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Items: 1 to 50 of 171

1.

Quantification of Hepatic Organic Anion Transport Proteins OAT2 and OAT7 in Human Liver Tissue and Primary Hepatocytes.

Vildhede A, Kimoto E, Rodrigues AD, Varma MVS.

Mol Pharm. 2018 Jun 25. doi: 10.1021/acs.molpharmaceut.8b00320. [Epub ahead of print]

PMID:
29906129
2.

Simultaneous Assessment of Transporter-Mediated Drug-Drug Interactions Using a Probe Drug Cocktail in Cynomolgus Monkey.

Kosa RE, Lazzaro S, Bi YA, Tierney B, Gates D, Modi S, Costales C, Rodrigues AD, Tremaine LM, Varma MV.

Drug Metab Dispos. 2018 Aug;46(8):1179-1189. doi: 10.1124/dmd.118.081794. Epub 2018 Jun 7.

PMID:
29880631
3.

Species differences in bile acids II. Bile acid metabolism.

Thakare R, Alamoudi JA, Gautam N, Rodrigues AD, Alnouti Y.

J Appl Toxicol. 2018 May 29. doi: 10.1002/jat.3645. [Epub ahead of print]

PMID:
29845631
4.

Species differences in bile acids I. Plasma and urine bile acid composition.

Thakare R, Alamoudi JA, Gautam N, Rodrigues AD, Alnouti Y.

J Appl Toxicol. 2018 May 21. doi: 10.1002/jat.3644. [Epub ahead of print]

PMID:
29785833
5.

Endogenous probes for human liver organic anion-transporting polypeptides: the intersection of bioanalytical and ADME science.

Rodrigues AD.

Bioanalysis. 2018 May 1;10(9):615-618. doi: 10.4155/bio-2017-0201. Epub 2018 May 16. No abstract available.

PMID:
29768033
6.

LC-MS/MS assay for N1-methylnicotinamide in humans, an endogenous probe for renal transporters.

Luo L, Kay J, Zhang J, Holliman CL, Rodrigues AD, Dowty M, Banfield C, Ramanathan R.

Bioanalysis. 2018 May 1;10(9):673-689. doi: 10.4155/bio-2017-0272. Epub 2018 May 11.

PMID:
29749253
7.

A multiplex HRMS assay for quantifying selected human plasma bile acids as candidate OATP biomarkers.

Rago B, Tierney B, Rodrigues AD, L Holliman C, Ramanathan R.

Bioanalysis. 2018 May 1;10(9):645-657. doi: 10.4155/bio-2017-0274. Epub 2018 May 11.

PMID:
29749252
8.

A fully automated and validated human plasma LC-MS/MS assay for endogenous OATP biomarkers coproporphyrin-I and coproporphyrin-III.

King-Ahmad A, Clemens S, Ramanathan R, Zhang Y, Raha N, Zhang Y, Holliman C, Rodrigues AD, Li F.

Bioanalysis. 2018 May 1;10(9):691-701. doi: 10.4155/bio-2017-0270. Epub 2018 May 11.

PMID:
29747517
9.

Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro-In Vivo Scaling of Hepatic Uptake Clearance.

De Bruyn T, Ufuk A, Cantrill C, Kosa RE, Bi YA, Niosi M, Modi S, Rodrigues AD, Tremaine LM, Varma MVS, Galetin A, Houston JB.

Drug Metab Dispos. 2018 Jul;46(7):989-1000. doi: 10.1124/dmd.118.081315. Epub 2018 May 2.

PMID:
29720472
10.

Mus musculus bone fluoride concentration as a useful biomarker for risk assessment of skeletal fluorosis in volcanic areas.

Linhares D, Camarinho R, Garcia PV, Rodrigues ADS.

Chemosphere. 2018 Aug;205:540-544. doi: 10.1016/j.chemosphere.2018.04.144. Epub 2018 Apr 23.

PMID:
29709804
11.

In Vitro-In Vivo Extrapolation of OATP1B-Mediated Drug-Drug Interactions in Cynomolgus Monkey.

Ufuk A, Kosa RE, Gao H, Bi YA, Modi S, Gates D, Rodrigues AD, Tremaine LM, Varma MVS, Houston JB, Galetin A.

J Pharmacol Exp Ther. 2018 Jun;365(3):688-699. doi: 10.1124/jpet.118.247767. Epub 2018 Apr 11.

