 Jul 14. Review.

PMID:
28560712
42.

Correction to Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.

Aleo MD, Shah F, He K, Bonin PD, Rodrigues AD.

Chem Res Toxicol. 2017 Jun 19;30(6):1365. doi: 10.1021/acs.chemrestox.7b00124. Epub 2017 May 18. No abstract available.

PMID:
28520417
43.

Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.

Aleo MD, Shah F, He K, Bonin PD, Rodrigues AD.

Chem Res Toxicol. 2017 May 15;30(5):1219-1229. doi: 10.1021/acs.chemrestox.7b00048. Epub 2017 May 4. Erratum in: Chem Res Toxicol. 2017 Jun 19;30(6):1365.

PMID:
28437613
44.

Evaluation of Renal Transporter Inhibition Using Creatinine as a Substrate In Vitro to Assess the Clinical Risk of Elevated Serum Creatinine.

Mathialagan S, Rodrigues AD, Feng B.

J Pharm Sci. 2017 Sep;106(9):2535-2541. doi: 10.1016/j.xphs.2017.04.009. Epub 2017 Apr 14.

PMID:
28416419
45.

Leveraging of Rifampicin-Dosed Cynomolgus Monkeys to Identify Bile Acid 3-O-Sulfate Conjugates as Potential Novel Biomarkers for Organic Anion-Transporting Polypeptides.

Thakare R, Gao H, Kosa RE, Bi YA, Varma MVS, Cerny MA, Sharma R, Kuhn M, Huang B, Liu Y, Yu A, Walker GS, Niosi M, Tremaine L, Alnouti Y, Rodrigues AD.

Drug Metab Dispos. 2017 Jul;45(7):721-733. doi: 10.1124/dmd.117.075275. Epub 2017 Apr 10.

PMID:
28396527
46.

Erratum to: Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes.

Bi YA, Scialis RJ, Lazzaro S, Mathialagan S, Kimoto E, Keefer J, Zhang H, Vildhede AM, Costales C, Rodrigues AD, Tremaine LM, Varma MVS.

AAPS J. 2017 May;19(3):882. doi: 10.1208/s12248-017-0061-0. No abstract available.

PMID:
28233243
47.

Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes.

Bi YA, Scialis RJ, Lazzaro S, Mathialagan S, Kimoto E, Keefer J, Zhang H, Vildhede AM, Costales C, Rodrigues AD, Tremaine LM, Varma MVS.

AAPS J. 2017 May;19(3):787-796. doi: 10.1208/s12248-017-0051-2. Epub 2017 Feb 10. Erratum in: AAPS J. 2017 May;19(3):882.

PMID:
28188574
48.

Mid-Atlantic elasmobranchs: Suitable metal scouts?

Torres P, Tristão da Cunha R, Rodrigues ADS.

Mar Pollut Bull. 2017 Apr 15;117(1-2):203-213. doi: 10.1016/j.marpolbul.2017.01.058. Epub 2017 Feb 5.

PMID:
28179057
49.

Discovery of Highly Potent Liver X Receptor β Agonists.

Kick EK, Busch BB, Martin R, Stevens WC, Bollu V, Xie Y, Boren BC, Nyman MC, Nanao MH, Nguyen L, Plonowski A, Schulman IG, Yan G, Zhang H, Hou X, Valente MN, Narayanan R, Behnia K, Rodrigues AD, Brock B, Smalley J, Cantor GH, Lupisella J, Sleph P, Grimm D, Ostrowski J, Wexler RR, Kirchgessner T, Mohan R.

ACS Med Chem Lett. 2016 Oct 23;7(12):1207-1212. eCollection 2016 Dec 8.

50.

Extended Clearance Classification System (ECCS) informed approach for evaluating investigational drugs as substrates of drug transporters.

Varma MV, El-Kattan AF, Feng B, Steyn SJ, Maurer TS, Scott DO, Rodrigues AD, Tremaine LM.

Clin Pharmacol Ther. 2017 Jul;102(1):33-36. doi: 10.1002/cpt.595. Epub 2017 Feb 3. No abstract available.

PMID:
27984654

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