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Items: 1 to 50 of 72

1.

The Role of the CXCL12/CXCR4/ACKR3 Axis in Autoimmune Diseases.

García-Cuesta EM, Santiago CA, Vallejo-Díaz J, Juarranz Y, Rodríguez-Frade JM, Mellado M.

Front Endocrinol (Lausanne). 2019 Aug 27;10:585. doi: 10.3389/fendo.2019.00585. eCollection 2019. Review.

2.

Activation of Th lymphocytes alters pattern expression and cellular location of VIP receptors in healthy donors and early arthritis patients.

Villanueva-Romero R, Gutiérrez-Cañas I, Carrión M, González-Álvaro I, Rodríguez-Frade JM, Mellado M, Martínez C, Gomariz RP, Juarranz Y.

Sci Rep. 2019 May 14;9(1):7383. doi: 10.1038/s41598-019-43717-2.

3.

Image Processing Protocol for the Analysis of the Diffusion and Cluster Size of Membrane Receptors by Fluorescence Microscopy.

Sorzano COS, Martínez-Muñoz L, Cascio G, García-Cuesta EM, Vargas J, Mellado M, Rodriguez Frade JM.

J Vis Exp. 2019 Apr 9;(146). doi: 10.3791/59314.

PMID:
31033950
4.

Separating Actin-Dependent Chemokine Receptor Nanoclustering from Dimerization Indicates a Role for Clustering in CXCR4 Signaling and Function.

Martínez-Muñoz L, Rodríguez-Frade JM, Barroso R, Sorzano CÓS, Torreño-Pina JA, Santiago CA, Manzo C, Lucas P, García-Cuesta EM, Gutierrez E, Barrio L, Vargas J, Cascio G, Carrasco YR, Sánchez-Madrid F, García-Parajo MF, Mellado M.

Mol Cell. 2018 Sep 6;71(5):873. doi: 10.1016/j.molcel.2018.08.012. No abstract available.

5.

Inhibitory Role of Growth Hormone in the Induction and Progression Phases of Collagen-Induced Arthritis.

Villares R, Criado G, Juarranz Y, Lopez-Santalla M, García-Cuesta EM, Rodríguez-Frade JM, Leceta J, Lucas P, Pablos JL, Martínez-A C, Garin MI, Gomariz RP, Mellado M.

Front Immunol. 2018 May 25;9:1165. doi: 10.3389/fimmu.2018.01165. eCollection 2018.

6.

Remodeling our concept of chemokine receptor function: From monomers to oligomers.

Martínez-Muñoz L, Villares R, Rodríguez-Fernández JL, Rodríguez-Frade JM, Mellado M.

J Leukoc Biol. 2018 Aug;104(2):323-331. doi: 10.1002/JLB.2MR1217-503R. Epub 2018 May 2. Review.

PMID:
29719064
7.

Separating Actin-Dependent Chemokine Receptor Nanoclustering from Dimerization Indicates a Role for Clustering in CXCR4 Signaling and Function.

Martínez-Muñoz L, Rodríguez-Frade JM, Barroso R, Sorzano CÓS, Torreño-Pina JA, Santiago CA, Manzo C, Lucas P, García-Cuesta EM, Gutierrez E, Barrio L, Vargas J, Cascio G, Carrasco YR, Sánchez-Madrid F, García-Parajo MF, Mellado M.

Mol Cell. 2018 Apr 5;70(1):106-119.e10. doi: 10.1016/j.molcel.2018.02.034. Erratum in: Mol Cell. 2018 Sep 6;71(5):873.

8.

Use of Lentiviral Particles As a Cell Membrane-Based mFasL Delivery System for In Vivo Treatment of Inflammatory Arthritis.

Rodríguez-Frade JM, Guedán A, Lucas P, Martínez-Muñoz L, Villares R, Criado G, Balomenos D, Reyburn HT, Mellado M.

Front Immunol. 2017 Apr 21;8:460. doi: 10.3389/fimmu.2017.00460. eCollection 2017.

9.

Use of Resonance Energy Transfer Techniques for In Vivo Detection of Chemokine Receptor Oligomerization.