PMID:
29643253
12.

Comparison of Proteomic Quantification Approaches for Hepatic Drug Transporters: Multiplexed Global Quantitation Correlates with Targeted Proteomic Quantitation.

Vildhede A, Nguyen C, Erickson BK, Kunz RC, Jones R, Kimoto E, Bourbonais F, Rodrigues AD, Varma MVS.

Drug Metab Dispos. 2018 May;46(5):692-696. doi: 10.1124/dmd.117.079285. Epub 2018 Feb 8.

PMID:
29439128
13.

Role of Hepatic Organic Anion Transporter 2 in the Pharmacokinetics of R- and S-Warfarin: In Vitro Studies and Mechanistic Evaluation.

Bi YA, Lin J, Mathialagan S, Tylaska L, Callegari E, Rodrigues AD, Varma MVS.

Mol Pharm. 2018 Mar 5;15(3):1284-1295. doi: 10.1021/acs.molpharmaceut.7b01108. Epub 2018 Feb 20.

PMID:
29433307
14.

Impacts of estrus expression and intensity during a timed-AI protocol on variables associated with fertility and pregnancy success in Bos indicus-influenced beef cows.

Rodrigues AD, Cooke RF, Cipriano RS, Silva LGT, Cerri RLA, Cruppe LH, Meneghetti M, Pohler KG, Vasconcelos JLM.

J Anim Sci. 2018 Feb 15;96(1):236-249. doi: 10.1093/jas/skx043.

PMID:
29408965
15.

Organic Anion Transporter 2 Mediates Hepatic Uptake of Tolbutamide, a CYP2C9 Probe Drug.

Bi YA, Mathialagan S, Tylaska L, Fu M, Keefer J, Vildhede A, Costales C, Rodrigues AD, Varma MVS.

J Pharmacol Exp Ther. 2018 Mar;364(3):390-398. doi: 10.1124/jpet.117.245951. Epub 2018 Jan 11.

PMID:
29326367
16.

A highly selective and sensitive LC-MS/HRMS assay for quantifying coproporphyrins as organic anion-transporting peptide biomarkers.

Ramanathan R, King-Ahmad AJ, Holliman CL, Rodrigues AD.

Bioanalysis. 2017 Nov;9(22):1787-1806. doi: 10.4155/bio-2017-0181. Epub 2017 Oct 5.

PMID:
28978230
17.

Impact of a timed-release FSH treatment from 2 to 6 months of age in bulls I: Endocrine and testicular development of beef bulls.

Harstine BR, Cruppe LH, Abreu FM, Rodrigues AD, Premanandan C, DeJarnette JM, Day ML.

Theriogenology. 2018 Jan 1;105:142-149. doi: 10.1016/j.theriogenology.2017.09.018. Epub 2017 Sep 21.

PMID:
28965026
18.

Impact of a timed-release FSH treatment from 2 to 6 months of age in bulls II: Endocrinology, puberty attainment, and mature sperm production in Holstein bulls.

Harstine BR, Cruppe LH, Abreu FM, Rodrigues AD, DeJarnette JM, Day ML.

Theriogenology. 2018 Jan 1;105:135-141. doi: 10.1016/j.theriogenology.2017.09.019. Epub 2017 Sep 21.

PMID:
28965025
19.

In vitro studies with two human organic anion transporters: OAT2 and OAT7.

Mathialagan S, Costales C, Tylaska L, Kimoto E, Vildhede A, Johnson J, Johnson N, Sarashina T, Hashizume K, Isringhausen CD, Vermeer LMM, Wolff AR, Rodrigues AD.

Xenobiotica. 2017 Oct 13:1-13. doi: 10.1080/00498254.2017.1384595. [Epub ahead of print]

PMID:
28945155
20.

Horticulture in Portugal 1850-1900: The role of science and public utility in shaping knowledge.

Rodrigues AD, Simões A.

Ann Sci. 2017 Jul;74(3):192-213. doi: 10.1080/00033790.2017.1357083. Epub 2017 Aug 7.

PMID:
28782460
21.

A recurrent synonymous mutation in the human androgen receptor gene causing complete androgen insensitivity syndrome.

Batista RL, Rodrigues ADS, Nishi MY, Gomes NL, Faria JAD Junior, Moraes DR, Carvalho LR, Costa EMF, Domenice S, Mendonca BB.

J Steroid Biochem Mol Biol. 2017 Nov;174:14-16. doi: 10.1016/j.jsbmb.2017.07.020. Epub 2017 Jul 22.

PMID:
28743543
22.

Endogenous Probes for Drug Transporters: Balancing Vision With Reality.

Rodrigues AD, Taskar KS, Kusuhara H, Sugiyama Y.

Clin Pharmacol Ther. 2018 Mar;103(3):434-448. doi: 10.1002/cpt.749. Epub 2017 Jul 14. Review.

PMID:
28560712
23.

Correction to Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.

Aleo MD, Shah F, He K, Bonin PD, Rodrigues AD.

Chem Res Toxicol. 2017 Jun 19;30(6):1365. doi: 10.1021/acs.chemrestox.7b00124. Epub 2017 May 18. No abstract available.

PMID:
28520417
24.

Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.

Aleo MD, Shah F, He K, Bonin PD, Rodrigues AD.

Chem Res Toxicol. 2017 May 15;30(5):1219-1229. doi: 10.1021/acs.chemrestox.7b00048. Epub 2017 May 4.

PMID:
28437613
25.

Evaluation of Renal Transporter Inhibition Using Creatinine as a Substrate In Vitro to Assess the Clinical Risk of Elevated Serum Creatinine.

Mathialagan S, Rodrigues AD, Feng B.

J Pharm Sci. 2017 Sep;106(9):2535-2541. doi: 10.1016/j.xphs.2017.04.009. Epub 2017 Apr 14.

PMID:
28416419
26.

Leveraging of Rifampicin-Dosed Cynomolgus Monkeys to Identify Bile Acid 3-O-Sulfate Conjugates as Potential Novel Biomarkers for Organic Anion-Transporting Polypeptides.

Thakare R, Gao H, Kosa RE, Bi YA, Varma MVS, Cerny MA, Sharma R, Kuhn M, Huang B, Liu Y, Yu A, Walker GS, Niosi M, Tremaine L, Alnouti Y, Rodrigues AD.

Drug Metab Dispos. 2017 Jul;45(7):721-733. doi: 10.1124/dmd.117.075275. Epub 2017 Apr 10.

27.

Erratum to: Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes.

Bi YA, Scialis RJ, Lazzaro S, Mathialagan S, Kimoto E, Keefer J, Zhang H, Vildhede AM, Costales C, Rodrigues AD, Tremaine LM, Varma MVS.

AAPS J. 2017 May;19(3):882. doi: 10.1208/s12248-017-0061-0. No abstract available.

PMID:
28233243
28.

Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes.

Bi YA, Scialis RJ, Lazzaro S, Mathialagan S, Kimoto E, Keefer J, Zhang H, Vildhede AM, Costales C, Rodrigues AD, Tremaine LM, Varma MVS.

AAPS J. 2017 May;19(3):787-796. doi: 10.1208/s12248-017-0051-2. Epub 2017 Feb 10. Erratum in: AAPS J. 2017 May;19(3):882.

PMID:
28188574
29.

Mid-Atlantic elasmobranchs: Suitable metal scouts?

Torres P, Tristão da Cunha R, Rodrigues ADS.

Mar Pollut Bull. 2017 Apr 15;117(1-2):203-213. doi: 10.1016/j.marpolbul.2017.01.058. Epub 2017 Feb 5.

PMID:
28179057
30.

Discovery of Highly Potent Liver X Receptor β Agonists.

Kick EK, Busch BB, Martin R, Stevens WC, Bollu V, Xie Y, Boren BC, Nyman MC, Nanao MH, Nguyen L, Plonowski A, Schulman IG, Yan G, Zhang H, Hou X, Valente MN, Narayanan R, Behnia K, Rodrigues AD, Brock B, Smalley J, Cantor GH, Lupisella J, Sleph P, Grimm D, Ostrowski J, Wexler RR, Kirchgessner T, Mohan R.

ACS Med Chem Lett. 2016 Oct 23;7(12):1207-1212. eCollection 2016 Dec 8.

31.

Extended Clearance Classification System (ECCS) informed approach for evaluating investigational drugs as substrates of drug transporters.

Varma MV, El-Kattan AF, Feng B, Steyn SJ, Maurer TS, Scott DO, Rodrigues AD, Tremaine LM.