Martínez-Muñoz L, Rodríguez-Frade JM, Mellado M.

Methods Mol Biol. 2016;1407:341-59. doi: 10.1007/978-1-4939-3480-5_24.

PMID:
27271913
10.

Chemokine Detection Using Receptors Immobilized on an SPR Sensor Surface.

Rodríguez-Frade JM, Martínez-Muñoz L, Villares R, Cascio G, Lucas P, Gomariz RP, Mellado M.

Methods Enzymol. 2016;570:1-18. doi: 10.1016/bs.mie.2015.09.013. Epub 2015 Nov 14. Review.

PMID:
26921939
11.

T Cell Migration in Rheumatoid Arthritis.

Mellado M, Martínez-Muñoz L, Cascio G, Lucas P, Pablos JL, Rodríguez-Frade JM.

Front Immunol. 2015 Jul 27;6:384. doi: 10.3389/fimmu.2015.00384. eCollection 2015. Review.

12.

Th17 polarization of memory Th cells in early arthritis: the vasoactive intestinal peptide effect.

Jimeno R, Leceta J, Garín M, Ortiz AM, Mellado M, Rodríguez-Frade JM, Martínez C, Pérez-García S, Gomariz RP, Juarranz Y.

J Leukoc Biol. 2015 Aug;98(2):257-69. doi: 10.1189/jlb.3A0714-327R. Epub 2015 May 8.

PMID:
25957307
13.

CXCL12 Regulates through JAK1 and JAK2 Formation of Productive Immunological Synapses.

Cascio G, Martín-Cófreces NB, Rodríguez-Frade JM, López-Cotarelo P, Criado G, Pablos JL, Rodríguez-Fernández JL, Sánchez-Madrid F, Mellado M.

J Immunol. 2015 Jun 1;194(11):5509-19. doi: 10.4049/jimmunol.1402419. Epub 2015 Apr 27.

14.

Methods to immobilize GPCR on the surface of SPR sensors.

Martínez-Muñoz L, Barroso R, Paredes AG, Mellado M, Rodríguez-Frade JM.

Methods Mol Biol. 2015;1272:173-88. doi: 10.1007/978-1-4939-2336-6_12.

PMID:
25563184
15.

CCR5/CD4/CXCR4 oligomerization prevents HIV-1 gp120IIIB binding to the cell surface.

Martínez-Muñoz L, Barroso R, Dyrhaug SY, Navarro G, Lucas P, Soriano SF, Vega B, Costas C, Muñoz-Fernández MÁ, Santiago C, Rodríguez Frade JM, Franco R, Mellado M.

Proc Natl Acad Sci U S A. 2014 May 13;111(19):E1960-9. doi: 10.1073/pnas.1322887111. Epub 2014 Apr 28.

16.

Implementation of a SPR immunosensor for the simultaneous detection of the 22K and 20K hGH isoforms in human serum samples.

de Juan-Franco E, Rodríguez-Frade JM, Mellado M, Lechuga LM.

Talanta. 2013 Sep 30;114:268-75. doi: 10.1016/j.talanta.2013.04.042. Epub 2013 Apr 30.

PMID:
23953470
17.

Real-time detection of the chemokine CXCL12 in urine samples by surface plasmon resonance.

Vega B, Calle A, Sánchez A, Lechuga LM, Ortiz AM, Armelles G, Rodríguez-Frade JM, Mellado M.

Talanta. 2013 May 15;109:209-15. doi: 10.1016/j.talanta.2013.02.018. Epub 2013 Feb 13.

PMID:
23618162
18.

CXCL12-mediated murine neural progenitor cell movement requires PI3Kβ activation.

Holgado BL, Martínez-Muñoz L, Sánchez-Alcañiz JA, Lucas P, Pérez-García V, Pérez G, Rodríguez-Frade JM, Nieto M, Marín O, Carrasco YR, Carrera AC, Alvarez-Dolado M, Mellado M.

Mol Neurobiol. 2013 Aug;48(1):217-31. doi: 10.1007/s12035-013-8451-5. Epub 2013 Apr 19.