Clin Pharmacol Ther. 2016 Dec 16. doi: 10.1002/cpt.595. [Epub ahead of print] No abstract available.

PMID:
27984654
32.

Post-artificial insemination supplementation with calcium salts of soybean oil influences pregnancy establishment factors in beef cows.

Cipriano RS, Cooke RF, Rodrigues AD, Silva LG, Bohnert DW, Marques RS, Vasconcelos JL, Pires AV, Cerri RL.

J Anim Sci. 2016 Nov;94(11):4892-4902. doi: 10.2527/jas.2016-0916.

PMID:
27898968
33.

Organic Anion Transporter 2: An Enigmatic Human Solute Carrier.

Shen H, Lai Y, Rodrigues AD.

Drug Metab Dispos. 2017 Feb;45(2):228-236. doi: 10.1124/dmd.116.072264. Epub 2016 Nov 21. Review.

34.

Inhibition of Hepatobiliary Transport Activity by the Antibacterial Agent Fusidic Acid: Insights into Factors Contributing to Conjugated Hyperbilirubinemia/Cholestasis.

Lapham K, Novak J, Marroquin LD, Swiss R, Qin S, Strock CJ, Scialis R, Aleo MD, Schroeter T, Eng H, Rodrigues AD, Kalgutkar AS.

Chem Res Toxicol. 2016 Oct 4. [Epub ahead of print]

PMID:
27676153
35.

Molecular Identification and Traceability of Illegal Trading in Lignobrycon myersi (Teleostei: Characiformes), a Threatened Brazilian Fish Species, Using DNA Barcode.

Rodrigues AD, Brandão JH, Bitencourt JA, Jucá-Chagas R, Sampaio I, Schneider H, Affonso PR.

ScientificWorldJournal. 2016;2016:9382613. Epub 2016 Sep 7.

36.

Optical and transport properties correlation driven by amorphous/crystalline disorder in InP nanowires.

Kamimura H, Gouveia RC, Carrocine SC, Souza LD, Rodrigues AD, Teodoro MD, Marques GE, Leite ER, Chiquito AJ.

J Phys Condens Matter. 2016 Nov 30;28(47):475303. doi: 10.1088/0953-8984/28/47/475303. Epub 2016 Sep 23.

PMID:
27662434
37.

Transporter-Mediated Hepatic Uptake Plays an Important Role in the Pharmacokinetics and Drug-Drug Interactions of Montelukast.

Varma MV, Kimoto E, Scialis R, Bi Y, Lin J, Eng H, Kalgutkar AS, El-Kattan AF, Rodrigues AD, Tremaine LM.

Clin Pharmacol Ther. 2017 Mar;101(3):406-415. doi: 10.1002/cpt.520. Epub 2016 Nov 18.

PMID:
27648490
38.

Bioaccumulation of metals and PCBs in Raja clavata.

Torres P, Tristão da Cunha R, Micaelo C, Rodrigues ADS.

Sci Total Environ. 2016 Dec 15;573:1021-1030. doi: 10.1016/j.scitotenv.2016.08.187. Epub 2016 Sep 5.

PMID:
27607905
39.

Comprehensive evaluation of liver microsomal cytochrome P450 3A (CYP3A) inhibition: comparison of cynomolgus monkey and human.

Haarhoff ZE, Kramer MA, Zvyaga TA, Zhang J, Bhutani P, Subramanian M, Rodrigues AD.

Xenobiotica. 2017 Jun;47(6):470-478. doi: 10.1080/00498254.2016.1203042. Epub 2016 Aug 8.

PMID:
27498589
40.

Sensitivity of two biomarkers for biomonitoring exposure to fluoride in children and women: A study in a volcanic area.

Linhares DPS, Garcia PV, Amaral L, Ferreira T, Cury JA, Vieira W, Rodrigues ADS.

Chemosphere. 2016 Jul;155:614-620. doi: 10.1016/j.chemosphere.2016.04.092. Epub 2016 May 5.

PMID:
27155929
41.

Effects of different supplemental soya bean oil levels on the performance of prepubertal Saanen goats: Oestrogen and progesterone release.

Bomfim GF, Merighe GK, de Oliveira SA, Rodrigues AD, Augusto L, Teixeira IA, de Resende KT, Negrao JA.

J Anim Physiol Anim Nutr (Berl). 2016 Dec;100(6):1097-1103. doi: 10.1111/jpn.12486. Epub 2016 Feb 22.

PMID:
26898245
42.

Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro.

Zhang Y, Han YH, Putluru SP, Matta MK, Kole P, Mandlekar S, Furlong MT, Liu T, Iyer RA, Marathe P, Yang Z, Lai Y, Rodrigues AD.

Drug Metab Dispos. 2016 Mar;44(3):320-8. doi: 10.1124/dmd.115.066944. Epub 2015 Dec 29.

43.

Cynomolgus Monkey as a Clinically Relevant Model to Study Transport Involving Renal Organic Cation Transporters: In Vitro and In Vivo Evaluation.

Shen H, Liu T, Jiang H, Titsch C, Taylor K, Kandoussi H, Qiu X, Chen C, Sukrutharaj S, Kuit K, Mintier G, Krishnamurthy P, Fancher RM, Zeng J, Rodrigues AD, Marathe P, Lai Y.

Drug Metab Dispos. 2016 Feb;44(2):238-49. doi: 10.1124/dmd.115.066852. Epub 2015 Nov 25.

44.

Vascular trauma in the Amazon - the challenge of great distances.

Góes Junior AM, Rodrigues AD, Braga FB, de Andrade MC, Abib Sde C.

Rev Col Bras Cir. 2015 Jul-Aug;42(4):244-52. doi: 10.1590/0100-69912015004009. English, Portuguese.

45.

Integrated Pharmacokinetic/Pharmacodynamic Analysis for Determining the Minimal Anticipated Biological Effect Level of a Novel Anti-CD28 Receptor Antagonist BMS-931699.

Yang Z, Wang H, Salcedo TW, Suchard SJ, Xie JH, Schneeweis LA, Fleener CA, Calore JD, Shi R, Zhang SX, Rodrigues AD, Car BD, Marathe PH, Nadler SG.

J Pharmacol Exp Ther. 2015 Dec;355(3):506-15. doi: 10.1124/jpet.115.227249. Epub 2015 Oct 6.

46.

Setting Clinical Exposure Levels of Concern for Drug-Induced Liver Injury (DILI) Using Mechanistic in vitro Assays.

Shah F, Leung L, Barton HA, Will Y, Rodrigues AD, Greene N, Aleo MD.

Toxicol Sci. 2015 Oct;147(2):500-14. doi: 10.1093/toxsci/kfv152. Epub 2015 Jul 23.

PMID:
26206150
47.

[Dietary patterns in menopausal women receiving outpatient care in Southern Brazil].

Hoffmann M, Mendes KG, Canuto R, Garcez Ada S, Theodoro H, Rodrigues AD, Olinto MT.

Cien Saude Colet. 2015 May;20(5):1565-74. doi: 10.1590/1413-81232015205.07942014. Portuguese.

48.

Quantitative Rationalization of Gemfibrozil Drug Interactions: Consideration of Transporters-Enzyme Interplay and the Role of Circulating Metabolite Gemfibrozil 1-O-β-Glucuronide.

Varma MV, Lin J, Bi YA, Kimoto E, Rodrigues AD.

Drug Metab Dispos. 2015 Jul;43(7):1108-18. doi: 10.1124/dmd.115.064303. Epub 2015 May 4.

49.

Evaluation of rosuvastatin as an organic anion transporting polypeptide (OATP) probe substrate: in vitro transport and in vivo disposition in cynomolgus monkeys.

Shen H, Su H, Liu T, Yao M, Mintier G, Li L, Fancher RM, Iyer R, Marathe P, Lai Y, Rodrigues AD.

J Pharmacol Exp Ther. 2015 May;353(2):380-91. doi: 10.1124/jpet.114.221804. Epub 2015 Mar 4.

50.

Organic anion transporting polypeptide-mediated transport of, and inhibition by, asunaprevir, an inhibitor of hepatitis C virus NS3 protease.

Eley T, Han YH, Huang SP, He B, Li W, Bedford W, Stonier M, Gardiner D, Sims K, Rodrigues AD, Bertz RJ.

Clin Pharmacol Ther. 2015 Feb;97(2):159-66. doi: 10.1002/cpt.4. Epub 2014 Dec 20.

PMID:
25670521

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