PMID:
23606281
19.

Janus kinases 1 and 2 regulate chemokine-mediated integrin activation and naïve T-cell homing.

Pérez-Rivero G, Cascio G, Soriano SF, Sanz ÁG, de Guinoa JS, Rodríguez-Frade JM, Gomariz RP, Holgado BL, Cabañas C, Carrasco YR, Stein JV, Mellado M.

Eur J Immunol. 2013 Jul;43(7):1745-57. doi: 10.1002/eji.201243178. Epub 2013 May 17.

20.

Suppressor of cytokine signaling 1 blocks mitosis in human melanoma cells.

Parrillas V, Martínez-Muñoz L, Holgado BL, Kumar A, Cascio G, Lucas P, Rodríguez-Frade JM, Malumbres M, Carrera AC, van Wely KH, Mellado M.

Cell Mol Life Sci. 2013 Feb;70(3):545-58. doi: 10.1007/s00018-012-1145-8. Epub 2012 Sep 23.

PMID:
23001011
21.

EBI2 regulates CXCL13-mediated responses by heterodimerization with CXCR5.

Barroso R, Martínez Muñoz L, Barrondo S, Vega B, Holgado BL, Lucas P, Baíllo A, Sallés J, Rodríguez-Frade JM, Mellado M.

FASEB J. 2012 Dec;26(12):4841-54. doi: 10.1096/fj.12-208876. Epub 2012 Aug 22.

PMID:
22913878
22.

Chemokine receptor oligomerization: a further step toward chemokine function.

Muñoz LM, Holgado BL, Martínez-A C, Rodríguez-Frade JM, Mellado M.

Immunol Lett. 2012 Jul 30;145(1-2):23-9. doi: 10.1016/j.imlet.2012.04.012. Review.

PMID:
22698180
23.

Receptor oligomerization: a pivotal mechanism for regulating chemokine function.

Muñoz LM, Lucas P, Holgado BL, Barroso R, Vega B, Rodríguez-Frade JM, Mellado M.

Pharmacol Ther. 2011 Sep;131(3):351-8. doi: 10.1016/j.pharmthera.2011.05.002. Epub 2011 May 11. Review.

PMID:
21600920
24.

Technical advance: Surface plasmon resonance-based analysis of CXCL12 binding using immobilized lentiviral particles.

Vega B, Muñoz LM, Holgado BL, Lucas P, Rodríguez-Frade JM, Calle A, Rodríguez-Fernández JL, Lechuga LM, Rodríguez JF, Gutiérrez-Gallego R, Mellado M.

J Leukoc Biol. 2011 Aug;90(2):399-408. doi: 10.1189/jlb.1010565. Epub 2011 May 18.

25.

Dynamic regulation of CXCR1 and CXCR2 homo- and heterodimers.

Martínez Muñoz L, Lucas P, Navarro G, Checa AI, Franco R, Martínez-A C, Rodríguez-Frade JM, Mellado M.

J Immunol. 2009 Dec 1;183(11):7337-46. doi: 10.4049/jimmunol.0901802. Epub 2009 Nov 4.

26.

Chemokine receptor oligomerization: functional considerations.

Thelen M, Muñoz LM, Rodríguez-Frade JM, Mellado M.

Curr Opin Pharmacol. 2010 Feb;10(1):38-43. doi: 10.1016/j.coph.2009.09.004. Epub 2009 Oct 12. Review.

PMID:
19828377
27.

Chemokine receptor dimerization and chemotaxis.

Rodríguez-Frade JM, Muñoz LM, Holgado BL, Mellado M.

Methods Mol Biol. 2009;571:179-98. doi: 10.1007/978-1-60761-198-1_12.

PMID:
19763967
28.

PI3Kgamma activation by CXCL12 regulates tumor cell adhesion and invasion.

Monterrubio M, Mellado M, Carrera AC, Rodríguez-Frade JM.

Biochem Biophys Res Commun. 2009 Oct 16;388(2):199-204. doi: 10.1016/j.bbrc.2009.07.153. Epub 2009 Aug 4.

PMID:
19660434
29.

Single- and multi-analyte determination of gonadotropic hormones in urine by Surface Plasmon Resonance immunoassay.

Treviño J, Calle A, Rodríguez-Frade JM, Mellado M, Lechuga LM.

Anal Chim Acta. 2009 Aug 11;647(2):202-9. doi: 10.1016/j.aca.2009.06.002. Epub 2009 Jun 7.

PMID:
19591706
30.

Surface plasmon resonance immunoassay analysis of pituitary hormones in urine and serum samples.

Treviño J, Calle A, Rodríguez-Frade JM, Mellado M, Lechuga LM.

Clin Chim Acta. 2009 May;403(1-2):56-62. doi: 10.1016/j.cca.2009.01.015. Epub 2009 Jan 27.

PMID:
19361471
31.

Determination of human growth hormone in human serum samples by surface plasmon resonance immunoassay.

Treviño J, Calle A, Rodríguez-Frade JM, Mellado M, Lechuga LM.

Talanta. 2009 May 15;78(3):1011-6. doi: 10.1016/j.talanta.2009.01.012. Epub 2009 Jan 20.

PMID:
19269465
32.

Drug testing in cellular chemotaxis assays.

Mellado M, Martínez-A C, Rodríguez-Frade JM.

Curr Protoc Pharmacol. 2008 Jun;Chapter 12:Unit 12.11. doi: 10.1002/0471141755.ph1211s41.

PMID:
22294218
33.

Ligand stabilization of CXCR4/delta-opioid receptor heterodimers reveals a mechanism for immune response regulation.

Pello OM, Martínez-Muñoz L, Parrillas V, Serrano A, Rodríguez-Frade JM, Toro MJ, Lucas P, Monterrubio M, Martínez-A C, Mellado M.

Eur J Immunol. 2008 Feb;38(2):537-49. doi: 10.1002/eji.200737630.

34.

Chemokine receptor 2 blockade prevents asthma in a cynomolgus monkey model.

Mellado M, Martín de Ana A, Gómez L, Martínez C, Rodríguez-Frade JM.

J Pharmacol Exp Ther. 2008 Feb;324(2):769-75. Epub 2007 Nov 20.

PMID:
18029547
35.

SOCS up-regulation mobilizes autologous stem cells through CXCR4 blockade.

Pello OM, Moreno-Ortiz Mdel C, Rodríguez-Frade JM, Martínez-Muñoz L, Lucas D, Gómez L, Lucas P, Samper E, Aracil M, Martínez C, Bernad A, Mellado M.

Blood. 2006 Dec 1;108(12):3928-37. Epub 2006 Aug 15.

PMID:
16912231
36.

G protein-coupled receptor dimerization and signaling.

Mellado M, Serrano A, Martínez C, Rodríguez-Frade JM.

Methods Mol Biol. 2006;332:141-57.

PMID:
16878690
37.

Activation pathways of alpha4beta1 integrin leading to distinct T-cell cytoskeleton reorganization, Rac1 regulation and Pyk2 phosphorylation.

Maqueda A, Moyano JV, Gutiérrez-López MD, Ovalle S, Rodríguez-Frade JM, Cabañas C, Garcia-Pardo A.

J Cell Physiol. 2006 Jun;207(3):746-56.

PMID:
16514607
38.

Opioids trigger alpha 5 beta 1 integrin-mediated monocyte adhesion.

Pello OM, Duthey B, García-Bernal D, Rodríguez-Frade JM, Stein JV, Teixido J, Martínez C, Mellado M.

J Immunol. 2006 Feb 1;176(3):1675-85.

39.

A framework for computational and experimental methods: identifying dimerization residues in CCR chemokine receptors.

de Juan D, Mellado M, Rodríguez-Frade JM, Hernanz-Falcón P, Serrano A, del Sol A, Valencia A, Martínez-A C, Rojas AM.

Bioinformatics. 2005 Sep 1;21 Suppl 2:ii13-8.

PMID:
16204091
40.

Chemokine signaling defines novel targets for therapeutic intervention.

Rodríguez-Frade JM, Martínez-A C, Mellado M.

Mini Rev Med Chem. 2005 Sep;5(9):781-9. Review.

PMID:
16178721
41.

CXCR4-mediated suppressor of cytokine signaling up-regulation inactivates growth hormone function.

Garzón R, Soriano SF, Rodríguez-Frade JM, Gómez L, Martín de Ana A, Sánchez-Gómez M, Martínez-A C, Mellado M.

J Biol Chem. 2004 Oct 22;279(43):44460-6. Epub 2004 Aug 10.

42.

Leukocyte attraction through the CCR5 receptor controls progress from insulitis to diabetes in non-obese diabetic mice.

Carvalho-Pinto C, García MI, Gómez L, Ballesteros A, Zaballos A, Flores JM, Mellado M, Rodríguez-Frade JM, Balomenos D, Martínez-A C.

Eur J Immunol. 2004 Feb;34(2):548-57.

43.

Identification of amino acid residues crucial for chemokine receptor dimerization.

Hernanz-Falcón P, Rodríguez-Frade JM, Serrano A, Juan D, del Sol A, Soriano SF, Roncal F, Gómez L, Valencia A, Martínez-A C, Mellado M.

Nat Immunol. 2004 Feb;5(2):216-23. Epub 2004 Jan 11.

PMID:
14716309
44.

Blocking HIV-1 infection via CCR5 and CXCR4 receptors by acting in trans on the CCR2 chemokine receptor.

Rodríguez-Frade JM, del Real G, Serrano A, Hernanz-Falcón P, Soriano SF, Vila-Coro AJ, de Ana AM, Lucas P, Prieto I, Martínez-A C, Mellado M.

EMBO J. 2004 Jan 14;23(1):66-76. Epub 2003 Dec 11.

45.

Chemokines integrate JAK/STAT and G-protein pathways during chemotaxis and calcium flux responses.

Soriano SF, Serrano A, Hernanz-Falcón P, Martín de Ana A, Monterrubio M, Martínez C, Rodríguez-Frade JM, Mellado M.

Eur J Immunol. 2003 May;33(5):1328-33.

46.

CCR7-mediated physiological lymphocyte homing involves activation of a tyrosine kinase pathway.

Stein JV, Soriano SF, M'rini C, Nombela-Arrieta C, de Buitrago GG, Rodríguez-Frade JM, Mellado M, Girard JP, Martínez-A C.

Blood. 2003 Jan 1;101(1):38-44. Epub 2002 Jun 28.

PMID:
12393730
47.

Analysis of G-protein-coupled receptor dimerization following chemokine signaling.

Mellado M, Martínez-A C, Rodríguez-Frade JM.

Methods. 2002 Aug;27(4):349-57. Review.

PMID:
12217651
48.

Functional inactivation of CXC chemokine receptor 4-mediated responses through SOCS3 up-regulation.

Soriano SF, Hernanz-Falcón P, Rodríguez-Frade JM, De Ana AM, Garzón R, Carvalho-Pinto C, Vila-Coro AJ, Zaballos A, Balomenos D, Martínez-A C, Mellado M.

J Exp Med. 2002 Aug 5;196(3):311-21.

49.

Autocrine production of IFN-gamma by macrophages controls their recruitment to kidney and the development of glomerulonephritis in MRL/lpr mice.

Carvalho-Pinto CE, García MI, Mellado M, Rodríguez-Frade JM, Martín-Caballero J, Flores J, Martínez-A C, Balomenos D.

J Immunol. 2002 Jul 15;169(2):1058-67.

50.

The chemokine stromal cell-derived factor-1 alpha modulates alpha 4 beta 7 integrin-mediated lymphocyte adhesion to mucosal addressin cell adhesion molecule-1 and fibronectin.

Wright N, Hidalgo A, Rodríguez-Frade JM, Soriano SF, Mellado M, Parmo-Cabañas M, Briskin MJ, Teixidó J.

J Immunol. 2002 May 15;168(10):5268-77.

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